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1. 发明授权

US08353858B2 Rapid exchange fluid jet catheter and method 有权
标题翻译：快速交换流体喷射导管和方法
公开(公告)号：US08353858B2
公开(公告)日：2013-01-15
申请号：US12793121
申请日：2010-06-03
申请人： Debra M. Kozak , Michael J. Bonnette , Eric J. Thor , David B. Morris , John L. Teschendorf , Douglas J. Ball , Stephen E. Weisel , Michael Schrom
发明人： Debra M. Kozak , Michael J. Bonnette , Eric J. Thor , David B. Morris , John L. Teschendorf , Douglas J. Ball , Stephen E. Weisel , Michael Schrom
IPC分类号： A61N1/30
CPC分类号： A61B17/22 , A61B17/32037 , A61B2017/22038 , A61B2017/22041 , A61M25/007 , A61M2025/0183
摘要： Catheters including guidewire tubes having a limited length and methods of using the catheters are described. The catheters may be delivered over guidewires in procedures that are commonly referred to as rapid-exchange delivery. In some embodiments, the catheters may be miniature flexible thrombectomy catheters that may be used to remove thrombus or other unwanted material from a body blood vessel or other small regions of body cavities in which the distal portion of the catheter has smaller external dimensions than the larger proximal portion.
摘要翻译：描述了包括有限长度的导丝管和使用导管的方法的导管。导管可以在通常被称为快速交换递送的程序中通过导线输送。在一些实施例中，导管可以是微型柔性血栓切除术导管，其可以用于从身体血管或体腔的其他小区域去除血栓或其它不需要的材料，其中导管的远端部分具有比较大的外部尺寸更小的外部尺寸近端部分。

2. 发明申请

US20050027341A1 System and method for providing a medical lead body having conductors that are wound in opposite directions 审中-公开
标题翻译：用于提供具有以相反方向缠绕的导体的医疗引线体的系统和方法
公开(公告)号：US20050027341A1
公开(公告)日：2005-02-03
申请号：US10630376
申请日：2003-07-29
申请人： Michael Schrom , Charles Lehman , Mark Schrom
发明人： Michael Schrom , Charles Lehman , Mark Schrom
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/0551
摘要： An implantable medical lead and lead body, method of manufacturing the same, and a system and method for stimulating a portion of a body are disclosed. A lead body assembly is formed by preparing a first layer unitary body comprising a first plurality of conductors wound in a first direction. An inner layer of extrusion material is placed on the first layer unitary body. A second plurality of conductors coated with extrusion material is placed on the inner layer. The second plurality of conductors is wound in a second opposite direction. An outer layer of extrusion material is placed over the second plurality of conductors. Heat shrink tubing is placed over the assembly. The extrusion material is heated and melted and compressed around the conductors. When the heat shrink tubing is removed, the solidified extrusion material forms a protective wall that encapsulates the conductors in the lead body.
摘要翻译：公开了一种植入式医疗用引线和引线体及其制造方法，以及用于刺激身体的一部分的系统和方法。通过制备包括沿第一方向缠绕的第一多个导体的第一层单体，形成引线体组件。挤出材料的内层被放置在第一层整体上。涂覆有挤出材料的第二组多个导体放置在内层上。第二组多个导体沿第二相反方向缠绕。挤出材料的外层放置在第二多个导体上。热收缩管放置在组件上。挤出材料被加热并熔化并围绕导体压缩。当热收缩管被去除时，凝固的挤压材料形成将导体封装在引线体内的保护壁。

3. 发明申请

US20050027339A1 System and method for providing a medical lead body 审中-公开
标题翻译：用于提供医疗引线体的系统和方法
公开(公告)号：US20050027339A1
公开(公告)日：2005-02-03
申请号：US10630219
申请日：2003-07-29
申请人： Michael Schrom , Charles Lehman , Mark Schrom
发明人： Michael Schrom , Charles Lehman , Mark Schrom
IPC分类号： A61N1/05 , A61N1/06
CPC分类号： A61N1/06 , A61N1/05
摘要： An implantable lead and lead body, method of manufacturing the same, and a system and method for stimulating a portion of a body is disclosed. In one advantageous embodiment, a lead body assembly is formed by placing an inner layer of extrusion material on a mandrel, wrapping a plurality of conductors coated with extrusion material around the inner layer, and placing an outer layer of extrusion material over the plurality of conductors. Heat shrink tubing is placed over the lead body assembly and the lead body assembly is heated to melt the extrusion material. The melted extrusion material is compressed around the plurality of conductors. The assembly is then cooled and the heat shrink tubing is removed. The solidified extrusion material forms a protective wall that encapsulates the plurality of conductors in the lead body.
摘要翻译：公开了可植入引线和引线体及其制造方法，以及用于刺激身体的一部分的系统和方法。在一个有利的实施例中，通过将挤压材料的内层放置在心轴上，将涂覆有挤出材料的多个导体缠绕在内层周围并将外部挤出材料层放置在多个导体上而形成引线本体组件。将热收缩管放置在引线主体组件上，并且引线主体组件被加热以熔化挤出材料。熔融的挤出材料围绕多个导体被压缩。然后将组件冷却并除去热收缩管。凝固的挤出材料形成将多个导体封装在引线主体中的保护壁。

4. 发明申请

US20120239065A1 Enhanced Cross Stream Mechanical Thrombectomy Catheter 失效
标题翻译：增强交叉流机械性血栓切除术导管
公开(公告)号：US20120239065A1
公开(公告)日：2012-09-20
申请号：US13453498
申请日：2012-04-23
申请人： Michael J. Bonnette , Eric J. Thor , Michael Schrom , Debra M. Kozak
发明人： Michael J. Bonnette , Eric J. Thor , Michael Schrom , Debra M. Kozak
IPC分类号： A61B17/22
CPC分类号： A61B17/32037 , A61B17/22 , A61B2017/22079 , A61B2017/22084 , A61B2217/005 , A61M25/0029 , A61M25/0032 , A61M25/0045 , A61M25/005 , A61M25/007 , A61M2025/0034 , Y10T29/49826
摘要： An enhanced cross stream mechanical thrombectomy catheter with backloading manifold having a distal end with outflow and inflow orifices at one side for producing concentrated cross stream jet flow for selective and concentrated thrombus ablation during thrombectomy procedures. The invention provides for suitable distancing of high powered ablation or suction forces from the near walls of the vasculature. Cross stream flow emanating from the one side of the distal end of the catheter resultantly urges the distal end of the catheter and thus the opposing non-orif iced side of the distal end of the catheter toward and against the vascular wall to inhibit contact of the inflow orifice with the vascular wall. Features of the invention include a geometrically configured insert to facilitate the backloading or exchange of guidewires.
摘要翻译：具有后支管道的增强的交叉流机械性血栓切除术导管，其具有在一侧具有流出和流入孔的远端，用于在血栓切除术过程中产生用于选择性和集中血栓消融的浓缩的交叉流射流。本发明提供从脉管系统的近壁适当地间隔大功率消融或吸力。从导管的远端的一侧发出的交叉流流动导致导管的远端，并因此促使导管的远端的相反的非顶端朝向血管壁并抵靠血管壁，以阻止接触流入孔与血管壁。本发明的特征包括几何构造的插入件，以便于引导线的后退或更换。

5. 发明申请

US20100312223A1 RAPID EXCHANGE FLUID JET CATHETER AND METHOD 有权
标题翻译：快速交换流体喷嘴导管和方法
公开(公告)号：US20100312223A1
公开(公告)日：2010-12-09
申请号：US12793121
申请日：2010-06-03
申请人： Debra M. Kozak , Michael J. Bonnette , Eric J. Thor , David B. Morris , John L. Teschendorf , Douglas J. Ball , Stephen E. Weisel , Michael Schrom
发明人： Debra M. Kozak , Michael J. Bonnette , Eric J. Thor , David B. Morris , John L. Teschendorf , Douglas J. Ball , Stephen E. Weisel , Michael Schrom
IPC分类号： A61M25/09
CPC分类号： A61B17/22 , A61B17/32037 , A61B2017/22038 , A61B2017/22041 , A61M25/007 , A61M2025/0183
摘要： Catheters including guidewire tubes having a limited length and methods of using the catheters are described. The catheters may be delivered over guidewires in procedures that are commonly referred to as rapid-exchange delivery. In some embodiments, the catheters may be miniature flexible thrombectomy catheters that may be used to remove thrombus or other unwanted material from a body blood vessel or other small regions of body cavities in which the distal portion of the catheter has smaller external dimensions than the larger proximal portion
摘要翻译：描述了包括有限长度的导丝管和使用导管的方法的导管。导管可以在通常被称为快速交换递送的程序中通过导线输送。在一些实施例中，导管可以是微型柔性血栓切除术导管，其可用于从身体血管或体腔的其他小区域去除血栓或其它不需要的材料，其中导管的远端部分具有比较大的外部尺寸更小的外部尺寸近端部分

6. 发明申请

US20060129091A1 Enhanced cross stream mechanical thrombectomy catheter with backloading manifold 审中-公开
标题翻译：增强交叉流机械性血栓切除术导管与背负歧管
公开(公告)号：US20060129091A1
公开(公告)日：2006-06-15
申请号：US11009720
申请日：2004-12-10
申请人： Michael Bonnette , Eric Thor , Michael Schrom
发明人： Michael Bonnette , Eric Thor , Michael Schrom
IPC分类号： A61M31/00
CPC分类号： A61B17/32037 , A61B17/22 , A61B2017/22079 , A61B2017/22084 , A61B2217/005 , A61M25/0029 , A61M25/0032 , A61M25/0045 , A61M25/005 , A61M25/007 , A61M2025/0034 , Y10T29/49826
摘要： An enhanced cross stream mechanical thrombectomy catheter with backloading manifold having a distal end with outflow and inflow orifices at one side for producing concentrated cross stream jet flow for selective and concentrated thrombus ablation during thrombectomy procedures. The invention provides for suitable distancing of high powered ablation or suction forces from the near walls of the vasculature. Cross stream flow emanating from the one side of the distal end of the catheter resultantly urges the distal end of the catheter and thus the opposing non-orificed side of the distal end of the catheter toward and against the vascular wall to inhibit contact of the inflow orifice with the vascular wall. Features of the invention include a geometrically configured insert to facilitate the backloading or exchange of guidewires.
摘要翻译：具有后支管道的增强的交叉流机械性血栓切除术导管，其具有在一侧具有流出和流入孔的远端，用于在血栓切除术过程中产生用于选择性和集中血栓消融的浓缩的交叉流射流。本发明提供从脉管系统的近壁适当地间隔大功率消融或吸力。从导管的远端的一侧发出的交叉流流动导致导管的远端，并因此促使导管的远端的相对的未通气的侧面朝向和抵靠血管壁，以阻止流入物的接触孔与血管壁。本发明的特征包括几何构造的插入件，以便于引导线的后退或更换。

7. 发明申请

US20060064123A1 Rapid exchange fluid jet thrombectomy device and method 有权
标题翻译：快速交换液喷射血栓切除装置及方法
公开(公告)号：US20060064123A1
公开(公告)日：2006-03-23
申请号：US11096592
申请日：2005-04-01
申请人： Michael Bonnette , Michael Schrom , Hieu Le
发明人： Michael Bonnette , Michael Schrom , Hieu Le
IPC分类号： A61B17/32
CPC分类号： A61B17/32037 , A61B17/22 , A61B17/3203 , A61B2017/00292 , A61B2017/00778 , A61B2017/22041 , A61B2090/034
摘要： A rapid exchange fluid jet thrombectomy device having a streamlined manifold and a catheter having multiple tubular segments where each tubular segment increases in flexibility in a distal direction. Torque response and pushability is enhanced by the arrangement of a proximally located tubular segment composed of a polymer-jacketed spiral metal tube in combination with an intermediate tubular section and a distal tubular section each having different degrees of flexibility. A guidewire tube exit region is provided where the intermediate tubular section joins the distal tubular section for over-the-wire guidewire usage. The polymer-jacketed spiral metal tube can extend along a partial or full length of the catheter and can include a basic continuous spiral cut which has regions of constant pitch or which has progressively increasing pitch, or in the alternative, can include an interlocking spiral cut having constant pitch regions or progressively decreasing pitch.
摘要翻译：具有流线型歧管的快速交换流体喷射血栓切除装置和具有多个管状区段的导管，其中每个管状区段在远端方向上的柔性增加。通过由聚合物夹套的螺旋金属管组成的近端定位的管状部分与中间管状部分和每个具有不同柔性程度的远端管状部分的组合来增强扭矩响应和推动性。提供导丝管出口区域，其中中间管状部分连接远端管状部分用于线上导丝使用。聚合物套管的螺旋金属管可以沿着导管的部分或全长延伸，并且可以包括具有恒定节距或具有逐渐增加的间距的区域的基本连续螺旋切口，或者替代地，可以包括互锁螺旋切口具有恒定的音调区域或逐渐减小音调。

8. 发明申请

US20050027340A1 System and method for providing a medical lead body having dual conductor layers 审中-公开
标题翻译：用于提供具有双导体层的医疗引线体的系统和方法
公开(公告)号：US20050027340A1
公开(公告)日：2005-02-03
申请号：US10630233
申请日：2003-07-29
申请人： Michael Schrom , Charles Lehman , Mark Schrom
发明人： Michael Schrom , Charles Lehman , Mark Schrom
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/0551
摘要： An implantable medical lead and lead body, method of manufacturing the same, and a system and method for stimulating a portion of a body is disclosed. In one advantageous embodiment, a lead body assembly is formed by preparing a first layer unitary body comprising a first plurality of conductors. An inner layer of extrusion material is placed on the first layer unitary body. A second plurality of conductors coated with extrusion material is placed on the inner layer. An outer layer of extrusion material is placed over the second plurality of conductors. Heat shrink tubing is placed over the assembly and the assembly is heated to melt the extrusion material. The extrusion material is compressed around the conductors. The assembly is cooled and the heat shrink tubing is removed. The solidified extrusion material forms a protective wall that encapsulates the first and second plurality of conductors in the lead body.
摘要翻译：公开了一种植入式医疗用引线和引线体及其制造方法，以及用于刺激身体的一部分的系统和方法。在一个有利的实施例中，通过制备包括第一多个导体的第一层单体，形成引线本体组件。挤出材料的内层被放置在第一层整体上。涂覆有挤出材料的第二组多个导体放置在内层上。挤出材料的外层放置在第二多个导体上。将热收缩管放置在组件上，并将组件加热以熔化挤出材料。挤出材料围绕导体被压缩。将组件冷却并除去热收缩管。固化的挤压材料形成将引导体中的第一和第二多个导体封装的保护壁。

9. 发明授权

US08597238B2 Enhanced cross stream mechanical thrombectomy catheter 失效
标题翻译：增强交叉流机械性血栓切除术导管
公开(公告)号：US08597238B2
公开(公告)日：2013-12-03
申请号：US13453498
申请日：2012-04-23
申请人： Michael J. Bonnette , Eric J. Thor , Michael Schrom , Debra M. Kozak
发明人： Michael J. Bonnette , Eric J. Thor , Michael Schrom , Debra M. Kozak
IPC分类号： A61M37/00
CPC分类号： A61B17/32037 , A61B17/22 , A61B2017/22079 , A61B2017/22084 , A61B2217/005 , A61M25/0029 , A61M25/0032 , A61M25/0045 , A61M25/005 , A61M25/007 , A61M2025/0034 , Y10T29/49826
摘要： An enhanced cross stream mechanical thrombectomy catheter having a distal end with outflow and inflow orifices at one side for producing concentrated cross stream jet flow for selective and concentrated thrombus ablation during thrombectomy procedures. A multidirectional fluid jet emanator positioned within the distal catheter lumen comprises high velocity fluid jets which produce jet flow that is directed toward distal and proximal ends of the catheter. Jet flow directed toward the proximal end provides a region of low pressure near an inflow orifice which acts to pull thrombotic particulate from the vasculature. The invention provides for suitable distancing of high powered ablation or suction forces from the near walls of the vasculature. Cross stream flow emanating from one side of the catheter distal end urges the opposing non-orificed side of the catheter distal end toward and against the vascular wall to inhibit contact of the inflow orifice with the vascular wall.
摘要翻译：一种增强的交叉流机械性血栓切除术导管，其具有在一侧具有流出和流入孔的远端，用于在血栓切除术过程中产生用于选择性和集中血栓消融的浓缩的交叉流射流。定位在远侧导管内腔内的多向流体喷射发射器包括产生朝向导管的远端和近端的射流的高速流体射流。朝向近端的喷射流提供靠近流入孔的低压区域，其用于从脉管系统拉动血栓形成的颗粒。本发明提供从脉管系统的近壁适当地间隔大功率消融或吸力。从导管远端的一侧发出的交叉流流动促使导管远端的相对的非引导侧朝向血管壁并抵靠血管壁，以阻止入口与血管壁接触。

10. 发明授权

US08162877B2 Enhanced cross stream mechanical thrombectomy catheter 失效
标题翻译：增强交叉流机械性血栓切除术导管
公开(公告)号：US08162877B2
公开(公告)日：2012-04-24
申请号：US12174978
申请日：2008-07-17
申请人： Michael J. Bonnette , Eric J. Thor , Michael Schrom , Debra M. Kozak
发明人： Michael J. Bonnette , Eric J. Thor , Michael Schrom , Debra M. Kozak
IPC分类号： A61M37/00
CPC分类号： A61B17/32037 , A61B17/22 , A61B2017/22079 , A61B2017/22084 , A61B2217/005 , A61M25/0029 , A61M25/0032 , A61M25/0045 , A61M25/005 , A61M25/007 , A61M2025/0034 , Y10T29/49826
摘要： An enhanced cross stream mechanical thrombectomy catheter with backloading manifold having a distal end with outflow and inflow orifices at one side for producing concentrated cross stream jet flow for selective and concentrated thrombus ablation during thrombectomy procedures. The invention provides for suitable distancing of high powered ablation or suction forces from the near walls of the vasculature. Cross stream flow emanating from the one side of the distal end of the catheter resultantly urges the distal end of the catheter and thus the opposing non-orificed side of the distal end of the catheter toward and against the vascular wall to inhibit contact of the inflow orifice with the vascular wall. Features of the invention include a geometrically configured insert to facilitate the backloading or exchange of guidewires.
摘要翻译：具有后支管道的增强的交叉流机械性血栓切除术导管，其具有在一侧具有流出和流入孔的远端，用于在血栓切除术过程中产生用于选择性和集中血栓消融的浓缩的交叉流射流。本发明提供从脉管系统的近壁适当地间隔大功率消融或吸力。从导管的远端的一侧发出的交叉流流动导致导管的远端，并因此促使导管的远端的相对的未通气的侧面朝向和抵靠血管壁，以阻止流入物的接触孔与血管壁。本发明的特征包括几何构造的插入件，以便于引导线的后退或更换。

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