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1. 发明授权

US5387402A Contact reactor for a quasi-isothermal catalytic oxidation of SO.sub.2 to SO.sub.3 and method of operating same 失效
标题翻译：接触反应器进行准等温催化氧化SO2至SO3及其操作方法
公开(公告)号：US5387402A
公开(公告)日：1995-02-07
申请号：US66301
申请日：1993-05-21
申请人： Michael Tacke , Peter Ahrens , Hugo Grimm , Heinz Neumann , Egon Winkler , Arend Werner , Walter Beitelschmidt , Bruno Triebskorn
发明人： Michael Tacke , Peter Ahrens , Hugo Grimm , Heinz Neumann , Egon Winkler , Arend Werner , Walter Beitelschmidt , Bruno Triebskorn
IPC分类号： B01J8/02 , C01B17/80 , F28D7/00 , B01D50/00 , F01N3/10
CPC分类号： B01J8/0285 , B01J8/0278 , C01B17/803 , B01J2208/00132
摘要： To effect a quasi-isothermal catalytic reaction of SO.sub.2 to SO.sub.3, a plurality of consecutive rows of banks of cooling tubes, are provided in the bed of shaped catalyst bodies in a contact reactor in such a manner that the banks of succeeding rows are staggered from the banks of the preceding rows. The distance between the cooling tubes in the banks is so selected that a penetration of entire catalyst bodies into the banks will virtually be prevented. The banks are so designed that the pressure drop of the gas in the banks is approximately the same as the pressure drop in the layer of catalyst between the bank. The distance between the banks is larger than the width of the banks.
摘要翻译：为了实现SO2与SO3的准等温催化反应，在接触反应器中的成形催化剂体床中设置多个连续排的冷却管排，使得后续排的排与前一行的行。两组中的冷却管之间的距离如此选择，从而实际上可以防止整个催化剂体渗入到组中。这些堤设计成使得堤岸中的气体的压降几乎与堤岸之间的催化剂层的压降相同。银行之间的距离大于银行的宽度。

2. 发明授权

US4910011A Process of purifying flue gases 失效
标题翻译：烟道气净化工艺
公开(公告)号：US4910011A
公开(公告)日：1990-03-20
申请号：US284210
申请日：1988-12-14
申请人： Karl-Heinz Dorr , Hugo Grimm , Heinz Neumann , Norbert Olhms
发明人： Karl-Heinz Dorr , Hugo Grimm , Heinz Neumann , Norbert Olhms
IPC分类号： B01D53/50 , B01D53/77 , B01D53/86 , B01D53/94
CPC分类号： B01D53/8637
摘要： In flue gases or other humid exhaust gases which are relatively cold and contain SO.sub.2, NO.sub.2 and other gaseous pollutants, the SO.sub.2 content is oxidized to SO.sub.3 and the NO content is reduced by a catalytic treatment, the SO.sub.3 content is condensed as sulfuric acid and other gaseous pollutants are removed by being scrubbed with aqueous liquids at low temperatures. In order to heat up the flue gas to the temperature required for the catalysis, the flue gas is heated up in a first heating-up stage by an indirect heat exchange with the catalytically treated gas before the catalytic treatment, the heated-up gas is heated up further in a second heating-up stage to the temperature required for the catalytic treatment, the catalytically treated gas which has been cooled in the first heating-up stage is cooled further in an indirect heat exchanger below the dew point temperature of sulfuric acid and is subsequently fed to an SO.sub.3 condenser. The remaining sulfuric acid vapor is absorbed by sprayed dilute sulfuric acid to form a dilute sulfuric acid having a predetermined concentration, the gas leaving the SO.sub.3 condenser is scrubbed in a scrubber with a sprayed aqueous liquid and is thus cooled to 40.degree. to 60.degree. C. and the purified gas is reheated to the required chimney inlet temperature.
摘要翻译：在相对较冷且含有SO2，NO2和其他气态污染物的烟道气或其他潮湿废气中，SO2含量被氧化为SO3，通过催化处理使NO含量降低，SO3含量以硫酸等浓缩通过在低温下用含水液体洗涤除去气态污染物。为了将烟气加热至催化所需的温度，在催化处理之前，通过与催化处理气体的间接热交换，在第一加热阶段将烟道气加热，加热气体为在第二加热阶段进一步加热到催化处理所需的温度，在第一加热阶段中被冷却的催化处理气体在低于硫酸露点温度的间接热交换器中进一步冷却并随后进料至SO 3冷凝器。剩余的硫酸蒸气被喷射的稀硫酸吸收，形成具有预定浓度的稀硫酸，离开SO 3冷凝器的气体在洗涤器中用喷射的水性液体洗涤，并被冷却至40℃至60℃ 并将净化的气体再加热至所需的烟囱入口温度。

3. 发明授权

US4842835A Process of purifying flue gases 失效
标题翻译：烟道气净化工艺
公开(公告)号：US4842835A
公开(公告)日：1989-06-27
申请号：US74645
申请日：1987-07-17
申请人： Karl H. Dorr , Hugo Grimm , Heinz Neumann , Wolfgang Fennemann , Norbert Ohlms
发明人： Karl H. Dorr , Hugo Grimm , Heinz Neumann , Wolfgang Fennemann , Norbert Ohlms
IPC分类号： B01D53/34 , B01D5/00 , B01D53/50 , B01D53/77 , B01D53/86 , C01B17/74
CPC分类号： B01D53/8637 , C01B17/74
摘要： Flue gases or other contaminated humid exhaust gases which contain SO.sub.3 are cooled by an indirect heat exchange in a heat exchanger to a temperature below the dew point temperature of sulfuric acid and are cooled further to a predetermined temperature in an SO.sub.3 condenser by means of dilute sulfuric acid, which is sprayed to flow in a countercurrent to the gas, whereby dilute sulfuric acid having a predetermined concentration is condensed. The gas leaving the SO.sub.3 condenser is scrubbed and cooled to a temperature from 40.degree. to 55.degree. C. in a fine scrubber by a treatment with a sprayed aqueous liquor. The exit gas is reheated to a predetermined temperature in a reheater by a treatment with sprayed dilute sulfuric acid from the SO.sub.3 and after the condensation of SO.sub.3 is passed through a filter. Dilute sulfuric acid from the reheater is sprayed into the SO.sub.3 condenser. The temperature of the gas in the reheater is so selected that the water which has been absorbed is not condensed but remains in the gaseous effluent. The exit temperature of the gas leaving the heat exchanger is approximately so selected that the temperature at which dilute sulfuric acid becomes available is approximately the same as the temperature of the gas in the reheater. The rate at which dilute sulfuric acid is sprayed is so adjusted that the dilute sulfuric acid withdrawn from the fine scrubber is at a temperature which is approximately the same as the required exit temperature of the gas leaving the SO.sub.3 condenser.
摘要翻译：含有SO 3的烟气或其它受污染的潮湿废气通过在热交换器中的间接热交换冷却到低于硫酸露点温度的温度，并通过稀硫酸在SO 3冷凝器中进一步冷却至预定温度酸，其被喷射以与气体逆流流动，由此浓缩具有预定浓度的稀硫酸。离开SO 3冷凝器的气体通过用喷射的含水液体处理在细洗涤器中被洗涤并冷却至40℃至55℃的温度。通过用SO 3的喷射稀硫酸处理并且在SO 3的冷凝通过过滤器之后，将出口气体在再热器中再加热至预定温度。将稀硫酸从再热器喷入SO 3冷凝器。再热器中的气体的温度如此选择，使得被吸收的水不会冷凝，而是保留在气态流出物中。离开热交换器的气体的出口温度大致如此选择，使得稀硫酸可用的温度与再热器中的气体的温度大致相同。调节稀硫酸的速率被调整为使得从精细洗涤器中排出的稀硫酸处于与离开SO 3冷凝器的气体的出口温度大致相同的温度。

4. 发明授权

US4834954A Process for cleaning flue gases 失效
标题翻译：清洁烟气的工艺
公开(公告)号：US4834954A
公开(公告)日：1989-05-30
申请号：US67658
申请日：1987-06-26
申请人： Karl H. Dorr , Hugo Grimm , Heinz Neumann , Rudolf Gerken , Gunter Lailach
发明人： Karl H. Dorr , Hugo Grimm , Heinz Neumann , Rudolf Gerken , Gunter Lailach
IPC分类号： F23J15/00 , B01D53/34 , B01D53/50 , B01D53/68 , B01D53/77 , F23J15/08
CPC分类号： B01D53/34 , B01D53/507 , B01D53/68 , F23J15/08
摘要： Cleaned flue gases normally accumulate as steam-saturated gases with temperatures of from 40.degree. to 55.degree. C. after wet cleaning processes for the removal of sulfur and/or nitrogen compounds. Before being let off through a stack, however, these gases have to be heated to at least 72.degree. C.This invention relates to a process for reheating flue gases after wet cleaning.
摘要翻译：清洁的烟道气体通常在湿法清洗过程中作为蒸汽饱和气体积聚，温度为40-55℃，以除去硫和/或氮化合物。然而，在通过堆放出之前，这些气体必须被加热到至少72℃。本发明涉及在湿清洗后再加热烟道气的方法。

5. 发明授权

US09868956B2 Methods 有权
公开(公告)号：US09868956B2
公开(公告)日：2018-01-16
申请号：US13376068
申请日：2010-06-02
申请人： Duy P. Nguyen , Heinz Neumann , Alexander Deiters , Jason Chin , Hrvoje Lusic
发明人： Duy P. Nguyen , Heinz Neumann , Alexander Deiters , Jason Chin , Hrvoje Lusic
IPC分类号： C12P21/06 , C12N15/67 , C07C233/49 , C07C271/22 , C12N9/00 , C12P21/02
CPC分类号： C12N15/67 , C07C233/49 , C07C271/22 , C12N9/93 , C12P21/02
摘要： The invention relates to a method of making a polypeptide comprising an orthogonal functional group, said orthogonal functional group being comprised by an aliphatic amino acid or amino acid derivative, said method comprising providing a host cell; providing a nucleic acid encoding the polypeptide of interest; providing a tRNA-tRNA synthetase pair orthogonal to said host cell; adding an amino acid or amino acid derivative comprising the orthogonal functional group of interest, wherein said amino acid or amino acid derivative is a substrate for said orthogonal tRNA synthetase, wherein said amino acid or amino acid derivative has an aliphatic carbon backbone; and incubating to allow incorporation of said amino acid or amino acid derivative into the polypeptide of interest via the orthogonal tRNA-tRNA synthetase pair. The invention also relates to certain amino acids, and to polypeptides comprising same.

6. 发明申请

US20120264926A1 Orthogonal Q-Ribosomes 审中-公开
标题翻译：正交Q-核糖体
公开(公告)号：US20120264926A1
公开(公告)日：2012-10-18
申请号：US13517372
申请日：2010-12-20
申请人： Jason Chin , Kaihang Wang , Heinz Neumann
发明人： Jason Chin , Kaihang Wang , Heinz Neumann
IPC分类号： C07H21/02 , C07H1/00
CPC分类号： C12N15/11 , C12P21/02
摘要： The invention relates to 16S rRNA comprising a mutation at A1196, and to 16S rRNA further comprising a mutation at C1195 and/or A1197, and to 16S rRNA which comprises (i) C1195A and A1196G; or (ii) C1195T, A1196G and A1197G; or (iii) A1196G and A1197G. The invention also relates to ribosomes comprising such 16S rRNAs and to use of same.
摘要翻译：本发明涉及包含A1196突变的16S rRNA和进一步包含C1195和/或A1197突变的16S rRNA和16S rRNA，其包含（i）C1195A和A1196G; 或（ii）C1195T，A1196G和A1197G; 或（iii）A1196G和A1197G。本发明还涉及包含这种16S rRNA的核糖体并使用它们。

7. 发明申请

US20110027829A1 Methods and Compositions 审中-公开
标题翻译：方法和组成
公开(公告)号：US20110027829A1
公开(公告)日：2011-02-03
申请号：US12739247
申请日：2008-10-27
申请人： Heinz Neumann , Jason Chin
发明人： Heinz Neumann , Jason Chin
IPC分类号： C12P21/00 , C12N9/00 , C07H21/00 , C07K2/00 , C07K14/00 , C12N15/63 , C12N1/00
CPC分类号： C12P21/02 , C12N9/93
摘要： The invention relates to a tRNA synthetase capable of binding N⊂-acetyl lysine, in particular, the invention relates to a tRNA synthetase capable of binding N∈-acetyl lysine wherein said synthetase comprises a polypeptide having at least 90% sequence identity to the amino acid sequence of MbPy1RS. The invention also relates to a method of making a polypeptide comprising N∈-acetyl lysine comprising arranging for the translation of a RNA encoding said polypeptide, wherein said RNA comprises an amber codon, wherein said translation is carried out in the presence of a polypeptide according to any of claims 1 to 11 and in the presence of tRNA capable of being charged with N∈-acetyl lysine, and in the presence of N∈-acetyl lysine.
摘要翻译：本发明涉及能够结合N-乙酰赖氨酸的tRNA合成酶，特别地，本发明涉及能够结合Nε-乙酰赖氨酸的tRNA合成酶，其中所述合成酶包含与氨基具有至少90％序列同一性的多肽 MbPy1RS的酸序列。本发明还涉及一种制备包含Nε-乙酰赖氨酸的多肽的方法，包括安排编码所述多肽的RNA的翻译，其中所述RNA包含琥珀密码子，其中所述翻译在多肽存在下进行，权利要求1至11中任一项，并且在存在能够被Nε-乙酰赖氨酸加载的tRNA存在下，并且在Nε-乙酰赖氨酸存在下。

8. 发明申请

US20100105565A1 Evolved Orthogonal Ribosomes 失效
标题翻译：进化正交核糖体
公开(公告)号：US20100105565A1
公开(公告)日：2010-04-29
申请号：US12516230
申请日：2007-11-28
申请人： Jason Chin , Kaihang Wang , Heinz Neumann
发明人： Jason Chin , Kaihang Wang , Heinz Neumann
IPC分类号： C40B30/00 , C07H21/02 , C12P21/06 , C12N1/21
CPC分类号： C12N15/11 , C12N15/111 , C12N2320/13 , C12P21/02 , C40B10/00 , C40B40/08
摘要： There is provided a method for evolving an orthogonal rRNA molecule, comprising the steps of: providing one or more libraries of mutant orthogonal rRNA molecules and introducing the libraries into cells such that the orthogonal rRNA is incorporated into ribosomes to provide orthogonal ribosomes; providing one or more orthogonal mRNA molecules which (i) are not translated by natural ribosomes, and (ii) comprise one or more orthogonal mRNA codons; assaying the translation of the of the orthogonal mRNA and selecting the orthogonal rRNA molecules which translate the orthogonal mRNA, wherein the assay in step (c) requires translation of one or more orthogonal mRNA codons in the orthogonal mRNA; and orthogonal ribosomes incorporating such rRNA molecules.
摘要翻译：提供了用于进化正交rRNA分子的方法，包括以下步骤：提供一个或多个突变正交rRNA分子文库，并将文库引入细胞，使得正交rRNA被并入核糖体中以提供正交核糖体; 提供（i）不被天然核糖体翻译的一个或多个正交mRNA分子，和（ii）包含一个或多个正交mRNA密码子; 测定正交mRNA的翻译并选择翻译正交mRNA的正交rRNA分子，其中步骤（c）中的测定需要在正交mRNA中翻译一个或多个正交mRNA密码子; 并结合这样的rRNA分子的正交核糖体。

9. 发明授权

US08497231B2 Evolved orthogonal ribosomes 失效
标题翻译：进化正交核糖体
公开(公告)号：US08497231B2
公开(公告)日：2013-07-30
申请号：US12516230
申请日：2007-11-28
申请人： Jason Chin , Kaihang Wang , Heinz Neumann
发明人： Jason Chin , Kaihang Wang , Heinz Neumann
IPC分类号： C40B50/06 , C07H21/02 , A61K38/00 , C07K4/00
CPC分类号： C12N15/11 , C12N15/111 , C12N2320/13 , C12P21/02 , C40B10/00 , C40B40/08
摘要： There is provided a method for evolving an orthogonal rRNA molecule, comprising the steps of: providing one or more libraries of mutant orthogonal rRNA molecules and introducing the libraries into cells such that the orthogonal rRNA is incorporated into ribosomes to provide orthogonal ribosomes; providing one or more orthogonal mRNA molecules which (i) are not translated by natural ribosomes, and (ii) comprise one or more orthogonal mRNA codons; assaying the translation of the orthogonal mRNA and selecting the orthogonal rRNA molecules which translate the orthogonal mRNA, wherein the assay in step (c) requires translation of one or more orthogonal mRNA codons in the orthogonal mRNA; and orthogonal ribosomes incorporating such rRNA molecules.
摘要翻译：提供了用于进化正交rRNA分子的方法，包括以下步骤：提供一个或多个突变正交rRNA分子文库，并将文库引入细胞，使得正交rRNA被并入核糖体中以提供正交核糖体; 提供（i）不被天然核糖体翻译的一个或多个正交mRNA分子，和（ii）包含一个或多个正交mRNA密码子; 测定正交mRNA的翻译并选择翻译正交mRNA的正交rRNA分子，其中步骤（c）中的测定需要在正交mRNA中翻译一个或多个正交的mRNA密码子; 并结合这样的rRNA分子的正交核糖体。

10. 发明申请

US20120077948A1 Methods 有权
标题翻译：方法
公开(公告)号：US20120077948A1
公开(公告)日：2012-03-29
申请号：US13376068
申请日：2010-06-02
申请人： Duy P. Nguyen , Heinz Neumann , Alexander Deiters , Jason Chin , Hrvoje Lusic
发明人： Duy P. Nguyen , Heinz Neumann , Alexander Deiters , Jason Chin , Hrvoje Lusic
IPC分类号： C12P21/00 , C07C233/49 , C07C271/22 , C08H1/00 , C07K14/00
CPC分类号： C12N15/67 , C07C233/49 , C07C271/22 , C12N9/93 , C12P21/02
摘要： The invention relates to a method of making a polypeptide comprising an orthogonal functional group, said orthogonal functional group being comprised by an aliphatic amino acid or amino acid derivative, said method comprising providing a host cell; providing a nucleic acid encoding the polypeptide of interest; providing a tRNA-tRNA synthetase pair orthogonal to said host cell; adding an amino acid or amino acid derivative comprising the orthogonal functional group of interest, wherein said amino acid or amino acid derivative is a substrate for said orthogonal tRNA synthetase, wherein said amino acid or amino acid derivative has an aliphatic carbon backbone; and incubating to allow incorporation of said amino acid or amino acid derivative into the polypeptide of interest via the orthogonal tRNA-tRNA synthetase pair. The invention also relates to certain amino acids, and to polypeptides comprising same.
摘要翻译：本发明涉及一种制备包含正交官能团的多肽的方法，所述正交官能团由脂肪族氨基酸或氨基酸衍生物构成，所述方法包括提供宿主细胞; 提供编码目的多肽的核酸; 提供与所述宿主细胞正交的tRNA-tRNA合成酶对; 加入包含所述正交官能团的氨基酸或氨基酸衍生物，其中所述氨基酸或氨基酸衍生物是所述正交tRNA合成酶的底物，其中所述氨基酸或氨基酸衍生物具有脂族碳骨架; 并孵育以允许所述氨基酸或氨基酸衍生物通过正交的tRNA-tRNA合成酶对引入目的多肽。本发明还涉及某些氨基酸，以及包含其的多肽。

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