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1. 发明申请

US20100021037A1 METHOD AND SYSTEM FOR IDENTIFYING BIOLOGICAL SPECIMEN SLIDES USING UNIQUE SLIDE FINGERPRINTS 有权
标题翻译：使用独特滑动指纹识别生物样本滑块的方法和系统
公开(公告)号：US20100021037A1
公开(公告)日：2010-01-28
申请号：US12340232
申请日：2008-12-19
申请人： Michael Zahniser , David Zahniser
发明人： Michael Zahniser , David Zahniser
IPC分类号： G06K9/00
CPC分类号： G02B21/244 , G02B21/34
摘要： Method and system for processing specimen slides. A first image of a unique feature, such as a fiducial mark, of a specimen slide is acquired, and a second image of the same region of a fiducial mark is acquired at a later time. The first and second fiducial mark images are compared in order to determine whether they are images of the same fiducial mark of the same specimen slide, thereby allowing the system to detect when one specimen slide has been swapped with another specimen slide. The comparison may also involve images of multiple features on the specimen carrier, e.g., sets of multiple fiducial marks.
摘要翻译：标本片的处理方法及系统。获取样本幻灯片的独特特征（例如基准标记）的第一图像，并且在稍后时间获取基准标记的相同区域的第二图像。比较第一和第二基准标记图像以确定它们是否是相同样本载玻片的相同基准标记的图像，从而允许系统检测何时一个标本载片与另一个标本载玻片交换。该比较还可以包括样本载体上的多个特征的图像，例如多个基准标记的集合。

2. 发明授权

US11047791B2 Systems and methods for sample display and review 有权
公开(公告)号：US11047791B2
公开(公告)日：2021-06-29
申请号：US13526223
申请日：2012-06-18
申请人： David Zahniser , Michael Zahniser , Adam Yie
发明人： David Zahniser , Michael Zahniser , Adam Yie
IPC分类号： G01N15/14 , G06T7/00 , G06T7/136 , G01N15/00 , G01N35/00
摘要： Methods and systems for displaying images of cells in a sample include obtaining a plurality of images of cells in the sample, where each image corresponds to one of the cells in the sample, determining values of at least one property for each of the cells based on the plurality of images, arranging the plurality of images to form a first image array, where the images are ordered in the first image array based on the values of the at least one property, displaying the first image array, sorting the plurality of images to form a second image array in which an ordering of the images is different from the first image array, and displaying the second image array, where the sample includes blood and the cells include red blood cells.

3. 发明授权

US09146247B2 Sample applicator sensing and positioning 有权
标题翻译：样品涂抹器感应和定位
公开(公告)号：US09146247B2
公开(公告)日：2015-09-29
申请号：US13549251
申请日：2012-07-13
申请人： Russell Zahniser , David Zahniser , Stephen Conroy , Eric Leknes , Michael Zahniser , Frank L. Pawlowski
发明人： Russell Zahniser , David Zahniser , Stephen Conroy , Eric Leknes , Michael Zahniser , Frank L. Pawlowski
IPC分类号： H04N7/18 , G01N35/00 , G01N1/31 , G01B11/14 , G01N35/10
CPC分类号： G01N35/00584 , G01B11/14 , G01N1/31 , G01N35/00029 , G01N35/1011 , G06K9/0014 , G06T7/11 , G06T7/12 , G06T7/50 , G06T7/70 , G06T2207/30004
摘要： Systems and methods for positioning a sample applicator relative to a substrate include: (a) obtaining an image of the sample applicator in proximity to the substrate, where the image includes a direct image region corresponding to the sample applicator and a first reflected image region corresponding to an image of the sample applicator reflected from a surface of the substrate; (b) determining a position of an edge of the sample applicator in the direct image region; (c) determining a position of a reflected edge of the sample applicator in the first reflected image region; (d) determining a distance between the edge of the sample applicator and the reflected edge of the sample applicator; and (e) determining the position of the sample applicator relative to the substrate based on the distance between the edges.
摘要翻译：用于定位样品施加器相对于基底的系统和方法包括：（a）获得样品施加器在基底附近的图像，其中图像包括对应于样品施加器的直接图像区域和对应于样品施加器的第一反射图像区域涉及从基板的表面反射的样品施加器的图像; （b）确定所述直接图像区域中所述样品施加器的边缘的位置; （c）确定所述第一反射图像区域中所述样品施加器的反射边缘的位置; （d）确定样品施加器的边缘与样品施加器的反射边缘之间的距离; 和（e）基于边缘之间的距离来确定样品施加器相对于基底的位置。

4. 发明申请

US20130002847A1 SYSTEMS AND METHODS FOR SAMPLE DISPLAY AND REVIEW 审中-公开
标题翻译：用于样品显示和评估的系统和方法
公开(公告)号：US20130002847A1
公开(公告)日：2013-01-03
申请号：US13526223
申请日：2012-06-18
申请人： David Zahniser , Michael Zahniser , Adam Yie
发明人： David Zahniser , Michael Zahniser , Adam Yie
IPC分类号： G09G5/32 , H04N7/18 , G09G5/02
CPC分类号： G01N15/1475 , G01N15/1429 , G01N2015/0073 , G01N2015/1465 , G01N2015/1472 , G01N2035/0091 , G06T7/0012 , G06T7/136 , G06T2207/10056 , G06T2207/30024
摘要： Methods and systems for displaying images of cells in a sample include obtaining a plurality of images of cells in the sample, where each image corresponds to one of the cells in the sample, determining values of at least one property for each of the cells based on the plurality of images, arranging the plurality of images to form a first image array, where the images are ordered in the first image array based on the values of the at least one property, displaying the first image array, sorting the plurality of images to form a second image array in which an ordering of the images is different from the first image array, and displaying the second image array, where the sample includes blood and the cells include red blood cells.
摘要翻译：用于显示样本中的细胞图像的方法和系统包括获得样本中的细胞的多个图像，其中每个图像对应于样本中的一个细胞，基于每个细胞确定至少一个特性的值所述多个图像，布置所述多个图像以形成第一图像阵列，其中基于所述至少一个属性的值在所述第一图像阵列中排列所述图像，显示所述第一图像阵列，将所述多个图像分类为形成第二图像阵列，其中图像的排序不同于第一图像阵列，并且显示第二图像阵列，其中样本包括血液，并且细胞包括红细胞。

5. 发明申请

US20080144169A1 ILLUMINATION SOURCE FOR STAINED BIOLOGICAL SAMPLES 有权
标题翻译：不良生物样品的照射源
公开(公告)号：US20080144169A1
公开(公告)日：2008-06-19
申请号：US11611123
申请日：2006-12-14
申请人： Michael Zahniser , David Zahniser , Daniel Parsons
发明人： Michael Zahniser , David Zahniser , Daniel Parsons
IPC分类号： G02B21/06
CPC分类号： G02B21/086
摘要： A microscope illumination system includes a light source having at least four LED light sources, each LED source emitting light within a different portion of the visible spectrum. Each of the at least four LED light sources may be independently controllable. The resultant light emitted from the at least four LED sources substantially approximates that from an incandescent light source. In one embodiment, the system includes at least one red LED, at least one green LED, at least one blue LED, and at least one yellow LED. Other color combinations are also possible. The illumination may be positioned to place a sample holder such as a slide within the optical path of the light source. The system further includes an optical magnification system for magnifying an image of the biological sample. This may include a camera or traditional magnification optics.
摘要翻译：显微镜照明系统包括具有至少四个LED光源的光源，每个LED源发射在可见光谱的不同部分内的光。所述至少四个LED光源中的每一个可以是独立可控的。从至少四个LED源发射的合成光基本上接近来自白炽光源的光。在一个实施例中，该系统包括至少一个红色LED，至少一个绿色LED，至少一个蓝色LED和至少一个黄色LED。其他颜色组合也是可能的。照明可以被定位成将诸如幻灯片的样本保持器放置在光源的光路内。该系统还包括用于放大生物样品的图像的光学放大系统。这可以包括相机或传统放大光学器件。

6. 发明授权

US08103072B2 Method and system for identifying biological specimen slides using unique slide fingerprints 有权
标题翻译：使用独特的幻灯片指纹识别生物标本载玻片的方法和系统
公开(公告)号：US08103072B2
公开(公告)日：2012-01-24
申请号：US12340232
申请日：2008-12-19
申请人： Michael Zahniser , David Zahniser
发明人： Michael Zahniser , David Zahniser
IPC分类号： G06K9/00
CPC分类号： G02B21/244 , G02B21/34
摘要： Method and system for processing specimen slides. A first image of a unique feature, such as a fiducial mark, of a specimen slide is acquired, and a second image of the same region of a fiducial mark is acquired at a later time. The first and second fiducial mark images are compared in order to determine whether they are images of the same fiducial mark of the same specimen slide, thereby allowing the system to detect when one specimen slide has been swapped with another specimen slide. The comparison may also involve images of multiple features on the specimen carrier, e.g., sets of multiple fiducial marks.
摘要翻译：标本片的处理方法及系统。获取样本幻灯片的独特特征（例如基准标记）的第一图像，并且在稍后时间获取基准标记的相同区域的第二图像。比较第一和第二基准标记图像以确定它们是否是相同样本载玻片的相同基准标记的图像，从而允许系统检测何时一个标本载片与另一个标本载玻片交换。该比较还可以包括样本载体上的多个特征的图像，例如多个基准标记的集合。

7. 发明授权

US07561329B2 Illumination source for stained biological samples 有权
标题翻译：染色生物样品的照明来源
公开(公告)号：US07561329B2
公开(公告)日：2009-07-14
申请号：US11611123
申请日：2006-12-14
申请人： Michael Zahniser , David Zahniser , Daniel Parsons
发明人： Michael Zahniser , David Zahniser , Daniel Parsons
IPC分类号： G02B21/06 , G02B21/00
CPC分类号： G02B21/086
摘要： A microscope illumination system includes a light source having at least four LED light sources, each LED source emitting light within a different portion of the visible spectrum. Each of the at least four LED light sources may be independently controllable. The resultant light emitted from the at least four LED sources substantially approximates that from an incandescent light source. In one embodiment, the system includes at least one red LED, at least one green LED, at least one blue LED, and at least one yellow LED. Other color combinations are also possible. The illumination may be positioned to place a sample holder such as a slide within the optical path of the light source. The system further includes an optical magnification system for magnifying an image of the biological sample. This may include a camera or traditional magnification optics.
摘要翻译：显微镜照明系统包括具有至少四个LED光源的光源，每个LED源发射在可见光谱的不同部分内的光。所述至少四个LED光源中的每一个可以是独立可控的。从至少四个LED源发射的合成光基本上接近来自白炽光源的光。在一个实施例中，该系统包括至少一个红色LED，至少一个绿色LED，至少一个蓝色LED和至少一个黄色LED。其他颜色组合也是可能的。照明可以被定位成将诸如幻灯片的样本保持器放置在光源的光路内。该系统还包括用于放大生物样品的图像的光学放大系统。这可以包括相机或传统放大光学器件。

8. 发明授权

US09070006B2 Method and system for processing an image of a biological specimen 有权
标题翻译：用于处理生物样本图像的方法和系统
公开(公告)号：US09070006B2
公开(公告)日：2015-06-30
申请号：US11957084
申请日：2007-12-14
申请人： Kam Lin Wong , David Zahniser , Kathy Mui , Jim Linder , Ellen Sheets
发明人： Kam Lin Wong , David Zahniser , Kathy Mui , Jim Linder , Ellen Sheets
IPC分类号： G06K9/00 , G06T7/00 , G06T7/40
CPC分类号： G06T7/0012 , G06K9/00147 , G06T7/42 , G06T2207/10056 , G06T2207/30024
摘要： Components, e.g., background, cytoplasm, nucleus and nucleolus, of a biological specimen are identified using multi-wavelength analysis. Specimen components, such as nucleoli, are selected, and a determination is made whether cells having nucleoli are cancer cells or regular repair cells based on one or more physical characteristics of the identified component. The physical characteristics can be one or more of a shape, size, texture and gray value.
摘要翻译：使用多波长分析来鉴定生物样本的组分，例如背景，细胞质，细胞核和核仁。选择样品组分，例如核仁，并且基于鉴定的组分的一种或多种物理特性来确定具有核仁的细胞是癌细胞还是常规修复细胞。物理特性可以是形状，尺寸，纹理和灰度值中的一个或多个。

9. 发明申请

US20090269799A1 METHOD OF DETERMINING A COMPLETE BLOOD COUNT AND A WHITE BLOOD CELL DIFFERENTIAL COUNT 有权
标题翻译：确定完全血液计数和白血病细胞差异计数的方法
公开(公告)号：US20090269799A1
公开(公告)日：2009-10-29
申请号：US12430885
申请日：2009-04-27
申请人： James Winkelman , Milenko Tanasijevic , David Zahniser
发明人： James Winkelman , Milenko Tanasijevic , David Zahniser
IPC分类号： C12Q1/02 , C12M1/34
CPC分类号： G01N15/1475 , G01N1/2813 , G01N1/312 , G01N21/255 , G01N33/49 , G01N35/00029 , G01N35/00871 , G01N35/1016 , G01N2015/0073 , G01N2015/008 , G01N2015/0084 , G01N2015/1006 , G01N2015/1472 , G01N2015/1486 , G01N2015/1497 , G01N2035/00138 , G01N2035/00465 , G01N2035/0091 , G01N2201/062 , G01N2201/126 , G01N2333/805 , G06K9/4652 , G06K9/6267 , G06T7/0012 , H04N5/2256 , H04N5/23293 , H04N5/265
摘要： Systems and methods analyzing body fluids such as blood and bone marrow are disclosed. The systems and methods may utilize an improved technique for applying a monolayer of cells to a slide to generate a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and methods for utilizing multi color microscopy for improving the quality of images captured by a light receiving device.
摘要翻译：公开了分析体液如血液和骨髓的系统和方法。系统和方法可以利用改进的技术将单层细胞施加到载玻片上以在载玻片上产生基本均匀的细胞分布。本发明的另外方面还涉及用于利用多色显微镜来提高由光接收装置捕获的图像的质量的系统和方法。

10. 发明申请

US20090087074A1 METHODS AND SYSTEMS FOR PROCESSING BIOLOGICAL SPECIMENS UTILIZING MULTIPLE WAVELENGTHS 有权
标题翻译：用于处理多个波长的生物样本的方法和系统
公开(公告)号：US20090087074A1
公开(公告)日：2009-04-02
申请号：US11864744
申请日：2007-09-28
申请人： Kam Lin Wong , David Zahniser , Kathy Mui , James Linder , Howard Kaufman
发明人： Kam Lin Wong , David Zahniser , Kathy Mui , James Linder , Howard Kaufman
IPC分类号： G06K9/00
CPC分类号： G06K9/00147 , G06K9/033 , G06K9/6253
摘要： Methods, systems and computer readable media for processing one or more biological specimens carried by specimen slides. Images of objects in a specimen are acquired and objects of interest in the acquired images are identified. Additional images of identified objects of interest may be acquired at multiple wavelengths. Cellular features of objects of interest are extracted from images and may be used for classifying the specimen, e.g., as normal or suspicious/abnormal, based a probabilistic model that utilizes the extracted features.
摘要翻译：方法，系统和计算机可读介质，用于处理标本载玻片携带的一个或多个生物样本。获取样本中的对象的图像，并且识别获取的图像中的感兴趣对象。可以在多个波长处获取所识别的感兴趣对象的附加图像。基于提取的特征的概率模型，从图像中提取感兴趣对象的细胞特征，并且可以将其用于分类样本，例如正常或可疑/异常。

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