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1. 发明授权

US06319675B1 Methods for detecting and/or identifying agents which bind and/or modulate function of “bonzo” chemokine receptor 失效
标题翻译：用于检测和/或鉴定结合和/或调节“bonzo”趋化因子受体功能的试剂的方法
公开(公告)号：US06319675B1
公开(公告)日：2001-11-20
申请号：US09449437
申请日：1999-11-24
申请人： Michael J. Briskin , Kristine E. Murphy , Alyson M. Wilbanks , Lijun Wu
发明人： Michael J. Briskin , Kristine E. Murphy , Alyson M. Wilbanks , Lijun Wu
IPC分类号： G01N3353
CPC分类号： C07K14/7158 , A61K38/00 , A61K39/00 , C07K16/24 , C07K16/2866 , C07K2317/34 , Y10S435/81
摘要： The invention relates to a method of detecting and/or identifying agents (molecules, compounds) which can bind to Bonzo and inhibit the binding of a ligand and/or modulate a function of Bonzo.
摘要翻译：本发明涉及检测和/或鉴定可结合Bonzo并抑制配体结合和/或调节Bonzo功能的试剂（分子，化合物）的方法。

2. 发明授权

US07208152B2 Antibodies for “Bonzo” chemokine receptor and therapeutic uses thereof 失效
标题翻译： “Bonzo”趋化因子受体的抗体及其治疗用途
公开(公告)号：US07208152B2
公开(公告)日：2007-04-24
申请号：US10174293
申请日：2002-06-17
申请人： Michael J. Briskin , Kristine E. Murphy , Alyson M. Wilbanks , Lijun Wu
发明人： Michael J. Briskin , Kristine E. Murphy , Alyson M. Wilbanks , Lijun Wu
IPC分类号： A61K39/395 , A61K39/00 , C12P21/08 , C07K16/28
CPC分类号： C07K16/24 , A61K38/00 , A61K39/00 , C07K14/7158 , C07K16/2866
摘要： The invention relates to an antibody or antigen-binding fragment thereof which binds to the CXC chemokine receptor Bonzo (also referred to as STRL33, TYMSTR, HBMBU14 and CXCR6) and blocks the binding of a ligand (e.g., SExCkine (also referred to as chemokine alpha-5 and CXCL16) to the receptor. The invention also relates to a method of identifying agents (molecules, compounds) which can bind to Bonzo and inhibit the binding of a ligand (e.g., SExCkine) and/or modulate a function of Bonzo. The invention relates to an antibody or antigen-binding fragment thereof which binds to the CXC chemokine SExCkine (also referred to as chemokine alpha-5) and inhibit binding of SExCkine to receptor (e.g., Bonzo). The invention also relates to targeting molecules which contain a first binding moiety which binds to mammalian Bonzo and a second binding moiety which binds to a molecule expressed on the surface of a target cell. The invention also relates to a method of promoting and/or effectuating the interaction of a Bonzo+ cell and a target cell. The invention further relates to a method of modulating a function of Bonzo, and to the use of the antibodies, antigen-binding fragments, targeting molecules and agents identified by the method of the invention in research, therapeutic, prophylactic and diagnostic methods.
摘要翻译：本发明涉及与CXC趋化因子受体Bonzo（也称为STRL33，TYMSTR，HBMBU14和CXCR6）结合的抗体或其抗原结合片段，并阻断配体（例如SExCkine（也称为趋化因子本发明还涉及鉴定可结合Bonzo并抑制配体（例如SExCkine）结合和/或调节Bonzo的功能的试剂（分子，化合物）的方法本发明涉及与CXC趋化因子SExCkine（也称为趋化因子α-5）结合并抑制SExCkine与受体结合的抗体或其抗原结合片段（例如Bonzo），本发明还涉及靶向分子其包含结合哺乳动物Bonzo的第一结合部分和与靶细胞表面上表达的分子结合的第二结合部分。本发明还涉及促进和/或实现i细胞的方法 Bonzo ^{+ 细胞和靶细胞的反应。本发明还涉及调节Bonzo的功能的方法，以及通过本发明的方法鉴定的抗体，抗原结合片段，靶向分子和试剂在研究，治疗，预防和诊断方法中的用途。}

3. 发明授权

US07038018B2 Antibodies and ligands for “Bonzo” chemokine receptor 失效
标题翻译： “Bonzo”趋化因子受体的抗体和配体
公开(公告)号：US07038018B2
公开(公告)日：2006-05-02
申请号：US09940063
申请日：2001-08-27
申请人： Michael J. Briskin , Kristine E. Murphy , Alyson M. Wilbanks , Lijun Wu
发明人： Michael J. Briskin , Kristine E. Murphy , Alyson M. Wilbanks , Lijun Wu
IPC分类号： C07K16/00 , C07K16/18 , C07K16/28 , C12N5/12 , G01N33/53
CPC分类号： C07K14/7158 , A61K38/00 , A61K39/00 , C07K16/24 , C07K16/2866 , C07K2317/34 , Y10S435/81
摘要： The invention relates to an antibody or antigen-binding fragment thereof which binds to the CXC chemokine receptor Bonzo (also referred to as STRL33, TYMSTR, HBMBU14 and CXCR6) and blocks the binding of a ligand (e.g., SExCkine (also referred to as chemokine alpha-5 and CXCL16) to the receptor. The invention also relates to a method of identifying agents (molecules, compounds) which can bind to Bonzo and inhibit the binding of a ligand (e.g., SExCkine) and/or modulate a function of Bonzo. The invention further relates to a method of modulating a function of Bonzo, and to the use of the antibodies, antigen-binding fragments, targeting molecules and agents identified by the method of the invention in research, therapeutic, prophylactic and diagnostic methods.
摘要翻译：本发明涉及与CXC趋化因子受体Bonzo（也称为STRL33，TYMSTR，HBMBU14和CXCR6）结合的抗体或其抗原结合片段，并阻断配体（例如SExCkine（也称为趋化因子本发明还涉及鉴定可结合Bonzo并抑制配体（例如SExCkine）结合和/或调节Bonzo的功能的试剂（分子，化合物）的方法本发明还涉及调节Bonzo的功能的方法，以及通过本发明的方法鉴定的抗体，抗原结合片段，靶向分子和试剂在研究，治疗，预防和诊断方法中的用途。

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