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1. 发明申请

US20110066227A1 Stent with Dynamic Drug Reservoirs 审中-公开
标题翻译：动态药物支架支架
公开(公告)号：US20110066227A1
公开(公告)日：2011-03-17
申请号：US12561781
申请日：2009-09-17
申请人： Michael P. Meyer , Timothy S. Girton , Dennis Boismier , Daniel Gregorich , Kim Robertson , Liza Davis , Cory Hitzman , Samuel Robaina , Doug Thesingh
发明人： Michael P. Meyer , Timothy S. Girton , Dennis Boismier , Daniel Gregorich , Kim Robertson , Liza Davis , Cory Hitzman , Samuel Robaina , Doug Thesingh
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2/90 , A61F2/91 , A61F2250/0035 , A61F2250/0068
摘要： A stent having one or more beneficial agents which enhance the healing effect of the stent. The agent is positioned within a reservoir. The reservoir dynamically releases the agent when the stent is expanded. The reservoir makes use of various changes in stent shape during expansion to assure proper release of the agent. Agent release can be modulated at various points along the stent and with various rates of release. The reservoirs can also be cooperatively combined with features that enhance stent flexibility, structural integrity, and which prevent recoil.
摘要翻译：具有增强支架愈合效果的一种或多种有益剂的支架。试剂位于储存器内。当支架扩张时，储层动态释放药剂。储存器在膨胀期间利用支架形状的各种变化，以确保试剂的适当释放。药剂释放可以在支架的各个点处以各种释放速率进行调节。储存器还可以与增强支架柔性，结构完整性以及防止反冲的特征协同结合。

2. 发明申请

US20100292777A1 Stent 审中-公开
标题翻译：支架
公开(公告)号：US20100292777A1
公开(公告)日：2010-11-18
申请号：US12465443
申请日：2009-05-13
申请人： Michael P. Meyer , Samuel Robaina , Dennis Boismier , Jason T. Lenz , Liza Davis , Kim Robertson , Doug Thesingh , Cory Hitzman , Timothy S. Girton
发明人： Michael P. Meyer , Samuel Robaina , Dennis Boismier , Jason T. Lenz , Liza Davis , Kim Robertson , Doug Thesingh , Cory Hitzman , Timothy S. Girton
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2002/9155 , A61F2002/91566 , A61F2002/91591 , A61F2230/0054 , A61F2250/0036 , A61F2250/0068
摘要： An expandable stent has a plurality of expandable rings formed of a plurality of struts and at least one first connector interconnecting adjacent expandable rings. The plurality of struts include a first strut and the at least one first connector has a first arm. A first portion of the first arm is engaged to a first portion of the first strut so that the first portion of the first arm and the first portion of the first strut define a through hole.
摘要翻译：可扩张支架具有由多个支柱形成的多个可膨胀环以及互连相邻可膨胀环的至少一个第一连接器。所述多个支柱包括第一支柱，并且所述至少一个第一连接器具有第一臂。第一臂的第一部分接合到第一支柱的第一部分，使得第一臂的第一部分和第一支柱的第一部分限定通孔。

3. 发明授权

US07951193B2 Drug-eluting stent 失效
标题翻译：药物洗脱支架
公开(公告)号：US07951193B2
公开(公告)日：2011-05-31
申请号：US12178180
申请日：2008-07-23
申请人： Samuel Robaina , Cory Hitzman , Kim Robertson , Liza Davis , Jason T. Lenz
发明人： Samuel Robaina , Cory Hitzman , Kim Robertson , Liza Davis , Jason T. Lenz
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2230/0054 , A61F2250/0036 , A61F2250/0068
摘要： A stent for delivering therapeutic agents to a body lumen includes a plurality of circumferential serpentine bands with each band comprising a plurality of struts. At least one strut has at least one first well region and at least one second well region. The at least one first well region has a first thickness, the at least one second well region has a second thickness, the first thickness being greater than the second thickness. Each well region defines a well having a depth. At least some of the wells contain a therapeutic agent.
摘要翻译：用于将治疗剂递送到体腔的支架包括多个周向蛇形带，每个带包括多个支柱。至少一个支柱具有至少一个第一阱区域和至少一个第二阱区域。所述至少一个第一阱区域具有第一厚度，所述至少一个第二阱区域具有第二厚度，所述第一厚度大于所述第二厚度。每个井区域定义具有深度的井。至少一些孔含有治疗剂。

4. 发明申请

US20100023115A1 DRUG-ELUTING STENT 失效
标题翻译：药物治疗
公开(公告)号：US20100023115A1
公开(公告)日：2010-01-28
申请号：US12178180
申请日：2008-07-23
申请人： Samuel Robaina , Cory Hitzman , Kim Robertson , Liza Davis , Jason T. Lenz
发明人： Samuel Robaina , Cory Hitzman , Kim Robertson , Liza Davis , Jason T. Lenz
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2230/0054 , A61F2250/0036 , A61F2250/0068
摘要： A stent for delivering therapeutic agents to a body lumen includes a plurality of circumferential serpentine bands with each band comprising a plurality of struts. At least one strut has at least one first well region and at least one second well region. The at least one first well region has a first thickness, the at least one second well region has a second thickness, the first thickness being greater than the second thickness. Each well region defines a well having a depth. At least some of the wells contain a therapeutic agent.
摘要翻译：用于将治疗剂递送到体腔的支架包括多个周向蛇形带，每个带包括多个支柱。至少一个支柱具有至少一个第一阱区域和至少一个第二阱区域。所述至少一个第一阱区域具有第一厚度，所述至少一个第二阱区域具有第二厚度，所述第一厚度大于所述第二厚度。每个井区域定义具有深度的井。至少一些孔含有治疗剂。

5. 发明申请

US20070269479A1 Medical devices coated with drug carrier macromolecules 有权
标题翻译：用药物载体大分子涂覆的医疗器械
公开(公告)号：US20070269479A1
公开(公告)日：2007-11-22
申请号：US11435690
申请日：2006-05-18
申请人： Liza Davis , Kim Robertson , Richard Tooley
发明人： Liza Davis , Kim Robertson , Richard Tooley
IPC分类号： A61K39/395 , A61F2/02
CPC分类号： A61L31/16 , A61L27/227 , A61L27/34 , A61L27/54 , A61L31/04 , A61L31/10 , A61L2300/602
摘要： A medical device coated with carrier macromolecules, wherein the carrier macromolecules are conjugated with a therapeutic agent. The carrier macromolecules may be antibodies which bind the therapeutic agent at the antigen binding site or by covalent bonding. The carrier macromolecules may be tethered to the surface of or dispersed within a coating on the medical device. The carrier macromolecules may release the therapeutic agent upon exposure to a trigger, which may be exposure to an aqueous environment, or a change in the pH or the ionic strength of the environment. The carrier macromolecules may also be bispecific antibodies directed to both a therapeutic agent and a target antigen. In some cases, binding of the target antigen causes the therapeutic agent to be released from the bispecific antibody. Also provided are methods of controlling the release and targeting of therapeutic agents eluted from a medical device.
摘要翻译：涂覆有载体大分子的医疗装置，其中载体大分子与治疗剂缀合。载体大分子可以是在抗原结合位点或通过共价键结合治疗剂的抗体。载体大分子可以连接到医疗装置上的涂层的表面或分散在其中。载体大分子可能暴露于可能暴露于水性环境的触发剂或pH或环境离子强度的变化下释放治疗剂。载体大分子也可以是针对治疗剂和靶抗原的双特异性抗体。在一些情况下，靶抗原的结合导致治疗剂从双特异性抗体释放。还提供了控制从医疗装置洗脱的治疗剂的释放和靶向的方法。

6. 外观设计

USD493301S1 Podium 失效
标题翻译：讲台
公开(公告)号：USD493301S1
公开(公告)日：2004-07-27
申请号：US29182173
申请日：2003-05-21
申请人： Kim Robertson
设计人： Kim Robertson

7. 发明授权

US09095324B2 Package assembly 有权
标题翻译：包装组装
公开(公告)号：US09095324B2
公开(公告)日：2015-08-04
申请号：US12143164
申请日：2008-06-20
申请人： James M. Peck , Ben Prusi , Diona Sommario , Kim Robertson , Samir Shrestha , Tom Arthur , Tony Suardini
发明人： James M. Peck , Ben Prusi , Diona Sommario , Kim Robertson , Samir Shrestha , Tom Arthur , Tony Suardini
IPC分类号： A61B17/06 , A61B19/02 , A61L2/20 , B65D33/01 , A61F2/00 , A61L2/26 , A61M25/00 , B65B55/10
CPC分类号： A61B19/026 , A61B50/30 , A61B2050/3004 , A61B2050/3014 , A61B2050/316 , A61B2050/318 , A61F2/0095 , A61L2/206 , A61L2/26 , A61L2202/181 , A61M25/002 , B65B55/10 , B65D33/01
摘要： A method and apparatus for packaging a medical device includes a package assembly that defines a multi-chambered interior. The interior chambers include a primary and a secondary chamber. A partition, which has a gas permeable vent, separates the primary chamber from the secondary chamber. The package is constructed from a variety of materials that provide the interior with a long term, low humidity, sterile environment.
摘要翻译：用于包装医疗装置的方法和装置包括限定多室内部的包装组件。内室包括主室和次室。具有透气孔的隔板将主室与次室隔开。该包装由各种材料构成，为内部提供长期，低湿度，无菌环境。

8. 发明申请

US20080274266A1 Selective Application Of Therapeutic Agent to a Medical Device 失效
标题翻译：治疗剂在医疗器械中的选择性应用
公开(公告)号：US20080274266A1
公开(公告)日：2008-11-06
申请号：US12113993
申请日：2008-05-02
申请人： Liza J. Davis , Thomas Priebe , Kim Robertson
发明人： Liza J. Davis , Thomas Priebe , Kim Robertson
IPC分类号： B05D3/12
CPC分类号： B05D1/36 , B05D1/26
摘要： A method of coating an implantable medical device may include providing an implantable medical device, applying a polymer base to the medical device, and directing a first solution including therapeutic agent and solvent through the nozzle onto a target zone of the polymer base coating to penetrate the polymer base coating. The solution may be directed at the target zone until a predetermined concentration of the therapeutic agent can be integrated within the polymer base coating.
摘要翻译：涂覆可植入医疗装置的方法可以包括提供可植入医疗装置，将聚合物基底施加到医疗装置，以及将包括治疗剂和溶剂的第一溶液通过喷嘴引导到聚合物基底涂层的靶区上以穿透聚合物基底涂层。溶液可以指向靶区，直到预定浓度的治疗剂可以整合在聚合物基底涂层内。

9. 发明授权

US08173200B2 Selective application of therapeutic agent to a medical device 失效
标题翻译：将治疗剂选择性应用于医疗器械
公开(公告)号：US08173200B2
公开(公告)日：2012-05-08
申请号：US12113993
申请日：2008-05-02
申请人： Liza J. Davis , Thomas Priebe , Kim Robertson
发明人： Liza J. Davis , Thomas Priebe , Kim Robertson
IPC分类号： A61L33/00 , B05D3/00 , A61K9/50 , A61K9/28 , A61M25/00 , A41D19/00 , B01J13/00
CPC分类号： B05D1/36 , B05D1/26
摘要： A method of coating an implantable medical device may include providing an implantable medical device, applying a polymer base to the medical device, and directing a first solution including therapeutic agent and solvent through the nozzle onto a target zone of the polymer base coating to penetrate the polymer base coating. The solution may be directed at the target zone until a predetermined concentration of the therapeutic agent can be integrated within the polymer base coating.
摘要翻译：涂覆可植入医疗装置的方法可以包括提供可植入医疗装置，将聚合物基底施加到医疗装置，以及将包括治疗剂和溶剂的第一溶液通过喷嘴引导到聚合物基底涂层的靶区上以穿透聚合物基底涂层。溶液可以指向靶区，直到预定浓度的治疗剂可以整合在聚合物基底涂层内。

10. 外观设计

USD485708S1 Easel 失效
标题翻译：画架
公开(公告)号：USD485708S1
公开(公告)日：2004-01-27
申请号：US29178777
申请日：2003-03-31
申请人： Kim Robertson
设计人： Kim Robertson

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