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1. 发明申请

US20060204562A1 Microprojection arrays with improved biocompatibility 审中-公开
标题翻译：具有改善的生物相容性的微型投影阵列
公开(公告)号：US20060204562A1
公开(公告)日：2006-09-14
申请号：US11355729
申请日：2006-02-15
申请人： Michel Cormier , WeiQi Lin , Cynthia Zhang , Ahmad Samiee , Rolfe Anderson
发明人： Michel Cormier , WeiQi Lin , Cynthia Zhang , Ahmad Samiee , Rolfe Anderson
IPC分类号： A61F13/02 , A61M31/00 , A61L15/16
CPC分类号： A61M37/0015 , A61K9/0021 , A61K9/06 , A61K47/10 , A61K47/38 , A61M2037/0046 , A61M2037/0053
摘要： A transdermal delivery member having a plurality of microprojections adapted to pierce the stratum corneum of a subject, each of the microprojection having a length less than 145 microns. In a preferred embodiment, each microprojection has a length in the range of approximately 50-145 microns.
摘要翻译：一种透皮递送部件，其具有适于刺穿受试者的角质层的多个微突出物，每个微突出物的长度小于145微米。在优选实施例中，每个微喷射体的长度在约50-145微米的范围内。

2. 发明申请

US20060142691A1 Apparatus and method for piercing skin with microprotrusions 有权
公开(公告)号：US20060142691A1
公开(公告)日：2006-06-29
申请号：US11092800
申请日：2005-03-28
申请人： Joseph Trautman , Richard Keenan , Ahmad Samiee , WeiQi Lin , Michel Cormier , James Matriano , Peter Daddona
发明人： Joseph Trautman , Richard Keenan , Ahmad Samiee , WeiQi Lin , Michel Cormier , James Matriano , Peter Daddona
IPC分类号： A61B17/20
CPC分类号： A61M37/0015 , A61B5/14514 , A61B5/150022 , A61B5/150908 , A61B5/150984 , A61B5/15113 , A61B5/15117 , A61B5/15142 , A61B17/205 , A61B2017/00747 , A61M2037/0023 , A61M2037/0046 , A61M2037/0061
摘要： A method and device are described for applying a microprotrusion member (44) including a plurality of microprotrusions (90) to the stratum corneum with impact. The method and device are used to improve transport of an agent across the skin for agent delivery or sampling. The applicator (10, 60, 80) causes the microprotrusion member (44) to impact the stratum corneum with a certain amount of impact determined to effectively pierce the skin with the microprotrusions (90). The preferred applicator (10, 60, 80) impacts the stratum corneum with the microprotrusion member (44) with an impact of at least 0.05 joules per cm2 of the microprotrusion member (44) in 10 msec or less.

3. 发明申请

US20050089554A1 Apparatus and method for enhancing transdermal drug delivery 审中-公开
标题翻译：用于增强透皮药物递送的装置和方法
公开(公告)号：US20050089554A1
公开(公告)日：2005-04-28
申请号：US10971430
申请日：2004-10-21
申请人： Michel Cormier , WeiQi Lin , Juanita Johnson , Kofi Nyam
发明人： Michel Cormier , WeiQi Lin , Juanita Johnson , Kofi Nyam
IPC分类号： A61K9/06 , A61K9/70 , A61K47/38 , A61L15/42 , A61L15/44 , A61L15/60 , A61M37/00 , A61F13/02 , A61L15/16 , A61M31/00
CPC分类号： A61M37/0015 , A61K9/0021 , A61K9/06 , A61K9/703 , A61K9/7084 , A61K47/38 , A61L15/425 , A61L15/44 , A61L15/60 , A61L2300/256 , A61L2300/414 , A61L2300/426 , A61L2300/43 , A61L2300/602 , A61L2300/606 , A61M2037/0023 , A61M2037/0038 , A61M2037/0046 , A61M2037/0053
摘要： An apparatus for transdermally delivering a biologically active agent comprising (i) a gel pack containing a hydrogel formulation and (ii) a microprojection member having top and bottom surfaces, a plurality of openings that extend through the microprojection member and a plurality of stratum corneum-piercing microprotrusions that project from said bottom surface of the microprojection member, the microprojection member being adapted to receive the gel pack whereby the hydrogel formulation flows through the microprojection member openings. Preferably, the hydrogel formulation comprises a water-based hydrogel.
摘要翻译：一种用于透皮递送生物活性剂的装置，包括（i）含有水凝胶制剂的凝胶组件和（ii）具有顶表面和底表面的微突出物构件，延伸穿过微喷射构件的多个开口和多个角质层 - 从微突出物构件的所述底表面突出的刺穿微突起，所述微突出物构件适于接收凝胶包，由此水凝胶制剂流过微突出物构件开口。优选地，水凝胶制剂包含水基水凝胶。

4. 发明申请

US20050106226A1 Pretreatment method and system for enhancing transdermal drug delivery 审中-公开
标题翻译：增强透皮药物输送的预处理方法和系统
公开(公告)号：US20050106226A1
公开(公告)日：2005-05-19
申请号：US10970901
申请日：2004-10-21
申请人： Michel Cormier , WeiQi Lin , Juanita Johnson , Kofi Nyam
发明人： Michel Cormier , WeiQi Lin , Juanita Johnson , Kofi Nyam
IPC分类号： A61F13/00 , A61K9/00 , A61K9/70 , A61M20060101 , A61M37/00
CPC分类号： A61K9/7084 , A61K9/0021 , A61K9/703 , A61M37/0015 , A61M2037/0023
摘要： A drug delivery system for delivering a biologically active agent through the skin of a patient comprises (i) a pretreatment patch adapted to be placed on the patient's skin, the pretreatment patch having a backing membrane and a microprojection array, the microprojection array being adhered to the backing membrane, the microprojection array including a plurality of microprojections adapted to pierce the stratum corneum of the patient, the pretreatment patch including a skin template that remains on the patient's skin after the pretreatment patch is applied to and removed from the patient's skin, and (ii) a gel patch having a top and bottom surface, the gel patch including a reservoir containing a hydrogel formulation, the gel patch having a skin contact area in the range of approximately 0.5-30 cm2.
摘要翻译：用于递送生物活性剂通过患者皮肤的药物递送系统包括（i）适于放置在患者皮肤上的预处理贴剂，所述预处理贴片具有背衬膜和微突出物阵列，所述微突出物阵列粘附到所述背衬膜，所述微突出物阵列包括适于刺穿所述患者角质层的多个微突出物，所述预处理贴片包括在将所述预处理贴片施加到患者皮肤并从患者皮肤移除之后残留在患者皮肤上的皮肤模板，以及（ii）具有顶部和底部表面的凝胶贴片，所述凝胶贴片包括含有水凝胶制剂的储存器，所述凝胶贴片具有在约0.5-30cm 2范围内的皮肤接触面积。

5. 发明申请

US20050153873A1 Frequency assisted transdermal agent delivery method and system 审中-公开
标题翻译：频率辅助透皮药物递送方法和系统
公开(公告)号：US20050153873A1
公开(公告)日：2005-07-14
申请号：US10971441
申请日：2004-10-21
申请人： Keith Chan , Michel Cormier , WeiQi Lin
发明人： Keith Chan , Michel Cormier , WeiQi Lin
IPC分类号： A61K31/4172 , A61K35/74 , A61K35/76 , A61K38/04 , A61K38/09 , A61K38/095 , A61K38/16 , A61K38/18 , A61K38/19 , A61K38/20 , A61K38/21 , A61K38/22 , A61K38/23 , A61K38/24 , A61K38/25 , A61K38/26 , A61K38/27 , A61K38/28 , A61K38/29 , A61K38/30 , A61K38/31 , A61K38/33 , A61K38/34 , A61K38/35 , A61K38/48 , A61K38/49 , A61K39/00 , A61M31/00 , A61M35/00 , A61M37/00
CPC分类号： A61M37/0092 , A61K9/0021 , A61K31/4172 , A61K38/00 , A61K2039/54 , A61M37/0015 , A61M2037/0023 , A61M2037/0046
摘要： An apparatus and method for transdermally delivering a biologically active agent comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers, a formulation containing the biologically active agent and an oscillation inducing device. In one embodiment, the biologically active agent is contained in a biocompatible coating that is applied to the microprojection member. In a further embodiment, the delivery system includes a gel pack having an agent-containing hydrogel formulation that is disposed on the microprojection member after application to the skin of a patient. In an alternative embodiment, the biologically active agent is contained in both the coating and the hydrogel formulation.
摘要翻译：一种用于透皮递送生物活性剂的装置和方法，包括具有微突出物构件（或系统）的递送系统，所述微突出物构件（或系统）包括多个微突出物（或阵列），其适于穿透角质层穿入下面的表皮层，或表皮和真皮层，含有生物活性剂和振荡诱导装置的制剂。在一个实施方案中，生物活性剂包含在施加到微喷射构件的生物相容性涂层中。在另一个实施方案中，递送系统包括具有含药剂的水凝胶制剂的凝胶包，其在施用到患者皮肤之后设置在微突出物构件上。在替代实施方案中，生物活性剂包含在涂层和水凝胶制剂中。

6. 发明申请

US20050123507A1 Formulations for coated microprojections having controlled solubility 审中-公开
标题翻译：具有受控溶解度的涂层微注射剂的制剂
公开(公告)号：US20050123507A1
公开(公告)日：2005-06-09
申请号：US11034891
申请日：2005-01-12
申请人： Mahmoud Ameri , WeiQi Lin , Michel Cormier , Yuh-Fun Maa
发明人： Mahmoud Ameri , WeiQi Lin , Michel Cormier , Yuh-Fun Maa
IPC分类号： A61B17/20 , A61K9/28 , A61M37/00 , A61K38/21 , A61K9/70 , A61K38/09 , A61K38/14 , A61K38/22 , A61K38/28
CPC分类号： A61K9/0021 , A61B17/205 , A61M37/0015 , A61M2037/0046 , A61M2037/0061
摘要： The invention provides for a formulation for coating one or more microprojections using a non-volatile counterion to improve solubility of a biologically active agent. The invention also includes formulations having a volatile counterion to reduce the solubility of a portion of the biologically active agent.
摘要翻译：本发明提供了使用非挥发性抗衡离子涂覆一种或多种微注射剂以改善生物活性剂的溶解度的制剂。本发明还包括具有挥发性抗衡离子以降低一部分生物活性剂的溶解度的制剂。

7. 发明申请

US20080226687A1 Drug delivery and method having coated microprojections incorporating vasoconstrictors 审中-公开
标题翻译：具有包含血管收缩剂的包被微粒体的药物递送和方法
公开(公告)号：US20080226687A1
公开(公告)日：2008-09-18
申请号：US12154373
申请日：2008-05-21
申请人： Michel Cormier , James Matriano , WeiQi Lin , Wendy Young
发明人： Michel Cormier , James Matriano , WeiQi Lin , Wendy Young
IPC分类号： A61K9/00 , A61K39/00 , A61K31/135 , A61K38/38
CPC分类号： A61K9/0021 , A61K45/06
摘要： A device and method are provided for percutaneous transdermal delivery of a biologically active agent. The coating formulation containing the biologically active agent and a vasoconstrictor is applied to the skin piercing elements using known coating techniques and then dried. The device is applied to the skin of a living animal, causing the microprojections to pierce the stratum corneum and to deliver an effective dose of the biologically active agent and vasoconstrictor to the animal.
摘要翻译：提供了用于经皮透皮递送生物活性剂的装置和方法。使用已知的涂覆技术将含有生物活性剂和血管收缩剂的包衣制剂施用于皮肤刺穿元件，然后干燥。将该装置应用于活的动物的皮肤，导致微突出物刺穿角质层并向动物输送有效剂量的生物活性剂和血管收缩剂。

8. 发明申请

US20050112135A1 Ultrasound assisted transdermal vaccine delivery method and system 审中-公开
标题翻译：超声辅助透皮疫苗递送方法和系统
公开(公告)号：US20050112135A1
公开(公告)日：2005-05-26
申请号：US10971338
申请日：2004-10-21
申请人： Michel Cormier , WeiQi Lin , Georg Widera
发明人： Michel Cormier , WeiQi Lin , Georg Widera
IPC分类号： A61B17/20 , A61K39/00 , A61K39/12 , A61K39/29 , A61M37/00 , A61M31/00
CPC分类号： A61B17/205 , A61K9/0009 , A61K9/0021 , A61K39/00 , A61K39/12 , A61K39/292 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61M37/0092 , C12N2730/10134
摘要： An apparatus and method for transdermally delivering a vaccine comprising a delivery system having (i) a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers and (ii) an ultrasonic device. In one embodiment, the vaccine is contained in a biocompatible coating that is applied to the microprojection member. In a further embodiment, the delivery system includes a gel pack having a vaccine-containing hydrogel formulation that is disposed on the microprojection member after application to the skin of a patient. In an alternative embodiment, the vaccine is contained in both the coating and the hydrogel formulation.
摘要翻译：一种用于经皮递送疫苗的装置和方法，包括递送系统，该递送系统具有（i）包括多个微突出物（或阵列）的微突出物构件（或系统），所述微突出物构件（或系统）适于穿透角质层进入下面的表皮层，或表皮和真皮层，和（ii）超声波装置。在一个实施方案中，疫苗被包含在施加到微喷射构件的生物相容性涂层中。在另一个实施方案中，递送系统包括具有含疫苗的水凝胶制剂的凝胶包，其在施用到患者皮肤之后设置在微突出物构件上。在替代实施方案中，疫苗包含在包衣和水凝胶制剂中。

9. 发明申请

US20060034902A1 Microprojection apparatus and system with low infection potential 审中-公开
标题翻译：具有低感染潜力的微型投影仪和系统
公开(公告)号：US20060034902A1
公开(公告)日：2006-02-16
申请号：US11201617
申请日：2005-08-10
申请人： Michel Cormier , Peter Daddona , Rolfe Anderson
发明人： Michel Cormier , Peter Daddona , Rolfe Anderson
IPC分类号： A61F13/02 , A61L15/16
CPC分类号： A61M37/0015 , A61K9/0021 , A61K9/06 , A61M2037/0023 , A61M2037/0046
摘要： A transdermal agent delivery apparatus and system having a low infection potential comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the microprojection member includes a biocompatible coating having at least one biologically active agent and at least one antimicrobial agent disposed therein. In another embodiment, the microprojection member includes a hydrogel formulation having at least one biologically active agent and at least one antimicrobial agent. In yet another embodiment, the microprojection member includes a hydrogel formulation having at least one antimicrobial agent and a solid film having at least one biologically active agent.
摘要翻译：具有低感染潜能的透皮药物递送装置和系统包括具有微突出物构件（或系统）的递送系统，所述微突出物构件（或系统）包括多个微突出物（或其阵列），所述微突出物构件（或阵列）适于穿透角质层穿入下面的表皮层，或表皮和真皮层。在一个实施方案中，微突出物构件包括具有至少一种生物活性剂和设置在其中的至少一种抗微生物剂的生物相容性涂层。在另一个实施方案中，微突出物构件包括具有至少一种生物活性剂和至少一种抗微生物剂的水凝胶制剂。在另一个实施方案中，微突出物构件包括具有至少一种抗微生物剂和具有至少一种生物活性剂的固体膜的水凝胶制剂。

10. 发明申请

US20070100274A1 Transdermal Electrotransport Delivery Device Including An Antimicrobial Compatible Reservoir Composition 有权
标题翻译：透皮电传递装置包括一种抗微生物兼容的储层组成
公开(公告)号：US20070100274A1
公开(公告)日：2007-05-03
申请号：US11556413
申请日：2006-11-03
申请人： Wendy Young , Michel Cormier
发明人： Wendy Young , Michel Cormier
IPC分类号： A61N1/30
CPC分类号： A61N1/30
摘要： A transdermal electrotransport drug delivery device having an anode, a cathode and a source of electrical power electrically connected to the anode and the cathode. At least one of the anode and the cathode includes an electrode and a reservoir comprised of a housing composed of a polymeric material and an aqueous medium in contact with the housing. The aqueous medium includes (i) a drug or an electrolyte salt or a mixture thereof, (ii) propylene glycol, and (iii) an antimicrobial agent in an amount sufficient to inhibit microbial growth in the aqueous medium. The propylene glycol prevents the antimicrobial agent from being adsorbed by other materials used in the construction of the delivery device. A process for preparing a transdermal electrotransport drug delivery device is also provided.
摘要翻译：具有电连接到阳极和阴极的阳极，阴极和电源的透皮电运输药物递送装置。阳极和阴极中的至少一个包括电极和由包含聚合物材料的外壳和与外壳接触的水性介质的容器。水性介质包括（i）药物或电解质盐或其混合物，（ii）丙二醇，和（iii）足以抑制水性介质中微生物生长的量的抗微生物剂。丙二醇防止抗微生物剂被用于构建输送装置的其它材料吸附。还提供了一种制备透皮电转运药物递送装置的方法。

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