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1. 发明申请

US20090319052A1 BIOMATERIALS, THEIR PREPARATION AND USE 审中-公开
标题翻译：生物材料，他们的准备和使用
公开(公告)号：US20090319052A1
公开(公告)日：2009-12-24
申请号：US12309789
申请日：2007-07-23
申请人： Michael Francis Butler , Mary Heppenstall-Butler , Yan Deng , Shaodian Shen , Guibo Zhu
发明人： Michael Francis Butler , Mary Heppenstall-Butler , Yan Deng , Shaodian Shen , Guibo Zhu
IPC分类号： A61F2/28 , C01B25/26 , C09K3/00 , A61F2/02
CPC分类号： A61L27/56 , A61K6/027 , A61K8/25 , A61L27/10 , A61L27/425 , A61Q11/00 , C03C1/006 , C03C3/04 , C03C4/0007 , C04B35/057 , C04B35/14 , C04B35/447 , C04B38/0032 , C04B38/0045 , C04B2111/00836 , C04B38/0054
摘要： A calcium oxide-silica composite biomaterial either in amorphous state or crystalline state having an average pore size, as determined by the BET method, in the range of from 0.8 to 4 nm, wherein the calcium oxide-silica content of the biomaterial is at least 80 wt %, the balance being optionally one or more other materials and wherein the molar ratio of calcium oxide to silica is at least 0.1.
摘要翻译：一种氧化钙 - 二氧化硅复合生物材料，其无定形状态或结晶态具有通过BET法测定的平均孔径，范围为0.8至4nm，其中生物材料的氧化钙 - 二氧化硅含量至少为 80重量％，余量可选地为一种或多种其它材料，并且其中氧化钙与二氧化硅的摩尔比为至少0.1。

2. 发明授权

US08257721B2 Oral care product 有权
标题翻译：口腔护理产品
公开(公告)号：US08257721B2
公开(公告)日：2012-09-04
申请号：US12517562
申请日：2007-12-04
申请人： Michael Francis Butler , Yan Deng , Mary Heppenstall-Butler , Andrew Joiner , Haiyan Li , Xiaoke Li
发明人： Michael Francis Butler , Yan Deng , Mary Heppenstall-Butler , Andrew Joiner , Haiyan Li , Xiaoke Li
IPC分类号： A61K8/25 , A61K8/02 , A61K8/24 , A61Q11/00 , A61C19/06
CPC分类号： A61K8/24 , A61K8/25 , A61K33/06 , A61K33/08 , A61K33/10 , A61K33/42 , A61K45/06 , A61Q11/00 , A61K2300/00
摘要： An oral care product comprising a source of calcium ions, a source of phosphate ions, and an insoluble whitening agent for deposition onto the teeth, characterized in that the source of calcium ions and the source of phosphate ions are physically separate prior to the use of the product.
摘要翻译：一种包含钙离子源，磷酸根离子源和用于沉积到牙齿上的不溶性增白剂的口腔护理产品，其特征在于钙离子源和磷酸根离子源在使用前该产品。

3. 发明授权

US09149419B2 Oral care product 有权
标题翻译：口腔护理产品
公开(公告)号：US09149419B2
公开(公告)日：2015-10-06
申请号：US12517560
申请日：2007-12-04
申请人： Michael Francis Butler , Yan Deng , Mary Heppenstall-Butler , Andrew Joiner , Haiyan Li
发明人： Michael Francis Butler , Yan Deng , Mary Heppenstall-Butler , Andrew Joiner , Haiyan Li
IPC分类号： A61K8/02 , A61K8/24 , A61K8/25 , A61K33/06 , A61K33/08 , A61K33/10 , A61K33/42 , A61K45/06 , A61Q11/00
CPC分类号： A61K8/24 , A61K8/25 , A61K33/06 , A61K33/08 , A61K33/10 , A61K33/42 , A61K45/06 , A61Q11/00 , A61K2300/00
摘要： An Oral care product is provided which includes a mesoporous calcium silicate biomaterial (MCSB) dispersed in a polymeric material matrix. MCSB is an insoluble composite material of calcium oxide-silica.
摘要翻译：提供了一种口腔护理产品，其包括分散在聚合材料基质中的介孔硅酸钙生物材料（MCSB）。 MCSB是氧化钙 - 二氧化硅的不溶性复合材料。

4. 发明申请

US20100136067A1 ORAL CARE PRODUCT 有权
标题翻译：口腔护理产品
公开(公告)号：US20100136067A1
公开(公告)日：2010-06-03
申请号：US12517560
申请日：2007-12-04
申请人： Michael Francis Butler , Yan Deng , Mary Heppenstall-Butler , Andrew Joiner , Haiyan Li
发明人： Michael Francis Butler , Yan Deng , Mary Heppenstall-Butler , Andrew Joiner , Haiyan Li
IPC分类号： A61K8/02 , A61Q11/00 , A61K8/19
CPC分类号： A61K8/24 , A61K8/25 , A61K33/06 , A61K33/08 , A61K33/10 , A61K33/42 , A61K45/06 , A61Q11/00 , A61K2300/00
摘要： An oral care product comprising a mesoporous calcium silicate biomaterial (MCBS) dispersed in a polymeric material matrix.
摘要翻译：一种包含分散在聚合材料基质中的介孔硅酸钙生物材料（MCBS）的口腔护理产品。

5. 发明申请

US20100150974A1 ORAL CARE PRODUCT 有权
标题翻译：口腔护理产品
公开(公告)号：US20100150974A1
公开(公告)日：2010-06-17
申请号：US12517562
申请日：2007-12-04
申请人： Michael Francis Butler , Yan Deng , Mary Heppenstall-Butler , Andrew Joiner , Haiyan Li , Xiaoke Li
发明人： Michael Francis Butler , Yan Deng , Mary Heppenstall-Butler , Andrew Joiner , Haiyan Li , Xiaoke Li
IPC分类号： A61K8/25 , A61K8/02 , A61K8/24 , A61Q11/00 , A61C19/06
CPC分类号： A61K8/24 , A61K8/25 , A61K33/06 , A61K33/08 , A61K33/10 , A61K33/42 , A61K45/06 , A61Q11/00 , A61K2300/00
摘要： An oral care product comprising a source of calcium ions, a source of phosphate ions, and an insoluble whitening agent for deposition onto the teeth, characterised in that the source of calcium ions and the source of phosphate ions are physically separate prior to the use of the product.
摘要翻译：一种包含钙离子源，磷酸根离子源和用于沉积到牙齿上的不溶性增白剂的口腔护理产品，其特征在于钙离子源和磷酸根离子源在使用前该产品。

6. 发明申请

US20100143423A1 ORAL CARE PRODUCT 审中-公开
标题翻译：口腔护理产品
公开(公告)号：US20100143423A1
公开(公告)日：2010-06-10
申请号：US12517365
申请日：2007-11-23
申请人： Michael Francis Butler , Yan Deng , Mary Heppenstall-Butler , Andrew Joiner , Haiyan Li , Xiaoke Li
发明人： Michael Francis Butler , Yan Deng , Mary Heppenstall-Butler , Andrew Joiner , Haiyan Li , Xiaoke Li
IPC分类号： A61K8/24 , A61K8/02 , A61Q11/00 , A61C19/06
CPC分类号： A61K8/24 , A61K8/25 , A61K33/06 , A61K33/08 , A61K33/10 , A61K33/42 , A61K45/06 , A61Q11/00 , A61K2300/00
摘要： An oral care product comprising a first composition comprising an insoluble calcium salt that is not a calcium phosphate salt, a second independent composition comprising a source of phosphate ions, and a means for delivering each of the compositions to the surface of the teeth.
摘要翻译：一种口腔护理产品，其包含第一组合物，所述第一组合物包含不是磷酸钙盐的不溶性钙盐，包含磷酸盐离子源的第二独立组合物和用于将每种组合物输送到牙齿表面的装置。

7. 发明授权

US07306814B2 Method of growing crystals 有权
标题翻译：生长晶体的方法
公开(公告)号：US07306814B2
公开(公告)日：2007-12-11
申请号：US11124892
申请日：2005-05-09
申请人： Michael Francis Butler , Mary Heppenstall-Butler , Christopher Rawlins
发明人： Michael Francis Butler , Mary Heppenstall-Butler , Christopher Rawlins
IPC分类号： A61K9/14 , A61K33/06 , A61K33/10
CPC分类号： B01J13/02 , Y10T428/2985
摘要： A composition is provided comprising a substance of interest encapsulated by a continuous layer of a plurality of salt crystals which layer is impermeable to the substance of interest. Also provided is a method of producing a continuous layer of a plurality of salt crystals, the salt comprising a cation and an anion, which method comprises (i) providing a substrate which comprises a plurality of negatively charged binding sites for the cation and/or a plurality of positively charged binding sites for the anion, and (ii) contacting the substrate with a solution of the salt under conditions which cause nucleation of salt crystals comprising the cation and the anion at a plurality of said binding sites, the plurality of charged binding sites being present on the surface of the substrate at a sufficient density so that the resulting plurality of salt crystals form a continuous layer.
摘要翻译：提供了一种组合物，其包含由多个盐晶体的连续层包封的感兴趣的物质，该层对于感兴趣的物质是不可渗透的。还提供了一种制备多个盐晶体的连续层的方法，该盐包含阳离子和阴离子，该方法包括（i）提供底物，其包含多个负电荷的阳离子和/或多个带正电荷的阴离子结合位点，和（ii）在多个所述结合位点处引起包含阳离子和阴离子的盐晶体成核的条件下使该底物与盐溶液接触，多个带电以足够的密度存在于基材表面上的结合位点，使得所得到的多个盐晶体形成连续层。

8. 发明申请

US20050282012A1 Method of growing crystals 有权
标题翻译：生长晶体的方法
公开(公告)号：US20050282012A1
公开(公告)日：2005-12-22
申请号：US11124892
申请日：2005-05-09
申请人： Michael Butler , Mary Heppenstall-Butler , Christopher Rawlins
发明人： Michael Butler , Mary Heppenstall-Butler , Christopher Rawlins
IPC分类号： A61K9/50 , B01J13/02 , B32B5/16
CPC分类号： B01J13/02 , Y10T428/2985
摘要： A composition is provided comprising a substance of interest encapsulated by a continuous layer of a plurality of salt crystals which layer is impermeable to the substance of interest. Also provided is a method of producing a continuous layer of a plurality of salt crystals, the salt comprising a cation and an anion, which method comprises (i) providing a substrate which comprises a plurality of negatively charged binding sites for the cation and/or a plurality of positively charged binding sites for the anion, and (ii) contacting the substrate with a solution of the salt under conditions which cause nucleation of salt crystals comprising the cation and the anion at a plurality of said binding sites, the plurality of charged binding sites being present on the surface of the substrate at a sufficient density so that the resulting plurality of salt crystals form a continuous layer.
摘要翻译：提供了一种组合物，其包含由多个盐晶体的连续层包封的感兴趣的物质，该层对于感兴趣的物质是不可渗透的。还提供了一种制备多个盐晶体的连续层的方法，该盐包含阳离子和阴离子，该方法包括（i）提供底物，其包含多个带负电荷的阳离子和/或多个带正电荷的阴离子结合位点，和（ii）在多个所述结合位点处引起包含阳离子和阴离子的盐晶体成核的条件下使该底物与盐溶液接触，多个带电以足够的密度存在于基材表面上的结合位点，使得所得到的多个盐晶体形成连续层。

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