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1. 发明申请

US20120082628A1 Oral Care Compositions With Improved Flavor 有权
标题翻译：具有改善风味的口腔护理组合
公开(公告)号：US20120082628A1
公开(公告)日：2012-04-05
申请号：US13248308
申请日：2011-09-29
申请人： John Christian Haught , Christine Marie Cahen , Koti Tatachar Sreekishna , Wenzhu Zhao , Yakang Lin , Cathy Renee Schinaman
发明人： John Christian Haught , Christine Marie Cahen , Koti Tatachar Sreekishna , Wenzhu Zhao , Yakang Lin , Cathy Renee Schinaman
IPC分类号： A61K8/58 , A61Q11/00 , A61K8/60 , A61K8/37 , A61K8/49
CPC分类号： A61K8/37 , A61Q11/00
摘要： Oral care compositions having improved taste, said compositions comprising: a carrier material; from about 0.001 to about 10%, by weight of the composition, of an oral care component selected from metal salts, antimicrobial agents, bad breath reduction agents, bleaching agents, surfactants, or a combination thereof; and from about 0.0001 to about 1%, by weight of the composition, of a TRPA1 agonist selected from vanillin esters; benzoate esters; hydroxybenzoate derivatives; methoxy benzoate derivatives; hydroxybutanedioate derivatives; benzamidobenzoate derivatives; methylpropanoate derivatives; phenyl acetate derivatives; hex-3-enoate derivatives; 2-(furan-2-ylmethylsulfanyl)-3-methylpyrazine; phenylmethoxymethylbenzene; (2R)-2-azaniumyl-3-[(2R)-2-azaniumyl-3-oxido-3-oxopropyl]disulfanylpropanoate; (3E)-2-hydroxy-4,8-dimethylnona-3,7-dienal; (2R)-2-azaniumyl-3-[(2S)-2-azaniumyl-3-oxido-3-oxopropyl]disulfanylpropanoate; (3Z)-3-butylidene-2-benzofuran-1-one; 3-methyl-N-(3-methylbutyl)butan-1-imine; 2-(furan-2-ylmethyldisulfanylmethyl)furan; and combinations thereof. Uses thereof and methods of improving the taste of an oral care composition.
摘要翻译：具有改善味道的口腔护理组合物，所述组合物包含：载体材料; 约0.001至约10重量％的选自金属盐，抗微生物剂，口臭减少剂，漂白剂，表面活性剂或其组合的口腔护理组分; 和约0.0001至约1重量％的选自香草醛酯的TRPA1激动剂; 苯甲酸酯; 羟基苯甲酸酯衍生物; 甲氧基苯甲酸酯衍生物; 羟基丁二酸衍生物; 苯甲酰胺基苯甲酸酯衍生物; 甲基丙酸酯衍生物; 苯基乙酸酯衍生物; 己烯-3-烯酸衍生物; 2-（呋喃-2-基甲基硫烷基）-3-甲基吡嗪; 苯基甲氧基甲基苯; （2R）-2-氮基-3 - [（2R）-2-氮氧基-3-氧代-3-氧代丙基]二硫代丙酸酯; （3E）-2-羟基-4,8-二甲基纳-3,7-二烯醛; （2R）-2-氨基-3 - [（2S）-2-氮丙基-3-氧代丙氧基]二硫代丙酸酯; （3Z）-3-亚丁基-2-苯并呋喃-1-酮; 3-甲基-N-（3-甲基丁基）丁-1-胺; 2-（呋喃-2-基甲基二硫基甲基）呋喃; 及其组合。其用途和改善口腔护理组合物的味道的方法。

2. 发明授权

US09937115B2 Oral care compositions with improved flavor 有权
公开(公告)号：US09937115B2
公开(公告)日：2018-04-10
申请号：US13248308
申请日：2011-09-29
申请人： John Christian Haught , Christine Marie Cahen , Koti Tatachar Sreekishna , Wenzhu Zhao , Yakang Lin , Cathy Renee Schinaman
发明人： John Christian Haught , Christine Marie Cahen , Koti Tatachar Sreekishna , Wenzhu Zhao , Yakang Lin , Cathy Renee Schinaman
IPC分类号： A61K8/58 , A61K8/37 , A61K8/49 , A61K8/60 , A61Q11/00
CPC分类号： A61K8/37 , A61Q11/00
摘要： Oral care compositions having improved taste, said compositions comprising: a carrier material; from about 0.001 to about 10%, by weight of the composition, of an oral care component selected from metal salts, antimicrobial agents, bad breath reduction agents, bleaching agents, surfactants, or a combination thereof; and from about 0.0001 to about 1%, by weight of the composition, of a TRPA1 agonist selected from vanillin esters; benzoate esters; hydroxybenzoate derivatives; methoxy benzoate derivatives; hydroxybutanedioate derivatives; benzamidobenzoate derivatives; methylpropanoate derivatives; phenyl acetate derivatives; hex-3-enoate derivatives; 2-(furan-2-ylmethylsulfanyl)-3-methylpyrazine; phenylmethoxymethylbenzene; (2R)-2-azaniumyl-3-[(2R)-2-azaniumyl-3-oxido-3-oxopropyl]disulfanylpropanoate; (3E)-2-hydroxy-4,8-dimethylnona-3,7-dienal; (2R)-2-azaniumyl-3-[(2S)-2-azaniumyl-3-oxido-3-oxopropyl]disulfanylpropanoate; (3Z)-3-butylidene-2-benzofuran-1-one; 3-methyl-N-(3-methylbutyl)butan-1-imine; 2-(furan-2-ylmethyldisulfanylmethyl)furan; and combinations thereof. Uses thereof and methods of improving the taste of an oral care composition.

3. 发明授权

US08962057B2 Methods for improving taste and oral care compositions with improved taste 有权
标题翻译：改善味道和改善口感的口腔护理组合物的方法
公开(公告)号：US08962057B2
公开(公告)日：2015-02-24
申请号：US12763933
申请日：2010-04-20
申请人： John Christian Haught , Koti Tatachar Sreekrishna , Yakang Lin , Lowell Alan Sanker
发明人： John Christian Haught , Koti Tatachar Sreekrishna , Yakang Lin , Lowell Alan Sanker
IPC分类号： A61K8/34 , A61Q11/00 , A61K8/19 , A61K8/22 , A61K8/27 , A61K8/35 , A61K8/42 , A61K8/49 , A61K8/97
CPC分类号： A61K8/347 , A61K8/19 , A61K8/21 , A61K8/22 , A61K8/27 , A61K8/35 , A61K8/365 , A61K8/42 , A61K8/49 , A61K8/4926 , A61K8/4973 , A61K8/97 , A61K2800/592 , A61Q11/00
摘要： Provided herein are compositions and methods relating to oral care compositions with improved taste. One such method includes providing an oral care composition comprising a metal salt, a peroxide, an antimicrobial agent, a bad breath reduction agent, a surfactant, or a combination thereof and adding to the oral care composition a TRPV1 activator and/or vanitrope.
摘要翻译：本文提供了与具有改善味道的口腔护理组合物相关的组合物和方法。一种这样的方法包括提供包含金属盐，过氧化物，抗微生物剂，口臭减少剂，表面活性剂或其组合的口腔护理组合物，并向口腔护理组合物中加入TRPV1活化剂和/或维生素。

4. 发明申请

US20100278991A1 Methods for Improving Taste and Oral Care Compositions With Improved Taste 有权
标题翻译：改善味道和口腔护理组合的方法，改善口味
公开(公告)号：US20100278991A1
公开(公告)日：2010-11-04
申请号：US12763933
申请日：2010-04-20
申请人： John Christian Haught , Koti Tatachar Sreekrishna , Yakang Lin , Lowell Alan Sanker
发明人： John Christian Haught , Koti Tatachar Sreekrishna , Yakang Lin , Lowell Alan Sanker
IPC分类号： A23L1/22
CPC分类号： A61K8/347 , A61K8/19 , A61K8/21 , A61K8/22 , A61K8/27 , A61K8/35 , A61K8/365 , A61K8/42 , A61K8/49 , A61K8/4926 , A61K8/4973 , A61K8/97 , A61K2800/592 , A61Q11/00
摘要： Provided herein are compositions and methods relating to oral care compositions with improved taste. One such method includes providing an oral care composition comprising a metal salt, a peroxide, an antimicrobial agent, a bad breath reduction agent, a surfactant, or a combination thereof and adding to the oral care composition a TRPV1 activator and/or vanitrope.
摘要翻译：本文提供了与具有改善味道的口腔护理组合物相关的组合物和方法。一种这样的方法包括提供包含金属盐，过氧化物，抗微生物剂，口臭减少剂，表面活性剂或其组合的口腔护理组合物，并向口腔护理组合物中加入TRPV1活化剂和/或维生素。

5. 发明授权

US09044429B2 Personal care compositions comprising a methyl naphthalenyl ketone or a derivative thereof 有权
标题翻译：包含甲基萘基酮或其衍生物的个人护理组合物
公开(公告)号：US09044429B2
公开(公告)日：2015-06-02
申请号：US12987532
申请日：2011-01-10
申请人： Katharine Anne Bakes , Timothy Woodrow Coffindaffer , John Christian Haught , Helen Rochelle Kemp , Yakang Lin , Kotikanyadanam Tatachar Sreekrishna
发明人： Katharine Anne Bakes , Timothy Woodrow Coffindaffer , John Christian Haught , Helen Rochelle Kemp , Yakang Lin , Kotikanyadanam Tatachar Sreekrishna
IPC分类号： A61K31/12 , A61Q19/00 , A61Q9/02 , A61K8/35 , A61Q19/10
CPC分类号： A61K31/12 , A61K8/35 , A61K2800/75 , A61Q9/02 , A61Q19/10
摘要： A personal care composition comprising a methyl naphthalenyl ketone or a derivative thereof, such as 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2naphthalenyl)-ethan-1-one, for down regulating at least one TRP receptor associated with a pain response, including but not limited to TRPV1 and TRPA1 receptors to reduce skin irritation associated with hair removal.
摘要翻译：包含甲基萘基酮或其衍生物的个人护理组合物，例如1-（1,2,3,4,5,6,7,8-八氢-2,3,8,8-四甲基-2H - 萘基） - 乙醇-1-酮用于下调至少一种与疼痛反应相关的TRP受体，包括但不限于TRPV1和TRPA1受体，以减少与脱毛相关的皮肤刺激。

6. 发明申请

US20110178181A1 Personal Care Compositions Comprising A Methyl Naphthalenyl Ketone Or A Derivative Thereof 有权
标题翻译：包含甲基萘基酮或其衍生物的个人护理组合物
公开(公告)号：US20110178181A1
公开(公告)日：2011-07-21
申请号：US12987532
申请日：2011-01-10
申请人： Katharine Anne Bakes , Timothy Woodrow Coffindaffer , John Christian Haught , Helen Rochelle Kemp , Yakang Lin , Kotikanyadanam Tatachar Sreekrishna
发明人： Katharine Anne Bakes , Timothy Woodrow Coffindaffer , John Christian Haught , Helen Rochelle Kemp , Yakang Lin , Kotikanyadanam Tatachar Sreekrishna
IPC分类号： A61K31/12 , A61Q19/00 , A61Q19/10
CPC分类号： A61K31/12 , A61K8/35 , A61K2800/75 , A61Q9/02 , A61Q19/10
摘要： A personal care composition comprising a methyl naphthalenyl ketone or a derivative thereof, such as 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2naphthalenyl)-ethan-1-one, for down regulating at least one TRP receptor associated with a pain response, including but not limited to TRPV1 and TRPA1 receptors to reduce skin irritation associated with hair removal.
摘要翻译：包含甲基萘基酮或其衍生物的个人护理组合物，例如1-（1,2,3,4,5,6,7,8-八氢-2,3,8,8-四甲基-2H - 萘基） - 乙醇-1-酮用于下调至少一种与疼痛反应相关的TRP受体，包括但不限于TRPV1和TRPA1受体，以减少与脱毛相关的皮肤刺激。

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