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1. 发明申请

US20070233202A1 METHOD OF STIMULATION FASTIGIUM NUCLEUS TO TREAT NEUROLOGICAL DISORDERS 有权
标题翻译：刺激核仁治疗神经病变的方法
公开(公告)号：US20070233202A1
公开(公告)日：2007-10-04
申请号：US11761330
申请日：2007-06-11
申请人： Michael Wallace , James Makous
发明人： Michael Wallace , James Makous
IPC分类号： A61N1/04
CPC分类号： A61N1/36082 , A61N1/36103
摘要： A method of treating a neurological disorder comprises introducing an electrical stimulation lead within a patient's head, locating the stimulation lead within the 4th ventricle of the patient's head, and placing the stimulation lead adjacent the fastigium nucleus of the patient's brain. The method may further comprise stimulating the fastigium nucleus with the stimulation lead to treat the neurological disorder, for example, by increasing the flow of blood within the patient's brain.
摘要翻译：治疗神经障碍的方法包括在患者头部内引入电刺激引线，将刺激引线定位在患者头部的第4 脑室内，并将刺激引线放置在邻近于病人的大脑该方法可以进一步包括用刺激引线刺激快镰核，以治疗神经障碍，例如通过增加患者脑内血液的流动。

2. 发明申请

US20090264973A1 Treatment Devices with Delivery-Activated Inflatable Members, and Associated Systems and Methods for Treating the Spinal Cord and Other Tissues 有权
标题翻译：具有交付活化的充气成员的治疗装置，以及用于治疗脊髓和其他组织的相关系统和方法
公开(公告)号：US20090264973A1
公开(公告)日：2009-10-22
申请号：US12104230
申请日：2008-04-16
申请人： C. Lance Boling , James Makous
发明人： C. Lance Boling , James Makous
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/0558
摘要： Treatment systems with delivery-activated inflatable members, and associated systems and methods for treating the spinal cord and other tissues are disclosed. A treatment system in accordance with one embodiment includes a lead body having an opening, an inner surface position around the opening, and an inflatable member carried by the lead body, with at least one of the inflatable member and the lead body including a frangible portion accessible from the opening. The inflatable member can have an expandable interior volume bounded at least in part by the frangible portion. The system can further include a delivery device received in the opening of the lead body and positioned to open a passage through the frangible portions between the interior volume of the inflatable member and the opening of the lead body when the delivery device is removed from the opening of the lead body.
摘要翻译：公开了具有递送活化的充气构件的治疗系统，以及用于治疗脊髓和其它组织的相关系统和方法。根据一个实施例的处理系统包括具有开口的引线主体，围绕开口的内表面位置以及由引线主体承载的可膨胀构件，所述可膨胀构件和引线主体中的至少一个包括易碎部分从开幕可以进入。可膨胀构件可以具有至少部分地由易碎部分界定的可膨胀内部体积。所述系统还可包括接纳在引线主体的开口中的输送装置，并定位成当将输送装置从开口移除时打开通过可膨胀构件的内部容积和引线本体的开口之间的易碎部分的通道的铅体。

3. 发明申请

US20070049988A1 Optimal electrode contact polarity configurations for implantable stimulation systems 审中-公开
标题翻译：可植入刺激系统的最佳电极接触极性配置
公开(公告)号：US20070049988A1
公开(公告)日：2007-03-01
申请号：US11322788
申请日：2005-12-30
申请人： Rafael Carbunaru , Kristen Jaax , Todd Whitehurst , James Makous
发明人： Rafael Carbunaru , Kristen Jaax , Todd Whitehurst , James Makous
IPC分类号： A61N1/00
CPC分类号： A61N1/375 , A61N1/3605 , A61N1/37205 , A61N1/3756
摘要： Systems for treating a patient with a medical condition include a lead having an array of electrode contacts each being programmable to have either a first polarity or a second polarity and a programming device configured to test a multiplicity of different electrode contact polarity configurations in which a programmed polarity of one or more of the electrode contacts is varied. Methods of using an implantable stimulator system include implanting a lead having an array of programmable electrode contacts disposed thereon in communication with a stimulation site, testing a multiplicity of different electrode contact polarity configurations in which a programmed polarity of one or more of the electrode contacts is varied, selecting an optimal electrode contact polarity configuration out of the multiplicity of different electrode contact polarity configurations, and applying the stimulation current via the optimal electrode contact polarity configuration to the stimulation site in accordance with one or more stimulation parameters.
摘要翻译：用于治疗患有医疗状况的患者的系统包括具有每个可编程为具有第一极性或第二极性的电极接触阵列的引线和被配置为测试多个不同电极接触极性配置的编程设备，其中编程一个或多个电极触点的极性是变化的。使用可植入刺激器系统的方法包括植入具有与刺激部位连通的可编程电极触点阵列的引线，测试多个不同的电极接触极性配置，其中一个或多个电极触点的编程极性为根据一个或多个刺激参数，通过不同电极接触极性配置的多重性选择最佳电极接触极性配置，并通过最佳电极接触极性配置将刺激电流施加到刺激部位。

4. 发明申请

US20110137372A1 METHODS AND APPARATUS FOR USING SENSORS WITH A DEEP BRAIN STIMULATION SYSTEM 有权
标题翻译：使用传感器与深层脑刺激系统的方法和装置
公开(公告)号：US20110137372A1
公开(公告)日：2011-06-09
申请号：US12959890
申请日：2010-12-03
申请人： James Makous , Brett Schleicher , Rafael Carbunaru , Kristen Jaax , Andrew DiGiore
发明人： James Makous , Brett Schleicher , Rafael Carbunaru , Kristen Jaax , Andrew DiGiore
IPC分类号： A61N1/36
CPC分类号： A61N1/36139 , A61N1/0534
摘要： A system and method for applying stimulation to a target stimulation site within a patient, while avoiding undesirable eye movement side effects of the stimulation, are provided. The method includes determining whether eye movement, sensed by internal or external electrodes, is a side effect of a conveyed electrical stimulus. If the eye movement is a side effect, the electrical current distribution of the stimulus is modified in order to steer a locus of the electrical stimulus from one tissue region of the patient to another different tissue region of the patient, thereby mitigating the eye movement side effects. For example, the locus of the electrical stimulus may be steered away from the oculomotor nerve. Eye movement side effects of DBS treatment may include apraxia of lid opening, downward movement and adduction of only one eyeball, and/or continuous deviation of both eyeballs.
摘要翻译：提供了一种用于将刺激应用于患者内的目标刺激部位同时避免刺激的不期望的眼睛运动副作用的系统和方法。该方法包括确定由内部或外部电极感测的眼睛运动是否是所传送的电刺激的副作用。如果眼睛运动是副作用，则刺激的电流分布被修改以便将电刺激的轨迹从患者的一个组织区域引导到患者的另一不同组织区域，从而减轻眼睛运动侧效果。例如，电刺激的轨迹可以被转向离开眼动神经。 DBS治疗的眼睛运动副作用可能包括盖开口的不适，仅有一只眼球的向下运动和内收，和/或两只眼球的连续偏差。

5. 发明申请

US20110019858A1 METHOD AND APPARATUS TO ENHANCE COMMUNICATION IN THE OPERATING ROOM 失效
标题翻译：提高操作室通信的方法和装置
公开(公告)号：US20110019858A1
公开(公告)日：2011-01-27
申请号：US12506938
申请日：2009-07-21
申请人： Todd K. Whitehurst , Rafael Carbunaru , Kristen Jaax , James Makous , Courtney Lane , Mark Pierre , Cliff Brainard , Charles Tilden Hagan, IV
发明人： Todd K. Whitehurst , Rafael Carbunaru , Kristen Jaax , James Makous , Courtney Lane , Mark Pierre , Cliff Brainard , Charles Tilden Hagan, IV
IPC分类号： H04R11/04
CPC分类号： H04R1/028 , H04R1/14 , H04R2201/023
摘要： A communication system is provided for a patient featuring a cushion with an opening for receiving the face of the patient. The cushion includes a microphone for receiving audible signals from the patient and one or more speakers for delivering audible signals to the patient. The microphone and speaker(s) are integrated with the cushion to avoid interfering with the comfort of the patient. In one embodiment, the audible signals are delivered to and from the patient via a communication port. In another embodiment, the system includes a display device, so the patient may view parts of the patient's body on the device and then communicate with system operators through the microphone and speaker(s).
摘要翻译：为患者提供通信系统，其特征在于具有用于接收患者面部的开口的缓冲垫。垫子包括用于从患者接收听觉信号的麦克风和用于向患者传递可听信号的一个或多个扬声器。麦克风和扬声器与衬垫集成，以避免干扰患者的舒适度。在一个实施例中，可听信号经由通信端口传递给患者和从患者传送。在另一个实施例中，系统包括显示装置，因此患者可以在装置上观察患者身体的部分，然后通过麦克风和扬声器与系统操作者通信。

6. 发明授权

US08670833B2 Methods and apparatus for using sensors with a deep brain stimulation system 有权
标题翻译：使用具有深脑刺激系统的传感器的方法和装置
公开(公告)号：US08670833B2
公开(公告)日：2014-03-11
申请号：US12959890
申请日：2010-12-03
申请人： James Makous , Brett Schleicher , Rafael Carbunaru , Kristen Jaax , Andrew DiGiore
发明人： James Makous , Brett Schleicher , Rafael Carbunaru , Kristen Jaax , Andrew DiGiore
IPC分类号： A61N1/00
CPC分类号： A61N1/36139 , A61N1/0534
摘要： A system and method for applying stimulation to a target stimulation site within a patient, while avoiding undesirable eye movement side effects of the stimulation, are provided. The method includes determining whether eye movement, sensed by internal or external electrodes, is a side effect of a conveyed electrical stimulus. If the eye movement is a side effect, the electrical current distribution of the stimulus is modified in order to steer a locus of the electrical stimulus from one tissue region of the patient to another different tissue region of the patient, thereby mitigating the eye movement side effects. For example, the locus of the electrical stimulus may be steered away from the oculomotor nerve. Eye movement side effects of DBS treatment may include apraxia of lid opening, downward movement and adduction of only one eyeball, and/or continuous deviation of both eyeballs.
摘要翻译：提供了一种用于将刺激应用于患者内的目标刺激部位同时避免刺激的不期望的眼睛运动副作用的系统和方法。该方法包括确定由内部或外部电极感测的眼睛运动是否是所传送的电刺激的副作用。如果眼睛运动是副作用，则刺激的电流分布被修改以便将电刺激的轨迹从患者的一个组织区域引导到患者的另一不同组织区域，从而减轻眼睛运动侧效果。例如，电刺激的轨迹可以被转向离开眼动神经。 DBS治疗的眼睛运动副作用可能包括盖开口的不适，仅有一只眼球的向下运动和内收，和/或两只眼球的连续偏差。

7. 发明授权

US08326439B2 Treatment devices with delivery-activated inflatable members, and associated systems and methods for treating the spinal cord and other tissues 有权
标题翻译：具有递送活化的充气构件的治疗装置，以及用于治疗脊髓和其他组织的相关系统和方法
公开(公告)号：US08326439B2
公开(公告)日：2012-12-04
申请号：US12104230
申请日：2008-04-16
申请人： C. Lance Boling , James Makous
发明人： C. Lance Boling , James Makous
IPC分类号： A61N1/04 , A61N1/375
CPC分类号： A61N1/05 , A61N1/0558
摘要： The present application includes treatment systems having delivery-activated inflatable members, and associated systems and methods for treating the spinal cord and other tissues. A treatment system in accordance with one embodiment includes a lead body having an opening, an inner surface position around the opening, and an inflatable member carried by the lead body, with at least one of the inflatable member and the lead body including a frangible portion accessible from the opening. The inflatable member can have an expandable interior volume bounded at least in part by the frangible portion. The system can further include a delivery device received in the opening of the lead body and positioned to open a passage through the frangible portions between the interior volume of the inflatable member and the opening of the lead body when the delivery device is removed from the opening of the lead body.
摘要翻译：本申请包括具有递送活化的可膨胀构件的治疗系统以及用于治疗脊髓和其他组织的相关系统和方法。根据一个实施例的处理系统包括具有开口的引线主体，围绕开口的内表面位置以及由引线主体承载的可膨胀构件，所述可膨胀构件和引线主体中的至少一个包括易碎部分从开幕可以进入。可膨胀构件可以具有至少部分地由易碎部分界定的可膨胀内部体积。所述系统还可包括接纳在引线主体的开口中的输送装置，并定位成当将输送装置从开口移除时打开通过可膨胀构件的内部容积和引线本体的开口之间的易碎部分的通道的铅体。

8. 发明授权

US08320600B2 Method and apparatus to enhance communication in the operating room 失效
标题翻译：加强手术室通讯的方法和装置
公开(公告)号：US08320600B2
公开(公告)日：2012-11-27
申请号：US12506938
申请日：2009-07-21
申请人： Todd K. Whitehurst , Rafael Carbunaru , Kristen Jaax , James Makous , Courtney Lane , Mark Pierre , Cliff Brainard , Charles Tilden Hagan, IV
发明人： Todd K. Whitehurst , Rafael Carbunaru , Kristen Jaax , James Makous , Courtney Lane , Mark Pierre , Cliff Brainard , Charles Tilden Hagan, IV
IPC分类号： H04R11/04
CPC分类号： H04R1/028 , H04R1/14 , H04R2201/023
摘要： A communication system is provided for a patient featuring a cushion with an opening for receiving the face of the patient. The cushion includes a microphone for receiving audible signals from the patient and one or more speakers for delivering audible signals to the patient. The microphone and speaker(s) are integrated with the cushion to avoid interfering with the comfort of the patient. In one embodiment, the audible signals are delivered to and from the patient via a communication port. In another embodiment, the system includes a display device, so the patient may view parts of the patient's body on the device and then communicate with system operators through the microphone and speaker(s).
摘要翻译：为患者提供通信系统，其特征在于具有用于接收患者面部的开口的缓冲垫。垫子包括用于从患者接收听觉信号的麦克风和用于向患者传递可听信号的一个或多个扬声器。麦克风和扬声器与衬垫集成，以避免干扰患者的舒适度。在一个实施例中，可听信号经由通信端口传递给患者和从患者传送。在另一个实施例中，系统包括显示装置，因此患者可以在装置上观察患者身体的部分，然后通过麦克风和扬声器与系统操作者通信。

9. 发明申请

US20060206165A1 Occipital nerve stimulation to treat headaches and other conditions 审中-公开
标题翻译：枕神经刺激治疗头痛等症状
公开(公告)号：US20060206165A1
公开(公告)日：2006-09-14
申请号：US11256356
申请日：2005-10-21
申请人： Kristen Jaax , Todd Whitehurst , Rafael Carbunaru , James Makous
发明人： Kristen Jaax , Todd Whitehurst , Rafael Carbunaru , James Makous
IPC分类号： A61N1/34
CPC分类号： A61N1/0529 , A61N1/0534 , A61N1/08 , A61N1/36071
摘要： A method of treating headaches includes stimulating a nerve in a patient's head with an electrode implanted over the skull on a posterior or superior portion of the patient's head to alleviate headache pain.
摘要翻译：治疗头痛的方法包括用位于患者头部的后部或上部的颅骨上植入的电极刺激患者头部的神经以减轻头痛。

10. 发明申请

US20050267555A1 Engagement tool for implantable medical devices 审中-公开
标题翻译：可植入医疗器械的接合工具
公开(公告)号：US20050267555A1
公开(公告)日：2005-12-01
申请号：US11136938
申请日：2005-05-24
申请人： Goran Marnfeldt , Rafael Carbunaru , Kelly McClure , Matthew Haller , Tom He , Todd Whitehurst , Meredith Anderson , James Makous , Kristen Jaax , Peter Johnson
发明人： Goran Marnfeldt , Rafael Carbunaru , Kelly McClure , Matthew Haller , Tom He , Todd Whitehurst , Meredith Anderson , James Makous , Kristen Jaax , Peter Johnson
IPC分类号： A61B17/22 , A61B17/32 , A61B17/34 , A61B19/00 , A61N1/00 , A61N1/05 , A61N1/08
CPC分类号： A61B17/3417 , A61B17/221 , A61B17/32056 , A61B17/3468 , A61B90/30 , A61B2017/00358 , A61B2017/22035 , A61B2017/2215 , A61B2017/320044 , A61N1/05 , A61N1/08
摘要： Systems for adjusting a position of an implanted medical device within a patient include an engagement tool configured to couple to the implanted medical device. The engagement tool adjusts the position of the medical device when coupled to the implanted medical device. Methods of adjusting a position of an implanted medical device within a patient include locating the implanted medical device, coupling an engagement tool to the medical device, and adjusting a position of the engagement tool to adjust the position of the medical device.
摘要翻译：用于调整患者内植入的医疗装置的位置的系统包括被配置为耦合到植入的医疗装置的接合工具。接合工具当耦合到植入的医疗装置时调节医疗装置的位置。调整患者内的植入医疗装置的位置的方法包括定位植入的医疗装置，将接合工具联接到医疗装置，以及调整接合工具的位置以调整医疗装置的位置。

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