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1. 发明申请

US20140219885A1 SYSTEMS AND METHODS FOR FAST TEST STRIP INTENSITY RECOGNITION 有权
标题翻译：用于快速测试条带强度识别的系统和方法
公开(公告)号：US20140219885A1
公开(公告)日：2014-08-07
申请号：US14169066
申请日：2014-01-30
申请人： Ge Cong , Lijun Wu , Richard Cong
发明人： Ge Cong , Lijun Wu , Richard Cong
IPC分类号： G01N21/17 , G06T7/00 , G01N33/558
CPC分类号： G06T7/00 , G01N21/8483 , G01N33/54393 , G01N33/558 , G01N2021/1748
摘要： Techniques for fast and accurate measuring test strip intensities are disclosed herein. A method for measuring a test strip intensity comprising steps of obtaining an image of a sample line in a test strip and a plurality of reference lines, wherein the reference lines have known intensities; determining grayscale values of the sample line and the reference lines from the image; constructing a standard curve based on the grayscale values versus the known intensities of the reference lines; and determining the intensity of the sample line by fitting the grayscale value of the sample line on the standard curve.
摘要翻译：本文公开了用于快速和精确测量测试条强度的技术。一种用于测量测试条强度的方法，包括以下步骤：获得测试条中的采样线的图像和多个参考线，其中所述参考线具有已知的强度; 从图像确定样本线和参考线的灰度值; 基于灰度值与参考线的已知强度构建标准曲线; 以及通过将样品线的灰度值拟合在标准曲线上来确定样品线的强度。

2. 发明授权

US06528625B1 Anti-CCR5 antibodies and kits comprising same 失效
标题翻译：抗CCR5抗体和包含其的试剂盒
公开(公告)号：US06528625B1
公开(公告)日：2003-03-04
申请号：US08893911
申请日：1997-07-11
申请人： Lijun Wu , Charles R. Mackay
发明人： Lijun Wu , Charles R. Mackay
IPC分类号： C07K1628
CPC分类号： C07K16/2866 , A61K38/00 , Y10S435/81 , Y10S530/866
摘要： The present invention relates to an antibody or functional portion thereof which binds to a mammalian (e.g., human) chemokine receptor 5 protein (CKR-5 or CCR5) or portion of the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR5 with a ligand thereof. Another aspect of the invention relates to a method of inhibiting HIV infection of a cell which expresses a mammalian CCR5 or portion thereof using the antibodies described herein. Also encompassed by the present invention are methods of treating or preventing HIV in a patient.
摘要翻译：本发明涉及与哺乳动物（例如人）趋化因子受体5蛋白（CKR-5或CCR5）或受体的一部分结合的抗体或其功能部分。本发明还涉及抑制携带哺乳动物CCR5的细胞与其配体的相互作用的方法。本发明的另一方面涉及使用本文所述的抗体抑制表达哺乳动物CCR5或其部分的细胞的HIV感染的方法。本发明还包括在患者体内治疗或预防HIV的方法。

3. 发明授权

US06319675B1 Methods for detecting and/or identifying agents which bind and/or modulate function of “bonzo” chemokine receptor 失效
标题翻译：用于检测和/或鉴定结合和/或调节“bonzo”趋化因子受体功能的试剂的方法
公开(公告)号：US06319675B1
公开(公告)日：2001-11-20
申请号：US09449437
申请日：1999-11-24
申请人： Michael J. Briskin , Kristine E. Murphy , Alyson M. Wilbanks , Lijun Wu
发明人： Michael J. Briskin , Kristine E. Murphy , Alyson M. Wilbanks , Lijun Wu
IPC分类号： G01N3353
CPC分类号： C07K14/7158 , A61K38/00 , A61K39/00 , C07K16/24 , C07K16/2866 , C07K2317/34 , Y10S435/81
摘要： The invention relates to a method of detecting and/or identifying agents (molecules, compounds) which can bind to Bonzo and inhibit the binding of a ligand and/or modulate a function of Bonzo.
摘要翻译：本发明涉及检测和/或鉴定可结合Bonzo并抑制配体结合和/或调节Bonzo功能的试剂（分子，化合物）的方法。

4. 发明申请

US20090137527A1 Compositions and methods for modulating immune function 审中-公开
标题翻译：调节免疫功能的组成和方法
公开(公告)号：US20090137527A1
公开(公告)日：2009-05-28
申请号：US12283616
申请日：2008-09-12
申请人： Per Gjorstrup , Shixin Qin , Lijun Wu
发明人： Per Gjorstrup , Shixin Qin , Lijun Wu
IPC分类号： A61K31/695 , A61K31/232 , A61K31/202 , A61K31/60 , A61P37/02
CPC分类号： A61K31/202
摘要： The invention relates to methods of modulating immune function, suppressing immune response, treating autoimmune diseases or autoimmune disorders, and treating diseases, sequelae or pathological conditions mediated by an activation of the immune system comprising administering a compound of formula A, a compound of any one of formulae 1-49, a lipoxin compound, or an oxylipin compound.
摘要翻译：本发明涉及调节免疫功能，抑制免疫应答，治疗自身免疫性疾病或自身免疫性疾病以及治疗由免疫系统的活化介导的疾病，后遗症或病理状态的方法，包括给予式A化合物，任意一种化合物式1-49，脂氧素化合物或氧环磷脂化合物。

5. 发明授权

US07138117B1 Anti-CCR4 antibodies and methods of use therefor 有权
公开(公告)号：US07138117B1
公开(公告)日：2006-11-21
申请号：US10055789
申请日：2002-01-18
申请人： Lijun Wu , Nancy Ruffing-Graham , David P. Andrew
发明人： Lijun Wu , Nancy Ruffing-Graham , David P. Andrew
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2866 , A61K2039/505
摘要： The present invention relates to an antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 4 (CCR4) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR4 with a ligand thereof, and to use of the antibodies and fragments in research, therapeutic, prophylactic and diagnostic methods.

6. 发明申请

US20060246062A1 ANTI-CCR4 ANTIBODIES AND METHODS OF USE THEREFOR 有权
标题翻译：抗CCR4抗体及其使用方法
公开(公告)号：US20060246062A1
公开(公告)日：2006-11-02
申请号：US10055789
申请日：2002-01-18
申请人： Lijun Wu , Nancy Ruffing-Graham , David Andrew
发明人： Lijun Wu , Nancy Ruffing-Graham , David Andrew
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2866 , A61K2039/505
摘要： The present invention relates to an antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 4 (CCR4) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR4 with a ligand thereof, and to use of the antibodies and fragments in research, therapeutic, prophylactic and diagnostic methods.
摘要翻译：本发明涉及与哺乳动物（例如人）CC趋化因子受体4（CCR4）或受体的一部分结合并阻断配体与受体结合的抗体或其功能片段。本发明还涉及抑制携带哺乳动物CCR4的细胞与其配体的相互作用的方法，以及在研究，治疗，预防和诊断方法中使用抗体和片段。

7. 发明授权

US06488930B1 Anti-CCR4 antibodies and methods of use therefor 有权
标题翻译：抗CCR4抗体及其使用方法
公开(公告)号：US06488930B1
公开(公告)日：2002-12-03
申请号：US09231759
申请日：1999-01-15
申请人： Lijun Wu , Nancy Ruffing , David Andrew
发明人： Lijun Wu , Nancy Ruffing , David Andrew
IPC分类号： A61K39395
CPC分类号： C07K16/2866 , A61K2039/505
摘要： The present invention relates to an antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 4 (CCR4) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR4 with a ligand thereof, and to use of the antibodies and fragments in research, therapeutic, prophylactic and diagnostic methods.
摘要翻译：本发明涉及与哺乳动物（例如人）CC趋化因子受体4（CCR4）或受体的一部分结合并阻断配体与受体结合的抗体或其功能片段。本发明还涉及抑制携带哺乳动物CCR4的细胞与其配体的相互作用的方法，以及在研究，治疗，预防和诊断方法中使用抗体和片段。

8. 发明授权

US06245332B1 Modulation of systemic memory T cell trafficking 有权
标题翻译：调节系统记忆T细胞运输
公开(公告)号：US06245332B1
公开(公告)日：2001-06-12
申请号：US09232878
申请日：1999-01-15
申请人： Eugene C. Butcher , James J. Campbell , Lijun Wu , James B. Rottman
发明人： Eugene C. Butcher , James J. Campbell , Lijun Wu , James B. Rottman
IPC分类号： A61K3938
CPC分类号： C07K16/2866 , A61K38/195 , A61K2039/505 , C07K16/24
摘要： Methods are provided to specifically modulate the trafficking of systemic memory T cells, particularly CD4+ T cells, without affecting naive T cells or intestinal memory T cells. It is shown that systemic memory T cells, which are characterized as CD45Ra−, and integrin &agr;4&bgr;7−, express high levels of CCR4. Ligands of CCR4, such as TARC or MDC, act as an adhesion trigger, wherein upon CCR4 binding, these cells undergo integrin-dependent arrest to the appropriate vascular receptor(s). This arrest acts to localize the cells at the target site. The methods of the invention manipulate this triggering, and CCR4 mediated chemotaxis, to affect the localization of T cells in targeted tissues. In one embodiment of the invention, the active agent is a CCR4 agonist, that acts to enhance T cell localization. In an alternative embodiment, the agent is an antagonist that blocks CCR4 biological activity. An advantage of the invention is the selectivity for systemic memory T cells, without affecting native T cells or intestinal memory T cells.
摘要翻译：提供方法以特异性调节系统记忆T细胞，特别是CD4 + T细胞的运输，而不影响幼稚T细胞或肠内记忆T细胞。其表现为CD45Rα和整合素α4β7-的全身记忆T细胞表达高水平的CCR4。 CCR4的配体如TARC或MDC作为粘附触发剂，其中在CCR4结合时，这些细胞经受整合素依赖性阻滞至合适的血管受体。这次逮捕行动使细胞在目标地点本地化。本发明的方法操纵这种触发和CCR4介导的趋化性，以影响T细胞在靶向组织中的定位。在本发明的一个实施方案中，活性剂是用于增强T细胞定位的CCR4激动剂。在替代实施方案中，所述试剂是阻断CCR4生物活性的拮抗剂。本发明的优点是对全身记忆性T细胞的选择性，而不影响天然T细胞或肠内记忆T细胞。

9. 发明授权

US07038018B2 Antibodies and ligands for “Bonzo” chemokine receptor 失效
标题翻译： “Bonzo”趋化因子受体的抗体和配体
公开(公告)号：US07038018B2
公开(公告)日：2006-05-02
申请号：US09940063
申请日：2001-08-27
申请人： Michael J. Briskin , Kristine E. Murphy , Alyson M. Wilbanks , Lijun Wu
发明人： Michael J. Briskin , Kristine E. Murphy , Alyson M. Wilbanks , Lijun Wu
IPC分类号： C07K16/00 , C07K16/18 , C07K16/28 , C12N5/12 , G01N33/53
CPC分类号： C07K14/7158 , A61K38/00 , A61K39/00 , C07K16/24 , C07K16/2866 , C07K2317/34 , Y10S435/81
摘要： The invention relates to an antibody or antigen-binding fragment thereof which binds to the CXC chemokine receptor Bonzo (also referred to as STRL33, TYMSTR, HBMBU14 and CXCR6) and blocks the binding of a ligand (e.g., SExCkine (also referred to as chemokine alpha-5 and CXCL16) to the receptor. The invention also relates to a method of identifying agents (molecules, compounds) which can bind to Bonzo and inhibit the binding of a ligand (e.g., SExCkine) and/or modulate a function of Bonzo. The invention further relates to a method of modulating a function of Bonzo, and to the use of the antibodies, antigen-binding fragments, targeting molecules and agents identified by the method of the invention in research, therapeutic, prophylactic and diagnostic methods.
摘要翻译：本发明涉及与CXC趋化因子受体Bonzo（也称为STRL33，TYMSTR，HBMBU14和CXCR6）结合的抗体或其抗原结合片段，并阻断配体（例如SExCkine（也称为趋化因子本发明还涉及鉴定可结合Bonzo并抑制配体（例如SExCkine）结合和/或调节Bonzo的功能的试剂（分子，化合物）的方法本发明还涉及调节Bonzo的功能的方法，以及通过本发明的方法鉴定的抗体，抗原结合片段，靶向分子和试剂在研究，治疗，预防和诊断方法中的用途。

10. 发明授权

US09240039B2 Method for fast test strip intensity recognition 有权
标题翻译：快速测试条强度识别方法
公开(公告)号：US09240039B2
公开(公告)日：2016-01-19
申请号：US14169066
申请日：2014-01-30
申请人： Ge Cong , Lijun Wu , Richard Cong
发明人： Ge Cong , Lijun Wu , Richard Cong
IPC分类号： G01N33/00 , G06T7/00 , G01N33/558 , G01N21/84 , G01N33/543 , G01N21/17
CPC分类号： G06T7/00 , G01N21/8483 , G01N33/54393 , G01N33/558 , G01N2021/1748
摘要： Techniques for fast and accurate measuring test strip intensities are disclosed herein. A method for measuring a test strip intensity comprising steps of obtaining an image of a sample line in a test strip and a plurality of reference lines, wherein the reference lines have known intensities; determining grayscale values of the sample line and the reference lines from the image; constructing a standard curve based on the grayscale values versus the known intensities of the reference lines; and determining the intensity of the sample line by fitting the grayscale value of the sample line on the standard curve.
摘要翻译：本文公开了用于快速和精确测量测试条强度的技术。一种用于测量测试条强度的方法，包括以下步骤：获得测试条中的采样线的图像和多个参考线，其中所述参考线具有已知的强度; 从图像确定样本线和参考线的灰度值; 基于灰度值与参考线的已知强度构建标准曲线; 并通过将样品线的灰度值拟合在标准曲线上来确定样品线的强度。

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