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1. 发明申请

US20050080347A1 Method and apparatus for detecting and discriminating arrhythmias 有权
标题翻译：用于检测和鉴别心律失常的方法和装置
公开(公告)号：US20050080347A1
公开(公告)日：2005-04-14
申请号：US10682982
申请日：2003-10-10
申请人： Nirav Sheth , Eduardo Warman , Michael Hess
发明人： Nirav Sheth , Eduardo Warman , Michael Hess
IPC分类号： A61B5/046 , A61B5/0464 , A61N1/362 , A61N1/368 , A61N1/39 , G06F17/00 , A61B5/0402
CPC分类号： A61B5/046 , A61B5/0464 , A61B5/7264 , A61N1/3622 , A61N1/3962
摘要： An apparatus and method for discriminating arrhythmias that includes sensing a heart rate indicative of an arrhythmia associated with a first portion of a heart, determining regularity of the sensed heart rate, determining an event interval variability associated with a second portion of the heart, and classifying the arrhythmia in response to the determined event interval variability.
摘要翻译：一种用于区分心律失常的装置和方法，包括感测指示与心脏的第一部分相关联的心律失常的心率，确定感测心率的规律性，确定与心脏的第二部分相关联的事件间隔变异性，以及分类响应于确定的事件间隔变异性的心律失常。

2. 发明申请

US20060247690A1 Device and method for providing atrial-synchronized ventricular pacing with selective atrial tracking 有权
标题翻译：用于提供心房同步心室起搏和选择性心房跟踪的装置和方法
公开(公告)号：US20060247690A1
公开(公告)日：2006-11-02
申请号：US11115597
申请日：2005-04-27
申请人： Michael Hess , Eduardo Warman
发明人： Michael Hess , Eduardo Warman
IPC分类号： A61N1/362
CPC分类号： A61N1/3622 , A61N1/3627 , A61N1/3684
摘要： A device for delivering pacing therapy includes an atrial and ventricular leads, sensing circuitry connected to the leads for detecting depolarizations, and pulse generation circuitry for delivering ventricular pacing pulses based on sensed atrial depolarizations. The device includes control circuitry for controlling the pulse generation circuitry in a first mode in which the pulse generation circuitry delivers atrial synchronized pulses to both the right and left ventricular leads in response to each atrial depolarization sensed. In response to a detected atrial arrhythmia, the control circuitry causes the pulse generation circuitry to deliver atrial synchronized ventricular pacing pulses in response only to selected atrial depolarizations.
摘要翻译：用于输送起搏治疗的装置包括心房和心室引线，连接到用于检测去极化的引线的感测电路以及用于基于感测的心房去极化来输送心室起搏脉冲的脉冲产生电路。该装置包括用于在第一模式中控制脉冲发生电路的控制电路，其中脉冲发生电路响应于感测到的每个心房去极化而将心房同步脉冲输送到右心室和左心室引线。响应于检测到的心房心律失常，控制电路使得脉冲发生电路仅响应于所选择的心房去极化来递送心房同步心室起搏脉冲。

3. 发明申请

US20050256522A1 Device and method for determining tissue thickness and creating cardiac ablation lesions 失效
标题翻译：用于确定组织厚度并产生心脏消融病变的装置和方法
公开(公告)号：US20050256522A1
公开(公告)日：2005-11-17
申请号：US10844213
申请日：2004-05-12
申请人： David Francischelli , Eduardo Warman , Rahul Mehra
发明人： David Francischelli , Eduardo Warman , Rahul Mehra
IPC分类号： A61B18/14 , A61B19/00
CPC分类号： A61B18/1442 , A61B2018/00666 , A61B2018/1861 , A61B2090/061 , A61B2090/064
摘要： A tissue ablation device has a handle and an ablation head coupled to the handle. The ablation head has a first jaw, a second jaw, and an ablative element coupled to at least one of the first and second jaws. A thickness measurement device may be coupled to the ablation device to indicate the distance separating the first and second jaws. Further, a force measurement device may be coupled to the ablation device to measure the force being applied by the first and second jaws to a piece of tissue. Further, a strain measurement device may be coupled to the ablation device to indicate the strain resulting in a piece of tissue disposed between the first and second jaws when a stress is applied to the tissue.
摘要翻译：组织消融装置具有手柄和联接到手柄的消融头。消融头具有联接到第一和第二钳口中的至少一个的第一钳口，第二钳口和消融元件。厚度测量装置可以联接到消融装置以指示分离第一和第二钳口的距离。此外，力测量装置可以联接到消融装置以测量由第一和第二钳口施加到一片组织上的力。此外，当应力施加到组织时，应变测量装置可以联接到消融装置以指示当应力施加到组织上时产生设置在第一和第二钳口之间的一片组织的应变。

4. 发明申请

US20120109245A1 CARDIAC THERAPY BASED UPON IMPEDANCE SIGNALS 有权
标题翻译：基于阻抗信号的心脏病治疗
公开(公告)号：US20120109245A1
公开(公告)日：2012-05-03
申请号：US12916012
申请日：2010-10-29
申请人： Douglas A. Hettrick , Todd M. Zielinski , Eduardo Warman , Shantanu Sarkar
发明人： Douglas A. Hettrick , Todd M. Zielinski , Eduardo Warman , Shantanu Sarkar
IPC分类号： A61N1/365
CPC分类号： A61N1/36521 , A61B5/0452 , A61B5/0535 , A61B5/7239 , A61N1/3627 , A61N1/3682 , A61N1/3684 , A61N1/3987
摘要： Methods and/or devices are disclosed herein for monitoring cardiac impedance signal and delivering therapy to a patient's heart based upon the monitored cardiac impedance.
摘要翻译：本文公开了用于监测心脏阻抗信号并基于所监测的心脏阻抗将治疗递送到患者心脏的方法和/或装置。

5. 发明授权

US08781582B2 Vagal stimulation 有权
标题翻译：迷走神经刺激
公开(公告)号：US08781582B2
公开(公告)日：2014-07-15
申请号：US13353802
申请日：2012-01-19
申请人： Paul D. Ziegler , Lilian Kornet , Xiaohong Zhou , Richard N. M. Cornelussen , Robert Stadler , Eduardo Warman , Karen J. Kleckner , Alberto Della Scala
发明人： Paul D. Ziegler , Lilian Kornet , Xiaohong Zhou , Richard N. M. Cornelussen , Robert Stadler , Eduardo Warman , Karen J. Kleckner , Alberto Della Scala
IPC分类号： A61N1/37
CPC分类号： A61N1/36139 , A61N1/36053 , A61N1/36114 , A61N1/3621 , A61N1/3627 , A61N1/36564 , A61N1/3682 , A61N1/3702 , A61N1/37235 , A61N1/3962
摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.
摘要翻译：本文的公开内容一般涉及使用迷走神经刺激治疗心脏病症的方法，还涉及用于进行这种治疗的系统和装置。这样的方法可以包括监测患者的生理参数，检测心脏状况，以及向患者输送迷走神经刺激（例如，对迷走神经或具有副交感神经功能的神经元的电刺激）以治疗检测到的心脏状况。

6. 发明申请

US20120185007A1 VAGAL STIMULATION 有权
标题翻译： VAGAL刺激
公开(公告)号：US20120185007A1
公开(公告)日：2012-07-19
申请号：US13353802
申请日：2012-01-19
申请人： Paul D. Ziegler , Lillian Kornet , Xiaohong Zhou , Richard Cornelussen , Robert Stadler , Eduardo Warman , Karen J. Kleckner , Alberto Della Scala
发明人： Paul D. Ziegler , Lillian Kornet , Xiaohong Zhou , Richard Cornelussen , Robert Stadler , Eduardo Warman , Karen J. Kleckner , Alberto Della Scala
IPC分类号： A61N1/365
CPC分类号： A61N1/36139 , A61N1/36053 , A61N1/36114 , A61N1/3621 , A61N1/3627 , A61N1/36564 , A61N1/3682 , A61N1/3702 , A61N1/37235 , A61N1/3962
摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.
摘要翻译：本文的公开内容一般涉及使用迷走神经刺激治疗心脏病症的方法，还涉及用于进行这种治疗的系统和装置。这样的方法可以包括监测患者的生理参数，检测心脏状况，以及向患者输送迷走神经刺激（例如，对迷走神经或具有副交感神经功能的神经元的电刺激）以治疗检测到的心脏状况。

7. 发明申请

US20050159783A1 Control of atrial defibrillation therapy based on hemodynamic sensor feedback 有权
标题翻译：基于血流动力学传感器反馈控制心房除颤治疗
公开(公告)号：US20050159783A1
公开(公告)日：2005-07-21
申请号：US10760155
申请日：2004-01-16
申请人： Douglas Hettrick , David Euler , Eduardo Warman , Michael Ujhelyi , Rahul Mehra , Paul Ziegler , Shailesh Kumar Musley , Charles Distad , David Ritscher
发明人： Douglas Hettrick , David Euler , Eduardo Warman , Michael Ujhelyi , Rahul Mehra , Paul Ziegler , Shailesh Kumar Musley , Charles Distad , David Ritscher
IPC分类号： A61N1/362 , A61N1/365 , A61N1/37 , A61N1/39
CPC分类号： A61N1/3702 , A61N1/3621 , A61N1/365 , A61N1/36564 , A61N1/395 , A61N1/3962
摘要： Control of defibrillation therapy delivered by implantable medical devices (IMDS) using hemodynamic sensor feedback is disclosed. The hemodynamic sensor feedback allows for increased control over application of atrial defibrillation therapy. Specifically, the therapy is delivered when a fibrillation episode results in a discrete loss of hemodynamic function. Defibrillation therapy is thus withheld for hemodynamically benign arrhythmias.
摘要翻译：公开了使用血液动力学传感器反馈控制由可植入医疗装置（IMDS）递送的除颤疗法。血液动力学传感器反馈允许增加对心房除颤治疗的应用的控制。具体来说，当纤维性颤动发作导致血液动力学功能的离散损失时，进行治疗。因此，对于血液动力学良性心律失常，禁止使用除颤疗法。

8. 发明申请

US20050148897A1 Implantable medical device with sleep disordered breathing monitoring 有权
标题翻译：可植入医疗器械，带有睡眠呼吸障碍监测
公开(公告)号：US20050148897A1
公开(公告)日：2005-07-07
申请号：US10746814
申请日：2003-12-24
申请人： Yong Cho , Eduardo Warman , Todd Sheldon
发明人： Yong Cho , Eduardo Warman , Todd Sheldon
IPC分类号： A61B5/00 , A61B5/0205 , A61B5/0215 , A61B5/022 , A61B5/0245 , A61B5/0456 , A61B5/0464 , A61B5/0476 , A61B5/08 , A61B5/083 , A61B5/087 , A61B5/11 , A61B5/113 , A61B7/00 , A61N1/36 , A61N1/365
CPC分类号： A61N1/3601 , A61B5/0031 , A61B5/01 , A61B5/0205 , A61B5/0215 , A61B5/022 , A61B5/0245 , A61B5/0456 , A61B5/0464 , A61B5/0476 , A61B5/0809 , A61B5/0816 , A61B5/0833 , A61B5/0836 , A61B5/087 , A61B5/0878 , A61B5/1116 , A61B5/1118 , A61B5/1135 , A61B5/4818 , A61B7/003 , A61N1/36521 , A61N1/36557
摘要： An implantable medical device (IMD) includes a sensor for monitoring parameters indicative of sleep disordered breathing. The IMD also includes a position sensor that indicates the relative position and/or activity level of the patient. The position sensor data is used in one or more ways in conjunction with the SDB sensing. The position data is used to confirm that such sensed data is likely indicative of SDB or to select the appropriate criteria for comparison.
摘要翻译：可植入医疗装置（IMD）包括用于监测指示睡眠呼吸紊乱的参数的传感器。 IMD还包括指示患者的相对位置和/或活动水平的位置传感器。位置传感器数据以一种或多种方式与SDB感测结合使用。位置数据用于确认这样的感测数据可能表示SDB或选择适当的比较标准。

9. 发明授权

US08725259B2 Vagal stimulation 有权
公开(公告)号：US08725259B2
公开(公告)日：2014-05-13
申请号：US13353861
申请日：2012-01-19
申请人： Lilian Kornet , Richard N. M. Cornelussen , Paul D. Ziegler , Xiaohong Zhou , Eduardo Warman , Karen J. Kleckner , Lucy Nichols , Alberto Della Scala
发明人： Lilian Kornet , Richard N. M. Cornelussen , Paul D. Ziegler , Xiaohong Zhou , Eduardo Warman , Karen J. Kleckner , Lucy Nichols , Alberto Della Scala
IPC分类号： A61N1/365
CPC分类号： A61N1/36114
摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.

10. 发明申请

US20120185009A1 VAGAL STIMULATION 有权
公开(公告)号：US20120185009A1
公开(公告)日：2012-07-19
申请号：US13353861
申请日：2012-01-19
申请人： Lilian Kornet , Richard N.M. Cornelussen , Paul D. Ziegler , Xiaohong Zhou , Eduardo Warman , Karen J. Kleckner , Lucy Nichols , Alberto Della Scala
发明人： Lilian Kornet , Richard N.M. Cornelussen , Paul D. Ziegler , Xiaohong Zhou , Eduardo Warman , Karen J. Kleckner , Lucy Nichols , Alberto Della Scala
IPC分类号： A61N1/365
CPC分类号： A61N1/36114
摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.

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