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1. 发明授权

US10527427B1 Multi-IMU guidance system and methods for high-accuracy location and guidance performance in GPS denied and/or degraded environments 有权
公开(公告)号：US10527427B1
公开(公告)日：2020-01-07
申请号：US15869208
申请日：2018-01-12
申请人： Michael Jankowski , Edward J. Rapp
发明人： Michael Jankowski , Edward J. Rapp
IPC分类号： G01C21/16 , F42B15/01 , F42B30/10
摘要： Systems and methods for providing location and guidance, and more particularly for providing location and guidance in environments where global position systems (GPS) are unavailable or unreliable (GPS denied and/or degraded environments), utilizing inertial measurement units (IMUs) to provide such location and guidance. A series of low-accuracy or low-resolution IMUs, in combination, are utilized to provide high-accuracy or high-resolution location and guidance results.

2. 发明授权

US10527425B1 Multi-IMU guidance measurement and control system with handshake capability to refine guidance control in response to changing conditions 有权
公开(公告)号：US10527425B1
公开(公告)日：2020-01-07
申请号：US15880591
申请日：2018-01-26
申请人： Michael Jankowski , Edward J. Rapp
发明人： Michael Jankowski , Edward J. Rapp
IPC分类号： G01C21/16 , F42B15/01 , F42B30/10
摘要： Systems and methods for providing location and guidance, and more particularly for providing location and guidance in environments where global position systems (GPS) are unavailable or unreliable (GPS denied and/or degraded environments) utilizing inertial measurement units IMUs to provide such location and guidance. A series of low-accuracy or low-resolution IMUs, in combination, are utilized to provide high-accuracy or high-resolution location and guidance results along with an electronics-control system for handing off control of the measurement and guidance of a body in flight between groups or subgroups of IMUs to alternate between high dynamic range/lower resolution and lower dynamic range/higher resolution measurement and guidance as the environment dictates.

3. 发明授权

US4713787A Electronic numeric generator 失效
标题翻译：电子数字发生器
公开(公告)号：US4713787A
公开(公告)日：1987-12-15
申请号：US646123
申请日：1984-08-31
申请人： Edward J. Rapp
发明人： Edward J. Rapp
IPC分类号： G07C15/00 , G06F1/02 , A63B71/00 , A63F1/00 , G06F15/28
CPC分类号： G07C15/006
摘要： An enhancement to a typical four-function calculator. With this enhanced calculator, lottery players may generate psuedo-random integer combinations for their use in selecting numbers on which to place their bets. The enhanced calculator allows users to select the type of lottery game for which the number combinations will be generated by specifying the quantity of numbers generated and the bounds of the range within which the numbers will be generated through two key strokes of dedicated keys. The first key stroke utilizes a key designated by the particular lottery game. The second key stroke utilizes a key designated by a popular range of numbers used by the various lotteries. This invention relieves the user from having to rely on his limited supply of "magical" dates, ages, social security numbers and so forth.
摘要翻译：增强典型的四功能计算器。使用这种增强的计算器，彩票玩家可以生成伪随机整数组合，用于选择要投注的数字。增强的计算器允许用户通过指定产生的数量的数量和通过专用键的两个关键行程产生数字的范围的范围来选择将产生数字组合的彩票游戏的类型。第一个关键笔划使用特定彩票游戏指定的键。第二个关键笔划使用由各种彩票使用的普遍数量的数字指定的键。本发明缓解了用户不得不依靠他有限的“魔法”日期，年龄，社会保障号码等。

4. 发明授权

US09492105B1 Device for sleep diagnosis 有权
标题翻译：睡眠诊断装置
公开(公告)号：US09492105B1
公开(公告)日：2016-11-15
申请号：US12370996
申请日：2009-02-13
申请人： Hani Kayyali , Matthew Tarler , Edward J. Rapp
发明人： Hani Kayyali , Matthew Tarler , Edward J. Rapp
IPC分类号： A61B5/00 , A61B5/08 , A61B5/087 , A61B5/113 , A61B5/0205 , A61B5/0432
CPC分类号： A61B5/08 , A61B5/02055 , A61B5/0402 , A61B5/04325 , A61B5/0488 , A61B5/0535 , A61B5/0806 , A61B5/0816 , A61B5/0836 , A61B5/087 , A61B5/1116 , A61B5/113 , A61B5/1135 , A61B5/14551 , A61B5/4806 , A61B5/4818 , A61B5/6801 , A61B5/6823 , A61B5/6831 , A61B7/003 , A61B2562/221 , A61B2562/227
摘要： The present invention is related to a compact, portable, user-friendly sleep disorder diagnosis and screening device. The present invention is further related to a single-ended respiratory inductance plethysmography belt used to monitor certain parameters of a subject's respiration while at the same time serving to position and mechanically stabilize a compact data acquisition system about a subject's thorax or abdomen. In one application of the present invention to screen for sleep disorders, the single-ended respiratory inductance plethysmography belt is worn by the subject and a compact data acquisition unit is attached to the belt to which appropriate additional sensors and components such as a pulse oximeter and a nasal cannula are connected. Data is then collected using the belt, compact data acquisition unit, and sensors and is used to determine whether the subject has, or is at risk of having, a sleep disorder.
摘要翻译：本发明涉及一种紧凑，便携，用户友好的睡眠障碍诊断和筛选装置。本发明还涉及用于监测被检者呼吸的某些参数的单端呼吸电感体积描记图，同时用于定位和机械地稳定关于受试者胸部或腹部的紧凑数据采集系统。在本发明的一个应用中，为了筛选睡眠障碍，单端呼吸电感体积描记图佩戴在受试者身上，紧凑型数据采集单元附接到皮带上，适当的附加传感器和部件如脉搏血氧计和连接鼻插管。然后使用皮带，紧凑型数据采集单元和传感器收集数据，并且用于确定受试者是否具有或具有睡眠障碍的风险。

5. 外观设计

USD663430S1 Sleep diagnostic device 有权
标题翻译：睡眠诊断装置
公开(公告)号：USD663430S1
公开(公告)日：2012-07-10
申请号：US29364922
申请日：2010-06-30
申请人： Edward J. Rapp , Sarah M. Weimer , Matthew J. Wunderle
设计人： Edward J. Rapp , Sarah M. Weimer , Matthew J. Wunderle

6. 发明申请

US20190053744A1 Assay and Point of Care Device Utilizing Saliva for Diagnosis and Treatment of Neurological Conditions Affecting Brain Health 审中-公开
公开(公告)号：US20190053744A1
公开(公告)日：2019-02-21
申请号：US15833160
申请日：2017-12-06
申请人： Damir Janigro , Aaron Dadas , Edward J. Rapp
发明人： Damir Janigro , Aaron Dadas , Edward J. Rapp
IPC分类号： A61B5/145 , G01N33/68 , C12Q1/6883 , A61B5/15 , G01N33/53
摘要： The present invention relates to systems and methods for assessing brain health and detecting neurological conditions. The invention more particularly relates to systems and methods for diagnosing neurological conditions and analyzing rain health from analysis of a biological fluid sample, such as a saliva sample, that looks for and determines the significance of peripheral markers of blood-brain barrier disruption. The present invention further provides a diagnostic system and method with a higher negative predictive value of brain injury than currently known tests are able to provide, so as to reduce the need for computerized tomography or magnetic resonance imaging scans to affirmatively determine that brain or cerebrovascular injury has not occurred, and thus to improve suspected brain injury patient health care while reducing the expense of such care.

7. 发明授权

US4199814A Computer numerical control machine tool 失效
标题翻译：电脑数控机床
公开(公告)号：US4199814A
公开(公告)日：1980-04-22
申请号：US841597
申请日：1977-10-12
申请人： Edward J. Rapp , Glen A. Johnson
发明人： Edward J. Rapp , Glen A. Johnson
IPC分类号： G05B19/4093 , G05B19/41 , G05B19/414 , G06F15/46 , G05B19/18
CPC分类号： G05B19/4141 , G05B19/4093 , G05B19/41 , G05B2219/34215 , G05B2219/35282 , G05B2219/35426 , G05B2219/35471 , G05B2219/35472 , G05B2219/35556 , G05B2219/36074 , G05B2219/36111 , G05B2219/36554 , G05B2219/36556 , G05B2219/49395 , G05B2219/50195 , Y02P90/265
摘要： This invention relates to a computer numerical control (CNC) machine tool system having a novel terminal controller and system therefor to control a machine tool generally with at least two axes and more probably three, with stepping motor controls for point-to-point positioning of the machine tool to an almost infinite variety of steps (generally not more than 200). The novelty resides in the ease of programming directly on the terminal controller of the CNC machine tool system. Generally at least some editing and offsets will be programmed from the machine tool.The terminal controller consists of a microprocessor with some RAM and ROM, together with address and data bus plus I/O for magnetic tape handling and display for 6 to 8 digits in each of the X and Y positions, together with numeric keyboard for data input to the program steps and functional keys to control operation-automatic, manual and step-by-step, as well as controls for program input from tape to memory and memory to tape.Particular features include the ease of inputting a program and preparing a tape and then editing the tape while in operation. Further features include circular and linear interpolation. For circular interpolation there are no quadrant limitations and a full or partial circle may be cut.
摘要翻译：本发明涉及一种具有新颖的终端控制器及其系统的计算机数控（CNC）机床系统，该系统用于通常具有至少两个轴并且更可能三个控制机床，步进电机控制用于点对点定位机床几乎无限多种步骤（一般不超过200台）。新颖之处在于直接在CNC机床系统的终端控制器上进行编程。通常至少有一些编辑和偏移将从机床编程。终端控制器由具有一些RAM和ROM的微处理器，以及地址和数据总线以及用于磁带处理的I / O和在X和Y位置的每个位置显示6到8位数字，以及用于数据输入的数字键盘程序步骤和功能键来控制操作 - 自动，手动和分步，以及从磁带到内存和内存到磁带的程序输入控制。特殊功能包括输入程序和准备磁带，然后在运行时编辑磁带的方便。其他功能包括圆形和线性插值。对于圆弧插补，没有象限限制，可以切割全部或部分圆。

8. 发明授权

US11717195B2 Assay and point of care device utilizing saliva for diagnosis and treatment of neurological conditions affecting brain health 有权
公开(公告)号：US11717195B2
公开(公告)日：2023-08-08
申请号：US15833160
申请日：2017-12-06
申请人： Damir Janigro , Aaron Dadas , Edward J. Rapp
发明人： Damir Janigro , Aaron Dadas , Edward J. Rapp
IPC分类号： A61B5/145 , C12Q1/6883 , G01N33/68 , A61B5/15 , G01N33/53
CPC分类号： A61B5/14546 , A61B5/150022 , A61B5/150358 , C12Q1/6883 , G01N33/6896 , A61B5/14517 , A61B5/150755 , G01N33/53 , G01N2800/60
摘要： The present invention relates to systems and methods for assessing brain health and detecting neurological conditions. The invention more particularly relates to systems and methods for diagnosing neurological conditions and analyzing rain health from analysis of a biological fluid sample, such as a saliva sample, that looks for and determines the significance of peripheral markers of blood-brain barrier disruption. The present invention further provides a diagnostic system and method with a higher negative predictive value of brain injury than currently known tests are able to provide, so as to reduce the need for computerized tomography or magnetic resonance imaging scans to affirmatively determine that brain or cerebrovascular injury has not occurred, and thus to improve suspected brain injury patient health care while reducing the expense of such care.

9. 发明申请

US20110189724A1 System for testing biological and chemical agents using two or more cartridges simulating systems in the body 审中-公开
标题翻译：使用两个或多个模拟体内系统的药筒测试生物和化学药剂的系统
公开(公告)号：US20110189724A1
公开(公告)日：2011-08-04
申请号：US13074936
申请日：2011-03-29
申请人： Edward J. Rapp
发明人： Edward J. Rapp
IPC分类号： C12Q1/02 , C12M1/34
CPC分类号： C12M23/42 , C12M23/44 , C12M23/58 , C12M25/10
摘要： The present invention relates to joining two or more cartridges containing cell or tissue cultures from different organs found in the human body in fluid connection. It includes a vitro method and system for testing chemicals and agents as they pass through organs other than the brain or combinations of body systems including the brain. It greatly enhances the ability for researchers to test a proposed chemical or agent on human cells and tissue prior to testing it in vivo. Often, it is found that chemicals or agents have different reactions when tested on a single organ in vitro or in animals, than it does in the human body.
摘要翻译：本发明涉及以流体连接的方式将来自人体中发现的来自不同器官的细胞或组织培养物接合在一起的两个或更多个盒。它包括用于测试化学品和试剂的体外方法和系统，当它们通过除脑以外的器官或包括脑的身体系统的组合时。它大大增强了研究人员在体内测试人类细胞和组织之前测试所提出的化学物质或试剂的能力。通常，发现当在体外或动物中的单一器官上测试时，化学品或试剂具有不同于在人体中的反应。

10. 发明授权

US07943371B1 System and testing biological and chemical agents using two or more cartridges simulating systems in the body and methods 有权
标题翻译：使用两个或多个模拟体内系统的药筒和方法测试生物和化学药剂的系统
公开(公告)号：US07943371B1
公开(公告)日：2011-05-17
申请号：US11546704
申请日：2006-10-12
申请人： Edward J. Rapp
发明人： Edward J. Rapp
IPC分类号： C12M1/12
CPC分类号： C12M23/42 , C12M23/44 , C12M23/58 , C12M25/10
摘要： The present invention relates to joining two or more cartridges containing cell or tissue cultures from different organs found in the human body in fluid connection. It includes a vitro method and system for testing chemicals and agents as they pass through organs other than the brain or combinations of body systems including the brain. It greatly enhances the ability for researchers to test a proposed chemical or agent on human cells and tissue prior to testing it in vivo. Often, it is found that chemicals or agents have different reactions when tested on a single organ in vitro or in animals, than it does in the human body.
摘要翻译：本发明涉及以流体连接的方式将来自人体中发现的来自不同器官的细胞或组织培养物接合在一起的两个或更多个盒。它包括用于测试化学品和试剂的体外方法和系统，当它们通过除脑以外的器官或包括脑的身体系统的组合时。它大大增强了研究人员在体内测试人类细胞和组织之前测试所提出的化学物质或试剂的能力。通常，发现当在体外或动物中的单一器官上测试时，化学品或试剂具有不同于在人体中的反应。

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