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1. 发明授权

US08961407B2 Surgical port assembly 有权
标题翻译：手术口组装
公开(公告)号：US08961407B2
公开(公告)日：2015-02-24
申请号：US12550595
申请日：2009-08-31
申请人： Gregory Piskun , Oleg Shikhman , Christopher Battles , Patrick N. Gutelius , Mark J. DeBisschop , Jeffrey H. MacDonald , Frank Rende , Michael Abrams , Anatoly Konik , Dan Rottenberg
发明人： Gregory Piskun , Oleg Shikhman , Christopher Battles , Patrick N. Gutelius , Mark J. DeBisschop , Jeffrey H. MacDonald , Frank Rende , Michael Abrams , Anatoly Konik , Dan Rottenberg
IPC分类号： A61B1/32 , A61B17/34
CPC分类号： A61B17/3423 , A61B17/0218 , A61B17/3421 , A61B17/3462 , A61B2017/3441 , A61B2017/3447 , A61B2017/3466 , A61B2017/349
摘要： A surgical port comprising a body and first and second cannula extending from the body and movable with respect to the body via an instrument inserted through the respective cannula. The cannulas can extend distally from the body and can include one or more seals. A port assembly and first and second instruments manipulatable in a crossed configuration are also disclosed.
摘要翻译：一种手术口，其包括主体和从所述主体延伸并且经由穿过相应插管插入的器具相对于所述主体移动的第一和第二插管。插管可以从身体向远侧延伸并且可以包括一个或多个密封件。还公开了一种端口组件和可交叉配置的第一和第二仪器。

2. 发明申请

US20100113886A1 SURGICAL PORT ASSEMBLY 有权
标题翻译：手术口组合
公开(公告)号：US20100113886A1
公开(公告)日：2010-05-06
申请号：US12550595
申请日：2009-08-31
申请人： Gregory Piskun , Oleg Shikhman , Christopher Battles , Patrick N. Gutelius , Mark J. DeBisschop , Jeffrey H. MacDonald , Frank Rende , Michael Abrams , Anatoly Konik , Dan Rottenberg
发明人： Gregory Piskun , Oleg Shikhman , Christopher Battles , Patrick N. Gutelius , Mark J. DeBisschop , Jeffrey H. MacDonald , Frank Rende , Michael Abrams , Anatoly Konik , Dan Rottenberg
IPC分类号： A61B1/32
CPC分类号： A61B17/3423 , A61B17/0218 , A61B17/3421 , A61B17/3462 , A61B2017/3441 , A61B2017/3447 , A61B2017/3466 , A61B2017/349
摘要： A surgical port comprising a body and first and second cannula extending from the body and movable with respect to the body via an instrument inserted through the respective cannula. The cannulas can extend distally from the body and can include one or more seals. A port assembly and first and second instruments manipulatable in a crossed configuration are also disclosed.
摘要翻译：一种手术口，其包括主体和从所述主体延伸并且经由穿过相应插管插入的器具相对于所述主体移动的第一和第二插管。插管可以从身体向远侧延伸并且可以包括一个或多个密封件。还公开了一种端口组件和可交叉配置的第一和第二仪器。

3. 发明授权

US08764765B2 Laparoscopic instrument and related surgical method 失效
标题翻译：腹腔镜仪及相关手术方法
公开(公告)号：US08764765B2
公开(公告)日：2014-07-01
申请号：US12550617
申请日：2009-08-31
申请人： Gregory Piskun , Oleg Shikhman , Anatoly Konik , Dan Rottenberg , Christopher Battles , Michael Abrams , Jeffrey Radziunas , Danial Ferreira
发明人： Gregory Piskun , Oleg Shikhman , Anatoly Konik , Dan Rottenberg , Christopher Battles , Michael Abrams , Jeffrey Radziunas , Danial Ferreira
IPC分类号： A61B1/04 , A61F11/00
CPC分类号： A61B17/29 , A61B17/2909 , A61B17/3417 , A61B17/3421 , A61B34/70 , A61B2017/003 , A61B2017/00314 , A61B2017/00738 , A61B2017/2904 , A61B2017/2929 , A61B2017/2946 , A61B2017/3447 , A61B2017/3456 , A61B2017/3466 , A61B2017/349 , A61B2034/301
摘要： A medical instrument insertable through a cannula, the instrument comprising an elongate shaft; and an operative tip having a first jaw and a second jaw movable with respect to the first jaw. The operative tip disposed at a distal end of said elongate shaft and being disposed on said shaft for rotation relative to at least a distal end portion of said shaft about a longitudinal axis of said distal end portion.
摘要翻译：可通过插管插入的医疗器械，所述器械包括细长轴; 以及具有相对于所述第一钳口可移动的第一钳口和第二钳口的操作尖端。所述操作尖端设置在所述细长轴的远端并且设置在所述轴上，用于相对于所述轴的至少远端部围绕所述远端部分的纵向轴线旋转。

4. 发明申请

US20100057121A1 LAPAROSCOPIC INSTRUMENT AND RELATED SURGICAL METHOD 失效
标题翻译： LAPAROSCOPIC仪器及相关手术方法
公开(公告)号：US20100057121A1
公开(公告)日：2010-03-04
申请号：US12550617
申请日：2009-08-31
申请人： Gregory Piskun , Oleg Shikhman , Anatoly Konik , Dan Rottenberg , Christopher Battles , Michael Abrams , Jeffrey Radziunas , Danial Ferreira
发明人： Gregory Piskun , Oleg Shikhman , Anatoly Konik , Dan Rottenberg , Christopher Battles , Michael Abrams , Jeffrey Radziunas , Danial Ferreira
IPC分类号： A61B17/29
CPC分类号： A61B17/29 , A61B17/2909 , A61B17/3417 , A61B17/3421 , A61B34/70 , A61B2017/003 , A61B2017/00314 , A61B2017/00738 , A61B2017/2904 , A61B2017/2929 , A61B2017/2946 , A61B2017/3447 , A61B2017/3456 , A61B2017/3466 , A61B2017/349 , A61B2034/301
摘要： A medical instrument insertable through a cannula, the instrument comprising an elongate shaft; and an operative tip having a first jaw and a second jaw movable with respect to the first jaw. The operative tip disposed at a distal end of said elongate shaft and being disposed on said shaft for rotation relative to at least a distal end portion of said shaft about a longitudinal axis of said distal end portion.
摘要翻译：可通过插管插入的医疗器械，所述器械包括细长轴; 以及具有相对于所述第一钳口可移动的第一钳口和第二钳口的操作尖端。所述操作尖端设置在所述细长轴的远端并且设置在所述轴上，用于相对于所述轴的至少远端部围绕所述远端部分的纵向轴线旋转。

5. 发明授权

US08911365B1 Laparoscopic port assembly 有权
标题翻译：腹腔镜口组装
公开(公告)号：US08911365B1
公开(公告)日：2014-12-16
申请号：US12228445
申请日：2008-08-13
申请人： Gregory Piskun , Christopher Battles , Frank Rende , Michael Abrams , Oleg Shikhman
发明人： Gregory Piskun , Christopher Battles , Frank Rende , Michael Abrams , Oleg Shikhman
IPC分类号： A61B1/32
CPC分类号： A61B17/3423 , A61B1/3132 , A61B1/32 , A61B17/3421 , A61B17/3439 , A61B2017/3427 , A61B2017/3445 , A61B2017/3447 , A61B2017/3466 , A61B2017/349
摘要： Various embodiments of a laparoscopic trocar assembly are disclosed. The port assemblies include inserted parts that protect the patient's tissues at the point of deployment. The port assemblies include seals for maintaining pneumoperitoneum both when instrument are being used and when instruments are not inserted.
摘要翻译：公开了腹腔镜套管针组件的各种实施例。端口组件包括在部署点保护患者组织的插入部件。端口组件包括用于在使用仪器和未插入仪器时保持气腹的密封。

6. 发明授权

US08876708B1 Laparoscopic port assembly 有权
公开(公告)号：US08876708B1
公开(公告)日：2014-11-04
申请号：US12228438
申请日：2008-08-13
申请人： Gregory Piskun , Christopher Battles , Frank Rende , Michael Abrams , Oleg Shikhman
发明人： Gregory Piskun , Christopher Battles , Frank Rende , Michael Abrams , Oleg Shikhman
IPC分类号： A61B1/32
CPC分类号： A61B17/3423 , A61B1/3132 , A61B1/32 , A61B17/3421 , A61B17/3439 , A61B2017/3427 , A61B2017/3445 , A61B2017/3447 , A61B2017/3466 , A61B2017/349
摘要： Various embodiments of a laparoscopic trocar assembly are disclosed. The port assemblies include inserted parts that protect the patient's tissues at the point of deployment. The port assemblies include seals for maintaining pneumoperitoneum both when instrument are being used and when instruments are not inserted.

7. 发明申请

US20080255519A1 Laparoscopic port assembly 有权
标题翻译：腹腔镜口组装
公开(公告)号：US20080255519A1
公开(公告)日：2008-10-16
申请号：US12079599
申请日：2008-03-27
申请人： Gregory Piskun , Christopher Battles , Frank Rende , Michael Abrams , Oleg Shikhman
发明人： Gregory Piskun , Christopher Battles , Frank Rende , Michael Abrams , Oleg Shikhman
IPC分类号： A61B17/94 , A61B17/34
CPC分类号： A61B17/3423 , A61B1/3132 , A61B1/32 , A61B17/3421 , A61B17/3439 , A61B2017/3427 , A61B2017/3445 , A61B2017/3447 , A61B2017/3466 , A61B2017/349
摘要： Various embodiments of a laparoscopic trocar assembly are disclosed. The port assemblies include inserted parts that protect the patient's tissues at the point of deployment. The port assemblies include seals for maintaining pneumoperitoneum both when instrument are being used and when instruments are not inserted.
摘要翻译：公开了腹腔镜套管针组件的各种实施例。端口组件包括在部署点保护患者组织的插入部件。端口组件包括用于在使用仪器和未插入仪器时保持气腹的密封。

8. 发明授权

US08888695B2 Laparoscopic port assembly 有权
公开(公告)号：US08888695B2
公开(公告)日：2014-11-18
申请号：US12079599
申请日：2008-03-27
申请人： Gregory Piskun , Christopher Battles , Frank Rende , Michael Abrams , Oleg Shikman
发明人： Gregory Piskun , Christopher Battles , Frank Rende , Michael Abrams , Oleg Shikman
IPC分类号： A61B1/32 , A61B17/34 , A61B1/313
CPC分类号： A61B17/3423 , A61B1/3132 , A61B1/32 , A61B17/3421 , A61B17/3439 , A61B2017/3427 , A61B2017/3445 , A61B2017/3447 , A61B2017/3466 , A61B2017/349
摘要： Various embodiments of a laparoscopic trocar assembly are disclosed. The port assemblies include inserted parts that protect the patient's tissues at the point of deployment. The port assemblies include seals for maintaining pneumoperitoneum both when instrument are being used and when instruments are not inserted.

9. 发明申请

US20080063624A1 METHODS TO MOBILIZE PROGENITOR/STEM CELLS 有权
标题翻译：移动原核细胞/干细胞的方法
公开(公告)号：US20080063624A1
公开(公告)日：2008-03-13
申请号：US11841837
申请日：2007-08-20
申请人： Gary Bridger , Michael Abrams , Geoffrey Henson , Ronald Macfarland , Gary Calandra , Hal Broxmeyer , David Dale
发明人： Gary Bridger , Michael Abrams , Geoffrey Henson , Ronald Macfarland , Gary Calandra , Hal Broxmeyer , David Dale
IPC分类号： A61K31/395 , A61K31/4427 , A61K38/19 , A61P9/00
CPC分类号： A61K31/395 , A61K31/33 , A61K31/4427 , A61K31/496 , A61K31/55 , A61K31/551 , A61K31/555 , A61K35/28 , A61K38/193 , A61K38/195 , A61K2035/124 , C12N5/0647 , A61K2300/00
摘要： Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed. Preferred embodiments of such compounds are of the formula Z-linker-Z′ (1) or pharmaceutically acceptable salt thereof wherein Z is a cyclic polyamine containing 9-32 ring members of which 3-8 are nitrogen atoms, said nitrogen atoms separated from each other by at least 2 carbon atoms, and wherein said heterocycle may optionally contain additional heteroatoms besides nitrogen and/or may be fused to an additional ring system; wherein A comprises a monocyclic or bicyclic fused ring system containing at least one N and B is H or an organic moiety of 1-20 atoms, Z′ may be embodied in a form as defined by Z above, or alternatively may be of the formula —N(R)—(CR2)n—X wherein each R is independently H or straight, branched or cyclic alkyl (1-6C), n is 1 or 2, and X is an aromatic ring, including heteroaromatic rings, or is a mercaptan; “linker” represents a bond, alkylene (1-6C) or may comprise aryl, fused aryl, oxygen atoms contained in an alkylene chain, or may contain keto groups or nitrogen or sulfur atoms.
摘要翻译：公开了使用结合趋化因子受体CXCR4的化合物来提高动物受试者祖细胞和干细胞计数的方法。这些化合物的优选实施方案具有式<？in-line-formula description =“In-line Formulas”end =“lead”？> Z-linker-Z'（1）<？in-line-formula description =“ 其中Z是含有9-32个环成员的环状多胺，其中3-8个是氮原子，所述氮原子彼此分开至少2个碳原子并且其中所述杂环可以任选地含有除氮之外的另外的杂原子和/或可以与另外的环系稠合; 其中A包含含有至少一个N的单环或双环稠环体系，B是H或1-20个原子的有机部分，Z'可以以上述Z所定义的形式实施，或者可以是式 <？in-line-formula description =“In-line Formulas”end =“lead”？> - N（R） - （CR 2）N < 其中每个R独立地为H或直链，支链或环状烷基（1-6C），n为1或2，X为芳环，包括杂芳环，或是硫醇; “接头”表示键，亚烷基（1-6C）或可包含亚烷基链中所含的芳基，稠合芳基，氧原子，或可含有酮基或氮或硫原子。

10. 发明申请

US20060193826A1 Methods to mobilize progenitor/stem cells 有权
标题翻译：调动祖细胞/干细胞的方法
公开(公告)号：US20060193826A1
公开(公告)日：2006-08-31
申请号：US11269773
申请日：2005-11-08
申请人： Gary Bridger , Michael Abrams , Geoffrey Henson , Ronald MacFarland , Gary Calandra , Hal Broxmeyer , David Dale
发明人： Gary Bridger , Michael Abrams , Geoffrey Henson , Ronald MacFarland , Gary Calandra , Hal Broxmeyer , David Dale
IPC分类号： A61K38/19 , A61K31/551 , A61K31/33
CPC分类号： A61K31/395 , A61K31/33 , A61K31/4427 , A61K31/496 , A61K31/55 , A61K31/551 , A61K31/555 , A61K35/28 , A61K38/193 , A61K38/195 , A61K2035/124 , C12N5/0647 , A61K2300/00
摘要： Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed. Preferred embodiments of such compounds are of the formula Z-linker-Z′ (1) or pharmaceutically acceptable salt thereof wherein Z is a cyclic polyamine containing 9-32 ring members of which 3-8 are nitrogen atoms, said nitrogen atoms separated from each other by at least 2 carbon atoms, and wherein said heterocycle may optionally contain additional heteroatoms besides nitrogen and/or may be fused to an additional ring system; or Z is of the formula N wherein A comprises a monocyclic or bicyclic fused ring system containing at least one N and B is H or an organic moiety of 1-20 atoms, Z′ may be embodied in a form as defined by Z above, or alternatively may be of the formula —N(R)—(CR2)n—X wherein each R is independently H or straight, branched or cyclic alkyl (1-6C), n is 1 or 2, and X is an aromatic ring, including heteroaromatic rings, or is a mercaptan; “linker” represents a bond, alkylene (1-6C) or may comprise aryl, fused aryl, oxygen atoms contained in an alkylene chain, or may contain keto groups or nitrogen or sulfur atoms.
摘要翻译：公开了使用结合趋化因子受体CXCR4的化合物来提高动物受试者祖细胞和干细胞计数的方法。这些化合物的优选实施方案具有式<？in-line-formula description =“In-line Formulas”end =“lead”？> Z-linker-Z'（1）<？in-line-formula description =“ 其中Z是含有9-32个环成员的环状多胺，其中3-8个是氮原子，所述氮原子彼此分开至少2个碳原子并且其中所述杂环可以任选地含有除氮之外的另外的杂原子和/或可以与另外的环系稠合; 或Z具有式N，其中A包含含有至少一个N的单环或双环稠合环体系，B是H或1-20个原子的有机部分，Z'可以以Z所定义的形式实施，或者可以具有公式<？in-line-formula description =“In-line Formulas”end =“lead”？> - N（R） - （CR 2 2 N）n 其中每个R独立地为H或直链，支链或环状的烷基（1-6C），n为1，其中每个R独立地为H或直链，支链或环状的烷基（1-6C）或2，X是芳环，包括杂芳环，或是硫醇; “接头”表示键，亚烷基（1-6C）或可包含亚烷基链中所含的芳基，稠合芳基，氧原子，或可含有酮基或氮或硫原子。

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