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1. 发明授权

US6121463A Alkyl-4-silylheterocyclic phenols and thiophenols useful as antioxidant agents 失效
标题翻译：烷基-4-甲硅烷基杂环苯酚和可用作抗氧化剂的苯硫酚
公开(公告)号：US6121463A
公开(公告)日：2000-09-19
申请号：US102869
申请日：1998-06-23
申请人： Roger A. Parker , Michael L. Edwards , Mark J. Vaal , James E. Matt , Kim S. Chen , Mark T. Yates , Paul S. Wright , Steven J. Busch
发明人： Roger A. Parker , Michael L. Edwards , Mark J. Vaal , James E. Matt , Kim S. Chen , Mark T. Yates , Paul S. Wright , Steven J. Busch
IPC分类号： C07F7/08 , C07D327/00 , C07D305/00 , C07D307/02 , C07D333/22
CPC分类号： C07F7/0814
摘要： The present invention provides compounds of the formula ##STR1## wherein R is hydrogen or --C(O)--(CH.sub.2).sub.m --Q wherein Q is hydrogen or --COOH and m is an integer 1, 2, 3 or 4;R.sub.1, R.sub.5 and R.sub.6 are independently a C.sub.1 -C.sub.6 alkyl group;R.sub.2, R.sub.3 and R.sub.4 are independently hydrogen or a C.sub.1 -C.sub.6 alkyl group;Z is thio, oxy or a methylene group;A is a C.sub.1 -C.sub.4 alkylene group;X is thio or oxy; andG.sub.1 and G.sub.2 are independently hydrogen, C.sub.1 -C.sub.6 alkyl or --C(O)--(CH.sub.2).sub.n --CH.sub.3 and n is an integer 0, 1, 2 or 3;or a pharmaceutically acceptable salt thereof; useful for the treatment of atherosclerosis and chronic inflammatory disorders; for inhibiting cytokine-induced expression of VCAM-1 and/or ICAM-1; for inhibiting the peroxidation of LDL lipid; for lowering plasma cholesterol; and as anti-oxidant chemical additives useful for preventing oxidative deterioration in organic materials.
摘要翻译：本发明提供下式的化合物其中R是氢或-C（O） - （CH 2）m-Q，其中Q是氢或-COOH，m是整数1,2,3或4; R1，R5和R6独立地为C1-C6烷基; R2，R3和R4独立地是氢或C1-C6烷基; Z是硫代，氧基或亚甲基; A是C1-C4亚烷基; X是硫或氧; 且G 1和G 2独立地为氢，C 1 -C 6烷基或-C（O） - （CH 2）n -CH 3，n为整数0,1,2或3; 或其药学上可接受的盐; 可用于治疗动脉粥样硬化和慢性炎症性疾病; 用于抑制VCAM-1和/或ICAM-1的细胞因子诱导的表达; 用于抑制LDL脂质的过氧化; 用于降低血浆胆固醇; 以及用作防止有机材料氧化变质的抗氧化剂。

2. 发明授权

US6133467A 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol 失效
标题翻译： 2,6-二叔丁基-4 - [（二甲基-4-甲氧基苯基甲硅烷基） - 甲氧基]苯酚和2,6-二叔丁基-4 - [（二甲基-2-甲氧基 - 苯基甲硅烷基）甲氧基 ]苯酚
公开(公告)号：US6133467A
公开(公告)日：2000-10-17
申请号：US103215
申请日：1998-06-23
申请人： Michael L. Edwards , Mark J. Vaal , Roger A. Parker , James E. Matt , Kim S. Chen , Mark T. Yates
发明人： Michael L. Edwards , Mark J. Vaal , Roger A. Parker , James E. Matt , Kim S. Chen , Mark T. Yates
IPC分类号： C07F7/08 , C07F7/04
CPC分类号： C07F7/0818
摘要： This invention relates to the compounds of 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)methyloxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxyphenylsilyl)methyloxy]phenol, polymorphs thereof and their pharmaceutically acceptable salts, useful as antiatherosclerotic agents.
摘要翻译：本发明涉及2,6-二叔丁基-4 - [（二甲基-4-甲氧基苯基甲硅烷基）甲氧基]苯酚和2,6-二叔丁基-4 - [（二甲基-2-甲氧基苯基甲硅烷基）甲氧基]苯酚，其多晶型物及其药学上可接受的盐，可用作抗动脉粥样硬化剂。

3. 发明授权

US5608095A Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents 失效
标题翻译：烷基-4-甲硅烷基 - 苯酚及其酯作为抗动脉粥样硬化剂
公开(公告)号：US5608095A
公开(公告)日：1997-03-04
申请号：US637968
申请日：1996-04-30
申请人： Roger A. Parker , Michael L. Edwards , Mark J. Vaal , James E. Matt, Jr. , Kim S. Chen , Mark T. Yates , Paul S. Wright , Steven J. Busch
发明人： Roger A. Parker , Michael L. Edwards , Mark J. Vaal , James E. Matt, Jr. , Kim S. Chen , Mark T. Yates , Paul S. Wright , Steven J. Busch
IPC分类号： A61K31/695 , A61P3/06 , A61P11/06 , A61P19/02 , A61P29/00 , A61P37/00 , A61P43/00 , C07F7/08 , C07F7/10 , C07F7/12 , C07F7/18
CPC分类号： C07F7/0818
摘要： This invention relates to compounds of the formula ##STR1## wherein R.sub.1 and R.sub.6 are each independently C.sub.1 -C.sub.6 alkyl;R.sub.2, R.sub.3 and R.sub.4 are each independently hydrogen or C.sub.1 -C.sub.6 alkyl;R is hydrogen or --C(O)--(CH.sub.2).sub.m --Q wherein Q is hydrogen or --COOH and m is an integer 1, 2, 3 or 4;Z is a thio, oxy or methylene group;A is a C.sub.1 -C.sub.4 alkylene group;R.sub.5 and R.sub.7 are each independently a C.sub.1 -C.sub.6 alkyl or --(CH.sub.2).sub.n --(Ar) wherein n is an integer 0, 1, 2 or 3; and Ar is phenyl or naphthyl unsubstituted or substituted with one to three substituents selected from the group consisting of hydroxy, methoxy, ethoxy, halogen, trifluoromethyl, C.sub.1 -C.sub.6 alkyl, or --NR.sub.8 R.sub.9, wherein R.sub.8 and R.sub.9 are each independently hydrogen or C.sub.1 -C.sub.6 alkyl; with the proviso that when R.sub.2 and at least one of R.sub.5 or R.sub.7 is C.sub.1 -C.sub.6 alkyl, and Ar is not substituted with trifluoromethyl or --NR.sub.8 R.sub.9, then R is --C(O)--(CH.sub.2).sub.m --Q; or a pharmaceutically acceptable salt thereof; useful for the treatment of atherosclerosis and chronic inflammatory disorders; for inhibiting cytokine-induced expression of VCAM-1 and/or ICAM-1; for inhibiting the peroxidation of LDL lipid; for lowering plasma cholesterol; and as antioxidant chemical additives useful for preventing oxidative deterioration in organic materials.
摘要翻译：本发明涉及式（1）的化合物，其中R 1和R 6各自独立地为C 1 -C 6烷基; R2，R3和R4各自独立地为氢或C1-C6烷基; R是氢或-C（O） - （CH 2）m-Q其中Q是氢或-COOH，m是整数1,2,3或4; Z是硫基，氧基或亚甲基; A是C1-C4亚烷基; R 5和R 7各自独立地为C 1 -C 6烷基或 - （CH 2）n - （Ar），其中n为整数0,1,2或3; 并且Ar是未取代的或被一至三个选自羟基，甲氧基，乙氧基，卤素，三氟甲基，C 1 -C 6烷基或-NR 8 R 9的取代基取代的苯基或萘基，其中R 8和R 9各自独立地为氢或C1- C6烷基; 条件是当R 2和R 5或R 7中的至少一个是C 1 -C 6烷基，并且Ar不被三氟甲基或-NR 8 R 9取代时，则R是-C（O） - （CH 2）m -Q; 或其药学上可接受的盐; 可用于治疗动脉粥样硬化和慢性炎症性疾病; 用于抑制VCAM-1和/或ICAM-1的细胞因子诱导的表达; 用于抑制LDL脂质的过氧化; 用于降低血浆胆固醇; 以及用作防止有机材料氧化变质的抗氧化剂添加剂。

4. 发明申请

US20130024336A1 Systems and Methods for Providing Controls for Aggregated Weather-Based Work 有权
标题翻译：提供总体天气工作控制系统和方法
公开(公告)号：US20130024336A1
公开(公告)日：2013-01-24
申请号：US13187364
申请日：2011-07-20
申请人： Raymond P. Jones, JR. , Gregory G. Gonzales , Michael L. Edwards , Douglas S., II Haymore
发明人： Raymond P. Jones, JR. , Gregory G. Gonzales , Michael L. Edwards , Douglas S., II Haymore
IPC分类号： G06Q10/00 , G06F17/00
CPC分类号： G06Q30/0202 , G06Q30/06 , G06Q50/188
摘要： Systems, methods, non-transitory computer-readable media storing computer program instructions for causing a computer device to implement methods, and the like utilize weather information from one or a variety of locations to estimate costs for providing weather-dependent work, and to provide financial controls for weather-dependent work allegedly performed. One method includes utilizing historical weather information relating to performance of weather-dependent work at a work location to generate an estimate of an anticipated frequency with which weather-dependent work will be necessary, utilizing information to estimate an anticipated cost per incident for performing weather-dependent work at the selected work location, and using such information at a plurality of locations to generate an aggregate bid for performing weather-dependent work at the locations. Weather information is also used to audit weather-dependent work allegedly performed at the work locations to provide financial controls to the aggregated weather-dependent work in compliance with law and regulation.
摘要翻译：存储用于使计算机设备实现方法的计算机程序指令的系统，方法，非暂时计算机可读介质等利用来自一个或多个位置的天气信息来估计用于提供与天气有关的工作的成本，并提供涉及天气依赖的工作的财务控制。一种方法包括利用与在工作场所执行天气依赖性工作相关的历史天气信息来产生对于天气依赖性工作将是必要的预期频率的估计，利用信息来估计每个事件的预期成本，并且在多个位置处使用这些信息来生成用于在该位置执行与天气有关的工作的总出价。天气信息也用于审计据称在工作地点执行的天气依赖工作，以便根据法律和法规为天气依赖的工作提供财务控制。

5. 发明授权

US08288425B2 Benzimidazoles 有权
标题翻译：苯并咪唑
公开(公告)号：US08288425B2
公开(公告)日：2012-10-16
申请号：US11029064
申请日：2005-01-04
申请人： Michael L. Edwards , Paul J. Cox , Shelley Amendola , Stephanie D. Deprets , Timothy A. Gillespy , Christopher D. Edlin , Andrew D. Morley , Charles J. Gardner , Brian Pedgrift , Herve Bouchard , Didier Babin , Laurence Gauzy , Alain Le-Brun , Tahir N. Majid , John C. Reader , Lloyd J. Payne , Nawaz M. Khan , Michael Cherry
发明人： Michael L. Edwards , Paul J. Cox , Shelley Amendola , Stephanie D. Deprets , Timothy A. Gillespy , Christopher D. Edlin , Andrew D. Morley , Charles J. Gardner , Brian Pedgrift , Herve Bouchard , Didier Babin , Laurence Gauzy , Alain Le-Brun , Tahir N. Majid , John C. Reader , Lloyd J. Payne , Nawaz M. Khan , Michael Cherry
IPC分类号： A61K31/4184 , C07D235/18
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D471/04 , C07D487/04 , C07D491/04
摘要： The invention is directed to physiologically active compounds of the general formula (Ix) and compositions containing such compounds, and their prodrugs, and pharmaceutically acceptable salts and solvates of such compounds and their prodrugs, as well as to novel compounds within the scope of formula (Ix), and to processes for their preparation. Such compounds and compositions have valuable pharmaceutical properties, in particular the ability to inhibit kinases.
摘要翻译：本发明涉及通式（Ix）的生理活性化合物和含有这些化合物及其前药以及这些化合物及其前药的药学上可接受的盐和溶剂合物的组合物，以及式（Ix）范围内的新化合物 Ix），以及它们的制备过程。这些化合物和组合物具有有价值的药物特性，特别是抑制激酶的能力。

6. 发明授权

US6114394A Polyamine derivatives as radioprotective agents 失效
标题翻译：聚胺衍生物作为放射防护剂
公开(公告)号：US6114394A
公开(公告)日：2000-09-05
申请号：US949536
申请日：1997-10-14
申请人： Michael L. Edwards , Ronald D. Snyder
发明人： Michael L. Edwards , Ronald D. Snyder
IPC分类号： A61K31/13 , A61K31/785 , A61K47/18 , A61K47/34 , A61P43/00 , C07C211/14 , C07C211/27 , C07C211/48 , C07C211/53 , C07C211/57 , C07C211/58 , A61K31/135 , C07C211/00
CPC分类号： C07C211/58 , A61K31/785 , C07C211/14 , C07C211/27 , C07C211/48
摘要： The present invention relates to polyamine derivatives of the formula RHN-(CH.sub.2).sub.m -NH-(CH.sub.2).sub.n -NHR wherein m is an integer from 2 to 4, n is an integer from 3 to 10 and R is C.sub.2 -C.sub.6 alkyl or --(CH.sub.2).sub.p -Ar wherein Ar is phenyl or naphthyl and p is an integer from 0 to 2; and the pharmaceutically acceptable addition salts thereof which are useful as radioprotective agents. It relates also to the use of polyamines of the formula RHN-(CH.sub.2).sub.m -NH-(CH.sub.2).sub.n -NH-(CH.sub.2).sub.m -NHR wherein m is an integer from 2 to 4, n is an integer from 3 to 10 and R is C.sub.2 -C.sub.6 alkyl or --(CH.sub.2).sub.p -Ar wherein Ar is phenyl or naphthyl and p is an integer from 0 to 2; and the pharmaceutically acceptable addition salts thereof as radioprotective agents.
摘要翻译：本发明涉及式RHN-（CH2）m-NH-（CH2）n-NHR的多胺衍生物，其中m为2至4的整数，n为3至10的整数，R为C 2 -C 6烷基或 - （CH 2）p-Ar，其中Ar为苯基或萘基，p为0至2的整数; 和其药学上可接受的加成盐，其可用作放射防护剂。它还涉及式RHN-（CH2）m-NH-（CH2）n-NH-（CH2）m-NHR的多胺的用途，其中m是2至4的整数，n是3至 10和R是C 2 -C 6烷基或 - （CH 2）p-Ar，其中Ar是苯基或萘基，p是0-2的整数; 和其药学上可接受的加成盐作为放射防护剂。

7. 发明授权

US5011859A Di- and tetra-fluoro analogs of squalene as inhibitors of squalene epoxidase 失效
标题翻译：角鲨烯的二氟和四氟类似物作为角鲨烯环氧酶的抑制剂
公开(公告)号：US5011859A
公开(公告)日：1991-04-30
申请号：US502203
申请日：1990-03-30
申请人： Esa T. Jarvi , Michael L. Edwards , James R. McCarthy
发明人： Esa T. Jarvi , Michael L. Edwards , James R. McCarthy
IPC分类号： A61K31/035 , A61K31/045 , A61P3/06 , A61P9/10 , A61P43/00 , C07C21/215 , C07C33/42
CPC分类号： C07C21/215
摘要： This invention relates to certain novel di- and tetra-fluoro analogs of squalene and to their methods of use in lowering plasma cholesterol and in inhibiting squalene epoxidase in patients in need thereof.

8. 发明授权

US4996308A Derivatives with unsaturated substitutions for the 5'-hydroxymethyl group 失效
标题翻译：具有5'-羟甲基不饱和取代基的衍生物
公开(公告)号：US4996308A
公开(公告)日：1991-02-26
申请号：US173782
申请日：1988-03-25
申请人： Michael L. Edwards , James R. McCarthy , Nellikunja J. Prakash
发明人： Michael L. Edwards , James R. McCarthy , Nellikunja J. Prakash
IPC分类号： A61K31/505 , A61K31/52 , A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7076 , A61P35/00 , C07D473/00 , C07D473/16 , C07D473/34 , C07D473/40 , C07D487/04 , C07H19/04 , C07H19/052 , C07H19/056 , C07H19/06 , C07H19/16
CPC分类号： C07D473/00 , C07H19/04 , C07H19/052 , C07H19/056 , C07H19/06 , C07H19/16
摘要： This invention relates to certain acetylenic, cyano and allenic aristeromycin/adenosine derivatives which are useful in inhibiting AdoMet-dependent transmethylation and in the treatment of patients afflicted with neoplastic or viral disease states.

9. 发明授权

US09228401B2 Method of determining borehole conditions from distributed measurement data 有权
标题翻译：从分布式测量数据确定井眼条件的方法
公开(公告)号：US09228401B2
公开(公告)日：2016-01-05
申请号：US12560158
申请日：2009-09-15
申请人： Stephen T. Edwards , Christopher J. Coley , Michael L. Edwards , Donald F. Shafer , Mark W. Alberty
发明人： Stephen T. Edwards , Christopher J. Coley , Michael L. Edwards , Donald F. Shafer , Mark W. Alberty
IPC分类号： E21B47/003 , E21B47/08 , E21B21/08 , E21B33/16 , E21B47/00
CPC分类号： E21B21/08 , E21B33/16 , E21B47/0003 , E21B47/08
摘要： Borehole conditions can be determined using distributed measurement data. Real time data measurements can be taken from sensors distributed along the length of a drill string to assess various conditions or properties of the borehole. In particular, the distributed data can be used for example, to track the progress of a chemical pill or also track the location of different types of borehole fluids, and also to determine the hole size or volume of the borehole.
摘要翻译：钻孔条件可以使用分布式测量数据确定。可以从沿着钻柱长度分布的传感器获取实时数据测量，以评估钻孔的各种条件或性质。特别地，分布式数据可以用于例如跟踪化学药丸的进程或跟踪不同类型的钻孔流体的位置，并且还可以确定钻孔的孔尺寸或体积。

10. 发明申请

US20150100380A1 SYSTEMS AND METHODS FOR PROVIDING FINANCIAL CONTROLS FOR AGGREGATED WEATHER-BASED WORK 审中-公开
标题翻译：用于提供基于天气的工作的财务控制系统和方法
公开(公告)号：US20150100380A1
公开(公告)日：2015-04-09
申请号：US14049044
申请日：2013-10-08
申请人： Raymond P. Jones, JR. , Gregory G. Gonzales , Michael L. Edwards , Douglas S. Haymore, II
发明人： Raymond P. Jones, JR. , Gregory G. Gonzales , Michael L. Edwards , Douglas S. Haymore, II
IPC分类号： G06Q30/02
CPC分类号： G06Q30/0206 , G06Q30/0202
摘要： Systems, methods, non-transitory computer-readable media storing computer program instructions for causing a computer device to implement methods, and the like utilize weather information from one or a variety of locations to estimate costs for providing weather-dependent work, and to provide financial controls for weather-dependent work allegedly performed. One method includes utilizing historical weather information relating to performance of weather-dependent work at a work location to generate an estimate of an anticipated frequency with which weather-dependent work will be necessary, utilizing information to estimate an anticipated cost per incident for performing weather-dependent work at the selected work location, and using such information at a plurality of locations to generate an aggregate bid for performing weather-dependent work at the locations. Weather information is also used to audit weather-dependent work allegedly performed at the work locations to provide financial controls to the aggregated weather-dependent work in compliance with law and regulation.
摘要翻译：存储用于使计算机设备实现方法的计算机程序指令的系统，方法，非暂时计算机可读介质等利用来自一个或多个位置的天气信息来估计用于提供与天气有关的工作的成本，并提供涉及天气依赖的工作的财务控制。一种方法包括利用与在工作场所执行天气依赖性工作相关的历史天气信息来产生对于天气依赖性工作将是必要的预期频率的估计，利用信息来估计每个事件的预期成本，并且在多个位置处使用这些信息来生成用于在该位置执行与天气有关的工作的总出价。天气信息也用于审计据称在工作地点执行的天气依赖工作，以便根据法律和法规为天气依赖的工作提供财务控制。

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