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    • 7. 发明申请
    • SCREENING ASSAYS FOR INHIBITORS OF BETA AMYLOID PEPTIDE ION CHANNEL FORMATION
    • β-淀粉样蛋白离子通道形成抑制剂筛选测定
    • US20100178658A1
    • 2010-07-15
    • US12602373
    • 2008-05-30
    • Michael MayerJerry Yang
    • Michael MayerJerry Yang
    • G01N33/567
    • G01N33/6896G01N2333/4709G01N2500/00G01N2800/2814
    • Screening assays and methods of employing the screening assays designed to identify potential inhibitors of amyloidal neurodegenerative disease. The screening assays comprises providing a membrane construct disposed on a substrate and contacting the membrane construct with Aβ peptide capable of forming an Aβ peptide ion channel in the construct. The membrane construct is then contacted with a test compound. Aβ peptide ion channel activity is determined after the construct has incubated with the Aβ peptide in the presence and in the absence of the test compound. A reduction in the Aβ peptide ion channel activity of the membrane construct contacted with the test compound in comparison to a different membrane construct contacted with the same Aβ peptide in the absence of said test compound indicates that the test compound is an inhibitor of amyloidal neurodegenerative disease.
    • 筛选试验和采用筛选试验的方法,设计用于鉴定淀粉样变性神经变性疾病的潜在抑制剂。 筛选测定法包括提供设置在基质上并使膜构建体与A&bgr接触的膜构建体; 能够形成A&bgr的肽; 肽离子通道在构建体中。 然后将膜构建体与测试化合物接触。 A&bgr 在构建体与A&bgr孵育后测定肽离子通道活性; 肽在存在和不存在测试化合物的情况下。 减少A&bgr; 与与相同A&Bgr接触的不同膜构建体相比,膜构建体与测试化合物接触的肽离子通道活性; 在不存在所述测试化合物的情况下,肽表明测试化合物是淀粉样神经变性疾病的抑制剂。
    • 8. 发明申请
    • Method and Device for Converting Thermal Energy Into Mechanical Work
    • 将热能转化为机械工作的方法和装置
    • US20090229265A1
    • 2009-09-17
    • US12227856
    • 2007-05-24
    • Michael MayerBernd Peter PfeiferFranz Peter JegelSteve Hargreaves
    • Michael MayerBernd Peter PfeiferFranz Peter JegelSteve Hargreaves
    • F01K27/00F01K25/00
    • F01K25/02F01K27/005
    • The invention relates to a method for converting thermal energy into mechanical work. Said method comprises the following steps which are performed as a cycle: A liquid work medium is fed from a supply reservoir (1) to a work container (3); the work medium in the work container (3) is heated by a first heat exchanger (5); a sub-amount of the work medium flows from the work container (3) to a pneumatic-hydraulic-converter (8), a hydraulic medium from the pneumatic-hydraulic-converter (8) is compressed in a work machine (9) in order to convert the hydraulic work of the hydraulic medium into mechanical work; the work medium from the pneumatic-hydraulic-converter (8) is fed back into the supply reservoir (1) and the hydraulic medium is returned into the pneumatic-hydraulic-converter (8). The invention also relates to a device for carrying out said method.
    • 本发明涉及一种将热能转换为机械作业的方法。 所述方法包括作为循环执行的以下步骤:液体工作介质从供应储存器(1)进给到工作容器(3); 工作容器(3)中的工作介质由第一热交换器(5)加热; 工作介质的分量从工作容器(3)流向气动 - 液压 - 转换器(8),来自气动 - 液压 - 转换器(8)的液压介质在工作机械(9)中被压缩 将液压介质的液压工作转换为机械作业; 来自气动 - 液压转换器(8)的工作介质被反馈到供应储存器(1)中,并且液压介质返回到气动 - 液压转换器(8)中。 本发明还涉及一种用于执行所述方法的装置。
    • 9. 发明申请
    • Apparatus for Treating Spinal Stenosis
    • 用于治疗脊柱狭窄的装置
    • US20090012528A1
    • 2009-01-08
    • US11997880
    • 2006-08-03
    • Felix AschmannPeter SennMichael MayerPaul Pavlov
    • Felix AschmannPeter SennMichael MayerPaul Pavlov
    • A61B17/58A61F5/00B25B21/00
    • A61B17/7065A61B17/848A61B17/8897A61B90/39
    • A device for treating spinal stenosis having an implant body structure sized and configured to be positioned between the spinous processes of two adjacent vertebrae. The device may have a body portion having a first end portion, a second end portion and a sleeve between the first and second end portions. The device may also have at least two retainers positioned in and extendable from the body portion. A mechanism positioned within the body portion may be used to move the retainers between a retracted position and a deployed position. When the retainers are in the deployed position, the retainers may be positioned around the spinous process of at least one of two adjacent vertebrae. A plurality of installation tools which may be used to install the device are also disclosed.
    • 一种用于治疗脊柱狭窄的装置,其具有植入物主体结构,其尺寸和构造被定位在两个相邻椎骨的棘突之间。 该装置可以具有在第一和第二端部之间具有第一端部,第二端部和套筒的主体部分。 该装置还可以具有定位在主体部分中并且可从本体部分延伸的至少两个保持器。 定位在主体部分内的机构可以用于在缩回位置和展开位置之间移动保持器。 当保持器处于展开位置时,保持器可以位于两个相邻椎骨中的至少一个椎骨的棘突周围。 还公开了可用于安装设备的多个安装工具。