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1. 发明授权

US08565851B2 Mono-phasic action potential electrogram recording catheter, and method 有权
公开(公告)号：US08565851B2
公开(公告)日：2013-10-22
申请号：US12533903
申请日：2009-07-31
申请人： Michael Lau , Randell Werneth , Timothy J. Corvi , Sumita Bhola , Mark T. Stewart , Michel Haïssaguerre , Meleze Hocini
发明人： Michael Lau , Randell Werneth , Timothy J. Corvi , Sumita Bhola , Mark T. Stewart , Michel Haïssaguerre , Meleze Hocini
IPC分类号： A61B5/042 , A61B18/14 , A61N1/05
CPC分类号： A61B5/042 , A61B5/6858 , A61B18/1492 , A61B2018/00214 , A61B2018/00839 , A61B2018/00898 , A61N1/06
摘要： Catheters and methods for obtaining monophasic action potential (“MAP”) electrograms include a flexible catheter body defining a longitudinal axis, and a distal assembly affixed to the catheter body distal end defining a distal tip. The distal assembly has at least three MAP recording electrodes, and at least one reference electrode for determining reference potential. The recording electrodes are each positioned a radial distance from the longitudinal axis in at least three different radial directions, defining a recording geometry substantially having radial symmetry. The reference electrode is a longitudinal distance from the recording geometry. Optional features include a steerable catheter shaft, one or more radio-frequency ablation electrodes, and a dedicated pacing electrode. Different possible embodiments include a dome housing having the recording electrodes in a fixed spatial arrangement, and a distal loop assembly having an array of electrodes on at least three flexible loop elements.

2. 发明授权

US08280477B2 Mono-phasic action potential electrogram recording catheter, and method 有权
标题翻译：单相动作电位记录导管及方法
公开(公告)号：US08280477B2
公开(公告)日：2012-10-02
申请号：US12511707
申请日：2009-07-29
申请人： Michael Lau , Randell Werneth , Timothy J. Corvi , Sumita Bhola , Mark T. Stewart , Michel Haïssaguerre , Meleze Hocini
发明人： Michael Lau , Randell Werneth , Timothy J. Corvi , Sumita Bhola , Mark T. Stewart , Michel Haïssaguerre , Meleze Hocini
IPC分类号： A61B5/042 , A61B18/14 , A61N1/05
CPC分类号： A61B5/042 , A61B5/6858 , A61B18/1492 , A61B2018/00214 , A61B2018/00839 , A61B2018/00898 , A61N1/06
摘要： Catheters and methods for obtaining monophasic action potential (“MAP”) electrograms include a flexible catheter body defining a longitudinal axis, and a distal assembly affixed to the catheter body distal end defining a distal tip. The distal assembly has at least three MAP recording electrodes, and at least one reference electrode for determining reference potential. The recording electrodes are each positioned a radial distance from the longitudinal axis in at least three different radial directions, defining a recording geometry substantially having radial symmetry. The reference electrode is a longitudinal distance from the recording geometry. Optional features include a steerable catheter shaft, one or more radio-frequency ablation electrodes, and a dedicated pacing electrode. Different possible embodiments include a dome housing having the recording electrodes in a fixed spatial arrangement, and a distal loop assembly having an array of electrodes on at least three flexible loop elements.
摘要翻译：用于获得单相动作电位（MAP）电描记图的导管和方法包括限定纵向轴线的柔性导管主体，以及固定到导管主体远端的远端组件，其限定远端尖端。远端组件具有至少三个MAP记录电极和用于确定参考电位的至少一个参考电极。记录电极各自在至少三个不同的径向方向上与纵向轴线径向距离，限定基本上具有径向对称性的记录几何形状。参考电极是与记录几何形状的纵向距离。可选功能包括可导向的导管轴，一个或多个射频消融电极和专用起搏电极。不同的可能实施例包括具有固定空间布置的记录电极的圆顶壳体和在至少三个柔性环形元件上具有电极阵列的远端环组件。

3. 发明授权

US09387035B2 Bi-modal catheter steering mechanism 有权
标题翻译：双向导管转导机制
公开(公告)号：US09387035B2
公开(公告)日：2016-07-12
申请号：US12546796
申请日：2009-08-25
申请人： Randell Werneth , Ricardo Roman , Timothy J. Corvi , Betty Hu
发明人： Randell Werneth , Ricardo Roman , Timothy J. Corvi , Betty Hu
IPC分类号： A61B18/14 , A61B17/00 , A61B18/00
CPC分类号： A61B18/1492 , A61B5/042 , A61B2017/003 , A61B2017/00323 , A61B2018/00797 , A61B2018/00821 , A61B2018/1407 , A61B2018/1422 , A61B2018/1467 , A61M25/0147 , A61N1/056
摘要： Medical devices, systems, and methods for treating patients with tissue ablation include catheter systems having bi-modal steering mechanisms, which are capable of both linear and loop ablation. In other words, the catheter system may have two different steering modes: two-dimensional and three-dimensional. In the first and second steering modes, the steering actuator may cause one or more portions of the catheter shaft to bend in different planes. A steerable ablation catheter may include treatment elements such as electrodes at its distal end and along the catheter shaft, each of which may map, pace, and ablate.
摘要翻译：用于治疗患有组织消融的患者的医疗装置，系统和方法包括具有双向转向机构的导管系统，其能够进行线性和环路消融。换句话说，导管系统可以具有两种不同的转向模式：二维和三维。在第一和第二转向模式中，转向致动器可导致导管轴的一个或多个部分在不同的平面中弯曲。可引导的消融导管可以包括治疗元件，例如其远端处的电极和沿着导管轴的每个可以映射，步伐和消融的治疗元件。

4. 发明授权

US09439721B2 Bi-modal linear and loop ablation catheter, and method 有权
标题翻译：双模线性和环路消融导管及方法
公开(公告)号：US09439721B2
公开(公告)日：2016-09-13
申请号：US12546750
申请日：2009-08-25
申请人： Randell Werneth , Ricardo Roman , Timothy J. Corvi , Betty Hu
发明人： Randell Werneth , Ricardo Roman , Timothy J. Corvi , Betty Hu
IPC分类号： A61B18/14 , A61B17/00 , A61B18/00
CPC分类号： A61B18/1492 , A61B2017/003 , A61B2018/00797 , A61B2018/00821 , A61B2018/1407
摘要： Medical devices, systems, and methods for treating patients with tissue ablation include catheter systems having bi-modal steering mechanisms, which are capable of both linear and loop ablation. In other words, the catheter system may have two different steering modes: two-dimensional and three-dimensional. In the first and second steering modes, the steering actuator may cause one or more portions of the catheter shaft to bend in different planes. A steerable ablation catheter may include treatment elements such as electrodes at its distal end and along the catheter shaft, each of which may map, pace, and ablate. Optional features include a series of thermocouples for monitoring local temperatures.
摘要翻译：用于治疗患有组织消融的患者的医疗装置，系统和方法包括具有双向转向机构的导管系统，其能够进行线性和环路消融。换句话说，导管系统可以具有两种不同的转向模式：二维和三维。在第一和第二转向模式中，转向致动器可导致导管轴的一个或多个部分在不同的平面中弯曲。可引导的消融导管可以包括治疗元件，例如其远端处的电极和沿着导管轴的每个可以映射，步伐和消融的治疗元件。可选功能包括一系列用于监测当地温度的热电偶。

5. 发明申请

US20070208401A1 Selective organ cooling apparatus and method 有权
标题翻译：选择性器官冷却装置及方法
公开(公告)号：US20070208401A1
公开(公告)日：2007-09-06
申请号：US11799191
申请日：2007-05-01
申请人： John Dobak , Juan Lasheras , Randell Werneth
发明人： John Dobak , Juan Lasheras , Randell Werneth
IPC分类号： A61F7/00
CPC分类号： A61B18/02 , A61B2017/00292 , A61B2018/0212 , A61F7/12 , A61F2007/0056 , A61F2007/126 , A61M25/00 , A61M25/0023 , A61M2025/0004 , A61M2025/006 , A61M2205/3606
摘要： An endovascular heat transfer device which can have a smooth exterior surface, or a surface with ridges and grooves. The device can have a plurality of elongated, articulated segments, with each having such a surface. A flexible joint connects adjacent elongated, articulated segments. The flexible joints can be bellows or flexible tubes. An inner lumen is disposed within the heat transfer segments. The inner lumen is capable of transporting a pressurized working fluid to a distal end of the heat transfer element.
摘要翻译：可以具有光滑的外表面或具有脊和凹槽的表面的血管内传热装置。该装置可以具有多个细长的关节部分，每个部分具有这样的表面。柔性接头连接相邻的细长铰接段。柔性接头可以是波纹管或柔性管。内腔设置在传热段内。内腔能够将加压工作流体输送到传热元件的远端。

6. 发明申请

US20060111701A1 Atrial ablation catheter adapted for treatment of septal wall arrhythmogenic foci and method of use 有权
公开(公告)号：US20060111701A1
公开(公告)日：2006-05-25
申请号：US10997713
申请日：2004-11-24
申请人： Hakan Oral , Randell Werneth , Thomas Castellano , Christopher Kunis
发明人： Hakan Oral , Randell Werneth , Thomas Castellano , Christopher Kunis
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/0016 , A61B2018/00214 , A61B2018/00267 , A61B2018/00351 , A61B2018/1475
摘要： An atrial ablation catheter with an electrode array particularly adapted to locate and ablate foci of arrhythmia which are required for sustained atrial fibrillation is provided. The array is easily deployed and retracted from the catheter, and presents a proximally oriented electrode array that can be pulled against the septal wall of the left atrium to engage the septal wall.

7. 发明授权

US06719723B2 Multipurpose catheter assembly 有权
标题翻译：多功能导管组件
公开(公告)号：US06719723B2
公开(公告)日：2004-04-13
申请号：US09731176
申请日：2000-12-06
申请人： Randell Werneth
发明人： Randell Werneth
IPC分类号： A61F712
CPC分类号： A61F7/12 , A61F2007/126
摘要： An apparatus for performing hypothermia of the body of a patient, or of a selected organ, while delivering a medicament to a selected blood vessel. A flexible coaxial catheter is inserted through the vascular system of a patient to place the distal tip of the catheter in a selected artery. A chilled fluid is pumped through an inner supply conduit of the catheter to cool a flexible heat transfer element in the distal tip of the catheter. The heat transfer element cools the blood flowing through the artery distal to the tip of the catheter. The medicament, such as a vaso-dilator, is delivered either separately or mixed with the chilled fluid, through a very small exit port in or near the heat transfer element.
摘要翻译：一种用于在将药物递送至所选择的血管的同时，对患者或选定器官的身体进行体温过低的装置。将柔性同轴导管穿过患者的血管系统插入导管的远端以选择动脉。冷冻流体被泵送通过导管的内部供应管道以冷却导管的远侧末端中的柔性传热元件。传热元件冷却流过导管末端的动脉的血液。药物，例如血管扩张器，分开地或与冷冻液体混合，通过传热元件内或附近的非常小的出口。

8. 发明申请

US20070083195A1 Low power tissue ablation system 有权
标题翻译：低功率组织消融系统
公开(公告)号：US20070083195A1
公开(公告)日：2007-04-12
申请号：US11484878
申请日：2006-07-11
申请人： Randell Werneth , Christopher Kunis , J. Flaherty , Marshall Sherman
发明人： Randell Werneth , Christopher Kunis , J. Flaherty , Marshall Sherman
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2017/00084 , A61B2017/00243 , A61B2018/00214 , A61B2018/00351 , A61B2018/00666 , A61B2018/00898 , A61B2018/1467 , A61B2018/1475
摘要： Devices, systems and methods are disclosed for the ablation of tissue. Embodiments include an ablation catheter that has an array of ablation elements attached to a deployable carrier assembly. The carrier assembly can be constrained within the lumen of a catheter, and deployed to take on an expanded condition. The carrier assembly includes multiple electrodes that are configured to ablate tissue at low power. Additional embodiments include a system that includes an interface unit for delivering one or more forms of energy to the ablation catheter.
摘要翻译：公开了用于组织消融的装置，系统和方法。实施例包括消融导管，其具有附接到可展开的载体组件的消融元件阵列。载体组件可以被限制在导管的内腔中，并且被部署以展开扩张状态。载体组件包括被配置成以低功率消融组织的多个电极。另外的实施例包括包括用于将一种或多种形式的能量递送到消融导管的接口单元的系统。

9. 发明申请

US20060116734A1 Selective organ cooling apparatus 有权
标题翻译：选择性器官冷却装置
公开(公告)号：US20060116734A1
公开(公告)日：2006-06-01
申请号：US11333986
申请日：2006-01-17
申请人： John Dobak , Juan Lasheras , Randell Werneth
发明人： John Dobak , Juan Lasheras , Randell Werneth
IPC分类号： A61B18/04
CPC分类号： A61B18/02 , A61B2017/00292 , A61B2018/0212 , A61F7/12 , A61F2007/0056 , A61F2007/126 , A61M25/00 , A61M25/0023 , A61M2025/0004 , A61M2025/006 , A61M2205/3606
摘要： An endovascular heat transfer device which can have a smooth exterior surface, or a surface with ridges and grooves. The device can have a plurality of elongated, articulated segments, with each having such a surface. A flexible joint connects adjacent elongated, articulated segments. The flexible joints can be bellows or flexible tubes. An inner lumen is disposed within the heat transfer segments. The inner lumen is capable of transporting a pressurized working fluid to a distal end of the heat transfer element.
摘要翻译：可以具有光滑的外表面或具有脊和凹槽的表面的血管内传热装置。该装置可以具有多个细长的关节部分，每个部分具有这样的表面。柔性接头连接相邻的细长铰接段。柔性接头可以是波纹管或柔性管。内腔设置在传热段内。内腔能够将加压工作流体输送到传热元件的远端。

10. 发明申请

US20060106375A1 Ablation system with feedback 有权
公开(公告)号：US20060106375A1
公开(公告)日：2006-05-18
申请号：US11179332
申请日：2005-07-12
申请人： Randell Werneth , Marshall Sherman , J. Flaherty
发明人： Randell Werneth , Marshall Sherman , J. Flaherty
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B8/0833 , A61B2017/00106 , A61B2017/00243 , A61B2018/00351 , A61B2018/00702 , A61B2018/00791
摘要： Devices, systems and methods are disclosed for the ablation of tissue and treatment of cardiac arrhythmia. An ablation system includes an ablation catheter that has an array of ablation elements and a location element, an esophageal probe also including a location element, and an interface unit that provides energy to the ablation catheter. The distance between the location elements, determined by calculating means of the system, can be used by the system to set or modify one or more system parameters.

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