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1. 发明授权

US08491526B2 Therapeutic cell applicator instrument with modular tips 有权
标题翻译：具有模块化提示的治疗细胞施用器械
公开(公告)号：US08491526B2
公开(公告)日：2013-07-23
申请号：US12779477
申请日：2010-05-13
申请人： Michael D. Cronin , Jerome R. Morgan , Patrick D. Dugan , Rebecca J. Mollere , John B. Schulte , David A. Witt , Joseph P. Schowalter , Eugene L. Timperman , Prasanna Malaviya , Shailendra K. Parihar , Shelby L. Cook Kornbluth , Richard W. Timm , Donna L. Korvick , James A. Woodard, Jr. , Peter K. Shires , Barbara L. Mattson , Matthew C. Miller , Frederick E. Shelton, IV
发明人： Michael D. Cronin , Jerome R. Morgan , Patrick D. Dugan , Rebecca J. Mollere , John B. Schulte , David A. Witt , Joseph P. Schowalter , Eugene L. Timperman , Prasanna Malaviya , Shailendra K. Parihar , Shelby L. Cook Kornbluth , Richard W. Timm , Donna L. Korvick , James A. Woodard, Jr. , Peter K. Shires , Barbara L. Mattson , Matthew C. Miller , Frederick E. Shelton, IV
IPC分类号： A61M37/00 , A61M1/00 , A61M5/00
CPC分类号： A61B17/00491 , A61B10/0275 , A61B10/0283 , A61B17/0057 , A61B17/07207 , A61B17/12099 , A61B17/12186 , A61B2017/00495 , A61B2017/00641 , A61B2017/22067 , A61F5/0083 , A61M3/0262 , A61M5/1407 , A61M5/16827 , A61M5/19 , A61M25/10 , A61M2039/1083 , A61M2039/1088 , A61M2205/502 , A61M2210/0662 , A61M2210/1053
摘要： A surgical device comprises a housing, a bioprocessing module, an end effector, and a pumping device. The bioprocessing module comprises media reservoirs, fluid conduits in communication with the reservoirs, and a port through which media is expelled. The end effector is configured for insertion into a lumen and delivering a tissue repair composition into that lumen. The end effector has at least one fluid conduit extending therethrough and at least one orifice in communication with the fluid conduit. The fluid conduit in the first end effector is in fluid communication with the port on the bioprocessing module. The pumping device is operable to urge a tissue repair composition comprising at least a portion of the contents of the media reservoirs through the fluid conduit of the first end effector such that the tissue repair composition is expelled from the at least one orifice.
摘要翻译：手术装置包括壳体，生物处理模块，末端执行器和泵送装置。生物处理模块包括介质储存器，与储存器连通的流体导管以及介质被排出的端口。末端执行器构造成用于插入内腔并将组织修复组合物递送到该内腔中。末端执行器具有延伸穿过其中的至少一个流体导管和与流体导管连通的至少一个孔口。第一末端执行器中的流体导管与生物处理模块上的端口流体连通。抽吸装置可操作以通过第一端部执行器的流体管道促使包含介质容器的内容物的至少一部分的组织修复组合物从组织修复组合物排出至少一个孔口。

2. 发明申请

US20110282381A1 Therapeutic Cell Applicator Instrument with Modular Tips 有权
标题翻译：具有模块化提示的治疗细胞应用仪器
公开(公告)号：US20110282381A1
公开(公告)日：2011-11-17
申请号：US12779477
申请日：2010-05-13
申请人： Michael D. Cronin , Jerome R. Morgan , Patrick D. Dugan , Rebecca J. Mollere , John B. Schulte , David A. Witt , Joseph P. Schowalter , Eugene L. Timperman , Prasanna Malaviya , Shailendra K. Parihar , Shelby L. Cook Kornbluth , Richard W. Timm , Donna L. Korvick , James A. Woodard, JR. , Peter K. Shires , Barbara L. Mattson , Matthew C. Miller , Frederick E. Shelton, IV
发明人： Michael D. Cronin , Jerome R. Morgan , Patrick D. Dugan , Rebecca J. Mollere , John B. Schulte , David A. Witt , Joseph P. Schowalter , Eugene L. Timperman , Prasanna Malaviya , Shailendra K. Parihar , Shelby L. Cook Kornbluth , Richard W. Timm , Donna L. Korvick , James A. Woodard, JR. , Peter K. Shires , Barbara L. Mattson , Matthew C. Miller , Frederick E. Shelton, IV
IPC分类号： A61M37/00 , A61M5/315 , A61B17/03 , A61M1/00
CPC分类号： A61B17/00491 , A61B10/0275 , A61B10/0283 , A61B17/0057 , A61B17/07207 , A61B17/12099 , A61B17/12186 , A61B2017/00495 , A61B2017/00641 , A61B2017/22067 , A61F5/0083 , A61M3/0262 , A61M5/1407 , A61M5/16827 , A61M5/19 , A61M25/10 , A61M2039/1083 , A61M2039/1088 , A61M2205/502 , A61M2210/0662 , A61M2210/1053
摘要： A surgical device comprises a housing, a bioprocessing module, an end effector, and a pumping device. The bioprocessing module comprises media reservoirs, fluid conduits in communication with the reservoirs, and a port through which media is expelled. The end effector is configured for insertion into a lumen and delivering a tissue repair composition into that lumen. The end effector has at least one fluid conduit extending therethrough and at least one orifice in communication with the fluid conduit. The fluid conduit in the first end effector is in fluid communication with the port on the bioprocessing module. The pumping device is operable to urge a tissue repair composition comprising at least a portion of the contents of the media reservoirs through the fluid conduit of the first end effector such that the tissue repair composition is expelled from the at least one orifice.
摘要翻译：手术装置包括壳体，生物处理模块，末端执行器和泵送装置。生物处理模块包括介质储存器，与储存器连通的流体导管以及介质被排出的端口。末端执行器构造成用于插入内腔并将组织修复组合物递送到该内腔中。末端执行器具有延伸穿过其中的至少一个流体导管和与流体导管连通的至少一个孔口。第一末端执行器中的流体导管与生物处理模块上的端口流体连通。抽吸装置可操作以通过第一端部执行器的流体管道促使包含介质容器的内容物的至少一部分的组织修复组合物从组织修复组合物排出至少一个孔口。

3. 发明授权

US08646674B2 Methods and apparatus for delivering tissue treatment compositions to stapled tissue 有权
标题翻译：将组织处理组合物递送到缝合组织的方法和装置
公开(公告)号：US08646674B2
公开(公告)日：2014-02-11
申请号：US12777424
申请日：2010-05-11
申请人： John B. Schulte , Rebecca J. Mollere , Patrick D. Dugan , Michael D. Cronin , Jerome R. Morgan , Stuart K. Morgan , Gary B. McAlister , Tamara S. Vetro Widenhouse , Stephen J. Balek , Joseph P. Schowalter , David A. Witt , Prasanna Malaviya , Frederick E. Shelton, IV
发明人： John B. Schulte , Rebecca J. Mollere , Patrick D. Dugan , Michael D. Cronin , Jerome R. Morgan , Stuart K. Morgan , Gary B. McAlister , Tamara S. Vetro Widenhouse , Stephen J. Balek , Joseph P. Schowalter , David A. Witt , Prasanna Malaviya , Frederick E. Shelton, IV
IPC分类号： A61B17/068
CPC分类号： A61B17/115 , A61B17/00491 , A61B17/07292 , A61B17/1155 , A61B50/30 , A61B2017/00889 , A61B2017/00893 , A61B2050/314
摘要： A surgical stapler includes first and second tissue clamping members and a knife member. The first tissue clamping member is configured to receive a plurality of staples. The second tissue clamping member comprises an anvil configured to form the staples. A tissue treatment member is positionable between the first and second tissue clamping members. The tissue treatment member comprises a rupturable pouch or baffle that is configured to receive a medical fluid including at least one tissue cell. The tissue treatment member may have a spiral shape, an annular disc shape, or an elongate sleeve shape. The tissue treatment member may also include outwardly extending tabs. The tissue treatment member may also include an injection port. In use, the staples and/or the knife pierce the tissue treatment member to release at least a portion of the medical fluid held by the tissue treatment member.
摘要翻译：手术吻合器包括第一和第二组织夹紧构件和刀构件。第一组织夹紧构件构造成容纳多个钉。第二组织夹紧构件包括构造成形成钉的砧座。组织处理构件可定位在第一和第二组织夹紧构件之间。组织处理构件包括可破裂袋或挡板，其构造成接收包括至少一个组织细胞的医用流体。组织处理构件可以具有螺旋形状，环形盘形或细长的套筒形状。组织处理构件还可以包括向外延伸的突片。组织处理构件还可以包括注射口。在使用中，订书针和/或刀刺穿组织处理构件以释放由组织处理构件保持的医用液体的至少一部分。

4. 发明申请

US20110282446A1 Methods and Apparatus for Delivering Tissue Treatment Compositions to Stapled Tissue 有权
标题翻译：用于将组织处理组合物递送至装订组织的方法和装置
公开(公告)号：US20110282446A1
公开(公告)日：2011-11-17
申请号：US12777424
申请日：2010-05-11
申请人： John B. Schulte , Rebecca J. Mollere , Patrick D. Dugan , Michael D. Cronin , Jerome R. Morgan , Stuart K. Morgan , Gary B. McAlister , Tamara S. Vetro Widenhouse , Stephen J. Balek , Joseph P. Schowalter , David A. Witt , Prasanna Malaviya , Frederick E. Shelton, IV
发明人： John B. Schulte , Rebecca J. Mollere , Patrick D. Dugan , Michael D. Cronin , Jerome R. Morgan , Stuart K. Morgan , Gary B. McAlister , Tamara S. Vetro Widenhouse , Stephen J. Balek , Joseph P. Schowalter , David A. Witt , Prasanna Malaviya , Frederick E. Shelton, IV
IPC分类号： A61B17/068 , A61F2/02 , A61B10/02
CPC分类号： A61B17/115 , A61B17/00491 , A61B17/07292 , A61B17/1155 , A61B50/30 , A61B2017/00889 , A61B2017/00893 , A61B2050/314
摘要： A surgical stapler includes first and second tissue clamping members and a knife member. The first tissue clamping member is configured to receive a plurality of staples. The second tissue clamping member comprises an anvil configured to form the staples. A tissue treatment member is positionable between the first and second tissue clamping members. The tissue treatment member comprises a rupturable pouch or baffle that is configured to receive a medical fluid including at least one tissue cell. The tissue treatment member may have a spiral shape, an annular disc shape, or an elongate sleeve shape. The tissue treatment member may also include outwardly extending tabs. The tissue treatment member may also include an injection port. In use, the staples and/or the knife pierce the tissue treatment member to release at least a portion of the medical fluid held by the tissue treatment member.
摘要翻译：手术吻合器包括第一和第二组织夹紧构件和刀构件。第一组织夹紧构件构造成容纳多个钉。第二组织夹紧构件包括构造成形成钉的砧座。组织处理构件可定位在第一和第二组织夹紧构件之间。组织处理构件包括可破裂袋或挡板，其构造成接收包括至少一个组织细胞的医用流体。组织处理构件可以具有螺旋形状，环形盘形或细长的套筒形状。组织处理构件还可以包括向外延伸的突片。组织处理构件还可以包括注射口。在使用中，订书针和/或刀刺穿组织处理构件以释放由组织处理构件保持的医用液体的至少一部分。

5. 发明申请

US20110295337A1 Systems and Methods For Regulating Metabolic Hormone Producing Tissue 审中-公开
标题翻译：用于调节代谢激素生产组织的系统和方法
公开(公告)号：US20110295337A1
公开(公告)日：2011-12-01
申请号：US13105262
申请日：2011-05-11
申请人： Thomas E. Albrecht , Jeffrey L. Aldridge , Edward G. Chekan , Sean P. Conlon , Michael S. Cropper , Daniel F. Dlugos, JR. , Jason L. Harris , Christopher J. Hess , Kevin L. Houser , John V. Hunt , Gary L. Long , Prasanna Malaviya , Amy L. Marcotte , Rudolph H. Nobis , Mark S. Ortiz , Mark D. Overmyer , Alessandro Pastorelli , David N. Plescia , Galen C. Robertson , Randy J. Seeley , Frederick E. Shelton, IV , Michael J. Stokes , Foster B. Stulen , Richard W. Timm , James W. Voegele , William B. Weisenburgh, II , James A. Woodard, JR. , David C. Yates , Andrew M. Zwolinski
发明人： Thomas E. Albrecht , Jeffrey L. Aldridge , Edward G. Chekan , Sean P. Conlon , Michael S. Cropper , Daniel F. Dlugos, JR. , Jason L. Harris , Christopher J. Hess , Kevin L. Houser , John V. Hunt , Gary L. Long , Prasanna Malaviya , Amy L. Marcotte , Rudolph H. Nobis , Mark S. Ortiz , Mark D. Overmyer , Alessandro Pastorelli , David N. Plescia , Galen C. Robertson , Randy J. Seeley , Frederick E. Shelton, IV , Michael J. Stokes , Foster B. Stulen , Richard W. Timm , James W. Voegele , William B. Weisenburgh, II , James A. Woodard, JR. , David C. Yates , Andrew M. Zwolinski
IPC分类号： A61N1/36
CPC分类号： A61N1/00 , A61F5/0026 , A61N1/0509 , A61N1/327 , A61N1/36007
摘要： A method for regulating hormone production comprises placing at least one electrode in a gastrointestinal tract of a patient and recording an electrical signal during a preselected event produced by the gastrointestinal tract. The method further involves the steps of storing the electrical signal, and playing back the electrical signal by activating the electrode during the absence of the preselected event.
摘要翻译：用于调节激素产生的方法包括将至少一个电极放置在患者的胃肠道中，并在由胃肠道产生的预选事件期间记录电信号。该方法还包括存储电信号的步骤，以及在没有预选事件期间激活电极来播放电信号。

6. 发明申请

US20110295178A1 Intestinal Brake Inducing Intraluminal Therapeutic Substance Eluting Devices and Methods 审中-公开
标题翻译：肠制动诱导腔内治疗物质洗脱装置及方法
公开(公告)号：US20110295178A1
公开(公告)日：2011-12-01
申请号：US13104321
申请日：2011-05-10
申请人： Thomas E. Albrecht , Jeffrey L. Aldridge , Gregory J. Bakos , Michael S. Cropper , Denzel Z. Herrera-Davis , Daniel F. Dlugos, JR. , Jason L. Harris , Christopher J. Hess , John V. Hunt , Prasanna Malaviya , Mark S. Ortiz , Mark D. Overmyer , Alessandro Pastorelli , Galen C. Robertson , Frederick E. Shelton, IV , Michael J. Stokes , Suzanne Thompson , Richard W. Timm , James W. Voegele , William B. Weisenburgh, II , Christopher W. Widenhouse , Tamara S. Vetro Widenhouse , James A. Woodard, JR. , David C. Yates , Mark S. Zeiner , Andrew M. Zwolinski
发明人： Thomas E. Albrecht , Jeffrey L. Aldridge , Gregory J. Bakos , Michael S. Cropper , Denzel Z. Herrera-Davis , Daniel F. Dlugos, JR. , Jason L. Harris , Christopher J. Hess , John V. Hunt , Prasanna Malaviya , Mark S. Ortiz , Mark D. Overmyer , Alessandro Pastorelli , Galen C. Robertson , Frederick E. Shelton, IV , Michael J. Stokes , Suzanne Thompson , Richard W. Timm , James W. Voegele , William B. Weisenburgh, II , Christopher W. Widenhouse , Tamara S. Vetro Widenhouse , James A. Woodard, JR. , David C. Yates , Mark S. Zeiner , Andrew M. Zwolinski
IPC分类号： A61M5/00
CPC分类号： A61F5/0079 , A61K9/0065 , A61M5/14276 , A61M31/002 , A61M39/0208 , A61M2210/106 , A61M2210/1064
摘要： Methods and devices create an intestinal braking effect, are non-invasive or minimally invasive, and may be reversible. These methods and devices may be accomplished via stabilized implantable systems and ingestible pills. In one aspect, a method of inducing satiety includes implanting an implant within a lumen of a gastrointestinal tract and retaining a portion of chyme that flows by the implant within a body of the implant. The method further involves re-releasing the retained chyme from the implant into the gastrointestinal tract at a predetermined rate slower than a rate caused by natural peristalsis.
摘要翻译：方法和装置产生肠道制动效果，是非侵入性的或微创的，并且可以是可逆的。这些方法和装置可以通过稳定的可植入系统和可摄取的药丸来实现。一方面，一种诱导饱腹感的方法包括将植入物植入胃肠道的内腔中，并且将植入物流动的部分保持在植入物的体内。该方法还包括以比由天然蠕动引起的速率慢的预定速率将留置的食糜从植入物再释放到胃肠道中。

7. 发明授权

US08349255B2 Tissue processing system and method 有权
标题翻译：组织加工系统及方法
公开(公告)号：US08349255B2
公开(公告)日：2013-01-08
申请号：US12777723
申请日：2010-05-11
申请人： Joseph P. Schowalter , Prasanna Malaviya , David A. Witt , Frederick E. Shelton, IV
发明人： Joseph P. Schowalter , Prasanna Malaviya , David A. Witt , Frederick E. Shelton, IV
IPC分类号： G01N21/00
CPC分类号： C12M45/02 , Y10T436/2575
摘要： A tissue processing system includes a tray and a processing component. The processing component has teeth configured to dice, mince, and mix the tissue in the tray. In some versions, teeth of a rotary member mesh with teeth of a stationary member, such that the tissue is ground between the meshing teeth. The rotary member may be moved in an orbital path relative to the stationary member. In some versions, the teeth of two rotary members mesh together, and the rotary members are rotated in opposite directions to grind the tissue. The rotary members may also be alternatingly moved up and down to perform initial dicing on the tissue. Once the tissue has been processed, the tissue may then be used in a therapeutic manner, such as by being incorporated with a scaffold and then implanted in the same patient from whom the tissue was originally harvested.
摘要翻译：纸巾处理系统包括托盘和处理部件。处理部件具有齿，其被配置成对托盘中的组织进行切割，切碎和混合。在一些形式中，旋转构件的齿与固定构件的齿啮合，使得组织在啮合齿之间被磨削。旋转构件可以相对于固定构件在轨道路径中移动。在一些形式中，两个旋转构件的齿啮合在一起，并且旋转构件沿相反方向旋转以研磨组织。旋转构件也可以交替地上下移动以对组织进行初始切割。一旦已经处理了组织，则组合物可以以治疗方式使用，例如通过与支架结合，然后植入与最初收获组织的同一患者中。

8. 发明申请

US20110281350A1 Tissue Processing System and Method 有权
标题翻译：组织加工系统与方法
公开(公告)号：US20110281350A1
公开(公告)日：2011-11-17
申请号：US12777723
申请日：2010-05-11
申请人： Joseph P. Schowalter , Prasanna Malaviya , David A. Witt , Frederick E. Shelton, IV
发明人： Joseph P. Schowalter , Prasanna Malaviya , David A. Witt , Frederick E. Shelton, IV
IPC分类号： C12N5/071 , C12M1/00
CPC分类号： C12M45/02 , Y10T436/2575
摘要： A tissue processing system includes a tray and a processing component. The processing component has teeth configured to dice, mince, and mix the tissue in the tray. In some versions, teeth of a rotary member mesh with teeth of a stationary member, such that the tissue is ground between the meshing teeth. The rotary member may be moved in an orbital path relative to the stationary member. In some versions, the teeth of two rotary members mesh together, and the rotary members are rotated in opposite directions to grind the tissue. The rotary members may also be alternatingly moved up and down to perform initial dicing on the tissue. Once the tissue has been processed, the tissue may then be used in a therapeutic manner, such as by being incorporated with a scaffold and then implanted in the same patient from whom the tissue was originally harvested.
摘要翻译：纸巾处理系统包括托盘和处理部件。处理部件具有齿，其被配置成对托盘中的组织进行切割，切碎和混合。在一些形式中，旋转构件的齿与固定构件的齿啮合，使得组织在啮合齿之间被磨削。旋转构件可以相对于固定构件在轨道路径中移动。在一些形式中，两个旋转构件的齿啮合在一起，并且旋转构件沿相反方向旋转以研磨组织。旋转构件也可以交替地上下移动以对组织进行初始切割。一旦组织被处理，组织然后可以以治疗方式使用，例如通过与支架结合，然后植入与组织最初收获的同一患者中。

9. 发明申请

US20110282372A1 Tissue Dicing and Particle Separation Device 有权
标题翻译：组织切片和颗粒分离装置
公开(公告)号：US20110282372A1
公开(公告)日：2011-11-17
申请号：US12777783
申请日：2010-05-11
申请人： Joseph P. Schowalter , Prasanna Malaviya , David A. Witt , Frederick E. Shelton, IV
发明人： Joseph P. Schowalter , Prasanna Malaviya , David A. Witt , Frederick E. Shelton, IV
IPC分类号： A61B17/32
CPC分类号： C12M45/02
摘要： A tissue dicing and separation device comprises a housing having an interior that receives tissue for dicing and separation. The device includes a blade assembly connected to a motor and solenoid. The solenoid reciprocates the blade assembly while the motor clocks the blade assembly during each reciprocation cycle. This reciprocating and clocking action of the blade assembly dices and/or minces the tissue. The housing is filled with a fluid and then the blade assembly is continuously rotated to create a vortex within the housing. The vortex causes the diced tissue particles to separate by particle size. Outlets at different positions along the housing permit withdrawal of a slurry of fluid and tissue particles with the tissue particles having a desired size range. The obtained slurry may be used in conjunction with a fistula plug treatment device and method.
摘要翻译：组织切片和分离装置包括具有容纳组织用于切割和分离的内部的壳体。该装置包括连接到电动机和螺线管的叶片组件。在电动机在每个往复循环期间对叶片组件进行时钟时，螺线管使叶片组件往复运动。叶片组件的这种往复运动和时钟作用切割和/或使组织变细。壳体填充有流体，然后叶片组件被连续旋转以在壳体内产生涡流。涡流使得切割的组织颗粒通过粒度分离。沿着壳体的不同位置处的出口允许流体和组织颗粒的浆料与组织颗粒具有期望的尺寸范围。所获得的浆液可以与瘘塞治疗装置和方法结合使用。

10. 发明授权

US08286899B2 Tissue dicing and particle separation device 有权
标题翻译：组织切片和颗粒分离装置
公开(公告)号：US08286899B2
公开(公告)日：2012-10-16
申请号：US12777783
申请日：2010-05-11
申请人： Joseph P. Schowalter , Prasanna Malaviya , David A. Witt , Frederick E. Shelton, IV
发明人： Joseph P. Schowalter , Prasanna Malaviya , David A. Witt , Frederick E. Shelton, IV
IPC分类号： B02C19/00
CPC分类号： C12M45/02
摘要： A tissue dicing and separation device comprises a housing having an interior that receives tissue for dicing and separation. The device includes a blade assembly connected to a motor and solenoid. The solenoid reciprocates the blade assembly while the motor clocks the blade assembly during each reciprocation cycle. This reciprocating and clocking action of the blade assembly dices and/or minces the tissue. The housing is filled with a fluid and then the blade assembly is continuously rotated to create a vortex within the housing. The vortex causes the diced tissue particles to separate by particle size. Outlets at different positions along the housing permit withdrawal of a slurry of fluid and tissue particles with the tissue particles having a desired size range. The obtained slurry may be used in conjunction with a fistula plug treatment device and method.
摘要翻译：组织切片和分离装置包括具有容纳组织用于切割和分离的内部的壳体。该装置包括连接到电动机和螺线管的叶片组件。在电动机在每个往复循环期间对叶片组件进行时钟时，螺线管使叶片组件往复运动。叶片组件的这种往复运动和时钟作用切割和/或使组织变细。壳体填充有流体，然后叶片组件被连续旋转以在壳体内产生涡流。涡流使得切割的组织颗粒通过粒度分离。沿着壳体的不同位置处的出口允许流体和组织颗粒的浆料与组织颗粒具有期望的尺寸范围。所获得的浆液可以与瘘塞治疗装置和方法结合使用。

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