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1. 发明授权

US08168799B2 Process for the preparation of tetrazolytetrahydrocyclopentapyrazoles 失效
标题翻译：制备四唑四氢环唑草唑的方法
公开(公告)号：US08168799B2
公开(公告)日：2012-05-01
申请号：US11919309
申请日：2006-04-20
申请人： Michael Stewart Ashwood , Matthew Bio , Edward Cleator , David Hands , Faye Julia Sheen , Robert Darrin Wilson
发明人： Michael Stewart Ashwood , Matthew Bio , Edward Cleator , David Hands , Faye Julia Sheen , Robert Darrin Wilson
IPC分类号： C07D403/04
CPC分类号： C07D403/04
摘要： A process for the preparation of a compound of formula (I), or a salt, hydrate or solvate thereof; wherein R1 and R2 are each independently hydrogen, or C1-6 alkyl groups or R1 and R2 are linked and, together with the cyclopentane carbon atoms to which they are attached, form a cyclopropyl ring.
摘要翻译：一种制备式（I）化合物或其盐，水合物或溶剂合物的方法; 其中R 1和R 2各自独立地为氢，或C 1-6烷基或R 1和R 2连接，并与其连接的环戊烷碳原子一起形成环丙基环。

2. 发明申请

US20100174091A1 Process for the preparation of tetrazolytetrahydrocyclopentapyrazoles 失效
标题翻译：制备四唑四氢环唑草唑的方法
公开(公告)号：US20100174091A1
公开(公告)日：2010-07-08
申请号：US11919309
申请日：2006-04-20
申请人： Michael Stewart Ashwood , Matthew Bio , Edward Cleator , David Hands , Faye Julia Sheen , Robert Darrin Wilson
发明人： Michael Stewart Ashwood , Matthew Bio , Edward Cleator , David Hands , Faye Julia Sheen , Robert Darrin Wilson
IPC分类号： C07D403/04 , C07D403/06
CPC分类号： C07D403/04
摘要： A process for the preparation of a compound of formula (I), or a salt, hydrate or solvate thereof; wherein R1 and R2 are each independently hydrogen, or C1-6 alkyl groups or R1 and R2 are linked and, together with the cyclopentane carbon atoms to which they are attached, form a cyclopropyl ring.
摘要翻译：一种制备式（I）化合物或其盐，水合物或溶剂合物的方法; 其中R 1和R 2各自独立地为氢，或C 1-6烷基或R 1和R 2连接，并与其连接的环戊烷碳原子一起形成环丙基环。

3. 发明授权

US07262169B1 Process for preparing peptide intermediates 失效
标题翻译：制备肽中间体的方法
公开(公告)号：US07262169B1
公开(公告)日：2007-08-28
申请号：US10111154
申请日：2000-10-18
申请人： Michael Stewart Ashwood , Brian Christopher Bishop , Ian Frank Cottrell , Khateeta Moneek Emerson , David Hands , Guo Jie Ho , Joseph Edward Lynch , Yao Jun Shi , Robert Darrin Wilson
发明人： Michael Stewart Ashwood , Brian Christopher Bishop , Ian Frank Cottrell , Khateeta Moneek Emerson , David Hands , Guo Jie Ho , Joseph Edward Lynch , Yao Jun Shi , Robert Darrin Wilson
IPC分类号： A61K31/00
CPC分类号： C07C69/42 , C07C2603/18 , C07K5/0821 , C07K5/1016 , C07K7/06
摘要： The present invention is directed to the improved synthesis of compounds of formula (I) an intermediate compound which is useful in the synthesis of the anticancer agents known as PSA conjugates.
摘要翻译：本发明涉及可用于合成称为PSA缀合物的抗癌剂的中间体化合物的式（I）化合物的改进合成。

4. 发明授权

US06297376B1 Chemical synthesis of morpholine derivatives 有权
标题翻译：吗啉衍生物的化学合成
公开(公告)号：US06297376B1
公开(公告)日：2001-10-02
申请号：US09719712
申请日：2000-12-15
申请人： Ian Frank Cottrell , Ulf H Dolling , David Hands , Robert Darrin Wilson
发明人： Ian Frank Cottrell , Ulf H Dolling , David Hands , Robert Darrin Wilson
IPC分类号： C07D41306
CPC分类号： C07D413/06 , C07D249/02
摘要： The present invention relates to a process for the preparation of mopholine derivatives of formula (I) which are useful as a therapeutic agents.
摘要翻译：本发明涉及制备可用作治疗剂的式（I）的吗啉衍生物的方法。

5. 发明授权

US06407255B2 Chemical synthesis of 1,2,4-triazolinone derivative 有权
标题翻译：化学合成1,2,4-三唑啉酮衍生物
公开(公告)号：US06407255B2
公开(公告)日：2002-06-18
申请号：US09950286
申请日：2001-09-10
申请人： Ian Frank Cottrell , Ulf H Dolling , David Hands , Robert Darrin Wilson
发明人： Ian Frank Cottrell , Ulf H Dolling , David Hands , Robert Darrin Wilson
IPC分类号： C07D24912
CPC分类号： C07D413/06 , C07D249/02
摘要： The present invention relates to a process for the preparation of morpholine derivatives of formula (I) which are useful as a therapeutic agents.
摘要翻译：本发明涉及制备可用作治疗剂的式（I）吗啉衍生物的方法。

6. 发明申请

US20100286203A1 PHARMACEUTICALLY ACCEPTABLE SALTS OF 2--2H-INDAZOLE-7-CARBOXAMIDE 有权
标题翻译： 2--2H-吲唑-7-羧酰胺的药学上可接受的盐
公开(公告)号：US20100286203A1
公开(公告)日：2010-11-11
申请号：US12811922
申请日：2009-01-08
申请人： Jennifer R. Foley , Robert Darrin Wilson
发明人： Jennifer R. Foley , Robert Darrin Wilson
IPC分类号： A61K31/454 , C07D401/10 , A61P35/00 , A61P29/00 , A61P9/10 , A61P3/10 , A61P25/28 , A61P31/12
CPC分类号： C07D401/10
摘要： The present invention relates to pharmaceutically acceptable salts of an amide substituted indazole which are inhibitors of the enzyme poly(ADP-ribose)polymerase (PARP), previously known as poly(ADP-ribose)synthase and poly(ADP-ribosyl) transferase. The compounds of the present invention are useful as mono-therapies in tumors with specific defects in DNA-repair pathways and as enhancers of certain DNA-damaging agents such as anticancer agents and radiotherapy. Further, the compounds of the present invention are useful for reducing cell necrosis (in stroke and myocardial infarction), down regulating inflammation and tissue injury, treating retroviral infections and protecting against the toxicity of chemotherapy.
摘要翻译：本发明涉及酰胺取代的吲唑的药学上可接受的盐，其是聚（ADP-核糖）聚合酶（PARP）的酶的抑制剂，先前称为聚（ADP-核糖）合成酶和聚（ADP-核糖基）转移酶。本发明的化合物可用作在DNA修复途径中具有特定缺陷的肿瘤中的单一疗法，并且可用作某些DNA损伤剂如抗癌剂和放射疗法的增强剂。此外，本发明的化合物可用于减少细胞坏死（中风和心肌梗塞），下调调节炎症和组织损伤，治疗逆转录病毒感染并防止化疗的毒性。

7. 发明授权

US08436185B2 Pharmaceutically acceptable salts of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide 有权
标题翻译： 2- {4 - [（3S） - 哌啶-3-基]苯基} -2H-吲唑-7-甲酰胺的药学上可接受的盐
公开(公告)号：US08436185B2
公开(公告)日：2013-05-07
申请号：US12811922
申请日：2009-01-08
申请人： Jennifer R. Foley , Robert Darrin Wilson
发明人： Jennifer R. Foley , Robert Darrin Wilson
IPC分类号： C07D211/32 , A61K31/445
CPC分类号： C07D401/10
摘要： The present invention relates to pharmaceutically acceptable salts of an amide substituted indazole which are inhibitors of the enzyme poly(ADP-ribose)polymerase (PARP), previously known as poly(ADP-ribose)synthase and poly(ADP-ribosyl) transferase. The compounds of the present invention are useful as mono-therapies in tumors with specific defects in DNA-repair pathways and as enhancers of certain DNA-damaging agents such as anticancer agents and radiotherapy. Further, the compounds of the present invention are useful for reducing cell necrosis (in stroke and myocardial infarction), down regulating inflammation and tissue injury, treating retroviral infections and protecting against the toxicity of chemotherapy.
摘要翻译：本发明涉及酰胺取代的吲唑的药学上可接受的盐，其是聚（ADP-核糖）聚合酶（PARP）的酶的抑制剂，先前称为聚（ADP-核糖）合成酶和聚（ADP-核糖基）转移酶。本发明的化合物可用作在DNA修复途径中具有特定缺陷的肿瘤中的单一疗法，并且可用作某些DNA损伤剂如抗癌剂和放射疗法的增强剂。此外，本发明的化合物可用于减少细胞坏死（中风和心肌梗塞），下调调节炎症和组织损伤，治疗逆转录病毒感染并防止化疗的毒性。

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