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1. 发明申请

US20100260832A1 COMBINATION THERAPY FOR OVARIAN CANCER 审中-公开
标题翻译： OVARIAN癌症的组合治疗
公开(公告)号：US20100260832A1
公开(公告)日：2010-10-14
申请号：US12781599
申请日：2010-05-17
申请人： Michael S. Perry , Hazel B. Breitz , Cheni Kwok , Robert De Jager
发明人： Michael S. Perry , Hazel B. Breitz , Cheni Kwok , Robert De Jager
IPC分类号： A61K31/704 , A61K9/127 , A61P35/00 , A61P15/00
CPC分类号： A61K9/0019 , A61K9/08 , A61K9/1271 , A61K31/555 , A61K31/573 , A61K31/704 , A61K2300/00
摘要： The present invention provides a method to treat ovarian cancer by the administration of effective amounts of picoplatin and doxorubicin.
摘要翻译：本发明提供了通过施用有效量的吡铂和多柔比星来治疗卵巢癌的方法。

2. 发明申请

US20120148661A1 HIGH BIOAVAILABILITY ORAL PICOPLATIN ANTI-CANCER THERAPY 审中-公开
标题翻译：高生物量口服皮脂素抗癌治疗
公开(公告)号：US20120148661A1
公开(公告)日：2012-06-14
申请号：US13264343
申请日：2010-03-11
申请人： Angelica F. Phillips , Robert H. Earhart, JR. , Michael S. Perry
发明人： Angelica F. Phillips , Robert H. Earhart, JR. , Michael S. Perry
IPC分类号： A61K31/555 , A61K9/14 , A61K9/127 , A61P35/00 , A61N5/00 , A61K9/48 , C07F15/00 , B82Y5/00
CPC分类号： A61K31/44 , A61K9/1623 , A61K9/4858 , A61K31/555 , A61K33/24
摘要： The invention provides a method of treatment of cancer, wherein a individual doses of picoplatin, each of less than about 200 mg picoplatin content, the individual doses having high oral bioavailability, are administered to a patient in need thereof. The oral bioavailability can be greater than about 50%, or greater than about 75%, or greater than about 90%, depending upon the particular dosage form and dosing regimen used. The invention provides a quasi-metronomic dosing schedule including drug dosing intervals and drug intermission intervals, optionally including fasting periods prior to and following administration of each individual dose of picoplatin.
摘要翻译：本发明提供了一种治疗癌症的方法，其中将单独剂量的吡铂，每种小于约200mg皮素含量，具有高口服生物利用度的单个剂量施用于有需要的患者。取决于具体的剂型和使用的给药方案，口服生物利用度可以大于约50％，或大于约75％，或大于约90％。本发明提供了包括药物给药间隔和药物中断间隔的准节律剂剂量方案，任选地包括在给予每个单独剂量的吡铂之前和之后的禁食期。

3. 发明授权

US5115243A Radar system with active array antenna, beam multiplex control and pulse integration control responsive to azimuth angle 失效
公开(公告)号：US5115243A
公开(公告)日：1992-05-19
申请号：US686092
申请日：1991-04-16
申请人： Michael S. Perry , Jerome E. Freedman , John J. Gallagher
发明人： Michael S. Perry , Jerome E. Freedman , John J. Gallagher
IPC分类号： G01S7/282 , G01S13/02 , G01S13/22 , G01S13/28 , G01S13/42 , G01S13/44 , G01S13/524 , G01S13/66 , G01S13/87
CPC分类号： G01S13/44 , G01S13/22 , G01S13/282 , G01S13/426 , G01S13/5246 , G01S13/66 , G01S13/87 , G01S7/282 , G01S2013/0254 , G01S2013/0272
摘要： A multipurpose system provides radar surveillance for air traffic control purposes. The system includes four separate active phased-array antennas, each with .+-.45.degree. coverage in azimuth, from 0.degree. to 60.degree. in elevation. Each antenna element of each phased-array antenna is coupled by a low-loss path to the solid-state amplifier associated with a transmit-receive (TR) module. Each antenna produces a sequence of pencil beams, which requires less transmitted power from the TR modules than a fan beam, but requires more time because the pencil beam must be sequenced to cover the same volume as the fan beam. In order to scan the volume in a short time, the PRF is responsive to the elevation angle of the beam, so higher elevation angles use a higher PRF. Low elevation angle beams receive long transmitter pulses for high power, and pulse compression is used to restore range resolution, but the long pulse results in a large minimum range within which targets cannot be detected. A second scan is provided at low elevation angles with a short transmitter pulse to fill in the short-range coverage. Beams at higher elevation angles transmit pulse widths which are shorter than beams at low elevation angles, so that the minimum range requirement is met without a second scan, which also reduces the time required for volumetric scan. The number of pulses which are integrated to produce a return increases off-axis, to restore system margin lost due to off-axis power gain reduction. The volumetric scan rate is increased by a dynamic scan regimen by which subsets of beams are pulsed with a high transmitter PRF but with a low effective beam PRF to reduce range ambiguity and preserve Doppler resolution without the usual increase of scan time. For best range resolution, Doppler processing is used, with range sidelobe pulse suppression applied separately to each Doppler frequency bin.

4. 发明授权

US10633963B1 Method and apparatus for removing gas from gas producing formations 有权
公开(公告)号：US10633963B1
公开(公告)日：2020-04-28
申请号：US15355929
申请日：2016-11-18
申请人： Michael S. Perry , Gerald Luken , Cory Luken
发明人： Michael S. Perry , Gerald Luken , Cory Luken
IPC分类号： E21B43/38 , E21B43/08 , E21B43/00
CPC分类号： E21B43/38 , E21B43/006 , E21B43/084 , E21B43/088
摘要： A method and apparatus for removing dissolved gas from a coal bed or other type of gas bearing formation is provided.

5. 发明授权

US5115244A Radar system with active array antenna, elevation-responsive PRF control, and pulse integration control responsive to azimuth angle 失效
公开(公告)号：US5115244A
公开(公告)日：1992-05-19
申请号：US686053
申请日：1991-04-16
申请人： Jerome E. Freedman , Michael S. Perry , John J. Gallagher
发明人： Jerome E. Freedman , Michael S. Perry , John J. Gallagher
IPC分类号： G01S13/22 , G01S13/28 , G01S13/42 , G01S13/44 , G01S13/66
CPC分类号： G01S13/282 , G01S13/22 , G01S13/426 , G01S13/44 , G01S13/66
摘要： A multipurpose system provides radar surveillance for air traffic control purposes. The system includes four separate active phased-array antennas, each with .+-.45.degree. coverage in azimuth, from 0.degree. to 60.degree. in elevation. Each antenna element of each phased-array antenna is coupled by a low-loss path to the solid-state amplifier associated with a transmit-receive (TR) module. Each antenna produces a sequence of pencil beams, which requires less transmitted power from the TR modules than a fan beam, but requires more time because the pencil beam must be sequenced to cover the same volume as the fan beam. In order to scan the volume in a short time, the PRF is responsive to the elevation angle of the beam, so higher elevation angles use a higher PRF. Low elevation angle beams receive long transmitter pulses for high power, and pulse compression is used to restore range resolution, but the long pulse results in a large minimum range within which targets cannot be detected. A second scan is provided at low elevation angles with a short transmitter pulse to fill in the short-range coverage. Beams at higher elevation angles transmit pulse widths which are shorter than beams at low elevation angles, so that the minimum range requirement is met without a second scan, which also reduces the time required for volumetric scan. The number of pulses which are integrated to produce a return increases off-axis, to restore system margin lost due to off-axis power gain reduction. The volumetric scan rate is increased by a dynamic scan regimen by which subsets of beams are pulsed with a high transmitter PRF but with a low effective beam PRF to reduce range ambiguity and preserve Doppler resolution without the usual increase of scan time. For best range resolution, Doppler processing is used, with range sidelobe pulse suppression applied separately to each Doppler frequency bin.

6. 发明授权

US5103233A Radar system with elevation-responsive PRF control, beam multiplex control, and pulse integration control responsive to azimuth angle 失效
公开(公告)号：US5103233A
公开(公告)日：1992-04-07
申请号：US686051
申请日：1991-04-16
申请人： John J. Gallagher , Jerome E. Freedman , Michael S. Perry
发明人： John J. Gallagher , Jerome E. Freedman , Michael S. Perry
IPC分类号： G01S13/22 , G01S13/28 , G01S13/42 , G01S13/44 , G01S13/58 , G01S13/95 , H01Q21/00
CPC分类号： H01Q21/0025 , G01S13/22 , G01S13/28 , G01S13/426 , G01S13/44 , G01S13/582 , G01S13/951
摘要： A multipurpose system provides radar surveillance for air traffic control purposes. The system includes four separate active phased-array antennas, each with .+-.45.degree. coverage in azimuth, from 0.degree. to 60.degree. in elevation. Each antenna element of each phased-array antenna is coupled by a low-loss path to the solid-state amplifier associated with a transmit-receive (TR) module. Each antenna produces a sequence of pencil beams, which requires less transmitted power from the TR modules than a fan beam, but requires more time because the pencil beam must be sequenced to cover the same volume as the fan beam. In order to scan the volume in a short time, the PRF is responsive to the elevation angle of the beam, so higher elevation angles use a higher PRF. Low elevation angle beams receive long transmitter pulses for high power, and pulse compression is used to restore range resolution, but the long pulse results in a large minimum range within which targets cannot be detected. A second scan is provided at low elevation angles with a short transmitter pulse to fill in the short-range coverage. Beams at higher elevation angles transmit pulse widths which are shorter than beams at low elevation angles so that the minimum range requirement is met without a second scan, which also reduces the time required for volumetric scan. The number of pulses which are integrated to produce a return increases off-axis, to restore system margin lost due to off-axis power gain reduction. The volumetric scan rate is increased by a dynamic scan regimen by which subsets of beams are pulsed with a high transmitter PRF but with a low effective beam PRF to reduce range ambiguity and preserve Doppler resolution without the usual increase of scan time. For best range resolution, Doppler processing is used, with range sidelobe pulse suppression applied separately to each Doppler frequency bin.

7. 发明授权

US5359339A Broadband short-horn antenna 失效
标题翻译：宽带短角天线
公开(公告)号：US5359339A
公开(公告)日：1994-10-25
申请号：US92645
申请日：1993-07-16
申请人： Ashok K. Agrawal , Michael S. Perry , Norman R. Landry
发明人： Ashok K. Agrawal , Michael S. Perry , Norman R. Landry
IPC分类号： H01Q13/02 , H01Q13/00
CPC分类号： H01Q13/0275
摘要： A short horn antenna (10) adapted for array use includes a rectangular waveguide with broad upper (12) and lower (14) walls and narrow side walls (16, 18), defining a radiating aperture (20) and a feed end closed off by a shorting plate (22). A stepped upper ridge (26) has a slot (50) adjacent the shorting plate, and a shorter stepped lower ridge (46) has a corresponding slot. An unbalanced transmission line (75) extends through the shorting wall, and the smaller conductor (76) extends into the waveguide as an electric probe (60). The probe includes a first portion (64), extending parallel to the waveguide axis (8) and into the slot in the upper ridge. The probe (60) also includes a second portion (66) extending at an angle (90.degree.) relative to the first portion (64) of the probe (60).
摘要翻译：适用于阵列使用的短喇叭天线（10）包括具有宽上（12）和下（14）壁的矩形波导和限定辐射孔（20）的窄侧壁（16,18），并且馈送端封闭通过短板（22）。阶梯状上脊（26）具有与短路板相邻的槽（50），较短的阶梯状下脊（46）具有相应的槽。不平衡传输线（75）延伸穿过短路壁，并且较小的导体（76）作为电探针（60）延伸到波导中。探针包括平行于波导轴线（8）延伸并进入上脊中的狭槽的第一部分（64）。探针（60）还包括相对于探针（60）的第一部分（64）以一定角度（90°）延伸的第二部分（66）。

8. 发明授权

US5128683A Radar system with active array antenna, elevation-responsive PRF control, and beam multiplex control 失效
标题翻译：具有有源阵列天线的雷达系统，仰角响应的PRF控制和波束多路复用控制
公开(公告)号：US5128683A
公开(公告)日：1992-07-07
申请号：US685791
申请日：1991-04-16
申请人： Jerome E. Freedman , John J. Gallagher , Michael S. Perry
发明人： Jerome E. Freedman , John J. Gallagher , Michael S. Perry
IPC分类号： G01S7/02 , G01S7/03 , G01S7/282 , G01S13/12 , G01S13/22 , G01S13/28 , G01S13/42 , G01S13/44 , G01S13/87 , G01S13/91 , G01S13/95 , H01Q3/26
CPC分类号： H01Q3/26 , G01S13/22 , G01S13/426 , G01S13/91 , G01S7/032 , G01S2013/0254
摘要： A multipurpose system provides radar surveillance for air traffic control purposes. The system includes four separate active phased-array antennas, each with .+-.45.degree. coverage in azimuth, from 0.degree. to 60.degree. in elevation. Each antenna element of each phased-array antenna is coupled by a low-loss path to the solid-state amplifier associated with a transmit-receive (TR) module. Each antenna produces a sequence of pencil beams, which requires less transmitted power from the TR modules than a fan beam, but requires more time because the pencil beam must be sequenced to cover the same volume as the fan beam. In order to scan the volume in a short time, the PRF is responsive to the elevation angle of the beam, so higher elevation angles use a higher PRF. Low elevation angle beams receive long transmitter pulses for high power, and pulse compression is used to restored range resolution, but the long pulse results in a large minimum range within which targets cannot be detected. A second can is provided at low elevation angles with a short transmitter pulse to fill in the short-range coverage. Beams at higher elevation angles transmit pulse widths which are shorter than beams at low elevation angles, so that the minimum range requirement is met without a second scan, which also reduces the time required for volumetric scan. The number of pulses which are integrated to produce a return increases off-axis, to restore system margin lost due to off-axis power gain reduction. The volumetric scan rate is increased by a dynamic scan regimen by which subsets of beams are pulsed with a high transmitter PRF but with a low effective beam PRF to reduce range ambiguity and preserve Doppler resolution without the usual increase of scan time. For best range resolution, Doppler processing is used, with range sidelobe pulse suppression applied separately to each Doppler frequency bin.

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