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1. 发明申请

US20070243105A1 Throughflow Device for Measuring Platelet Function of Primary Hemostasis, Aggregation and/or Coagulation and/or Viscosity of Blood 失效
标题翻译：用于测量原发性止血，聚集和/或凝血和/或血液粘度的血小板功能的通流装置
公开(公告)号：US20070243105A1
公开(公告)日：2007-10-18
申请号：US10589034
申请日：2005-02-04
申请人： Michael Kratzer , Volker Von Der Goltz
发明人： Michael Kratzer , Volker Von Der Goltz
IPC分类号： B01L11/00
CPC分类号： G01N33/4905
摘要： The invention relates to a throughflow device for measuring platelet function of primary hemostasis, aggregation and/or coagulation and/or viscosity of the blood. A reservoir (8), from which blood can be taken for measurement and transported through an aperture (7), is arranged in a housing (2). A stirring device (10,11,12,13) is provided in the reservoir (8) and can be moved in such a way that a stirrer part (11) of the stirring device (10,11,12,13) mixes the blood which is located in the storage chamber (8) during measurement and maintains it in a state of motion.
摘要翻译：本发明涉及一种用于测量血液的初步止血，凝血和/或凝血和/或粘度的血小板功能的通流装置。可以从壳体（2）中设置有用于测量血液并通过孔（7）传送血液的储存器（8）。搅拌装置（10,11,12,13）设置在储存器（8）中，并且可以以使得搅拌装置（10,11,12,13）的搅拌器部分（11）将搅拌装置在测量期间位于储存室（8）中的血液并将其维持在运动状态。

2. 发明授权

US07763207B2 Throughflow device for measuring platelet function of primary hemostasis, aggregation and/or coagulation and/or viscosity of blood 失效
标题翻译：用于测量原发性止血，聚集和/或凝血和/或血液粘度的血小板功能的通流装置
公开(公告)号：US07763207B2
公开(公告)日：2010-07-27
申请号：US10589034
申请日：2005-02-04
申请人： Michael Kratzer , Volker Von Der Goltz
发明人： Michael Kratzer , Volker Von Der Goltz
IPC分类号： G01N15/06
CPC分类号： G01N33/4905
摘要： The invention relates to a throughflow device for measuring platelet function of primary hemostasis, aggregation and/or coagulation and/or viscosity of the blood. A reservoir (8), from which blood can be taken for measurement and transported through an aperture (7), is arranged in a housing (2). A stirring device (10,11,12,13) is provided in the reservoir (8) and can be moved in such a way that a stirrer part (11) of the stirring device (10,11,12,13) mixes the blood which is located in the storage chamber (8) during measurement and maintains it in a state of motion.
摘要翻译：本发明涉及一种用于测量血液的初步止血，凝血和/或凝血和/或粘度的血小板功能的通流装置。可以从壳体（2）中设置有用于测量血液并通过孔（7）传送血液的储存器（8）。搅拌装置（10,11,12,13）设置在储存器（8）中，并且可以以使得搅拌装置（10,11,12,13）的搅拌器部分（11）将搅拌装置在测量期间位于储存室（8）中的血液并将其维持在运动状态。

3. 发明授权

US4780418A Method and apparatus for measuring the aggregation of blood platelets or the coagulation of blood 失效
标题翻译：用于测量血小板聚集或血液凝结的方法和装置
公开(公告)号：US4780418A
公开(公告)日：1988-10-25
申请号：US932422
申请日：1986-11-19
申请人： Michael Kratzer
发明人： Michael Kratzer
IPC分类号： G01N33/86 , G01N33/49 , G01N7/00
CPC分类号： G01N33/4905
摘要： A method and apparatus are disclosed for measuring the aggregation of blood platelets or the coagulation of blood, the apparatus including a capillary tube for drawing blood, a piston in communication with the capillary tube and connected to a motor means for linear displacement thereof, a pressure sensor in the space located between the drawn blood and piston, and a computing means or microprocessing means for comparing the sensed pressure from the pressure sensor with a predetermined value, and providing a measured regulating output to the motor means. The method for measuring the aggregation of blood platelets and coagulation of blood includes the steps of drawing blood into the capillary tube of the moveable piston until the desired pressure is achieved within the capillary tube, and allowing the computing means to then maintain by adjustment of the piston position the pressure within the capillary tube. The computing means is able to determine the amount of blood flowing into the capillary tube during constant pressure regulation, and hence the amount of aggregate of blood platelets and blood coagulation due to a known relationship relating movement of the piston to blood drawn into the cylinder.
摘要翻译：公开了一种用于测量血小板聚集或血液凝固的方法和装置，该装置包括用于抽血的毛细管，与毛细管连通的活塞，并连接到用于其线性位移的马达装置，压力传感器，其位于抽取的血液和活塞之间的空间中，以及计算装置或微处理装置，用于将来自压力传感器的感测压力与预定值进行比较，并向马达装置提供测量的调节输出。用于测量血小板聚集和血液凝固的方法包括以下步骤：将血液吸入可移动活塞的毛细管中，直到毛细管内达到所需的压力，然后允许计算装置通过调节活塞定位毛细管内的压力。计算装置能够确定在恒定压力调节期间流入毛细管的血液量，并因此确定由于已知关系使血小板凝集的聚集体和血液凝固的量，使活塞与吸入气缸的血液相关。

4. 发明授权

US4604894A System for measuring bleeding time in vitro 失效
标题翻译：体外测量出血时间的系统
公开(公告)号：US4604894A
公开(公告)日：1986-08-12
申请号：US563454
申请日：1983-12-20
申请人： Michael Kratzer , Gustav V. R. Born
发明人： Michael Kratzer , Gustav V. R. Born
IPC分类号： G01N33/86 , A61B5/145 , A61B5/1459 , G01N33/48 , G01N33/49 , G01N11/04
CPC分类号： G01N33/48 , G01N33/4905
摘要： A system for measuring bleeding time in vitro is disclosed in which blood is passed under pressure through a porous element and the resulting volumetric flow is measured. The porous element is provided with a through aperture and supported in such a manner that the blood moves through the aperture and not laterally into the porous element. The porous element can be soaked in a solution, for example, adenosine diphosphate, which coagulates the platelets and in this manner it is possible to reproduce in vivo bleeding conditions.
摘要翻译：公开了一种用于测量体外出血时间的系统，其中血液通过多孔元件在压力下通过，并且测量所得的体积流量。多孔元件设置有通孔并以使得血液通过孔而不横向地移入多孔元件的方式被支撑。可以将多孔元件浸泡在溶液中，例如二磷酸腺苷，其使血小板凝结，并且以这种方式可以在体内出血条件下再生。

5. 发明申请

US20110244508A1 Method for investigating the thrombocyte function of the blood 审中-公开
标题翻译：调查血液血小板功能的方法
公开(公告)号：US20110244508A1
公开(公告)日：2011-10-06
申请号：US13064475
申请日：2011-03-28
申请人： Michael Kratzer
发明人： Michael Kratzer
IPC分类号： C12Q1/02
CPC分类号： G01N33/4905
摘要： A method for investigating the thrombocyte function of the blood, and particularly of platelet aggregation, wherein the following steps are carried out: a) cross-flowing an aperture with blood or blood components; b) determining the active radius of the aperture depending on time and c) evaluating the time-dependent modification of the radius as a measure for blood cell and/or thrombocyte function.
摘要翻译：一种用于调查血液，特别是血小板聚集的血小板功能的方法，其中执行以下步骤：a）使血液或血液成分的孔交叉流动; b）根据时间确定孔径的有效半径，以及c）评估半径的时间依赖性修改作为血细胞和/或血小板功能的量度。

6. 发明授权

US5744098A Device for the automatic examination of blood samples 失效
标题翻译：血液样本自动检查装置
公开(公告)号：US5744098A
公开(公告)日：1998-04-28
申请号：US460352
申请日：1995-06-02
申请人： Michael Kratzer , Volker Freiherr von der Goltz
发明人： Michael Kratzer , Volker Freiherr von der Goltz
IPC分类号： G01N1/00 , G01N33/49 , G01N35/00 , G01N35/02 , G01N33/48
CPC分类号： G01N35/02 , G01N33/4905 , G01N1/14 , G01N35/00009 , Y10T436/114165
摘要： A measuring unit for performing plural bleeding time analyses has a vessel divided into at least two chambers by a separating wall. Each chamber has a capillary coupled to an outlet in the chamber base wall, and the outlet is also in communication with an aperture of an apertured filter unit placed adjacent the base wall.
摘要翻译：用于执行多次出血时间分析的测量单元具有通过分隔壁分成至少两个室的容器。每个室具有耦合到室底壁中的出口的毛细管，并且出口也与邻近底壁放置的有孔过滤器单元的孔连通。

7. 发明授权

US5460779A Device for the automatic examination of blood samples 失效
标题翻译：血液样本自动检查装置
公开(公告)号：US5460779A
公开(公告)日：1995-10-24
申请号：US430140
申请日：1994-04-26
申请人： Michael Kratzer , Volker F. von der Goltz
发明人： Michael Kratzer , Volker F. von der Goltz
IPC分类号： G01N1/00 , G01N33/49 , G01N35/00 , G01N35/02
CPC分类号： G01N35/02 , G01N33/4905 , G01N1/14 , G01N35/00009 , Y10T436/114165
摘要： The invention pertains to a device for the automatic examination of blood samples with one test station, in which blood is taken from a supply vessel and is fed through an aperture in a part held in an aperture holder. At least one test head is provided, to which is fed from a first magazine holder, supply vessels with blood, and from a second magazine holder, aperture holders are fed. After performance of at least one measurement on one aperture holder, the used aperture holder and the used supply vessel are removed from the test head and the test head is cleaned by a cleaning device.
摘要翻译：本发明涉及一种用于使用一个测试站自动检查血液样本的装置，其中血液从供应容器中取出并且通过保持在孔保持器中的部分中的孔进给。提供至少一个测试头，从第一盒保持器向其供应血液，并且从第二盒保持器馈送孔保持器。在一个孔架上执行至少一次测量之后，将所使用的孔保持器和用过的供应容器从测试头上移除，并且测试头由清洁装置清洁。

8. 发明申请

US20050227361A1 Method for investigating the thrombocyte function of the blood 失效
标题翻译：调查血液血小板功能的方法
公开(公告)号：US20050227361A1
公开(公告)日：2005-10-13
申请号：US10513815
申请日：2003-05-09
申请人： Michael Kratzer
发明人： Michael Kratzer
IPC分类号： G01N33/49 , G01N33/48
CPC分类号： G01N33/4905
摘要： The invention relates to a method for investigating the thrombocyte function of the blood, wherein the following steps are carried out: a) cross-flowing an aperture (3) with blood or blood components; b) determining the active radius of the aperture (3) depending on time and c) evaluating the time-dependent modification of the radius as a measure for blood cell and/or thrombocyte function.
摘要翻译：本发明涉及一种用于研究血液的血细胞功能的方法，其中执行以下步骤：a）使具有血液或血液成分的孔（3）交叉流动; b）根据时间确定孔径（3）的有效半径，以及c）评估半径的时间依赖性修改作为血细胞和/或血小板功能的量度。

9. 发明授权

US5352413A Device for the safe removal of blood from a supply vessel 失效
标题翻译：用于从供应容器中安全清除血液的装置
公开(公告)号：US5352413A
公开(公告)日：1994-10-04
申请号：US889328
申请日：1992-08-28
申请人： Michael Kratzer , Volker F. von der Goltz
发明人： Michael Kratzer , Volker F. von der Goltz
IPC分类号： A61J1/05 , B01L3/14 , B01L99/00 , G01N33/49 , B01L3/02 , G01N33/00
CPC分类号： G01N33/4905 , B01L3/0293 , B01L3/5082
摘要： The invention pertains to a device for the safe removal of blood from a supply vessel with an aperture holder in which a part having an aperture is held and to which a capillary is attached, whereby the supply vessel can be closed by a cover part. The cover part a region through which the capillary can be inserted into the supply vessel when the cover part is closed. Furthermore, the supply vessel and the aperture holder have a locking mechanism, so that the supply vessel can be locked to the aperture holder.
摘要翻译：本发明涉及一种用于从具有孔保持器的供应容器中安全除去血液的装置，其中具有孔的部分被保持并且附着有毛细管，由此供给容器可以被盖部封闭。盖部分是当盖部件关闭时毛细管可以穿过该区域插入供应容器的区域。此外，供应容器和孔保持器具有锁定机构，使得供应容器可以锁定到孔保持器。

10. 发明授权

US5188633A Device for selective destruction of cells 失效
标题翻译：选择性破坏细胞的装置
公开(公告)号：US5188633A
公开(公告)日：1993-02-23
申请号：US736379
申请日：1991-07-26
申请人： Michael Kratzer , Eberhard Unsold
发明人： Michael Kratzer , Eberhard Unsold
IPC分类号： A61B18/18 , A61M1/36
CPC分类号： A61M1/3681 , A61B2018/1807
摘要： Apparatus for selective destruction or inactivation of cells is disclosed wherein cells are arrayed in a plane for successive illumination, by optical X-Y scanning devices, with a first low powered light beam to produce in particular cells certain radiations responsive to the illumination. These response radiations are detected and used to enable a second higher powered light beam directed through substantially the same optical scanning paths, to destroy or inactivate the cells producing the response radiations. The illumination, response, detection, and high power radiation steps are accomplished by devices acting in times short as compared to the X-Y scanning devices so as to make the accurate treatment of each of large numbers of cells highly effective. Alternate embodiments disclose the use of a single laser light source to selectively provide both the low and high powered light beams, various X-Y scanning arrangements, and various devices for correcting the spherical aberration of the scanned beams in variously positioned image planes.
摘要翻译：公开了用于细胞的选择性破坏或灭活的装置，其中通过光学X-Y扫描装置将细胞排列在用于连续照明的平面中，其中第一低功率光束特别地产生响应于照明的某些辐射。这些响应辐射被检测并用于使通过基本上相同的光学扫描路径的第二较高功率的光束能够破坏或失活产生响应辐射的单元。与X-Y扫描装置相比，照明，响应，检测和高功率辐射步骤由与时间相比短的装置实现，从而使得大量细胞中的每一个的精确处理非常有效。替代实施例公开了使用单个激光光源来选择性地提供低功率和高功率光束，各种X-Y扫描装置以及用于校正在各种定位的图像平面中的扫描光束的球面像差的各种装置。

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