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    • 5. 发明申请
    • Oral Care Compositions With Improved Flavor
    • 具有改善风味的口腔护理组合
    • US20120082628A1
    • 2012-04-05
    • US13248308
    • 2011-09-29
    • John Christian HaughtChristine Marie CahenKoti Tatachar SreekishnaWenzhu ZhaoYakang LinCathy Renee Schinaman
    • John Christian HaughtChristine Marie CahenKoti Tatachar SreekishnaWenzhu ZhaoYakang LinCathy Renee Schinaman
    • A61K8/58A61Q11/00A61K8/60A61K8/37A61K8/49
    • A61K8/37A61Q11/00
    • Oral care compositions having improved taste, said compositions comprising: a carrier material; from about 0.001 to about 10%, by weight of the composition, of an oral care component selected from metal salts, antimicrobial agents, bad breath reduction agents, bleaching agents, surfactants, or a combination thereof; and from about 0.0001 to about 1%, by weight of the composition, of a TRPA1 agonist selected from vanillin esters; benzoate esters; hydroxybenzoate derivatives; methoxy benzoate derivatives; hydroxybutanedioate derivatives; benzamidobenzoate derivatives; methylpropanoate derivatives; phenyl acetate derivatives; hex-3-enoate derivatives; 2-(furan-2-ylmethylsulfanyl)-3-methylpyrazine; phenylmethoxymethylbenzene; (2R)-2-azaniumyl-3-[(2R)-2-azaniumyl-3-oxido-3-oxopropyl]disulfanylpropanoate; (3E)-2-hydroxy-4,8-dimethylnona-3,7-dienal; (2R)-2-azaniumyl-3-[(2S)-2-azaniumyl-3-oxido-3-oxopropyl]disulfanylpropanoate; (3Z)-3-butylidene-2-benzofuran-1-one; 3-methyl-N-(3-methylbutyl)butan-1-imine; 2-(furan-2-ylmethyldisulfanylmethyl)furan; and combinations thereof. Uses thereof and methods of improving the taste of an oral care composition.
    • 具有改善味道的口腔护理组合物,所述组合物包含:载体材料; 约0.001至约10重量%的选自金属盐,抗微生物剂,口臭减少剂,漂白剂,表面活性剂或其组合的口腔护理组分; 和约0.0001至约1重量%的选自香草醛酯的TRPA1激动剂; 苯甲酸酯; 羟基苯甲酸酯衍生物; 甲氧基苯甲酸酯衍生物; 羟基丁二酸衍生物; 苯甲酰胺基苯甲酸酯衍生物; 甲基丙酸酯衍生物; 苯基乙酸酯衍生物; 己烯-3-烯酸衍生物; 2-(呋喃-2-基甲基硫烷基)-3-甲基吡嗪; 苯基甲氧基甲基苯; (2R)-2-氮基-3 - [(2R)-2-氮氧基-3-氧代-3-氧代丙基]二硫代丙酸酯; (3E)-2-羟基-4,8-​​二甲基纳-3,7-二烯醛; (2R)-2-氨基-3 - [(2S)-2-氮丙基-3-氧代丙氧基]二硫代丙酸酯; (3Z)-3-亚丁基-2-苯并呋喃-1-酮; 3-甲基-N-(3-甲基丁基)丁-1-胺; 2-(呋喃-2-基甲基二硫基甲基)呋喃; 及其组合。 其用途和改善口腔护理组合物的味道的方法。
    • 6. 发明申请
    • Personal Care Compositions Providing Enhanced Cooling Sensation
    • 个人护理组合提供增强的冷却感觉
    • US20100086498A1
    • 2010-04-08
    • US12636096
    • 2009-12-11
    • John Christian HaughtWilliam Michael GlandorfChristine Lula JohnsonLowell Alan Sanker
    • John Christian HaughtWilliam Michael GlandorfChristine Lula JohnsonLowell Alan Sanker
    • A61K8/34A61Q11/00
    • A61K8/345A61K8/19A61K8/20A61K8/22A61K8/24A61K8/347A61K8/37A61K8/41A61K8/42A61K8/4973A61K8/55A61K2800/244A61Q11/00
    • Disclosed are personal care compositions for use on hair, skin, oral cavity, throat and other mucosal surfaces containing a flavor/perfume system comprising one or more coolants, wherein the pleasant cool and refreshing sensation provided by the coolant is enhanced in terms of quicker onset, greater intensity or impact and/or longer duration, thereby improving appeal and acceptability of the compositions to consumers. In one embodiment the invention provides oral care compositions comprising (a) a flavor composition comprising one or more non-menthol coolants and optionally one or more additional flavor ingredients, (b) a calcium ion source and/or a calcium transport agent sufficient to potentiate and/or modulate the cooling and refreshing sensation provided by the coolant(s), and (c) an orally-acceptable carrier. Upon application to the oral cavity, the compositions provide an immediate onset of cooling sensation which lasts longer than about 15 minutes thereby providing long-lasting clean and fresh mouth impression and encouraging user compliance and repeated use of the compositions.
    • 公开了用于头发,皮肤,口腔,咽喉和其它粘膜表面的个人护理组合物,其含有包含一种或多种冷却剂的调味剂/香料系统,其中由冷却剂提供的令人愉快的凉爽和清爽的感觉在更快的发作方面得到增强 ,更大的强度或冲击力和/或更长的持续时间,从而改善组合物对消费者的吸引力和可接受性。 在一个实施方案中,本发明提供口腔护理组合物,其包含(a)包含一种或多种非薄荷醇冷却剂和任选的一种或多种另外的风味成分的风味组合物,(b)足以加强的钙离子源和/或钙转运剂 和/或调节由冷却剂提供的冷却和清爽感觉,和(c)口服可接受的载体。 当施用到口腔时,组合物提供持续长于约15分钟的冷却感觉的立即开始,从而提供持久的清洁和新鲜的口感,并鼓励使用者顺应并重复使用组合物。