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1. 发明授权

US08647294B2 Direct stream hydrodynamic catheter system 有权
标题翻译：直流流体动力导管系统
公开(公告)号：US08647294B2
公开(公告)日：2014-02-11
申请号：US12933520
申请日：2009-03-20
申请人： Michael J. Bonnette , Eric J. Thor , Debra M. Kozak , Douglas J. Ball , Stephen E. Weisel , David B. Morris
发明人： Michael J. Bonnette , Eric J. Thor , Debra M. Kozak , Douglas J. Ball , Stephen E. Weisel , David B. Morris
IPC分类号： A61B17/20 , A61M31/00 , A61M37/00 , A61M5/00 , A61M25/00 , A61M5/32
CPC分类号： A61M25/0068 , A61B17/32037 , A61M25/10
摘要： A direct stream hydrodynamic catheter system is provided for the removal of thrombus, lesions and the like including provisions for the infusion of drugs, lysing fluids and the like into a blood vessel. Physician controlled high powered direct fluid jet streams emanate from a fluid jet emanator in the form of robust radially directed fluid jet streams to impinge upon and ablate difficult and strong thrombus or lesions within a blood vessel. Effluent aspiration is controlled by an exhaust regulator in the form of a roller pump, but effluent removal can be assistingly influenced by the fluid pressure associated with the radially directed fluid jet streams.
摘要翻译：提供了一种用于去除血栓，病变等的直流流体动力导管系统，包括用于将药物输注，将流体等裂解成血管的规定。医师控制的高功率直接流体射流从流体喷射发射器发出，形式为坚固的径向指向的流体射流，以冲击和消融血管内的困难和强烈的血栓或病变。流出物抽吸由辊式泵的排气调节器控制，但流出物的去除可能受到与径向定向的流体喷流相关联的流体压力的帮助。

2. 发明申请

US20130131594A1 BALLOON CATHETER WITH EXTERNAL DELIVERY TUBE 有权
标题翻译：带外部输送管的气压管
公开(公告)号：US20130131594A1
公开(公告)日：2013-05-23
申请号：US13813221
申请日：2011-08-03
申请人： Michael J. Bonnette , Debra M. Kozak , Eric J. Thor , Richard R. Prather
发明人： Michael J. Bonnette , Debra M. Kozak , Eric J. Thor , Richard R. Prather
IPC分类号： A61M25/10 , A61M29/00
CPC分类号： A61M25/10 , A61F2/958 , A61M25/0032 , A61M25/0097 , A61M25/1002 , A61M25/1034 , A61M25/1036 , A61M25/104 , A61M2025/105 , A61M2025/1086
摘要： A balloon catheter (10) having a shaft (16), a balloon (14), and an external delivery tube (12) is disclosed. Methods of using the balloon catheter having an external delivery tube are also disclosed. In one example, the balloon catheter is an agent delivery catheter including a catheter body extending between catheter proximal and distal portions. An inflatable balloon assembly (100) is coupled with the catheter body. An agent delivery assembly (102) is coupled with the catheter body and the inflatable balloon assembly. The agent delivery assembly includes a delivery lumen (32) extending through the catheter body, and an agent delivery tube extending along an exterior balloon surface (64). The agent delivery tube includes at least one delivery orifice (70) directed outside of the exterior balloon surface. The agent delivery assembly is isolated from fluid communication with the inflatable balloon assembly.
摘要翻译：公开了一种具有轴（16），气球（14）和外部输送管（12）的球囊导管（10）。还公开了使用具有外部输送管的气囊导管的方法。在一个示例中，气囊导管是包括在导管近端部分和远端部分之间延伸的导管主体的药剂输送导管。可充气球囊组件（100）与导管主体联接。药剂输送组件（102）与导管主体和可充气球囊组件联接。药剂输送组件包括延伸穿过导管主体的递送腔（32）和沿外部气囊表面（64）延伸的药剂输送管。药剂输送管包括指向外气囊表面外部的至少一个输送孔（70）。药剂输送组件与可充气球囊组件的流体连通隔离。

3. 发明授权

US08439878B2 Rheolytic thrombectomy catheter with self-inflating proximal balloon with drug infusion capabilities 有权
标题翻译：溶血性血栓切除术导管带有自充气近端球囊药物输注能力
公开(公告)号：US08439878B2
公开(公告)日：2013-05-14
申请号：US12338376
申请日：2008-12-18
申请人： Michael J. Bonnette , Eric J. Thor , Debra M. Kozak
发明人： Michael J. Bonnette , Eric J. Thor , Debra M. Kozak
IPC分类号： A61M5/178
CPC分类号： A61B17/32037 , A61B2017/22062 , A61B2017/22065
摘要： A thrombectomy catheter with a self-inflating proximal balloon having drug infusion capabilities is described. A self-inflating balloon is formed from an inflatable thin walled section of a flexible catheter tube. The self-inflating balloon includes a plurality of outflow orifices located about the peripheral circumference thereof and located proximal to an inflow gap interposed between a fluid jet emanator and the self-inflating balloon. The self-inflating balloon is inflated and expanded by internal operating pressures by proximal composite flow of fluid from the fluid jet emanator and entrained fluid from the inflow gap to uniformly space and position the outflow orifices of the self-inflating balloon in close proximity to the thrombus or vessel walls of a blood vessel. The thrombectomy catheter may be used for, among other things, thrombectomies, embolectomies, thrombus or vessel dilation, and for the delivery of drugs to a thrombus or vessel site.
摘要翻译：描述了具有药物输注能力的具有自充气近端球囊的血栓切除术导管。自充气气囊由柔性导管的可膨胀薄壁部分形成。自膨胀气囊包括多个位于其周边周围的流出孔，位于流体喷射发生器和自膨胀气囊之间的入口间隙附近。自充气气球通过内部操作压力通过来自流体喷射发生器的流体的近似复合流动和来自流入间隙的夹带的流体膨胀和膨胀，以将自膨胀气囊的流出孔均匀地间隔并定位在紧邻血栓或血管壁。血栓切除术导管可以用于血栓切除术，静脉血栓栓塞，血栓或血管扩张，以及用于将药物递送至血栓或血管部位。

4. 发明授权

US08353858B2 Rapid exchange fluid jet catheter and method 有权
标题翻译：快速交换流体喷射导管和方法
公开(公告)号：US08353858B2
公开(公告)日：2013-01-15
申请号：US12793121
申请日：2010-06-03
申请人： Debra M. Kozak , Michael J. Bonnette , Eric J. Thor , David B. Morris , John L. Teschendorf , Douglas J. Ball , Stephen E. Weisel , Michael Schrom
发明人： Debra M. Kozak , Michael J. Bonnette , Eric J. Thor , David B. Morris , John L. Teschendorf , Douglas J. Ball , Stephen E. Weisel , Michael Schrom
IPC分类号： A61N1/30
CPC分类号： A61B17/22 , A61B17/32037 , A61B2017/22038 , A61B2017/22041 , A61M25/007 , A61M2025/0183
摘要： Catheters including guidewire tubes having a limited length and methods of using the catheters are described. The catheters may be delivered over guidewires in procedures that are commonly referred to as rapid-exchange delivery. In some embodiments, the catheters may be miniature flexible thrombectomy catheters that may be used to remove thrombus or other unwanted material from a body blood vessel or other small regions of body cavities in which the distal portion of the catheter has smaller external dimensions than the larger proximal portion.
摘要翻译：描述了包括有限长度的导丝管和使用导管的方法的导管。导管可以在通常被称为快速交换递送的程序中通过导线输送。在一些实施例中，导管可以是微型柔性血栓切除术导管，其可以用于从身体血管或体腔的其他小区域去除血栓或其它不需要的材料，其中导管的远端部分具有比较大的外部尺寸更小的外部尺寸近端部分。

5. 发明申请

US20110015564A1 Direct Stream Hydrodynamic Catheter System 有权
标题翻译：直流流体动力导管系统
公开(公告)号：US20110015564A1
公开(公告)日：2011-01-20
申请号：US12933520
申请日：2009-03-20
申请人： Michael J. Bonnette , Eric J. Thor , Debra M. Kozak , Douglas J. Ball , Stephen E. Weisel , Richard R. Prather , David B. Morris
发明人： Michael J. Bonnette , Eric J. Thor , Debra M. Kozak , Douglas J. Ball , Stephen E. Weisel , Richard R. Prather , David B. Morris
IPC分类号： A61B17/22 , A61M25/00
CPC分类号： A61M25/0068 , A61B17/32037 , A61M25/10
摘要： A direct stream hydrodynamic catheter system is provided for the removal of thrombus, lesions and the like including provisions for the infusion of drugs, lysing fluids and the like into a blood vessel. Physician controlled high powered direct fluid jet streams emanate from a fluid jet emanator in the form of robust radially directed fluid jet streams to impinge upon and ablate difficult and strong thrombus or lesions within a blood vessel. Effluent aspiration is controlled by an exhaust regulator in the form of a roller pump, but effluent removal can be assistingly influenced by the fluid pressure associated with the radially directed fluid jet streams.
摘要翻译：提供了一种用于去除血栓，病变等的直流流体动力导管系统，包括用于将药物输注，将流体等裂解成血管的规定。医师控制的高功率直接流体射流从流体喷射发射器发出，形式为坚固的径向指向的流体射流，以冲击和消融血管内的困难和强烈的血栓或病变。流出物抽吸由辊式泵的排气调节器控制，但流出物的去除可能受到与径向定向的流体喷流相关联的流体压力的帮助。

6. 发明申请

US20090156983A1 RHEOLYTIC THROMBECTOMY CATHETER WITH SELF-INFLATING DISTAL BALLOON 有权
标题翻译：具有自动离子气球的流变色谱柱导管
公开(公告)号：US20090156983A1
公开(公告)日：2009-06-18
申请号：US12336750
申请日：2008-12-17
申请人： Michael J. Bonnette , Eric J. Thor , Debra M. Kozak
发明人： Michael J. Bonnette , Eric J. Thor , Debra M. Kozak
IPC分类号： A61B17/22
CPC分类号： A61B17/32037 , A61B2017/22062 , A61B2017/22067 , A61B2017/22068 , A61B2017/22084
摘要： The devices of the present disclosure are rheolytic thrombectomy catheters with a self-inflating distal balloon. A self-inflating balloon is located distal to an inflow gap or orifice and distal to a fluid jet emanator, which self-inflating balloon is inflated and expanded by the utilization of internal operating forces consisting of forwardly directed high velocity fluid jet streams and/or entrained thrombus particulate therein. The self-inflating balloon, when inflated, impinges on the wall of the blood vessel to isolate sections of the blood vessel distal and proximal to the inflated balloon in order to prevent flow of thrombus particulate, fluids and the like distal to the self-inflating balloon and to provide a stagnant nonflow region proximal to the self-inflating balloon. The devices of the present disclosure also provide for a uniform spacing of the catheter tube with respect to the thrombus and/or wall of the blood vessel.
摘要翻译：本公开的装置是具有自充气远端气囊的溶血性血栓切除术导管。自充气球囊位于流入间隙或孔口的远侧并且远离流体射流喷射器，该自膨胀球囊通过利用由向前定向的高速流体射流和/或组合的内部操作力而膨胀和膨胀其中夹带血栓颗粒。充气气囊充气时会撞击到血管壁上，以将血管的远端和近侧的血管部分隔开，以防止血栓微粒，流体等远离自膨胀的流动并且提供靠近自充气气球的停滞的非流动区域。本公开的装置还提供导管管相对于血管的血栓和/或壁的均匀间隔。

7. 发明申请

US20080319386A1 Forwardly directable fluid jet crossing catheter 审中-公开
标题翻译：向心指向的流体射流交叉导管
公开(公告)号：US20080319386A1
公开(公告)日：2008-12-25
申请号：US11891450
申请日：2007-08-10
申请人： Michael J. Bonnette , Eric J. Thor , David B. Morris , Debra M. Kozak
发明人： Michael J. Bonnette , Eric J. Thor , David B. Morris , Debra M. Kozak
IPC分类号： A61M25/085
CPC分类号： A61B17/32037 , A61B2017/003 , A61B2017/00331 , A61B2017/00867 , A61B2017/22094
摘要： A forwardly directable fluid jet crossing catheter having a positionable jet body which can be longitudinally and rotationally positioned in order to direct a fluid jet stream to impinge, break through, and cross a chronic total occlusion. The distal end of the catheter includes a tip of super-elastic material having a flexible bend aligned within the distal portion of a sheath which tip is directable in response to the longitudinal and rotational orientation of a positionable jet body, whereby a fluid jet stream can be controlled in angular and rotational directions.
摘要翻译：可向前可定向的流体喷射交叉导管，其具有可定位的喷射体，其可以纵向和旋转地定位，以便引导流体喷射流冲击，穿透并穿过慢性完全闭塞。导管的远端包括超弹性材料的尖端，其具有在护套的远端部分内对准的柔性弯曲部，该尖端可响应于可定位的喷射体的纵向和旋转取向而被定向，由此流体喷射流可在角度和旋转方向上进行控制。

8. 发明授权

US08597238B2 Enhanced cross stream mechanical thrombectomy catheter 失效
标题翻译：增强交叉流机械性血栓切除术导管
公开(公告)号：US08597238B2
公开(公告)日：2013-12-03
申请号：US13453498
申请日：2012-04-23
申请人： Michael J. Bonnette , Eric J. Thor , Michael Schrom , Debra M. Kozak
发明人： Michael J. Bonnette , Eric J. Thor , Michael Schrom , Debra M. Kozak
IPC分类号： A61M37/00
CPC分类号： A61B17/32037 , A61B17/22 , A61B2017/22079 , A61B2017/22084 , A61B2217/005 , A61M25/0029 , A61M25/0032 , A61M25/0045 , A61M25/005 , A61M25/007 , A61M2025/0034 , Y10T29/49826
摘要： An enhanced cross stream mechanical thrombectomy catheter having a distal end with outflow and inflow orifices at one side for producing concentrated cross stream jet flow for selective and concentrated thrombus ablation during thrombectomy procedures. A multidirectional fluid jet emanator positioned within the distal catheter lumen comprises high velocity fluid jets which produce jet flow that is directed toward distal and proximal ends of the catheter. Jet flow directed toward the proximal end provides a region of low pressure near an inflow orifice which acts to pull thrombotic particulate from the vasculature. The invention provides for suitable distancing of high powered ablation or suction forces from the near walls of the vasculature. Cross stream flow emanating from one side of the catheter distal end urges the opposing non-orificed side of the catheter distal end toward and against the vascular wall to inhibit contact of the inflow orifice with the vascular wall.
摘要翻译：一种增强的交叉流机械性血栓切除术导管，其具有在一侧具有流出和流入孔的远端，用于在血栓切除术过程中产生用于选择性和集中血栓消融的浓缩的交叉流射流。定位在远侧导管内腔内的多向流体喷射发射器包括产生朝向导管的远端和近端的射流的高速流体射流。朝向近端的喷射流提供靠近流入孔的低压区域，其用于从脉管系统拉动血栓形成的颗粒。本发明提供从脉管系统的近壁适当地间隔大功率消融或吸力。从导管远端的一侧发出的交叉流流动促使导管远端的相对的非引导侧朝向血管壁并抵靠血管壁，以阻止入口与血管壁接触。

9. 发明授权

US08162877B2 Enhanced cross stream mechanical thrombectomy catheter 失效
标题翻译：增强交叉流机械性血栓切除术导管
公开(公告)号：US08162877B2
公开(公告)日：2012-04-24
申请号：US12174978
申请日：2008-07-17
申请人： Michael J. Bonnette , Eric J. Thor , Michael Schrom , Debra M. Kozak
发明人： Michael J. Bonnette , Eric J. Thor , Michael Schrom , Debra M. Kozak
IPC分类号： A61M37/00
CPC分类号： A61B17/32037 , A61B17/22 , A61B2017/22079 , A61B2017/22084 , A61B2217/005 , A61M25/0029 , A61M25/0032 , A61M25/0045 , A61M25/005 , A61M25/007 , A61M2025/0034 , Y10T29/49826
摘要： An enhanced cross stream mechanical thrombectomy catheter with backloading manifold having a distal end with outflow and inflow orifices at one side for producing concentrated cross stream jet flow for selective and concentrated thrombus ablation during thrombectomy procedures. The invention provides for suitable distancing of high powered ablation or suction forces from the near walls of the vasculature. Cross stream flow emanating from the one side of the distal end of the catheter resultantly urges the distal end of the catheter and thus the opposing non-orificed side of the distal end of the catheter toward and against the vascular wall to inhibit contact of the inflow orifice with the vascular wall. Features of the invention include a geometrically configured insert to facilitate the backloading or exchange of guidewires.
摘要翻译：具有后支管道的增强的交叉流机械性血栓切除术导管，其具有在一侧具有流出和流入孔的远端，用于在血栓切除术过程中产生用于选择性和集中血栓消融的浓缩的交叉流射流。本发明提供从脉管系统的近壁适当地间隔大功率消融或吸力。从导管的远端的一侧发出的交叉流流动导致导管的远端，并因此促使导管的远端的相对的未通气的侧面朝向和抵靠血管壁，以阻止流入物的接触孔与血管壁。本发明的特征包括几何构造的插入件，以便于引导线的后退或更换。

10. 发明授权

US08012117B2 Miniature flexible thrombectomy catheter 有权
标题翻译：微型柔性血栓切除术导管
公开(公告)号：US08012117B2
公开(公告)日：2011-09-06
申请号：US11702990
申请日：2007-02-06
申请人： Michael J. Bonnette , Eric J. Thor , Debra M. Kozak , David B. Morris , John L. Teschendorf , Douglas J. Ball , Stephen E. Weisel
发明人： Michael J. Bonnette , Eric J. Thor , Debra M. Kozak , David B. Morris , John L. Teschendorf , Douglas J. Ball , Stephen E. Weisel
IPC分类号： A61M1/00 , A61B17/20
CPC分类号： A61M25/0097 , A61B17/22 , A61B17/32037 , A61B2017/22079 , A61M25/0054 , A61M25/0069 , A61M25/007 , A61M2025/0059 , A61M2025/0073
摘要： The present invention pertains to a miniature flexible thrombectomy catheter having one or more flexible miniature noncollapsing tubular portions including pushable and torqueable structure for introduction into the smaller vessels in neurovascular regions. A jet body having an arcuate fluid jet emanator is incorporated in order to minimize size at the distal portion of a minimally sized catheter tube.
摘要翻译：本发明涉及一种微型柔性血栓切除术导管，其具有一个或多个柔性微型非皱缩管状部分，其包括用于引入神经血管区域中的较小血管的可推挤和可扭转的结构。引入具有弓形流体喷射发射器的喷射体，以便使最小尺寸的导管管的远端处的尺寸最小化。

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