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1. 发明申请

US20180112164A1 Device for Observation, Imaging and Uninterrupted Culturing of Embryos and Cells 审中-公开
公开(公告)号：US20180112164A1
公开(公告)日：2018-04-26
申请号：US15334953
申请日：2016-10-26
申请人： Michael D. Cecchi , Timothy Schimmel , Jacques Cohen , Monica Mezezi , Michael Ryan Cecchi
发明人： Michael D. Cecchi , Timothy Schimmel , Jacques Cohen , Monica Mezezi , Michael Ryan Cecchi
IPC分类号： C12M1/00 , C12M3/00 , C12M1/34 , G01N21/84
CPC分类号： G01N21/84 , C12M23/22 , C12M23/48 , C12M23/50 , C12M31/02 , C12M41/14 , C12M41/34 , C12M41/36
摘要： A device for the observation, imaging and uninterrupted culturing of embryos and cells, the device comprising: an incubator; a mixing box located above the incubator; gas sensors located in the mixing box; solenoid valves attached to the mixing box; a first clear panel located on the top of the incubator, and configured to allow one to see into the incubator; a first light source located above the first clear panel, and the first light source configured to provide light into the incubator; a door attached to the incubator, the door configured to provide access to the inside of the incubator, and the door located below the access door; a rotatable platter located below the incubator, the rotatable platter comprising: a first insert configured to removably sit on the platter; a first culture dish configured to removably sit in the first insert; a second insert configured to removably sit on the platter; a second culture dish configured to removably sit in the second insert; a first moveable camera located under the rotatable platter, and configured to view a culture dish located generally directly above the first moveable camera, and the first moveable camera generally in alignment with the first light source; a computer in communication with the first moveable camera, rotatable platter, sensors, solenoid valves, touchscreen display, and light source. A device for the observation, imaging and uninterrupted culturing of embryos and cells, the device comprising: a top portion, the top portion comprising: a housing; a horizontal surface on the housing; an angled surface abutting the horizontal surface; an access door located generally on the housing; a first heating surface located on the horizontal surface; a touch screen display located on the angled surface; a middle portion abutting the top portion; the middle portion comprising: an incubator; a mixing box located above the incubator; gas sensors located in the mixing box; solenoid valves attached to the mixing box; a first clear panel located on the top of the incubator, and configured to allow one to see into the incubator; a first light source located above the first clear panel, and the first light source configured to provide light into the incubator; a door attached to the incubator, the door configured to provide access to the inside of the incubator, and the door located below the access door; a bottom portion abutting the middle portion, the bottom portion comprising: a rotatable platter, the rotatable platter comprising: a first insert configured to removably sit on the platter; a first culture dish configured to removably sit in the first insert; a second insert configured to removably sit on the platter; a second culture dish configured to removably sit in the second insert; a first moveable camera located under the rotatable platter, and configured to view a culture dish located generally directly above the first moveable camera, and the first moveable camera generally in alignment with the first light source; a computer in communication with the camera, rotatable platter, sensors, solenoid valves, touchscreen display, and light source.

2. 发明授权

US06623956B1 Embryo-culturing incubator assembly 有权
标题翻译：胚胎培养箱组装
公开(公告)号：US06623956B1
公开(公告)日：2003-09-23
申请号：US09693595
申请日：2000-10-20
申请人： Michael D. Cecchi , Jacques Cohen , Timothy Schimmel , Monica Mezezi
发明人： Michael D. Cecchi , Jacques Cohen , Timothy Schimmel , Monica Mezezi
IPC分类号： C12M100
CPC分类号： C12M41/14 , C12M21/06 , C12M23/48 , Y10S435/809
摘要： An embryo culturing incubator is provided with a shelf configuration that enhances air circulation inside of the incubator, and enables unimpeded access to the individual embryo culture plates that are disposed on the shelves in the incubator. The incubator has an access door which allows one contact with the embryo culture plates on the incubator shelves. The shelves are configured so as to provide a useful free space between the inner surface of the incubator door and the frontal surface of the shelves in the incubator. The size of the free space allows a technician to reach all of the culture plates in the incubator without interfering with other culture plates in the incubator. The free space also allows for exemplary air circulation inside of the incubator.
摘要翻译：胚胎培养培养箱具有能够增强培养箱内的空气循环的架子结构，能够不受阻碍地进入设置在培养箱的架子上的各个胚胎培养板。培养箱具有进入门，允许与培养箱上的胚胎培养板接触。搁架被构造成在孵化器门的内表面和培养箱中的货架的前表面之间提供有用的自由空间。自由空间的大小允许技术人员到达孵化器中的所有培养皿，而不会干扰培养箱中的其他培养皿。自由空间还允许培养箱内部示例性的空气循环。

3. 发明申请

US20170146460A1 CONTROLLED ENVIRONMENT OBSERVATION DEVICE 审中-公开
公开(公告)号：US20170146460A1
公开(公告)日：2017-05-25
申请号：US15352195
申请日：2016-11-15
申请人： Michael D. Cecchi , Monica Mezezi , Michael Ryan Cecchi , Aami Mezezi
发明人： Michael D. Cecchi , Monica Mezezi , Michael Ryan Cecchi , Aami Mezezi
IPC分类号： G01N21/84 , C12Q1/02
CPC分类号： C12M41/36 , C12M21/06 , C12M23/22 , C12M41/12
摘要： A controlled environment observation device comprising: a body; a heated shelf located in the body; a plurality of shelf openings in the heated shelf; a plurality of embryonic chambers removably installed in the plurality of shelf openings, each of the plurality of embryonic chambers comprising: an optically transparent heated shelf; a specimen dish removably attached to the top of the optically transparent heated shelf, the specimen dish having a generally optically transparent bottom; an x,y,z camera system located in each of the embryonic chambers and below the specimen dish and the optically transparent heated shelf; a computer located in the controlled environment observation device; and a controller in signal communication with the xyz camera system and the computer. A controlled environment observation device comprising: a body; at least one multi-area embryonic chamber located in the body, the multi-area embryonic chamber comprising: at least one outer wall forming a perimeter; a platform generally located within the perimeter; an opening in the platform; an optically transparent heated shelf located in the opening; a first plurality of inner walls forming a second plurality of volumes with the at least one outer wall; a second plurality of specimen dishes configured to be removeably attached to the optically transparent heated shelf in each of the second plurality of volumes, each of the specimen dishes having a generally optically transparent bottom; an x,y,z camera system located beneath the optically transparent heated shelf, and configured to move a camera to any of the specimen dishes.

4. 发明申请

US20140120620A1 Culturing solution and method of using the same, which solution is used for in-vitro support of the growth of fertilized oocytes though embryonic development to the implantation stage 审中-公开
标题翻译：培养溶液及其使用方法，该方法用于体外支持受精卵的生长，但胚胎发育至植入阶段
公开(公告)号：US20140120620A1
公开(公告)日：2014-05-01
申请号：US13694097
申请日：2012-10-26
申请人： Michael D. Cecchi , Monica Mezezi
发明人： Michael D. Cecchi , Monica Mezezi
IPC分类号： C12N5/02
CPC分类号： C12N5/0604 , C12N2500/14
摘要： This invention relates to a media solution, which has been shown to be a stabilized balance of growth media, which may contain a combination of proteins, insulin, growth hormones, and/or steroids to assist an embryo to grow from the retrieval stage through the return implantation. The media has shown consistent, improved results and overall embryonic outcome and may be used for culturing the embryos through each stage of growth, will reduce shock and stress to the embryos during the culturing process.
摘要翻译：本发明涉及一种介质溶液，其已显示为生长培养基的稳定平衡，其可以含有蛋白质，胰岛素，生长激素和/或类固醇的组合，以帮助胚胎从检索阶段通过返回植入。培养基显示出一致的，改进的结果和整个胚胎的结果，可用于通过每个生长阶段培养胚胎，在培养过程中减少对胚胎的冲击和压力。

5. 发明授权

US07015031B2 Biological specimen-culturing system and method with onboard specimen development sensors 失效
公开(公告)号：US07015031B2
公开(公告)日：2006-03-21
申请号：US10053944
申请日：2002-01-24
申请人： Michael D. Cecchi , Monica Mezezi
发明人： Michael D. Cecchi , Monica Mezezi
IPC分类号： C12M1/34
CPC分类号： C12M21/06 , C12M23/10 , C12M23/22 , C12M41/14 , C12M41/36 , Y10S435/809
摘要： A specimen culturing system and method is employed to culture biological specimens, preferably embryos. The embryos are cultured in an incubator in separate culturing sites, such as wells, which can each hold an embryo container, such as a Petrie dish, that contains one or more of the embryos. The culturing wells are disposed in one or more shelves in the incubator. The culturing containers are formed from a transparent material such as tempered glass. Each of the wells are provided with embryo development-monitoring adjuncts. The development-monitoring adjuncts are preferably embryo-imaging devices and sound-monitoring devices. The system includes image and sound recording components which can record periodic images of the embryos during the culturing cycle; and can record sounds emanating from the specimens. The embryo-imaging devices can include CCD imaging devices which are connected to image viewing and recording adjuncts by means of electrical connections. Each embryo development-monitoring site in the incubator can be provided with its own CCD embryo-imaging device which can be periodically activated by an incubator processor controller to produce and record images of the embryos at selected time intervals during the culturing cycle. The sound monitoring can be performed periodically or continuously during the culturing cycle. Both the imaging and sound monitoring can be recorded, and the resultant data can be chronologically stored so that a technician can monitor and review the embryo development without having to remove the embryos from the incubator. Images and audio signals can be digitized and transmitted from the incubator to remote worldwide sites for expert analysis and evaluation.

6. 发明申请

US20160312169A1 TEMPERATURE AND GAS CONTROLLED INCUBATOR 审中-公开
公开(公告)号：US20160312169A1
公开(公告)日：2016-10-27
申请号：US15138926
申请日：2016-04-26
申请人： Michael Cecchi , Monica Mezezi , Timothy Schimmel , Michael R. Cecchi
发明人： Michael Cecchi , Monica Mezezi , Timothy Schimmel , Michael R. Cecchi
IPC分类号： C12M1/00 , H04N7/18 , C12M1/34
CPC分类号： C12M41/14 , C12M41/34 , H04N7/183
摘要： A temperature and gas controlled incubator for the culturing and observation of biological specimens comprising: a first wall; a second wall abutting the first wall; a third wall abutting the second wall; a top abutting the first, second and third walls; a door attached to first wall and configured to close against the third wall and top and when closed created an enclosed temperature and gas controlled volume; a first glass panel located on the first wall; a second glass panel located on the top; a third glass panel located on the third wall; a fourth glass panel located on the door; a first thin film layer located on the first glass panel, the first thin film layer configured to heat the first glass panel to a desired temperature; a second thin film layer located on the second glass panel, the second thin film layer configured to heat the second glass panel to a desired temperature; a third thin film layer located on the third glass panel, the third thin film layer configured to heat the third glass panel to a desired temperature; a fourth thin film layer located on the fourth glass panel, the fourth thin film layer configured to heat the fourth glass panel to a desired temperature; where the four thin film layers are configured to maintain a desired temperature in the enclosed temperature and gas controlled volume. A temperature and gas controlled incubator for the culturing and observation of biological specimens comprising: a first wall; a second wall abutting the first wall; a third wall abutting the second wall; a top abutting the first, second and third walls; a door attached to first wall and configured to close against the third wall and top and when closed created an enclosed temperature and gas controlled volume; a first glass panel located on the first wall; a second glass panel located on the third wall; a third glass panel abutting the first wall and third wall and forming a shelf inside the enclosed temperature and gas controlled volume, the shelf configured to hold at least one embryo culture dish; a first thin film layer located on the first glass panel, the first thin film layer configured to heat the first glass panel to a desired temperature; a second thin film layer located on the second glass panel, the second thin film layer configured to heat the second glass panel to a desired temperature; a third thin film layer located on the third glass panel, the third thin film layer configured to heat the third glass panel to a desired temperature; where the three thin film layers are configured to maintain a desired temperature in the enclosed temperature and gas controlled volume. A temperature and gas controlled incubator system for the culturing and observation of biological specimens comprising: a gas system configured to circulate, supply, and maintain proper levels of CO2, N2, and O2 to at least one temperature and gas controlled volume; a first temperature and gas controlled incubator comprising: a first wall; a second wall abutting the first wall; a third wall abutting the second wall; a top abutting the first, second and third walls; a first glass panel located on the first wall; a second glass panel located on the third wall; a first thin film layer located on the first glass panel, the first thin film layer configured to heat the first glass panel to a desired temperature; a second thin film layer located on the second glass panel, the second thin film layer configured to heat the second glass panel to a desired temperature; a door attached to first wall and configured to close against the third wall and top and when closed creates a first enclosed temperature and gas controlled volume, the first enclosed temperature and gas controlled volume in fluid communication with the gas system; a second temperature and gas controlled incubator comprising: a secondary first wall; a secondary second wall abutting the secondary first wall; a secondary third wall abutting the secondary second wall; a secondary top abutting the secondary first, secondary second and secondary third walls; a secondary first glass panel located on the secondary first wall; a secondary second glass panel located on the secondary third wall; a secondary first thin film layer located on the secondary first glass panel, the secondary first thin film layer configured to heat the secondary first glass panel to a desired temperature; a secondary second thin film layer located on the secondary second glass panel, the secondary second thin film layer configured to heat the secondary second glass panel to a desired temperature; a secondary door attached to secondary first wall and configured to close against the secondary third wall and secondary top and when closed creates a second enclosed temperature and gas controlled volume, the second enclosed temperature and gas controlled volume in fluid communication with the gas system; and where the first thin film layer and second thin film layer are configured to maintain a desired temperature in the first enclosed temperature and gas controlled volume; and where the secondary first thin film layer and secondary second thin film layer are configured to maintain a desired temperature in the second enclosed temperature and gas controlled volume. A temperature and gas controlled incubator system for the culturing and observation of biological specimens comprising: a gas system configured to circulate, supply, and maintain proper levels of CO2, N2, and O2 to at least one temperature and gas controlled volume; a first temperature and gas controlled incubator comprising: a first wall; a second wall abutting the first wall; a third wall abutting the second wall; a top abutting the first, second and third walls; a first glass panel located on the first wall; a second glass panel located on the third wall; a first heating element located on the first wall; a second heating element located on the second wall; a third heating element located on the third wall; a fourth heating element located on the top; a door attached to first wall and configured to close against the third wall and top and when closed creates a first enclosed temperature and gas controlled volume, the first enclosed temperature and gas controlled volume in fluid communication with the gas system; second temperature and gas controlled incubator comprising: a secondary first wall; a secondary second wall abutting the secondary first wall; a secondary third wall abutting the secondary second wall; a secondary top abutting the secondary first, secondary second and secondary third walls; a secondary first glass panel located on the secondary first wall; a secondary second glass panel located on the secondary third wall; a secondary first heating element located on the secondary first wall; a secondary second heating element located on the secondary second wall; a secondary third heating element located on the secondary third wall; a secondary fourth heating element located on the secondary top; a secondary door attached to secondary first wall and configured to close against the secondary third wall and secondary top and when closed creates a second enclosed temperature and gas controlled volume, the second enclosed temperature and gas controlled volume in fluid communication with the gas system; and where the first, second, third and fourth heating elements are configured to maintain a desired temperature in the first enclosed temperature and gas controlled volume; and where the secondary first, secondary second, secondary third, and secondary fourth heating elements are configured to maintain a desired temperature in the second enclosed temperature and gas controlled volume.

7. 发明授权

US09694308B2 Air filtration and air purification apparatus 有权
公开(公告)号：US09694308B2
公开(公告)日：2017-07-04
申请号：US14633812
申请日：2015-02-27
申请人： Cecchi Michael , Monica Mezezi
发明人： Cecchi Michael , Monica Mezezi
IPC分类号： B01D46/44 , B01D46/00 , B01D46/42 , B01D46/10 , F24F1/02 , F24F3/16
CPC分类号： B01D46/44 , B01D46/002 , B01D46/10 , B01D46/42 , B01D2267/40 , F24F1/02 , F24F3/1603
摘要： An air filtration and air purification apparatus comprising: a first air channel; a second air channel; a divider that separates the first air channel from the second air channel; a first filter located in first air channel; a first filter located in the second air channel; a first air blower configured to pull air from the ambient environment generally into the first air channel, moving said air through the first filter, and returning said air into the ambient environment, creating generally a first air stream; a second air blower configured to pull air from the ambient environment generally into the second air channel, moving said air through the second filter and returning said air into the ambient environment, creating generally a second air stream; a control system that controls the activation and deactivation of the first and second air blower.

8. 发明申请

US20070104801A1 Fertility and anti-aging supplement for the fertility health of females and males 审中-公开
标题翻译：生育能力和抗衰老补充对女性和男性的生育健康
公开(公告)号：US20070104801A1
公开(公告)日：2007-05-10
申请号：US11267267
申请日：2005-11-07
申请人： Michael Cecchi , Monica Mezezi , Klaus Weimer
发明人： Michael Cecchi , Monica Mezezi , Klaus Weimer
IPC分类号： A61K36/185 , A61K31/525 , A61K33/26 , A61K33/04 , A61K33/32 , A61K36/82 , A61K36/87
CPC分类号： A61K36/185 , A61K31/355 , A61K31/4415 , A61K31/519 , A61K31/7008 , A61K31/714 , A61K31/728 , A61K33/04 , A61K33/06 , A61K33/26 , A61K33/30 , A61K36/296 , A61K36/31 , A61K36/82 , A61K36/87 , A61K45/06 , A61K2300/00
摘要： A fertility-enhancing supplement contains a balance of compositions and ingredients that will enhance the reproduction system in the female and male to help support conception, while also supporting the anti-aging of the reproductive system, taken in balance to aid in the uptake by the body of certain and particular compositions that are included in this invention. The supplement can include ingredients to assist the female reproductive system to conceive and in the male to aid in the production of more healthy sperm. Such ingredients as glucosamine sulfate are included separately or in conjunction to help the female reproductive system to maintain a youthfulness in the female and are important to the maintaining of the vitality of eggs and reducing the aging process in the development of fertilized eggs, embryos and facilitating the implantation of embryos. The supplement will help in the preservation of the eggs and the reproductive system and the overall reproductive health, as the female ages, and assist the male in sperm production throughout the child bearing years.
摘要翻译：生育力增强补充剂包含组合物和成分的平衡，将增强女性和男性的生殖系统，以帮助支持观念，同时也支持生殖系统的抗衰老，平衡起来，以帮助吸收本发明包括的某些特定组合物的主体。该补充物可以包括帮助女性生殖系统构想的成分和在男性中帮助生产更健康的精子的成分。这些成分如葡萄糖胺硫酸盐分别或联合地包括以帮助女性生殖系统保持女性的青春，并且对维持卵的活力和减少受精卵，胚胎的发育和促进老化过程是重要的植入胚胎。该补充将有助于维护卵子，生殖系统和整体生殖健康，如女性年龄，并协助男性在整个育儿年份的精子生产。

9. 发明申请

US20150165361A1 Air Filtration and Air Purification Apparatus 有权
标题翻译：空气过滤和空气净化装置
公开(公告)号：US20150165361A1
公开(公告)日：2015-06-18
申请号：US14633812
申请日：2015-02-27
申请人： Cecchi Michael , Monica Mezezi
发明人： Cecchi Michael , Monica Mezezi
IPC分类号： B01D46/44
CPC分类号： B01D46/44 , B01D46/002 , B01D46/10 , B01D46/42 , B01D2267/40 , F24F1/02 , F24F3/1603
摘要： An air filtration and air purification apparatus comprising: a first air channel; a second air channel; a divider that separates the first air channel from the second air channel; a first filter located in first air channel; a first filter located in the second air channel; a first air blower configured to pull air from the ambient environment generally into the first air channel, moving said air through the first filter, and returning said air into the ambient environment, creating generally a first air stream; a second air blower configured to pull air from the ambient environment generally into the second air channel, moving said air through the second filter and returning said air into the ambient environment, creating generally a second air stream; a control system that controls the activation and deactivation of the first and second air blower.
摘要翻译：一种空气过滤和空气净化装置，包括：第一空气通道; 第二个航道; 分隔器，其将第一空气通道与第二空气通道分离; 位于第一空气通道中的第一过滤器; 位于第二空气通道中的第一过滤器; 第一鼓风机，其构造成将空气从周围环境拉入第一空气通道，使空气通过第一过滤器移动，并将所述空气返回到周围环境中，从而产生一般的第一空气流; 第二鼓风机，其构造成将空气从周围环境中大体拉入第二空气通道，使所述空气通过第二过滤器并将所述空气返回到周围环境中，从而产生一般的第二空气流; 控制系统，其控制第一和第二鼓风机的启动和停用。

10. 发明授权

US08974565B2 Air filtration and air purification apparatus 有权
标题翻译：空气过滤和空气净化装置
公开(公告)号：US08974565B2
公开(公告)日：2015-03-10
申请号：US13225511
申请日：2011-09-05
申请人： Michael Cecchi , Monica Mezezi
发明人： Michael Cecchi , Monica Mezezi
IPC分类号： B01D46/00 , B01D46/42 , B01D46/10
CPC分类号： B01D46/44 , B01D46/002 , B01D46/10 , B01D46/42 , B01D2267/40 , F24F1/02 , F24F3/1603
摘要： An air filtration and air purification apparatus comprising: a first air channel; a second air channel; a divider that separates the first air channel from the second air channel; a first filter located in first air channel; a first filter located in the second air channel; a first air blower configured to pull air from the ambient environment generally into the first air channel, moving said air through the first filter, and returning said air into the ambient environment, creating generally a first air stream; a second air blower configured to pull air from the ambient environment generally into the second air channel, moving said air through the second filter and returning said air into the ambient environment, creating generally a second air stream; a control system that controls the activation and deactivation of the first and second air blower.
摘要翻译：一种空气过滤和空气净化装置，包括：第一空气通道; 第二个航道; 分隔器，其将第一空气通道与第二空气通道分离; 位于第一空气通道中的第一过滤器; 位于第二空气通道中的第一过滤器; 第一鼓风机，其构造成将空气从周围环境拉入第一空气通道，使空气通过第一过滤器移动，并将所述空气返回到周围环境中，从而产生一般的第一空气流; 第二鼓风机，其构造成将空气从环境环境中大致拉入第二空气通道，使空气通过第二过滤器移动并将所述空气返回到周围环境中，从而产生一般的第二空气流; 控制系统，其控制第一和第二鼓风机的启动和停用。

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