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1. 发明申请

US20070266747A1 DEADBOLT LOCK 有权
标题翻译：死板锁
公开(公告)号：US20070266747A1
公开(公告)日：2007-11-22
申请号：US11738762
申请日：2007-04-23
申请人： Michael Rafferty , John Grosz , Andrew Terrill , Jerry Smith , Mike Enslow
发明人： Michael Rafferty , John Grosz , Andrew Terrill , Jerry Smith , Mike Enslow
IPC分类号： E05B65/06 , G06K9/00
CPC分类号： E05B13/00 , E05B13/004 , E05B2047/0028 , Y10S292/27 , Y10T70/5319 , Y10T70/5341 , Y10T70/5398 , Y10T70/5482 , Y10T70/5805 , Y10T70/5827 , Y10T70/7062 , Y10T292/96
摘要： A deadbolt lock includes a deadbolt, a user rotatable actuator, and a lock interface. The user rotatable actuator is operatively connected with the deadbolt for movement of the deadbolt between locked and unlocked conditions when the actuator is changed from an inoperable condition to an operable condition. The lock interface is configured to change the actuator from the inoperable condition to the operable condition in response to proper user manipulation of the lock interface.
摘要翻译：锁死锁包括一个锁死螺栓，用户可旋转的致动器和锁定接口。当致动器从不可操作状态改变为可操作状态时，用户可旋转致动器可操作地与锁死螺栓相连接，以在锁定和解锁状态之间移动锁死螺栓。锁定接口被配置为响应于适当的用户操纵锁定接口而将致动器从不可操作的状态改变到可操作状态。

2. 发明申请

US20120059008A1 DIALKYLAMINO ALKYL ESTERS OF PIVAGABINE AS MEDICAMENTS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS 审中-公开
标题翻译：维生素D作为药物治疗中枢神经系统疾病的药代动力学
公开(公告)号：US20120059008A1
公开(公告)日：2012-03-08
申请号：US13293159
申请日：2011-11-10
申请人： Michael Rafferty
发明人： Michael Rafferty
IPC分类号： A61K31/5375 , A61P15/00 , A61P25/18 , A61P3/04 , A61P3/00 , A61P25/30 , A61P25/32 , A61P25/00 , A61P19/02 , A61P1/00 , A61P13/00 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/14 , A61P25/28 , A61K31/221
CPC分类号： C07D295/088
摘要： The present embodiments are related to the compound of Formula 1 or Formula 2 below and pharmaceutical formulations thereof as well as treatments for a wide variety of Central Nervous System disorders with the pharmaceutical formulations. Some embodiments include the use of a variety of the instant compounds which surprisingly and advantageously exhibit improved pharmacokinetic and therapeutic profiles in comparison to pivagabine.
摘要翻译：本发明的实施方案涉及下面的式1或式2的化合物及其药物制剂以及与各种中枢神经系统疾病与药物制剂的治疗。一些实施方案包括使用各种本发明的化合物，其与枢纽加布比较，令人惊奇地和有利地表现出改善的药代动力学和治疗特征。

3. 发明授权

US07632836B2 Dialkylamino alkyl esters of pivagabine as medicaments for the treatment of central nervous system disorders 失效
标题翻译：作为治疗中枢神经系统疾病的药物的枢纽他布的二烷基氨基烷基酯
公开(公告)号：US07632836B2
公开(公告)日：2009-12-15
申请号：US11946708
申请日：2007-11-28
申请人： Michael Rafferty
发明人： Michael Rafferty
IPC分类号： A61K31/5375 , A61K31/225 , A61P25/00 , A61P3/00 , A61P15/00 , A61P29/00 , A61P19/00
CPC分类号： C07D295/088
摘要： The present embodiments are related to the compound of Formula 1 or Formula 2 below and pharmaceutical formulations thereof as well as treatments for a wide variety of Central Nervous System disorders with the pharmaceutical formulations. Some embodiments include the use of a variety of the instant compounds which surprisingly and advantageously exhibit improved pharmacokinetic and therapeutic profiles in comparison to pivagabine.
摘要翻译：本发明的实施方案涉及下面的式1或式2的化合物及其药物制剂以及与各种中枢神经系统疾病与药物制剂的治疗。一些实施方案包括使用各种本发明的化合物，其与枢纽加布比较，令人惊奇地和有利地表现出改善的药代动力学和治疗特征。

4. 发明申请

US20140174830A1 HIGH PRESSURE SHEAR NOZZLE FOR INLINE CONDITIONING OF DRILLING MUD 审中-公开
标题翻译：高压剪切喷嘴用于钻孔机的在线调节
公开(公告)号：US20140174830A1
公开(公告)日：2014-06-26
申请号：US13637933
申请日：2011-03-29
申请人： Richard Bingham , Michael Rafferty , Neal Smothers
发明人： Richard Bingham , Michael Rafferty , Neal Smothers
IPC分类号： E21B21/06
CPC分类号： E21B21/06 , B01F5/0268 , B01F5/0688 , E21B21/062
摘要： A system for conditioning drilling fluid includes a conditioning device having a first conduit configured to receive the drilling fluid, a flow restriction disposed adjacent the first conduit, the flow restriction comprising a fluid inlet and a fluid outlet, an impact plate disposed downstream of the flow restriction, a first chamber disposed between the flow restriction and the impact plate, and a second chamber disposed downstream of the impact plate, wherein the first chamber is fluidly connected to the second chamber. A method for conditioning drilling fluid using a conditioning device, includes pumping a drilling fluid through a flow restriction, accelerating the drilling fluid into a mixing chamber, subjecting the drilling fluid to elongational shearing, decelerating the drilling fluid against an impact plate, subjecting the drilling fluid to impact shearing, and emptying drilling fluid from the mixing chamber.
摘要翻译：用于调节钻井流体的系统包括调节装置，其具有构造成接收钻井流体的第一导管，邻近第一导管设置的流动限制器，流动限制器包括流体入口和流体出口，设置在流动下游的冲击板设置在流量限制器和冲击板之间的第一腔室以及设置在冲击板下游的第二腔室，其中第一腔室流体地连接到第二腔室。一种使用调节装置调节钻井液的方法，包括通过流动限制泵送钻井液，将钻井液加速到混合室中，对钻井液进行伸长剪切，将钻井液减压到冲击板上，流体冲击剪切，并从混合室排空钻井液。

5. 发明授权

US08080548B2 Dialkylamino alkyl esters of pivagabine as medicaments for the treatment of central nervous system disorders 失效
标题翻译：作为治疗中枢神经系统疾病的药物的枢纽他布的二烷基氨基烷基酯
公开(公告)号：US08080548B2
公开(公告)日：2011-12-20
申请号：US12538683
申请日：2009-08-10
申请人： Michael Rafferty
发明人： Michael Rafferty
IPC分类号： A61K31/5375 , A61K31/195 , A61P25/22 , A61P25/24 , A61P25/18 , A61P3/04 , A61P29/00 , A61P25/06 , A61P25/16 , A61P25/28
CPC分类号： C07D295/088
摘要： The present embodiments are related to the compound of Formula 1 or Formula 2 below and pharmaceutical formulations thereof as well as treatments for a wide variety of Central Nervous System disorders with the pharmaceutical formulations. Some embodiments include the use of a variety of the instant compounds which surprisingly and advantageously exhibit improved pharmacokinetic and therapeutic profiles in comparison to pivagabine.
摘要翻译：本发明的实施方案涉及下面的式1或式2的化合物及其药物制剂以及与各种中枢神经系统疾病与药物制剂的治疗。一些实施方案包括使用各种本发明的化合物，其与枢纽加布比较，令人惊奇地和有利地表现出改善的药代动力学和治疗特征。

6. 发明申请

US20100099678A1 DIALKYLAMINO ALKYL ESTERS OF PIVAGABINE AS MEDICAMENTS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS 失效
标题翻译：维生素D作为药物治疗中枢神经系统疾病的药代动力学
公开(公告)号：US20100099678A1
公开(公告)日：2010-04-22
申请号：US12538683
申请日：2009-08-10
申请人： Michael Rafferty
发明人： Michael Rafferty
IPC分类号： A61K31/5375 , A61K31/195 , A61P25/22 , A61P25/24 , A61P25/18 , A61P3/04 , A61P29/00 , A61P25/06 , A61P25/16 , A61P25/28
CPC分类号： C07D295/088
摘要： The present embodiments are related to the compound of Formula 1 or Formula 2 below and pharmaceutical formulations thereof as well as treatments for a wide variety of Central Nervous System disorders with the pharmaceutical formulations. Some embodiments include the use of a variety of the instant compounds which surprisingly and advantageously exhibit improved pharmacokinetic and therapeutic profiles in comparison to pivagabine.
摘要翻译：本发明的实施方案涉及下面的式1或式2的化合物及其药物制剂以及与各种中枢神经系统疾病与药物制剂的治疗。一些实施方案包括使用各种本发明的化合物，其与枢纽加布比较，令人惊奇地和有利地表现出改善的药代动力学和治疗特征。

7. 发明申请

US20050004167A1 Branched chain amino acid-dependent aminotransferase inhibitors and their use in the treatment of neurodegenerative diseases 审中-公开
标题翻译：支链氨基酸依赖性氨基转移酶抑制剂及其在治疗神经退行性疾病中的应用
公开(公告)号：US20050004167A1
公开(公告)日：2005-01-06
申请号：US10765002
申请日：2004-01-26
申请人： Keenan Bora , Lain-Yen Hu , Suzanne Kesten , Huanyshu Lei , David Moreland , Michael Rafferty , Todd Ryder , Jeffrey Scholten , David Wustrow
发明人： Keenan Bora , Lain-Yen Hu , Suzanne Kesten , Huanyshu Lei , David Moreland , Michael Rafferty , Todd Ryder , Jeffrey Scholten , David Wustrow
IPC分类号： C07D317/62 , A61K31/18 , A61K31/343 , A61K31/36 , A61K31/403 , A61K31/404 , A61K31/47 , A61K31/472 , A61P3/08 , A61P3/10 , A61P7/02 , A61P7/04 , A61P9/10 , A61P13/00 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/06 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/28 , A61P25/30 , A61P27/02 , A61P27/06 , A61P27/16 , A61P43/00 , C07C311/49 , C07D209/08 , C07D209/30 , C07D209/42 , C07D209/88 , C07D215/48 , C07D215/50 , C07D215/54 , C07D217/26 , C07D307/79 , C07D307/84 , C07D307/85 , C07D307/91 , C07D307/92 , C07D317/68 , A61K31/381 , A61K31/405
CPC分类号： C07D307/79 , C07C311/49 , C07D209/08 , C07D209/30 , C07D209/88 , C07D215/48 , C07D215/50 , C07D307/84 , C07D307/91 , C07D307/92
摘要： The invention relates to BCAT inhibitor compounds of formula (I) and use thereof for treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease and Down's syndrome, treating or preventing the adverse consequences of the overstimulation of the excitatory amino acids, treating anxiety, psychosis, convulsions, aminoglycoside antibiotics-induced hearing loss, migraine headache, chronic pain, neuropathic pain, Parkinson's disease, diabetic retinopathy, glaucoma, CMV retinitis, urinary incontinence, opioid tolerance or withdrawal, and inducing anesthesia, as well as for enhancing cognition.
摘要翻译：本发明涉及式（I）的BCAT抑制剂化合物及其用于治疗或预防与中风，局部缺血，CNS创伤，低血糖和手术相关的神经元损失的用途，以及治疗神经变性疾病，包括阿尔茨海默病，肌萎缩性侧索硬化，亨廷顿病治疗或预防兴奋性氨基酸过度刺激的不良后果，治疗焦虑症，精神病，抽搐，氨基糖苷类抗生素诱发的听力损失，偏头痛，慢性疼痛，神经性疼痛，帕金森病，糖尿病性视网膜病变，青光眼， CMV视网膜炎，尿失禁，阿片样物质耐受或戒断，诱导麻醉以及增强认知。

8. 发明申请

US20050241977A1 Nestable containers with coverings having a fold 有权
标题翻译：具有折叠的覆盖物的可嵌套容器
公开(公告)号：US20050241977A1
公开(公告)日：2005-11-03
申请号：US11083870
申请日：2005-03-18
申请人： Curtis Herbert , James Kolar , Michael Brock , Michael Rafferty , David Woods
发明人： Curtis Herbert , James Kolar , Michael Brock , Michael Rafferty , David Woods
IPC分类号： B65D20060101 , B65D6/12 , B65D21/02 , B65D41/06 , B65D51/18
CPC分类号： B65D21/0233 , Y02W30/807
摘要： Embodiments include sets of nestable containers with each container having a cover comprises a fold. The covers are disposable between two of the nestable containers when the containers are nested with each other. Uses of the containers include, for example, food, craft, and home storage.
摘要翻译：实施例包括一组可嵌套的容器，每个容器具有盖子，其包括折叠部。当容器彼此嵌套时，盖子可以在两个可嵌套的容器之间一次性使用。容器的使用包括例如食品，工艺和家庭存储。

9. 发明授权

US4397333A Fuel collector assembly 失效
标题翻译：燃油收集器组件
公开(公告)号：US4397333A
公开(公告)日：1983-08-09
申请号：US299373
申请日：1981-09-04
申请人： Joseph Liba , Michael Rafferty
发明人： Joseph Liba , Michael Rafferty
IPC分类号： B60K15/077 , F02M37/02 , F17B1/00
CPC分类号： B60K15/077 , F02M37/025 , B60K2015/03105 , B60K2015/03236 , Y10T137/86212 , Y10T137/86228
摘要： A liquid fuel collecting and damming assembly located in a vehicle fuel tank to aid the intake of fuel to the engine by elevating the level of fuel about the fuel inlet particularly when the liquid level in the tank is relatively low. The assembly provides an open-ended cylindrical wall which is supported on the fuel tank bottom so that the inlet to the fuel line extends through the resultant open top so as to extend downward toward the bottom. A fuel return conduit extends through the collector assembly's wall and has an outlet end portion spaced vertically upward from the inlet portion so that fuel is discharged therethrough into the collector assembly and enters at an elevated level. The fuel supply in the collector assembly remains at the elevated level with respect to fuel in the tank at a low level condition due to the raised outlet portion of the return conduit.
摘要翻译：一种位于车辆燃料箱中的液体燃料收集和阻塞组件，用于通过提高燃料入口附近的燃料水平，特别是当储罐中的液位相对较低时，有助于向发动机吸入燃料。该组件提供一个敞开的圆柱形壁，其被支撑在燃料箱底部上，使得燃料管线的入口延伸通过所得的开口顶部，以向下延伸到底部。燃料返回导管延伸穿过收集器组件的壁并且具有从入口部分垂直向上间隔开的出口端部分，使得燃料通过其排出到收集器组件中并以升高的水平进入。收集器组件中的燃料供应由于回流管道的升高的出口部分而在低水平状态下相对于罐中的燃料保持在升高的水平。

10. 发明申请

US20090111813A1 Dialkylamino alkyl esters of pivagabine as medicaments for the treatment of central nervous system disorders 失效
公开(公告)号：US20090111813A1
公开(公告)日：2009-04-30
申请号：US11946708
申请日：2007-11-28
申请人： Michael Rafferty
发明人： Michael Rafferty
IPC分类号： A61K31/5375 , C07D295/15 , C07C229/26 , A61K31/225 , A61P25/00 , A61P3/00 , A61P15/00 , A61P29/00 , A61P19/00
CPC分类号： C07D295/088
摘要： The present embodiments are related to the compound of Formula 1 or Formula 2 below and pharmaceutical formulations thereof as well as treatments for a wide variety of Central Nervous System disorders with the pharmaceutical formulations. Some embodiments include the use of a variety of the instant compounds which surprisingly and advantageously exhibit improved pharmacokinetic and therapeutic profiles in comparison to pivagabine.

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