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    • 2. 发明申请
    • Device for Observation, Imaging and Uninterrupted Culturing of Embryos and Cells
    • US20180112164A1
    • 2018-04-26
    • US15334953
    • 2016-10-26
    • Michael D. CecchiTimothy SchimmelJacques CohenMonica MezeziMichael Ryan Cecchi
    • Michael D. CecchiTimothy SchimmelJacques CohenMonica MezeziMichael Ryan Cecchi
    • C12M1/00C12M3/00C12M1/34G01N21/84
    • G01N21/84C12M23/22C12M23/48C12M23/50C12M31/02C12M41/14C12M41/34C12M41/36
    • A device for the observation, imaging and uninterrupted culturing of embryos and cells, the device comprising: an incubator; a mixing box located above the incubator; gas sensors located in the mixing box; solenoid valves attached to the mixing box; a first clear panel located on the top of the incubator, and configured to allow one to see into the incubator; a first light source located above the first clear panel, and the first light source configured to provide light into the incubator; a door attached to the incubator, the door configured to provide access to the inside of the incubator, and the door located below the access door; a rotatable platter located below the incubator, the rotatable platter comprising: a first insert configured to removably sit on the platter; a first culture dish configured to removably sit in the first insert; a second insert configured to removably sit on the platter; a second culture dish configured to removably sit in the second insert; a first moveable camera located under the rotatable platter, and configured to view a culture dish located generally directly above the first moveable camera, and the first moveable camera generally in alignment with the first light source; a computer in communication with the first moveable camera, rotatable platter, sensors, solenoid valves, touchscreen display, and light source. A device for the observation, imaging and uninterrupted culturing of embryos and cells, the device comprising: a top portion, the top portion comprising: a housing; a horizontal surface on the housing; an angled surface abutting the horizontal surface; an access door located generally on the housing; a first heating surface located on the horizontal surface; a touch screen display located on the angled surface; a middle portion abutting the top portion; the middle portion comprising: an incubator; a mixing box located above the incubator; gas sensors located in the mixing box; solenoid valves attached to the mixing box; a first clear panel located on the top of the incubator, and configured to allow one to see into the incubator; a first light source located above the first clear panel, and the first light source configured to provide light into the incubator; a door attached to the incubator, the door configured to provide access to the inside of the incubator, and the door located below the access door; a bottom portion abutting the middle portion, the bottom portion comprising: a rotatable platter, the rotatable platter comprising: a first insert configured to removably sit on the platter; a first culture dish configured to removably sit in the first insert; a second insert configured to removably sit on the platter; a second culture dish configured to removably sit in the second insert; a first moveable camera located under the rotatable platter, and configured to view a culture dish located generally directly above the first moveable camera, and the first moveable camera generally in alignment with the first light source; a computer in communication with the camera, rotatable platter, sensors, solenoid valves, touchscreen display, and light source.
    • 4. 发明申请
    • CONTROLLED ENVIRONMENT OBSERVATION DEVICE
    • US20170146460A1
    • 2017-05-25
    • US15352195
    • 2016-11-15
    • Michael D. CecchiMonica MezeziMichael Ryan CecchiAami Mezezi
    • Michael D. CecchiMonica MezeziMichael Ryan CecchiAami Mezezi
    • G01N21/84C12Q1/02
    • C12M41/36C12M21/06C12M23/22C12M41/12
    • A controlled environment observation device comprising: a body; a heated shelf located in the body; a plurality of shelf openings in the heated shelf; a plurality of embryonic chambers removably installed in the plurality of shelf openings, each of the plurality of embryonic chambers comprising: an optically transparent heated shelf; a specimen dish removably attached to the top of the optically transparent heated shelf, the specimen dish having a generally optically transparent bottom; an x,y,z camera system located in each of the embryonic chambers and below the specimen dish and the optically transparent heated shelf; a computer located in the controlled environment observation device; and a controller in signal communication with the xyz camera system and the computer. A controlled environment observation device comprising: a body; at least one multi-area embryonic chamber located in the body, the multi-area embryonic chamber comprising: at least one outer wall forming a perimeter; a platform generally located within the perimeter; an opening in the platform; an optically transparent heated shelf located in the opening; a first plurality of inner walls forming a second plurality of volumes with the at least one outer wall; a second plurality of specimen dishes configured to be removeably attached to the optically transparent heated shelf in each of the second plurality of volumes, each of the specimen dishes having a generally optically transparent bottom; an x,y,z camera system located beneath the optically transparent heated shelf, and configured to move a camera to any of the specimen dishes.
    • 5. 发明申请
    • Air Filtration and Air Purification Apparatus
    • 空气过滤和空气净化装置
    • US20150165361A1
    • 2015-06-18
    • US14633812
    • 2015-02-27
    • Cecchi MichaelMonica Mezezi
    • Cecchi MichaelMonica Mezezi
    • B01D46/44
    • B01D46/44B01D46/002B01D46/10B01D46/42B01D2267/40F24F1/02F24F3/1603
    • An air filtration and air purification apparatus comprising: a first air channel; a second air channel; a divider that separates the first air channel from the second air channel; a first filter located in first air channel; a first filter located in the second air channel; a first air blower configured to pull air from the ambient environment generally into the first air channel, moving said air through the first filter, and returning said air into the ambient environment, creating generally a first air stream; a second air blower configured to pull air from the ambient environment generally into the second air channel, moving said air through the second filter and returning said air into the ambient environment, creating generally a second air stream; a control system that controls the activation and deactivation of the first and second air blower.
    • 一种空气过滤和空气净化装置,包括:第一空气通道; 第二个航道; 分隔器,其将第一空气通道与第二空气通道分离; 位于第一空气通道中的第一过滤器; 位于第二空气通道中的第一过滤器; 第一鼓风机,其构造成将空气从周围环境拉入第一空气通道,使空气通过第一过滤器移动,并将所述空气返回到周围环境中,从而产生一般的第一空气流; 第二鼓风机,其构造成将空气从周围环境中大体拉入第二空气通道,使所述空气通过第二过滤器并将所述空气返回到周围环境中,从而产生一般的第二空气流; 控制系统,其控制第一和第二鼓风机的启动和停用。
    • 7. 发明授权
    • Air filtration and air purification apparatus
    • 空气过滤和空气净化装置
    • US08974565B2
    • 2015-03-10
    • US13225511
    • 2011-09-05
    • Michael CecchiMonica Mezezi
    • Michael CecchiMonica Mezezi
    • B01D46/00B01D46/42B01D46/10
    • B01D46/44B01D46/002B01D46/10B01D46/42B01D2267/40F24F1/02F24F3/1603
    • An air filtration and air purification apparatus comprising: a first air channel; a second air channel; a divider that separates the first air channel from the second air channel; a first filter located in first air channel; a first filter located in the second air channel; a first air blower configured to pull air from the ambient environment generally into the first air channel, moving said air through the first filter, and returning said air into the ambient environment, creating generally a first air stream; a second air blower configured to pull air from the ambient environment generally into the second air channel, moving said air through the second filter and returning said air into the ambient environment, creating generally a second air stream; a control system that controls the activation and deactivation of the first and second air blower.
    • 一种空气过滤和空气净化装置,包括:第一空气通道; 第二个航道; 分隔器,其将第一空气通道与第二空气通道分离; 位于第一空气通道中的第一过滤器; 位于第二空气通道中的第一过滤器; 第一鼓风机,其构造成将空气从周围环境拉入第一空气通道,使空气通过第一过滤器移动,并将所述空气返回到周围环境中,从而产生一般的第一空气流; 第二鼓风机,其构造成将空气从环境环境中大致拉入第二空气通道,使空气通过第二过滤器移动并将所述空气返回到周围环境中,从而产生一般的第二空气流; 控制系统,其控制第一和第二鼓风机的启动和停用。
    • 9. 发明授权
    • Biological specimen-culturing system and method with onboard specimen development sensors
    • US07015031B2
    • 2006-03-21
    • US10053944
    • 2002-01-24
    • Michael D. CecchiMonica Mezezi
    • Michael D. CecchiMonica Mezezi
    • C12M1/34
    • C12M21/06C12M23/10C12M23/22C12M41/14C12M41/36Y10S435/809
    • A specimen culturing system and method is employed to culture biological specimens, preferably embryos. The embryos are cultured in an incubator in separate culturing sites, such as wells, which can each hold an embryo container, such as a Petrie dish, that contains one or more of the embryos. The culturing wells are disposed in one or more shelves in the incubator. The culturing containers are formed from a transparent material such as tempered glass. Each of the wells are provided with embryo development-monitoring adjuncts. The development-monitoring adjuncts are preferably embryo-imaging devices and sound-monitoring devices. The system includes image and sound recording components which can record periodic images of the embryos during the culturing cycle; and can record sounds emanating from the specimens. The embryo-imaging devices can include CCD imaging devices which are connected to image viewing and recording adjuncts by means of electrical connections. Each embryo development-monitoring site in the incubator can be provided with its own CCD embryo-imaging device which can be periodically activated by an incubator processor controller to produce and record images of the embryos at selected time intervals during the culturing cycle. The sound monitoring can be performed periodically or continuously during the culturing cycle. Both the imaging and sound monitoring can be recorded, and the resultant data can be chronologically stored so that a technician can monitor and review the embryo development without having to remove the embryos from the incubator. Images and audio signals can be digitized and transmitted from the incubator to remote worldwide sites for expert analysis and evaluation.
    • 10. 发明申请
    • TEMPERATURE AND GAS CONTROLLED INCUBATOR
    • US20160312169A1
    • 2016-10-27
    • US15138926
    • 2016-04-26
    • Michael CecchiMonica MezeziTimothy SchimmelMichael R. Cecchi
    • Michael CecchiMonica MezeziTimothy SchimmelMichael R. Cecchi
    • C12M1/00H04N7/18C12M1/34
    • C12M41/14C12M41/34H04N7/183
    • A temperature and gas controlled incubator for the culturing and observation of biological specimens comprising: a first wall; a second wall abutting the first wall; a third wall abutting the second wall; a top abutting the first, second and third walls; a door attached to first wall and configured to close against the third wall and top and when closed created an enclosed temperature and gas controlled volume; a first glass panel located on the first wall; a second glass panel located on the top; a third glass panel located on the third wall; a fourth glass panel located on the door; a first thin film layer located on the first glass panel, the first thin film layer configured to heat the first glass panel to a desired temperature; a second thin film layer located on the second glass panel, the second thin film layer configured to heat the second glass panel to a desired temperature; a third thin film layer located on the third glass panel, the third thin film layer configured to heat the third glass panel to a desired temperature; a fourth thin film layer located on the fourth glass panel, the fourth thin film layer configured to heat the fourth glass panel to a desired temperature; where the four thin film layers are configured to maintain a desired temperature in the enclosed temperature and gas controlled volume. A temperature and gas controlled incubator for the culturing and observation of biological specimens comprising: a first wall; a second wall abutting the first wall; a third wall abutting the second wall; a top abutting the first, second and third walls; a door attached to first wall and configured to close against the third wall and top and when closed created an enclosed temperature and gas controlled volume; a first glass panel located on the first wall; a second glass panel located on the third wall; a third glass panel abutting the first wall and third wall and forming a shelf inside the enclosed temperature and gas controlled volume, the shelf configured to hold at least one embryo culture dish; a first thin film layer located on the first glass panel, the first thin film layer configured to heat the first glass panel to a desired temperature; a second thin film layer located on the second glass panel, the second thin film layer configured to heat the second glass panel to a desired temperature; a third thin film layer located on the third glass panel, the third thin film layer configured to heat the third glass panel to a desired temperature; where the three thin film layers are configured to maintain a desired temperature in the enclosed temperature and gas controlled volume. A temperature and gas controlled incubator system for the culturing and observation of biological specimens comprising: a gas system configured to circulate, supply, and maintain proper levels of CO2, N2, and O2 to at least one temperature and gas controlled volume; a first temperature and gas controlled incubator comprising: a first wall; a second wall abutting the first wall; a third wall abutting the second wall; a top abutting the first, second and third walls; a first glass panel located on the first wall; a second glass panel located on the third wall; a first thin film layer located on the first glass panel, the first thin film layer configured to heat the first glass panel to a desired temperature; a second thin film layer located on the second glass panel, the second thin film layer configured to heat the second glass panel to a desired temperature; a door attached to first wall and configured to close against the third wall and top and when closed creates a first enclosed temperature and gas controlled volume, the first enclosed temperature and gas controlled volume in fluid communication with the gas system; a second temperature and gas controlled incubator comprising: a secondary first wall; a secondary second wall abutting the secondary first wall; a secondary third wall abutting the secondary second wall; a secondary top abutting the secondary first, secondary second and secondary third walls; a secondary first glass panel located on the secondary first wall; a secondary second glass panel located on the secondary third wall; a secondary first thin film layer located on the secondary first glass panel, the secondary first thin film layer configured to heat the secondary first glass panel to a desired temperature; a secondary second thin film layer located on the secondary second glass panel, the secondary second thin film layer configured to heat the secondary second glass panel to a desired temperature; a secondary door attached to secondary first wall and configured to close against the secondary third wall and secondary top and when closed creates a second enclosed temperature and gas controlled volume, the second enclosed temperature and gas controlled volume in fluid communication with the gas system; and where the first thin film layer and second thin film layer are configured to maintain a desired temperature in the first enclosed temperature and gas controlled volume; and where the secondary first thin film layer and secondary second thin film layer are configured to maintain a desired temperature in the second enclosed temperature and gas controlled volume. A temperature and gas controlled incubator system for the culturing and observation of biological specimens comprising: a gas system configured to circulate, supply, and maintain proper levels of CO2, N2, and O2 to at least one temperature and gas controlled volume; a first temperature and gas controlled incubator comprising: a first wall; a second wall abutting the first wall; a third wall abutting the second wall; a top abutting the first, second and third walls; a first glass panel located on the first wall; a second glass panel located on the third wall; a first heating element located on the first wall; a second heating element located on the second wall; a third heating element located on the third wall; a fourth heating element located on the top; a door attached to first wall and configured to close against the third wall and top and when closed creates a first enclosed temperature and gas controlled volume, the first enclosed temperature and gas controlled volume in fluid communication with the gas system; second temperature and gas controlled incubator comprising: a secondary first wall; a secondary second wall abutting the secondary first wall; a secondary third wall abutting the secondary second wall; a secondary top abutting the secondary first, secondary second and secondary third walls; a secondary first glass panel located on the secondary first wall; a secondary second glass panel located on the secondary third wall; a secondary first heating element located on the secondary first wall; a secondary second heating element located on the secondary second wall; a secondary third heating element located on the secondary third wall; a secondary fourth heating element located on the secondary top; a secondary door attached to secondary first wall and configured to close against the secondary third wall and secondary top and when closed creates a second enclosed temperature and gas controlled volume, the second enclosed temperature and gas controlled volume in fluid communication with the gas system; and where the first, second, third and fourth heating elements are configured to maintain a desired temperature in the first enclosed temperature and gas controlled volume; and where the secondary first, secondary second, secondary third, and secondary fourth heating elements are configured to maintain a desired temperature in the second enclosed temperature and gas controlled volume.