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    • 4. 发明申请
    • METHODS TO MOBILIZE PROGENITOR/STEM CELLS
    • 移动原核细胞/干细胞的方法
    • US20080063624A1
    • 2008-03-13
    • US11841837
    • 2007-08-20
    • Gary BridgerMichael AbramsGeoffrey HensonRonald MacfarlandGary CalandraHal BroxmeyerDavid Dale
    • Gary BridgerMichael AbramsGeoffrey HensonRonald MacfarlandGary CalandraHal BroxmeyerDavid Dale
    • A61K31/395A61K31/4427A61K38/19A61P9/00
    • A61K31/395A61K31/33A61K31/4427A61K31/496A61K31/55A61K31/551A61K31/555A61K35/28A61K38/193A61K38/195A61K2035/124C12N5/0647A61K2300/00
    • Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed. Preferred embodiments of such compounds are of the formula Z-linker-Z′  (1) or pharmaceutically acceptable salt thereof wherein Z is a cyclic polyamine containing 9-32 ring members of which 3-8 are nitrogen atoms, said nitrogen atoms separated from each other by at least 2 carbon atoms, and wherein said heterocycle may optionally contain additional heteroatoms besides nitrogen and/or may be fused to an additional ring system; wherein A comprises a monocyclic or bicyclic fused ring system containing at least one N and B is H or an organic moiety of 1-20 atoms, Z′ may be embodied in a form as defined by Z above, or alternatively may be of the formula —N(R)—(CR2)n—X wherein each R is independently H or straight, branched or cyclic alkyl (1-6C), n is 1 or 2, and X is an aromatic ring, including heteroaromatic rings, or is a mercaptan; “linker” represents a bond, alkylene (1-6C) or may comprise aryl, fused aryl, oxygen atoms contained in an alkylene chain, or may contain keto groups or nitrogen or sulfur atoms.
    • 公开了使用结合趋化因子受体CXCR4的化合物来提高动物受试者祖细胞和干细胞计数的方法。 这些化合物的优选实施方案具有式<?in-line-formula description =“In-line Formulas”end =“lead”?> Z-linker-Z'(1)<?in-line-formula description =“ 其中Z是含有9-32个环成员的环状多胺,其中3-8个是氮原子,所述氮原子彼此分开至少2个碳原子 并且其中所述杂环可以任选地含有除氮之外的另外的杂原子和/或可以与另外的环系稠合; 其中A包含含有至少一个N的单环或双环稠环体系,B是H或1-20个原子的有机部分,Z'可以以上述Z所定义的形式实施,或者可以是式 <?in-line-formula description =“In-line Formulas”end =“lead”?> - N(R) - (CR 2)N < 其中每个R独立地为H或直链,支链或环状烷基(1-6C),n为1或2,X为 芳环,包括杂芳环,或是硫醇; “接头”表示键,亚烷基(1-6C)或可包含亚烷基链中所含的芳基,稠合芳基,氧原子,或可含有酮基或氮或硫原子。
    • 6. 发明申请
    • Methods to mobilize progenitor/stem cells
    • 调动祖细胞/干细胞的方法
    • US20060193826A1
    • 2006-08-31
    • US11269773
    • 2005-11-08
    • Gary BridgerMichael AbramsGeoffrey HensonRonald MacFarlandGary CalandraHal BroxmeyerDavid Dale
    • Gary BridgerMichael AbramsGeoffrey HensonRonald MacFarlandGary CalandraHal BroxmeyerDavid Dale
    • A61K38/19A61K31/551A61K31/33
    • A61K31/395A61K31/33A61K31/4427A61K31/496A61K31/55A61K31/551A61K31/555A61K35/28A61K38/193A61K38/195A61K2035/124C12N5/0647A61K2300/00
    • Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed. Preferred embodiments of such compounds are of the formula Z-linker-Z′   (1) or pharmaceutically acceptable salt thereof wherein Z is a cyclic polyamine containing 9-32 ring members of which 3-8 are nitrogen atoms, said nitrogen atoms separated from each other by at least 2 carbon atoms, and wherein said heterocycle may optionally contain additional heteroatoms besides nitrogen and/or may be fused to an additional ring system; or Z is of the formula N wherein A comprises a monocyclic or bicyclic fused ring system containing at least one N and B is H or an organic moiety of 1-20 atoms, Z′ may be embodied in a form as defined by Z above, or alternatively may be of the formula —N(R)—(CR2)n—X wherein each R is independently H or straight, branched or cyclic alkyl (1-6C), n is 1 or 2, and X is an aromatic ring, including heteroaromatic rings, or is a mercaptan; “linker” represents a bond, alkylene (1-6C) or may comprise aryl, fused aryl, oxygen atoms contained in an alkylene chain, or may contain keto groups or nitrogen or sulfur atoms.
    • 公开了使用结合趋化因子受体CXCR4的化合物来提高动物受试者祖细胞和干细胞计数的方法。 这些化合物的优选实施方案具有式<?in-line-formula description =“In-line Formulas”end =“lead”?> Z-linker-Z'(1)<?in-line-formula description =“ 其中Z是含有9-32个环成员的环状多胺,其中3-8个是氮原子,所述氮原子彼此分开至少2个碳原子 并且其中所述杂环可以任选地含有除氮之外的另外的杂原子和/或可以与另外的环系稠合; 或Z具有式N,其中A包含含有至少一个N的单环或双环稠合环体系,B是H或1-20个原子的有机部分,Z'可以以Z所定义的形式实施, 或者可以具有公式<?in-line-formula description =“In-line Formulas”end =“lead”?> - N(R) - (CR 2 2 N)n 其中每个R独立地为H或直链,支链或环状的烷基(1-6C),n为1,其中每个R独立地为H或直链,支链或环状的烷基(1-6C) 或2,X是芳环,包括杂芳环,或是硫醇; “接头”表示键,亚烷基(1-6C)或可包含亚烷基链中所含的芳基,稠合芳基,氧原子,或可含有酮基或氮或硫原子。
    • 7. 发明授权
    • Playing court
    • 玩法庭
    • US5340118A
    • 1994-08-23
    • US70269
    • 1993-06-02
    • Richard B. JacobsonMichael Abrams
    • Richard B. JacobsonMichael Abrams
    • A63B67/00A63C19/00A63B71/04
    • A63B67/002A63C19/00
    • An enclosed or open playing court, of generally rectangular shape, has two vertical end walls and two vertical side walls with four traps or alcoves spaced along the side walls. The court is bounded by a floor below, and optionally a ceiling above. The vertical end walls at each end of the court are the scoring walls. Players typically stand at each end of the court and face each other. A resilient rubber ball is caught and thrown by hand. The play consists of throwing the ball towards the opponent's scoring wall. The ball must bounce twice on the floor within a designated area, before being caught by the other player, or striking the opponent's scoring wall at a minimum height above the floor. In normal play, after the ball is caught by the other player, it is returned by throwing the ball towards the scoring wall defended by first player. To score a point, the ball must pass the other player and hit the back wall.
    • 一个大致矩形的封闭或开放的游戏场具有两个垂直的端壁和两个垂直的侧壁,四个陷阱或壁壁沿着侧壁隔开。 法院受地板下面的限制,也可以是上面的天花板。 场地两端的垂直端壁是得分墙。 玩家通常站在法庭的每一端,彼此面对面。 弹性橡胶球被手抓住并投掷。 这场比赛包括将球扔向对手的得分墙。 球必须在指定区域内的地板上反弹两次,然后被另一名玩家抓住,或者在地板上方的最小高度打击对方的得分墙。 在正常的比赛中,在球被另一名球员抓住之后,通过将球投向由第一名球员防守的得分球而返回。 要得分,球必须通过另一个球员并击中后墙。