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1. 发明申请

US20080144169A1 ILLUMINATION SOURCE FOR STAINED BIOLOGICAL SAMPLES 有权
标题翻译：不良生物样品的照射源
公开(公告)号：US20080144169A1
公开(公告)日：2008-06-19
申请号：US11611123
申请日：2006-12-14
申请人： Michael Zahniser , David Zahniser , Daniel Parsons
发明人： Michael Zahniser , David Zahniser , Daniel Parsons
IPC分类号： G02B21/06
CPC分类号： G02B21/086
摘要： A microscope illumination system includes a light source having at least four LED light sources, each LED source emitting light within a different portion of the visible spectrum. Each of the at least four LED light sources may be independently controllable. The resultant light emitted from the at least four LED sources substantially approximates that from an incandescent light source. In one embodiment, the system includes at least one red LED, at least one green LED, at least one blue LED, and at least one yellow LED. Other color combinations are also possible. The illumination may be positioned to place a sample holder such as a slide within the optical path of the light source. The system further includes an optical magnification system for magnifying an image of the biological sample. This may include a camera or traditional magnification optics.
摘要翻译：显微镜照明系统包括具有至少四个LED光源的光源，每个LED源发射在可见光谱的不同部分内的光。所述至少四个LED光源中的每一个可以是独立可控的。从至少四个LED源发射的合成光基本上接近来自白炽光源的光。在一个实施例中，该系统包括至少一个红色LED，至少一个绿色LED，至少一个蓝色LED和至少一个黄色LED。其他颜色组合也是可能的。照明可以被定位成将诸如幻灯片的样本保持器放置在光源的光路内。该系统还包括用于放大生物样品的图像的光学放大系统。这可以包括相机或传统放大光学器件。

2. 发明授权

US07561329B2 Illumination source for stained biological samples 有权
标题翻译：染色生物样品的照明来源
公开(公告)号：US07561329B2
公开(公告)日：2009-07-14
申请号：US11611123
申请日：2006-12-14
申请人： Michael Zahniser , David Zahniser , Daniel Parsons
发明人： Michael Zahniser , David Zahniser , Daniel Parsons
IPC分类号： G02B21/06 , G02B21/00
CPC分类号： G02B21/086
摘要： A microscope illumination system includes a light source having at least four LED light sources, each LED source emitting light within a different portion of the visible spectrum. Each of the at least four LED light sources may be independently controllable. The resultant light emitted from the at least four LED sources substantially approximates that from an incandescent light source. In one embodiment, the system includes at least one red LED, at least one green LED, at least one blue LED, and at least one yellow LED. Other color combinations are also possible. The illumination may be positioned to place a sample holder such as a slide within the optical path of the light source. The system further includes an optical magnification system for magnifying an image of the biological sample. This may include a camera or traditional magnification optics.
摘要翻译：显微镜照明系统包括具有至少四个LED光源的光源，每个LED源发射在可见光谱的不同部分内的光。所述至少四个LED光源中的每一个可以是独立可控的。从至少四个LED源发射的合成光基本上接近来自白炽光源的光。在一个实施例中，该系统包括至少一个红色LED，至少一个绿色LED，至少一个蓝色LED和至少一个黄色LED。其他颜色组合也是可能的。照明可以被定位成将诸如幻灯片的样本保持器放置在光源的光路内。该系统还包括用于放大生物样品的图像的光学放大系统。这可以包括相机或传统放大光学器件。

3. 发明申请

US20100021037A1 METHOD AND SYSTEM FOR IDENTIFYING BIOLOGICAL SPECIMEN SLIDES USING UNIQUE SLIDE FINGERPRINTS 有权
标题翻译：使用独特滑动指纹识别生物样本滑块的方法和系统
公开(公告)号：US20100021037A1
公开(公告)日：2010-01-28
申请号：US12340232
申请日：2008-12-19
申请人： Michael Zahniser , David Zahniser
发明人： Michael Zahniser , David Zahniser
IPC分类号： G06K9/00
CPC分类号： G02B21/244 , G02B21/34
摘要： Method and system for processing specimen slides. A first image of a unique feature, such as a fiducial mark, of a specimen slide is acquired, and a second image of the same region of a fiducial mark is acquired at a later time. The first and second fiducial mark images are compared in order to determine whether they are images of the same fiducial mark of the same specimen slide, thereby allowing the system to detect when one specimen slide has been swapped with another specimen slide. The comparison may also involve images of multiple features on the specimen carrier, e.g., sets of multiple fiducial marks.
摘要翻译：标本片的处理方法及系统。获取样本幻灯片的独特特征（例如基准标记）的第一图像，并且在稍后时间获取基准标记的相同区域的第二图像。比较第一和第二基准标记图像以确定它们是否是相同样本载玻片的相同基准标记的图像，从而允许系统检测何时一个标本载片与另一个标本载玻片交换。该比较还可以包括样本载体上的多个特征的图像，例如多个基准标记的集合。

4. 发明授权

US11047791B2 Systems and methods for sample display and review 有权
公开(公告)号：US11047791B2
公开(公告)日：2021-06-29
申请号：US13526223
申请日：2012-06-18
申请人： David Zahniser , Michael Zahniser , Adam Yie
发明人： David Zahniser , Michael Zahniser , Adam Yie
IPC分类号： G01N15/14 , G06T7/00 , G06T7/136 , G01N15/00 , G01N35/00
摘要： Methods and systems for displaying images of cells in a sample include obtaining a plurality of images of cells in the sample, where each image corresponds to one of the cells in the sample, determining values of at least one property for each of the cells based on the plurality of images, arranging the plurality of images to form a first image array, where the images are ordered in the first image array based on the values of the at least one property, displaying the first image array, sorting the plurality of images to form a second image array in which an ordering of the images is different from the first image array, and displaying the second image array, where the sample includes blood and the cells include red blood cells.

5. 发明授权

US09146247B2 Sample applicator sensing and positioning 有权
标题翻译：样品涂抹器感应和定位
公开(公告)号：US09146247B2
公开(公告)日：2015-09-29
申请号：US13549251
申请日：2012-07-13
申请人： Russell Zahniser , David Zahniser , Stephen Conroy , Eric Leknes , Michael Zahniser , Frank L. Pawlowski
发明人： Russell Zahniser , David Zahniser , Stephen Conroy , Eric Leknes , Michael Zahniser , Frank L. Pawlowski
IPC分类号： H04N7/18 , G01N35/00 , G01N1/31 , G01B11/14 , G01N35/10
CPC分类号： G01N35/00584 , G01B11/14 , G01N1/31 , G01N35/00029 , G01N35/1011 , G06K9/0014 , G06T7/11 , G06T7/12 , G06T7/50 , G06T7/70 , G06T2207/30004
摘要： Systems and methods for positioning a sample applicator relative to a substrate include: (a) obtaining an image of the sample applicator in proximity to the substrate, where the image includes a direct image region corresponding to the sample applicator and a first reflected image region corresponding to an image of the sample applicator reflected from a surface of the substrate; (b) determining a position of an edge of the sample applicator in the direct image region; (c) determining a position of a reflected edge of the sample applicator in the first reflected image region; (d) determining a distance between the edge of the sample applicator and the reflected edge of the sample applicator; and (e) determining the position of the sample applicator relative to the substrate based on the distance between the edges.
摘要翻译：用于定位样品施加器相对于基底的系统和方法包括：（a）获得样品施加器在基底附近的图像，其中图像包括对应于样品施加器的直接图像区域和对应于样品施加器的第一反射图像区域涉及从基板的表面反射的样品施加器的图像; （b）确定所述直接图像区域中所述样品施加器的边缘的位置; （c）确定所述第一反射图像区域中所述样品施加器的反射边缘的位置; （d）确定样品施加器的边缘与样品施加器的反射边缘之间的距离; 和（e）基于边缘之间的距离来确定样品施加器相对于基底的位置。

6. 发明授权

US08103072B2 Method and system for identifying biological specimen slides using unique slide fingerprints 有权
标题翻译：使用独特的幻灯片指纹识别生物标本载玻片的方法和系统
公开(公告)号：US08103072B2
公开(公告)日：2012-01-24
申请号：US12340232
申请日：2008-12-19
申请人： Michael Zahniser , David Zahniser
发明人： Michael Zahniser , David Zahniser
IPC分类号： G06K9/00
CPC分类号： G02B21/244 , G02B21/34
摘要： Method and system for processing specimen slides. A first image of a unique feature, such as a fiducial mark, of a specimen slide is acquired, and a second image of the same region of a fiducial mark is acquired at a later time. The first and second fiducial mark images are compared in order to determine whether they are images of the same fiducial mark of the same specimen slide, thereby allowing the system to detect when one specimen slide has been swapped with another specimen slide. The comparison may also involve images of multiple features on the specimen carrier, e.g., sets of multiple fiducial marks.
摘要翻译：标本片的处理方法及系统。获取样本幻灯片的独特特征（例如基准标记）的第一图像，并且在稍后时间获取基准标记的相同区域的第二图像。比较第一和第二基准标记图像以确定它们是否是相同样本载玻片的相同基准标记的图像，从而允许系统检测何时一个标本载片与另一个标本载玻片交换。该比较还可以包括样本载体上的多个特征的图像，例如多个基准标记的集合。

7. 发明申请

US20130002847A1 SYSTEMS AND METHODS FOR SAMPLE DISPLAY AND REVIEW 审中-公开
标题翻译：用于样品显示和评估的系统和方法
公开(公告)号：US20130002847A1
公开(公告)日：2013-01-03
申请号：US13526223
申请日：2012-06-18
申请人： David Zahniser , Michael Zahniser , Adam Yie
发明人： David Zahniser , Michael Zahniser , Adam Yie
IPC分类号： G09G5/32 , H04N7/18 , G09G5/02
CPC分类号： G01N15/1475 , G01N15/1429 , G01N2015/0073 , G01N2015/1465 , G01N2015/1472 , G01N2035/0091 , G06T7/0012 , G06T7/136 , G06T2207/10056 , G06T2207/30024
摘要： Methods and systems for displaying images of cells in a sample include obtaining a plurality of images of cells in the sample, where each image corresponds to one of the cells in the sample, determining values of at least one property for each of the cells based on the plurality of images, arranging the plurality of images to form a first image array, where the images are ordered in the first image array based on the values of the at least one property, displaying the first image array, sorting the plurality of images to form a second image array in which an ordering of the images is different from the first image array, and displaying the second image array, where the sample includes blood and the cells include red blood cells.
摘要翻译：用于显示样本中的细胞图像的方法和系统包括获得样本中的细胞的多个图像，其中每个图像对应于样本中的一个细胞，基于每个细胞确定至少一个特性的值所述多个图像，布置所述多个图像以形成第一图像阵列，其中基于所述至少一个属性的值在所述第一图像阵列中排列所述图像，显示所述第一图像阵列，将所述多个图像分类为形成第二图像阵列，其中图像的排序不同于第一图像阵列，并且显示第二图像阵列，其中样本包括血液，并且细胞包括红细胞。

8. 发明授权

US09041791B2 Fast auto-focus in imaging 有权
标题翻译：快速自动对焦成像
公开(公告)号：US09041791B2
公开(公告)日：2015-05-26
申请号：US13019118
申请日：2011-02-01
申请人： Michael Zahniser
发明人： Michael Zahniser
IPC分类号： H04N9/47 , H04N7/18 , H04N5/232 , G02B21/24
CPC分类号： H04N5/23212 , G02B21/244 , G06T2207/10148
摘要： The disclosure relates to methods and systems for automatically focusing multiple images of one or more objects on a substrate. The methods include obtaining, by a processor, a representative focal distance for a first location on the substrate based on a set of focal distances at known locations on the substrate. The methods also include acquiring, by an image acquisition device, a set of at least two images of the first location. The images are each acquired using a different focal distance at an offset from the representative focal distance. The methods further include estimating, by a processor, an ideal focal distance corresponding to the first location based on comparing a quality of focus for each of the images, and storing the estimated ideal focal distance and the first location in the set of focal distances at known locations.
摘要翻译：本公开涉及用于将一个或多个物体的多个图像自动聚焦在基底上的方法和系统。所述方法包括基于在基板上的已知位置处的焦距的集合，由处理器获得基板上的第一位置的代表性焦距。所述方法还包括通过图像获取装置获取第一位置的至少两个图像的集合。在与代表性的焦距偏移的情况下，使用不同的焦距来获取图像。所述方法还包括：通过处理器估计与第一位置对应的理想焦距，基于比较每个图像的焦点质量，以及将估计的理想焦距和第一位置存储在焦距集合中已知位置。

9. 发明授权

US08964171B2 Identifying and measuring reticulocytes 有权
标题翻译：识别和测量网织红细胞
公开(公告)号：US08964171B2
公开(公告)日：2015-02-24
申请号：US13549211
申请日：2012-07-13
申请人： Michael Zahniser , Russell Zahniser
发明人： Michael Zahniser , Russell Zahniser
IPC分类号： G01N33/48 , G06K9/00 , A61B5/00 , G01N15/14 , G06T7/00 , G06T7/60 , G01N15/00
CPC分类号： G01N15/1475 , G01N15/1429 , G01N15/1463 , G01N2015/0076 , G01N2015/1006 , G01N2015/1465 , G01N2015/1472 , G06K9/0014 , G06K9/46 , G06K9/4652 , G06K9/52 , G06K2009/4666 , G06T7/0012 , G06T7/62 , G06T2207/10024 , G06T2207/30004 , G06T2207/30024 , G06T2207/30242 , H04N7/18
摘要： Methods and systems for identifying reticulocytes in a blood sample deposited on a substrate include: illuminating the sample with incident light at two different wavelengths, obtaining a two-dimensional image of the sample corresponding to a first one of the wavelengths, and obtaining a two-dimensional image of the sample corresponding to a second one of the wavelengths; analyzing the images to identify a set of representative red blood cells; determining an area of each of the red blood cells in the set; determining a color value of each of the red blood cells in the set; and, for each one of the red blood cells in the set, identifying the red blood cell as a reticulocyte if the area of the red blood cell exceeds an area cutoff value and the color value of the red blood cell is less than a color cutoff value.
摘要翻译：用于识别沉积在基板上的血液样品中的网织红细胞的方法和系统包括：用两个不同波长的入射光照射样品，获得对应于第一波长的样品的二维图像，对应于第二波长的样本的三维图像; 分析图像以鉴定一组代表性的红细胞; 确定组中每个红细胞的面积; 确定所述组中的每个红细胞的颜色值; 并且对于集合中的每个红细胞，如果红细胞的面积超过区域截止值并且红细胞的颜色值小于颜色截止值，则将红细胞识别为网织红细胞值。

10. 发明申请

US20120262704A1 Measuring Volume and Constituents of Cells 有权
标题翻译：测量体积和细胞成分
公开(公告)号：US20120262704A1
公开(公告)日：2012-10-18
申请号：US13447045
申请日：2012-04-13
申请人： Michael Zahniser , Russell Zahniser
发明人： Michael Zahniser , Russell Zahniser
IPC分类号： G01N33/49
CPC分类号： G01N15/0227 , G01N15/1475 , G01N33/49 , G01N2015/0073 , G01N2015/1472 , G06K9/00127 , G06K9/0014 , G06T7/62 , G06T2207/10056 , G06T2207/30024
摘要： A method for determining a mean cell volume for a blood sample includes: illuminating the sample with incident light at a plurality of illumination wavelengths and obtaining a two-dimensional image of the sample at each of the plurality of illumination wavelengths; identifying a plurality of cells that appear in each of the images; for each one of the plurality of cells, determining an integrated optical density corresponding to each of the plurality of illumination wavelengths; for each one of the plurality of cells, determining a cell volume based on the integrated optical densities corresponding to each of the plurality of illumination wavelengths; and determining the mean cell volume for the blood sample from the cell volumes for each one of the plurality of cells.
摘要翻译：用于确定血液样本的平均细胞体积的方法包括：用多个照明波长的入射光照射样品，并在多个照明波长中的每一个处获得样品的二维图像; 识别出现在每个图像中的多个单元格; 对于所述多个单元中的每一个单元，确定与所述多个照明波长中的每一个相对应的积分光密度; 对于所述多个单元中的每一个单元，基于对应于所述多个照明波长中的每一个的所述积分光密度来确定单元体积; 以及从所述多个细胞中的每个细胞的细胞体积确定所述血液样品的平均细胞体积。

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