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1. 发明申请

US20050256522A1 Device and method for determining tissue thickness and creating cardiac ablation lesions 失效
标题翻译：用于确定组织厚度并产生心脏消融病变的装置和方法
公开(公告)号：US20050256522A1
公开(公告)日：2005-11-17
申请号：US10844213
申请日：2004-05-12
申请人： David Francischelli , Eduardo Warman , Rahul Mehra
发明人： David Francischelli , Eduardo Warman , Rahul Mehra
IPC分类号： A61B18/14 , A61B19/00
CPC分类号： A61B18/1442 , A61B2018/00666 , A61B2018/1861 , A61B2090/061 , A61B2090/064
摘要： A tissue ablation device has a handle and an ablation head coupled to the handle. The ablation head has a first jaw, a second jaw, and an ablative element coupled to at least one of the first and second jaws. A thickness measurement device may be coupled to the ablation device to indicate the distance separating the first and second jaws. Further, a force measurement device may be coupled to the ablation device to measure the force being applied by the first and second jaws to a piece of tissue. Further, a strain measurement device may be coupled to the ablation device to indicate the strain resulting in a piece of tissue disposed between the first and second jaws when a stress is applied to the tissue.
摘要翻译：组织消融装置具有手柄和联接到手柄的消融头。消融头具有联接到第一和第二钳口中的至少一个的第一钳口，第二钳口和消融元件。厚度测量装置可以联接到消融装置以指示分离第一和第二钳口的距离。此外，力测量装置可以联接到消融装置以测量由第一和第二钳口施加到一片组织上的力。此外，当应力施加到组织时，应变测量装置可以联接到消融装置以指示当应力施加到组织上时产生设置在第一和第二钳口之间的一片组织的应变。

2. 发明申请

US20060142753A1 Ablation system and method of use 有权
公开(公告)号：US20060142753A1
公开(公告)日：2006-06-29
申请号：US11355465
申请日：2006-02-16
申请人： David Francischelli , Eduardo Warman , Rahul Mehra , Mark Stewart , James Skarda , Harry Puryear , David Schwartzman
发明人： David Francischelli , Eduardo Warman , Rahul Mehra , Mark Stewart , James Skarda , Harry Puryear , David Schwartzman
IPC分类号： A61B18/18
CPC分类号： A61B18/1445 , A61B5/04 , A61B18/12 , A61B2018/00065 , A61B2018/00363 , A61B2018/00577 , A61B2018/00654 , A61B2018/00702 , A61B2018/00755 , A61B2018/00779 , A61B2018/00791 , A61B2018/00839 , A61B2018/00875 , A61B2018/1226 , A61B2018/1253 , A61B2018/126 , A61B2018/1467 , A61B2018/1472 , A61B2218/002 , A61N1/403
摘要： A system and method for creating lesions and assessing their completeness or transmurality. Assessment of transmurality of a lesion is accomplished by monitoring the depolarization signal in a local electrogram taken using electrodes located adjacent the tissue to be ablated. Following onset of application of ablation energy to heart tissue, the local electrogram is measured with electrodes located adjacent tissue to be ablated so that the ablation energy to ablation elements can be selectively reduced or terminated when transmurality is detected.

3. 发明申请

US20050159783A1 Control of atrial defibrillation therapy based on hemodynamic sensor feedback 有权
标题翻译：基于血流动力学传感器反馈控制心房除颤治疗
公开(公告)号：US20050159783A1
公开(公告)日：2005-07-21
申请号：US10760155
申请日：2004-01-16
申请人： Douglas Hettrick , David Euler , Eduardo Warman , Michael Ujhelyi , Rahul Mehra , Paul Ziegler , Shailesh Kumar Musley , Charles Distad , David Ritscher
发明人： Douglas Hettrick , David Euler , Eduardo Warman , Michael Ujhelyi , Rahul Mehra , Paul Ziegler , Shailesh Kumar Musley , Charles Distad , David Ritscher
IPC分类号： A61N1/362 , A61N1/365 , A61N1/37 , A61N1/39
CPC分类号： A61N1/3702 , A61N1/3621 , A61N1/365 , A61N1/36564 , A61N1/395 , A61N1/3962
摘要： Control of defibrillation therapy delivered by implantable medical devices (IMDS) using hemodynamic sensor feedback is disclosed. The hemodynamic sensor feedback allows for increased control over application of atrial defibrillation therapy. Specifically, the therapy is delivered when a fibrillation episode results in a discrete loss of hemodynamic function. Defibrillation therapy is thus withheld for hemodynamically benign arrhythmias.
摘要翻译：公开了使用血液动力学传感器反馈控制由可植入医疗装置（IMDS）递送的除颤疗法。血液动力学传感器反馈允许增加对心房除颤治疗的应用的控制。具体来说，当纤维性颤动发作导致血液动力学功能的离散损失时，进行治疗。因此，对于血液动力学良性心律失常，禁止使用除颤疗法。

4. 发明授权

US07364578B2 System and method of performing an electrosurgical procedure 有权
标题翻译：执行电外科手术的系统和方法
公开(公告)号：US07364578B2
公开(公告)日：2008-04-29
申请号：US11003451
申请日：2004-12-03
申请人： David Francischelli , Rahul Mehra , Alison Lutterman
发明人： David Francischelli , Rahul Mehra , Alison Lutterman
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B2018/00029 , A61B2018/00351 , A61B2018/00363 , A61B2018/00577 , A61B2018/00738 , A61B2018/1253 , A61B2018/1472
摘要： A system and method of making a lesion on living tissue including providing an electrosurgical system, determining a desired lesion depth, selecting a power setting, and applying electrical energy to the living tissue. The system includes an instrument having an electrode at a distal portion thereof, and a power source having multiple available power settings. The power source is electrically connected to the electrode. The step of applying electrical energy includes energizing the electrode at the selected power setting for a recommended energization time period that is determined by reference to predetermined length of time information and based upon the desired lesion depth and the selected power setting. The system preferably further includes a fluid source for irrigating the electrode at an irrigation rate. In this regard, the predetermined length of time information is generated as a function of irrigation rate.
摘要翻译：一种在活体组织上形成损伤的系统和方法，包括提供电外科系统，确定期望的病变深度，选择功率设定以及向生物体组织施加电能。该系统包括在其远端部分具有电极的仪器和具有多个可用功率设置的电源。电源电连接到电极。施加电能的步骤包括以所选择的功率设置激励电极，以建立通电时间段，该推荐通电时间周期参考预定时间长度信息确定，并且基于期望的病变深度和所选择的功率设置。该系统优选地还包括用于以灌溉速率冲洗电极的流体源。在这方面，根据灌溉速率产生预定长度的时间信息。

5. 发明申请

US20050165392A1 System and method of performing an electrosurgical procedure 有权
标题翻译：执行电外科手术的系统和方法
公开(公告)号：US20050165392A1
公开(公告)日：2005-07-28
申请号：US11003451
申请日：2004-12-03
申请人： David Francischelli , Rahul Mehra , Alison Lutterman
发明人： David Francischelli , Rahul Mehra , Alison Lutterman
IPC分类号： A61B18/00 , A61B18/14
CPC分类号： A61B18/1492 , A61B2018/00029 , A61B2018/00351 , A61B2018/00363 , A61B2018/00577 , A61B2018/00738 , A61B2018/1253 , A61B2018/1472
摘要： A system and method of making a lesion on living tissue including providing an electrosurgical system, determining a desired lesion depth, selecting a power setting, and applying electrical energy to the living tissue. The system includes an instrument having an electrode at a distal portion thereof, and a power source having multiple available power settings. The power source is electrically connected to the electrode. The step of applying electrical energy includes energizing the electrode at the selected power setting for a recommended energization time period that is determined by reference to predetermined length of time information and based upon the desired lesion depth and the selected power setting. The system preferably further includes a fluid source for irrigating the electrode at an irrigation rate. In this regard, the predetermined length of time information is generated as a function of irrigation rate.
摘要翻译：一种在活体组织上形成损伤的系统和方法，包括提供电外科系统，确定期望的病变深度，选择功率设定以及向生物体组织施加电能。该系统包括在其远端部分具有电极的仪器和具有多个可用功率设置的电源。电源电连接到电极。施加电能的步骤包括以所选择的功率设置激励电极，以建立通电时间段，该推荐通电时间周期通过参考预定时间长度信息确定，并且基于期望的病变深度和所选择的功率设置。该系统优选地还包括用于以灌溉速率冲洗电极的流体源。在这方面，根据灌溉速率产生预定长度的时间信息。

6. 发明申请

US20050143729A1 Method of irrigated ablation 有权
标题翻译：灌溉消融方法
公开(公告)号：US20050143729A1
公开(公告)日：2005-06-30
申请号：US11061425
申请日：2005-02-18
申请人： David Francischelli , Richard Comben , Michael Hoey , Rahul Mehra , Jon Ocel , Robert Pearson , Paul Trescony , Scott Jahns
发明人： David Francischelli , Richard Comben , Michael Hoey , Rahul Mehra , Jon Ocel , Robert Pearson , Paul Trescony , Scott Jahns
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B18/1445 , A61B2018/00065 , A61B2018/00351 , A61B2018/00577 , A61B2018/1435 , A61B2018/1472 , A61B2218/002
摘要： A device for ablating tissue is provided. The device comprises a conductive element with a channel for irrigating fluid formed therein, which is in contact with a non-conductive microporous interface. All or a portion of the interface may be removable. When the interface is removed, a portion of the conductive element is exposed for use in ablating tissue. Methods of using the device and of removing the interface are also provided.
摘要翻译：提供了用于消融组织的装置。该装置包括导电元件，其具有用于在其中形成的冲洗流体的通道，其与非导电微孔界面接触。界面的全部或部分可以是可移动的。当界面被去除时，导电元件的一部分被暴露以用于消融组织。还提供了使用设备和移除界面的方法。

7. 发明申请

US20050033280A1 Method and system for treatment of atrial tachyarrhythmias 有权
标题翻译：治疗房性快速性心律失常的方法和系统
公开(公告)号：US20050033280A1
公开(公告)日：2005-02-10
申请号：US10923073
申请日：2004-08-20
申请人： David Francischelli , Rahul Mehra
发明人： David Francischelli , Rahul Mehra
IPC分类号： A61B18/14
CPC分类号： A61B18/1445 , A61B18/1402 , A61B2017/2945 , A61B2018/00994 , A61B2018/126 , A61B2018/1432 , A61B2018/1472
摘要： A method of and a system for treatment of atrial tachyarrhythmias. The system includes a set of hemostats having elongated opposing jaws carrying mechanisms for applying ablation energy along the jaws. The jaws having straight and curved configurations selected to allow arrangement of the jaws of along opposite sides of walls of a patient's atrium. Treatment is accomplished by applying of ablation energy to the walls of a patient's artria to create lines of lesion corresponding generally to incisions employed in a Maze type procedure.
摘要翻译：一种治疗房性快速性心律失常的方法和系统。该系统包括一组具有延长的相对的夹爪的止血器，该钳口携带用于沿钳口施加消融能量的机构。钳口具有直的和弯曲的构造，其被选择为允许沿着病人心房的壁的相对侧布置钳口。通过将消融能量施加到患者的肌肉的壁上来实现治疗，以产生通常对于迷宫类型手术中使用的切口相应的损伤线。

8. 发明授权

US06827715B2 System and method of performing an electrosurgical procedure 有权
标题翻译：执行电外科手术的系统和方法
公开(公告)号：US06827715B2
公开(公告)日：2004-12-07
申请号：US10056806
申请日：2002-01-25
申请人： David Francischelli , Rahul Mehra , Alison Lutterman
发明人： David Francischelli , Rahul Mehra , Alison Lutterman
IPC分类号： A61B1818
CPC分类号： A61B18/1492 , A61B2018/00029 , A61B2018/00351 , A61B2018/00363 , A61B2018/00577 , A61B2018/00738 , A61B2018/1253 , A61B2018/1472
摘要： A system and method of making a lesion on living tissue including providing an electrosurgical system, determining a desired lesion depth, selecting a power setting, and applying electrical energy to the living tissue. The system includes an instrument having an electrode at a distal portion thereof, and a power source having multiple available power settings. The power source is electrically connected to the electrode. The step of applying electrical energy includes energizing the electrode at the selected power setting for a recommended energization time period that is determined by reference to predetermined length of time information and based upon the desired lesion depth and the selected power setting. The system preferably further includes a fluid source for irrigating the electrode at an irrigation rate. In this regard, the predetermined length of time information is generated as a function of irrigation rate.
摘要翻译：一种在活体组织上形成损伤的系统和方法，包括提供电外科系统，确定期望的病变深度，选择功率设定以及向生物体组织施加电能。该系统包括在其远端部分具有电极的仪器和具有多个可用功率设置的电源。电源电连接到电极。施加电能的步骤包括以所选择的功率设置激励电极，以建立通电时间段，该推荐通电时间周期参考预定时间长度信息确定，并且基于期望的病变深度和所选择的功率设置。该系统优选地还包括用于以灌溉速率冲洗电极的流体源。在这方面，根据灌溉速率产生预定长度的时间信息。

9. 发明授权

US08512337B2 Method and system for treatment of atrial tachyarrhythmias 有权
标题翻译：治疗房性快速性心律失常的方法和系统
公开(公告)号：US08512337B2
公开(公告)日：2013-08-20
申请号：US10923073
申请日：2004-08-20
申请人： David E. Francischelli , Rahul Mehra
发明人： David E. Francischelli , Rahul Mehra
IPC分类号： A61B18/12
CPC分类号： A61B18/1445 , A61B18/1402 , A61B2017/2945 , A61B2018/00994 , A61B2018/126 , A61B2018/1432 , A61B2018/1472
摘要： A method of and a system for treatment of atrial tachyarrhythmias. The system includes a set of hemostats having elongated opposing jaws carrying mechanisms for applying ablation energy along the jaws. The jaws having straight and curved configurations selected to allow arrangement of the jaws of along opposite sides of walls of a patient's atrium. Treatment is accomplished by applying of ablation energy to the walls of a patient's artria to create lines of lesion corresponding generally to incisions employed in a Maze type procedure.
摘要翻译：一种治疗房性快速性心律失常的方法和系统。该系统包括一组具有延长的相对的夹爪的止血器，该钳口携带用于沿钳口施加消融能量的机构。钳口具有直的和弯曲的构造，其被选择为允许沿着病人心房的壁的相对侧布置钳口。通过将消融能量施加到患者的肌肉的壁上来实现治疗，以产生通常对于迷宫类型手术中使用的切口相应的损伤线。

10. 发明授权

US07561913B2 Automatic adjusting R-wave synchronization algorithm for atrial cardioversion and defibrillation 有权
标题翻译：自动调整心律转复和除颤的R波同步算法
公开(公告)号：US07561913B2
公开(公告)日：2009-07-14
申请号：US10426284
申请日：2003-04-30
申请人： Luc R. Mongeon , Rahul Mehra
发明人： Luc R. Mongeon , Rahul Mehra
IPC分类号： A61N1/39
CPC分类号： A61N1/3956 , A61N1/3987
摘要： An implantable medical device system and method are provided for synchronizing atrial cardioversion shocks to the ventricular rhythm using an adjustable atrial cardioversion/defibrillation ventricular refractory period. Upon determining a need for an atrial shock therapy, the method determines if the ventricular rate meets synchronization criteria based on an upper ventricular refractory period limit. If synchronization criteria are not met, the refractory period is automatically adjusted in stepwise decrements until the synchronization criteria are met, or until a lower refractory period limit is exceeded. If synchronization criteria are met, an atrial shock is synchronized to the next ventricular depolarization occurring outside the current refractory period. If the lower refractory period limit is exceeded, the atrial therapy is aborted.
摘要翻译：提供了一种植入式医疗装置系统和方法，用于使用可调节心房复律/除颤心室不应期使心房心律转复冲击与心室节律同步。在确定需要心房休克治疗后，该方法确定心室率是否满足基于上心室不应期限的同步标准。如果不符合同步标准，则可以逐步递减地自动调整不应期，直到达到同步标准，或直到超过较低的不应期限为止。如果符合同步标准，心房休克与当前不应期以外发生的下一次心室去极化同步。如果超过较低的不应期限，则中止心房治疗。

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