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1. 发明授权

US07951328B2 Device and method for automatically analyzing blood samples 失效
标题翻译：血液样本自动分析装置及方法
公开(公告)号：US07951328B2
公开(公告)日：2011-05-31
申请号：US11632439
申请日：2005-07-12
申请人： Michael Kratzer , Volker Freiherr Von Der Goltz
发明人： Michael Kratzer , Volker Freiherr Von Der Goltz
IPC分类号： G01N21/00 , G01N15/06
CPC分类号： G01N33/4905 , G01N1/14 , G01N35/025 , G01N35/10
摘要： A device for automatically analyzing blood samples includes an extraction station (I), where blood can be extracted from a storage vessel (40) by an extraction device (15); a measuring station (II), where the extracted blood can be passed via a head part (46) through an aperture (26) of an aperture holder (30) arranged in a measuring part (9), the measuring part (9) being connected to the head part (46); a receiving station (III), for receiving measuring parts (9) configured as disposable parts; and a device (3) for moving the extraction device (15) and the head part (46) between the extraction station (I), the measuring station (II) and the receiving station (III).
摘要翻译：用于自动分析血液样本的装置包括提取站（I），其中可以通过提取装置（15）从存储容器（40）中提取血液; 测量站（II），其中所提取的血液可以经由头部（46）通过布置在测量部分（9）中的孔保持器（30）的孔（26）通过，所述测量部分（9）为连接到头部（46）; 接收站（III），用于接收被配置为一次性部件的测量部件（9）; 以及用于在提取站（I），测量站（II）和接收站（III）之间移动提取装置（15）和头部（46）的装置（3）。

2. 发明授权

US07915049B2 Method for investigating the thrombocyte function of the blood 失效
公开(公告)号：US07915049B2
公开(公告)日：2011-03-29
申请号：US10513815
申请日：2003-05-09
申请人： Michael Kratzer
发明人： Michael Kratzer
IPC分类号： G01N33/48 , G01N11/02
CPC分类号： G01N33/4905
摘要： A method for investigating the thrombocyte function of the blood, and particularly of platelet aggregation, wherein the following steps are carried out: a) cross-flowing an aperture with blood or blood components; b) determining the active radius of the aperture depending on time and c) evaluating the time-dependent modification of the radius as a measure for blood cell and/or thrombocyte function.

3. 发明授权

US07763207B2 Throughflow device for measuring platelet function of primary hemostasis, aggregation and/or coagulation and/or viscosity of blood 失效
标题翻译：用于测量原发性止血，聚集和/或凝血和/或血液粘度的血小板功能的通流装置
公开(公告)号：US07763207B2
公开(公告)日：2010-07-27
申请号：US10589034
申请日：2005-02-04
申请人： Michael Kratzer , Volker Von Der Goltz
发明人： Michael Kratzer , Volker Von Der Goltz
IPC分类号： G01N15/06
CPC分类号： G01N33/4905
摘要： The invention relates to a throughflow device for measuring platelet function of primary hemostasis, aggregation and/or coagulation and/or viscosity of the blood. A reservoir (8), from which blood can be taken for measurement and transported through an aperture (7), is arranged in a housing (2). A stirring device (10,11,12,13) is provided in the reservoir (8) and can be moved in such a way that a stirrer part (11) of the stirring device (10,11,12,13) mixes the blood which is located in the storage chamber (8) during measurement and maintains it in a state of motion.
摘要翻译：本发明涉及一种用于测量血液的初步止血，凝血和/或凝血和/或粘度的血小板功能的通流装置。可以从壳体（2）中设置有用于测量血液并通过孔（7）传送血液的储存器（8）。搅拌装置（10,11,12,13）设置在储存器（8）中，并且可以以使得搅拌装置（10,11,12,13）的搅拌器部分（11）将搅拌装置在测量期间位于储存室（8）中的血液并将其维持在运动状态。

4. 发明申请

US20070258859A1 Device and Method for Automatically Analyzing Blood Samples 失效
标题翻译：自动分析血液样本的装置和方法
公开(公告)号：US20070258859A1
公开(公告)日：2007-11-08
申请号：US11632439
申请日：2005-07-12
申请人： Michael Kratzer , Volker Freiherr Von Der Goltz
发明人： Michael Kratzer , Volker Freiherr Von Der Goltz
IPC分类号： G01N33/48
CPC分类号： G01N33/4905 , G01N1/14 , G01N35/025 , G01N35/10
摘要： A device for automatically analyzing blood samples includes an extraction station (I), where blood can be extracted from a storage vessel (40) by means of an extraction device (15); a measuring station (II), where the extracted blood can be passed via a head part (46) through an aperture (26) of an aperture holder (30) arranged in a measuring part (9), the measuring part (9) being connected to the head part (46); a receiving station (III), where the measuring parts (9) configured as disposable parts are provided and can be connected to the head part (46) and a device (3) for moving the extraction device (15) and the head part (46) between the extraction station (I), the measuring station (II) and the receiving station (III).
摘要翻译：用于自动分析血液样本的装置包括提取站（I），其中借助于提取装置（15）可以从储存容器（40）中提取血液; 测量站（II），其中所提取的血液可以经由头部（46）通过布置在测量部分（9）中的孔保持器（30）的孔（26）通过，所述测量部分（9）为连接到头部（46）; 接收站（III），其中设置为一次性部件的测量部件（9）并且可以连接到头部部分（46），以及用于使提取装置（15）和头部（（I），测量站（II）和接收站（III）之间。

5. 发明授权

US06082798A Device for gripping magazines 失效
标题翻译：用于夹杂杂志的装置
公开(公告)号：US06082798A
公开(公告)日：2000-07-04
申请号：US178391
申请日：1998-10-23
申请人： Gerhard Moges , Michael Kratzer , Mark Ogden
发明人： Gerhard Moges , Michael Kratzer , Mark Ogden
IPC分类号： H01L21/673 , B25J15/00
CPC分类号： H01L21/6734 , H01L2924/0002 , Y10S294/902 , Y10S414/14
摘要： A robotic gripper, the grippers of which engage as positive-fit elements on a magazine wall. The gripper is used to grip magazines for lead frames. This prevents any pressure stress on the magazines. The positive-fit elements furthermore, because of their shape, prevent the lead frames from slipping out of the magazine under high accelerations.
摘要翻译：机器人夹具，其夹持器作为正装配元件在匣壁上接合。夹具用于抓住引线框架的杂志。这可以防止杂志上的压力受到压力。此外，正配合元件由于其形状而防止引线框架在高加速度下从盒中滑出。

6. 发明授权

US5213577A Device for examining the functions of the endothelium or the intima of blood vessels 失效
标题翻译：用于检查血管内皮或内膜功能的装置
公开(公告)号：US5213577A
公开(公告)日：1993-05-25
申请号：US629811
申请日：1990-12-21
申请人： Michael Kratzer
发明人： Michael Kratzer
IPC分类号： A61B10/00 , A61B10/02 , A61B17/22 , A61M25/00
CPC分类号： A61B10/02 , A61M25/007 , A61B2017/22054 , A61B2017/22082 , A61M2025/1052
摘要： The invention relates to a device for examining the functions of the endothelium or the intima of blood vessels. A tube (1) has at least one outlet (6) and at least one inlet (7) spaced along the wall thereof. Outlet (6) communicates with a connector (8), inlet (7) communicates with another connector (9). Connectors (8, 9) are provided in tube (1) at the end thereof projecting from blood vessel (4).
摘要翻译：本发明涉及一种用于检查血管内皮或内膜功能的装置。管（1）具有至少一个出口（6）和沿其壁间隔开的至少一个入口（7）。出口（6）与连接器（8）连通，入口（7）与另一连接器（9）连通。连接器（8,9）在其从血管（4）突出的端部处设置在管（1）中。

7. 发明授权

US4780418A Method and apparatus for measuring the aggregation of blood platelets or the coagulation of blood 失效
标题翻译：用于测量血小板聚集或血液凝结的方法和装置
公开(公告)号：US4780418A
公开(公告)日：1988-10-25
申请号：US932422
申请日：1986-11-19
申请人： Michael Kratzer
发明人： Michael Kratzer
IPC分类号： G01N33/86 , G01N33/49 , G01N7/00
CPC分类号： G01N33/4905
摘要： A method and apparatus are disclosed for measuring the aggregation of blood platelets or the coagulation of blood, the apparatus including a capillary tube for drawing blood, a piston in communication with the capillary tube and connected to a motor means for linear displacement thereof, a pressure sensor in the space located between the drawn blood and piston, and a computing means or microprocessing means for comparing the sensed pressure from the pressure sensor with a predetermined value, and providing a measured regulating output to the motor means. The method for measuring the aggregation of blood platelets and coagulation of blood includes the steps of drawing blood into the capillary tube of the moveable piston until the desired pressure is achieved within the capillary tube, and allowing the computing means to then maintain by adjustment of the piston position the pressure within the capillary tube. The computing means is able to determine the amount of blood flowing into the capillary tube during constant pressure regulation, and hence the amount of aggregate of blood platelets and blood coagulation due to a known relationship relating movement of the piston to blood drawn into the cylinder.
摘要翻译：公开了一种用于测量血小板聚集或血液凝固的方法和装置，该装置包括用于抽血的毛细管，与毛细管连通的活塞，并连接到用于其线性位移的马达装置，压力传感器，其位于抽取的血液和活塞之间的空间中，以及计算装置或微处理装置，用于将来自压力传感器的感测压力与预定值进行比较，并向马达装置提供测量的调节输出。用于测量血小板聚集和血液凝固的方法包括以下步骤：将血液吸入可移动活塞的毛细管中，直到毛细管内达到所需的压力，然后允许计算装置通过调节活塞定位毛细管内的压力。计算装置能够确定在恒定压力调节期间流入毛细管的血液量，并因此确定由于已知关系使血小板凝集的聚集体和血液凝固的量，使活塞与吸入气缸的血液相关。

8. 发明授权

US4604894A System for measuring bleeding time in vitro 失效
标题翻译：体外测量出血时间的系统
公开(公告)号：US4604894A
公开(公告)日：1986-08-12
申请号：US563454
申请日：1983-12-20
申请人： Michael Kratzer , Gustav V. R. Born
发明人： Michael Kratzer , Gustav V. R. Born
IPC分类号： G01N33/86 , A61B5/145 , A61B5/1459 , G01N33/48 , G01N33/49 , G01N11/04
CPC分类号： G01N33/48 , G01N33/4905
摘要： A system for measuring bleeding time in vitro is disclosed in which blood is passed under pressure through a porous element and the resulting volumetric flow is measured. The porous element is provided with a through aperture and supported in such a manner that the blood moves through the aperture and not laterally into the porous element. The porous element can be soaked in a solution, for example, adenosine diphosphate, which coagulates the platelets and in this manner it is possible to reproduce in vivo bleeding conditions.
摘要翻译：公开了一种用于测量体外出血时间的系统，其中血液通过多孔元件在压力下通过，并且测量所得的体积流量。多孔元件设置有通孔并以使得血液通过孔而不横向地移入多孔元件的方式被支撑。可以将多孔元件浸泡在溶液中，例如二磷酸腺苷，其使血小板凝结，并且以这种方式可以在体内出血条件下再生。

9. 发明申请

US20110244508A1 Method for investigating the thrombocyte function of the blood 审中-公开
标题翻译：调查血液血小板功能的方法
公开(公告)号：US20110244508A1
公开(公告)日：2011-10-06
申请号：US13064475
申请日：2011-03-28
申请人： Michael Kratzer
发明人： Michael Kratzer
IPC分类号： C12Q1/02
CPC分类号： G01N33/4905
摘要： A method for investigating the thrombocyte function of the blood, and particularly of platelet aggregation, wherein the following steps are carried out: a) cross-flowing an aperture with blood or blood components; b) determining the active radius of the aperture depending on time and c) evaluating the time-dependent modification of the radius as a measure for blood cell and/or thrombocyte function.
摘要翻译：一种用于调查血液，特别是血小板聚集的血小板功能的方法，其中执行以下步骤：a）使血液或血液成分的孔交叉流动; b）根据时间确定孔径的有效半径，以及c）评估半径的时间依赖性修改作为血细胞和/或血小板功能的量度。

10. 发明授权

US5744098A Device for the automatic examination of blood samples 失效
标题翻译：血液样本自动检查装置
公开(公告)号：US5744098A
公开(公告)日：1998-04-28
申请号：US460352
申请日：1995-06-02
申请人： Michael Kratzer , Volker Freiherr von der Goltz
发明人： Michael Kratzer , Volker Freiherr von der Goltz
IPC分类号： G01N1/00 , G01N33/49 , G01N35/00 , G01N35/02 , G01N33/48
CPC分类号： G01N35/02 , G01N33/4905 , G01N1/14 , G01N35/00009 , Y10T436/114165
摘要： A measuring unit for performing plural bleeding time analyses has a vessel divided into at least two chambers by a separating wall. Each chamber has a capillary coupled to an outlet in the chamber base wall, and the outlet is also in communication with an aperture of an apertured filter unit placed adjacent the base wall.
摘要翻译：用于执行多次出血时间分析的测量单元具有通过分隔壁分成至少两个室的容器。每个室具有耦合到室底壁中的出口的毛细管，并且出口也与邻近底壁放置的有孔过滤器单元的孔连通。

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