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1. 发明申请

US20100228325A1 SHORT DURATION PRE-PULSING TO REDUCE STIMULATION-EVOKED SIDE-EFFECTS 有权
标题翻译：短暂的预处理可以减少刺激反应的副作用
公开(公告)号：US20100228325A1
公开(公告)日：2010-09-09
申请号：US12782589
申请日：2010-05-18
申请人： Michael A. Moffitt , David K.L. Peterson
发明人： Michael A. Moffitt , David K.L. Peterson
IPC分类号： A61N1/08 , A61N1/36
CPC分类号： A61N1/36128 , A61N1/0553 , A61N1/36017 , A61N1/36071 , A61N1/36164 , A61N1/36167
摘要： A method and neurostimulation system of providing therapy to a patient is provided. At least one electrode is place in contact with tissue of a patient. A sub-threshold, hyperpolarizing, conditioning pre-pulse (e.g., an anodic pulse) is conveyed from the electrode(s) to render a first region of the tissue (e.g., dorsal root fibers) less excitable to stimulation, and a depolarizing stimulation pulse (e.g., a cathodic pulse) is conveyed from the electrode(s) to stimulate a second different region of the tissue (e.g., dorsal column fibers). The conditioning pre-pulse has a relatively short duration (e.g., less than 200 μs).
摘要翻译：提供了向患者提供治疗的方法和神经刺激系统。至少一个电极与患者的组织接触放置。从电极传送亚阈值超极化调理预脉冲（例如阳极脉冲），以使得组织的第一区域（例如，背根根纤维）对刺激不太兴奋，并且去极化刺激脉冲（例如，阴极脉冲）从电极传送以刺激组织的第二不同区域（例如，背部柱状纤维）。调节预脉冲具有相对短的持续时间（例如，小于200μs）。

2. 发明申请

US20080294226A1 SHORT DURATION PRE-PULSING TO REDUCE STIMULATION-EVOKED SIDE-EFFECTS 有权
标题翻译：短暂的预处理可以减少刺激反应的副作用
公开(公告)号：US20080294226A1
公开(公告)日：2008-11-27
申请号：US11752895
申请日：2007-05-23
申请人： Michael A. Moffitt , David K.L. Peterson
发明人： Michael A. Moffitt , David K.L. Peterson
IPC分类号： A61N1/32
CPC分类号： A61N1/36128 , A61N1/0553 , A61N1/36017 , A61N1/36071 , A61N1/36164 , A61N1/36167
摘要： A method and neurostimulation system of providing therapy to a patient is provided. At least one electrode is place in contact with tissue of a patient. A sub-threshold, hyperpolarizing, conditioning pre-pulse (e.g., an anodic pulse) is conveyed from the electrode(s) to render a first region of the tissue (e.g., dorsal root fibers) less excitable to stimulation, and a depolarizing stimulation pulse (e.g., a cathodic pulse) is conveyed from the electrode(s) to stimulate a second different region of the tissue (e.g., dorsal column fibers). The conditioning pre-pulse has a relatively short duration (e.g., less than 200 μs).
摘要翻译：提供了向患者提供治疗的方法和神经刺激系统。至少一个电极与患者的组织接触放置。从电极传送亚阈值超极化调节预脉冲（例如阳极脉冲），以使得组织的第一区域（例如，背根根纤维）对刺激不太兴奋，并且去极化刺激脉冲（例如，阴极脉冲）从电极传送以刺激组织的第二不同区域（例如，背部柱状纤维）。调理预脉冲具有相对较短的持续时间（例如，小于200μA）。

3. 发明申请

US20120290040A1 MANAGEMENT OF STIMULATION SAFETY LIMITS IN A NEUROSTIMULATION SYSTEM 有权
公开(公告)号：US20120290040A1
公开(公告)日：2012-11-15
申请号：US13470328
申请日：2012-05-13
申请人： Michael A. Moffitt , Sridhar Kothandaraman , David K.L. Peterson
发明人： Michael A. Moffitt , Sridhar Kothandaraman , David K.L. Peterson
IPC分类号： A61N1/36
CPC分类号： A61N1/36142 , A61N1/36185 , A61N1/37241
摘要： A neurostimulation system for management of stimulation safety limits. The system determines a tissue charge injection metric at each electrode, compares the metric to the hard stop charge limit, and prevents the neurostimulator from delivering stimulation energy to the tissue region in accordance based on the comparison. The hard stop limit may be user-programmable or may be automatically modified in response to detection of electrode characteristics. The system may quantitatively notify a user of a value of the injected charge injected into the tissue. The electrodes may be organized into different sets, in which case, the system may directly control tissue charge independently at each of the electrode sets. If current steering is provided, the system may displace the electrical stimulation energy along the tissue region in one direction, while preventing the charge injection value at each of the electrodes from meeting or exceeding the hard stop charge limit.

4. 发明申请

US20100268298A1 DEEP BRAIN STIMULATION CURRENT STEERING WITH SPLIT ELECTRODES 有权
标题翻译：深层脑刺激电流转向与分离电极
公开(公告)号：US20100268298A1
公开(公告)日：2010-10-21
申请号：US12761622
申请日：2010-04-16
申请人： Michael A. Moffitt , Thomas A. Oleksyn , Kerry Bradley , David K.L. Peterson , Courtney Lane , Anne Margaret Pianca
发明人： Michael A. Moffitt , Thomas A. Oleksyn , Kerry Bradley , David K.L. Peterson , Courtney Lane , Anne Margaret Pianca
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/0534 , A61N1/20 , A61N1/3606 , A61N1/36082 , A61N1/36182
摘要： A device for brain stimulation includes a lead having a longitudinal surface, a proximal end, a distal end and a lead body. The device also includes a plurality of electrodes disposed along the longitudinal surface of the lead near the distal end of the lead. The plurality of electrodes includes a first set of segmented electrodes comprising at least two segmented electrodes disposed around a circumference of the lead at a first longitudinal position along the lead; and a second set of segmented electrodes comprising at least two segmented electrodes disposed around a circumference of the lead at a second longitudinal position along the lead. The device further includes one or more conductors that electrically couple together all of the segmented electrodes of the first set of segmented electrodes.
摘要翻译：用于脑刺激的装置包括具有纵向表面，近端，远端和引线主体的引线。该装置还包括沿引线的远端附近的铅的纵向表面设置的多个电极。所述多个电极包括第一组分段电极，所述第一组分段电极包括沿着所述引线在第一纵向位置处围绕所述引线的圆周设置的至少两个分段电极; 以及第二组分段电极，其包括在沿着引线的第二纵向位置处围绕引线的圆周设置的至少两个分段电极。该装置还包括一个或多个导体，其将所有第一组分段电极组的所有分段电极电耦合在一起。

5. 发明申请

US20120290038A1 MANAGEMENT OF STIMULATION SAFETY LIMITS IN A NEUROSTIMULATION SYSTEM 审中-公开
公开(公告)号：US20120290038A1
公开(公告)日：2012-11-15
申请号：US13470158
申请日：2012-05-11
申请人： Michael A. Moffitt , Sridhar Kothandaraman , David K.L. Peterson
发明人： Michael A. Moffitt , Sridhar Kothandaraman , David K.L. Peterson
IPC分类号： A61N1/36
CPC分类号： A61N1/36142 , A61N1/36185 , A61N1/37241
摘要： A neurostimulation system for management of stimulation safety limits. The system determines a tissue charge injection metric at each electrode, compares the metric to the hard stop charge limit, and prevents the neurostimulator from delivering stimulation energy to the tissue region in accordance based on the comparison. The hard stop limit may be user-programmable or may be automatically modified in response to detection of electrode characteristics. The system may quantitatively notify a user of a value of the injected charge injected into the tissue. The electrodes may be organized into different sets, in which case, the system may directly control tissue charge independently at each of the electrode sets. If current steering is provided, the system may displace the electrical stimulation energy along the tissue region in one direction, while preventing the charge injection value at each of the electrodes from meeting or exceeding the hard stop charge limit.

6. 发明申请

US20120290039A1 MANAGEMENT OF STIMULATION SAFETY LIMITS IN A NEUROSTIMULATION SYSTEM 有权
标题翻译：神经系统中刺激安全限制的管理
公开(公告)号：US20120290039A1
公开(公告)日：2012-11-15
申请号：US13470326
申请日：2012-05-13
申请人： Michael A. Moffitt , Sridhar Kothandaraman , David K.L. Peterson
发明人： Michael A. Moffitt , Sridhar Kothandaraman , David K.L. Peterson
IPC分类号： A61N1/36
CPC分类号： A61N1/36142 , A61N1/36185 , A61N1/37241
摘要： A neurostimulation system for management of stimulation safety limits. The system determines a tissue charge injection metric at each electrode, compares the metric to the hard stop charge limit, and prevents the neurostimulator from delivering stimulation energy to the tissue region in accordance based on the comparison. The hard stop limit may be user-programmable or may be automatically modified in response to detection of electrode characteristics. The system may quantitatively notify a user of a value of the injected charge injected into the tissue. The electrodes may be organized into different sets, in which case, the system may directly control tissue charge independently at each of the electrode sets. If current steering is provided, the system may displace the electrical stimulation energy along the tissue region in one direction, while preventing the charge injection value at each of the electrodes from meeting or exceeding the hard stop charge limit.
摘要翻译：用于管理刺激安全限值的神经刺激系统。系统确定每个电极处的组织电荷注入度量，将该度量与硬停止电荷限制进行比较，并且根据比较来防止神经刺激器将刺激能量递送至组织区域。硬停止极限可以是用户可编程的，或者可以响应于电极特性的检测而被自动修改。该系统可以定量地向使用者通知注入到组织中的注入电荷的值。电极可以组织成不同的组，在这种情况下，系统可以在每个电极组中独立地直接控制组织电荷。如果提供电流转向，则系统可以沿着一个方向沿着组织区域移位电刺激能量，同时防止每个电极处的电荷注入值达到或超过硬停止充电极限。

7. 发明授权

US09643015B2 Collection of clinical data for graphical representation and analysis 有权
公开(公告)号：US09643015B2
公开(公告)日：2017-05-09
申请号：US13481524
申请日：2012-05-25
申请人： Michael A. Moffitt , John J. Reinhold
发明人： Michael A. Moffitt , John J. Reinhold
IPC分类号： A61N1/36 , A61N1/372
CPC分类号： A61N1/37247 , A61N1/3615 , A61N1/36185 , A61N1/37235 , A61N1/37241 , G06F19/00
摘要： A method of treating a patient and an external programmer for use with a neurostimulator. Electrical stimulation energy is conveyed into tissue of the patient via a specified combination of a plurality of electrodes, thereby creating one or more clinical effects. An influence of the specified electrode combination on the clinical effect(s) is determined. An anatomical region of interest is displayed in registration with a graphical representation of the plurality of electrodes. The displayed anatomical region of interest is modified based on the determined influence of the specified electrode combination on the clinical effect(s).

8. 发明授权

US09358398B2 Collection of clinical data for graphical representation and analysis 有权
标题翻译：收集用于图形表示和分析的临床数据
公开(公告)号：US09358398B2
公开(公告)日：2016-06-07
申请号：US13481497
申请日：2012-05-25
申请人： Michael A. Moffitt , John J. Reinhold
发明人： Michael A. Moffitt , John J. Reinhold
IPC分类号： A61B5/05 , A61N1/372 , A61N1/36
CPC分类号： A61N1/37247 , A61N1/3615 , A61N1/36185 , A61N1/37235 , A61N1/37241 , G06F19/00
摘要： A method of treating a patient and an external programmer for use with a neurostimulator. Electrical stimulation energy is serially conveyed into tissue of the patient via different combinations of electrodes implanted within the patient, thereby creating one or more clinical effects for each of the different electrode combinations. An influence of each of the different electrode combinations on the clinical effect(s) is determined. A graphical indication of the one or more clinical effects is generated based on the determined electrode combination influences. A graphical representation of the electrodes is displayed. The graphical indication of the clinical effect(s) is displayed adjacent the graphical electrode representation, such that a user can view an extent to which each of the different electrode combinations influences the clinical effect(s).
摘要翻译：一种治疗患者和外部程序员以用于神经刺激器的方法。通过植入患者体内的电极的不同组合将电刺激能量连续地输送到患者的组织中，从而为每个不同的电极组合产生一个或多个临床效果。确定每个不同电极组合对临床效果的影响。基于确定的电极组合影响产生一种或多种临床效果的图形指示。显示电极的图形表示。临床效果的图形指示显示在图形电极表示附近，使得用户可以观察每个不同电极组合影响临床效果的程度。

9. 发明授权

US08934979B2 Neurostimulation system for selectively estimating volume of activation and providing therapy 有权
标题翻译：神经刺激系统，用于选择性地估计活化量并提供治疗
公开(公告)号：US08934979B2
公开(公告)日：2015-01-13
申请号：US13336580
申请日：2011-12-23
申请人： Michael A. Moffitt
发明人： Michael A. Moffitt
IPC分类号： A61N1/00 , A61N1/372
CPC分类号： A61N1/36128 , A61N1/0534 , A61N1/36067 , A61N1/37247 , G06F19/00 , G16H40/63
摘要： An external control device, neurostimulation system, and method of programming a neurostimulator. A volume of tissue activation for each of a first one or more candidate stimulation parameter sets is simulated without conveying electrical stimulation energy into the tissue. One of the first candidate stimulation parameter set(s) is selected based on each simulated volume of tissue activation. Electrical stimulation energy is conveyed into the tissue in accordance with a second one or more candidate stimulation parameter sets, wherein the initial one of the second candidate stimulation parameter set(s) is the selected one of the first candidate stimulation parameter set(s). One of the second candidate stimulation parameter set(s) is selected based on a therapeutic efficacy of the electrical stimulation energy conveyed into the tissue. The neurostimulator is programmed with the selected one of the second candidate stimulation parameter set(s).
摘要翻译：外部控制装置，神经刺激系统和神经刺激器编程方法。模拟第一个或多个候选刺激参数组中的每一个的组织激活的体积，而不将电刺激能量输送到组织中。基于每个模拟体积的组织激活来选择第一候选刺激参数组之一。根据第二个一个或多个候选刺激参数组将电刺激能量输送到组织中，其中第二候选刺激参数组中的初始一个是第一候选刺激参数组中选定的一个。基于传递到组织中的电刺激能量的治疗功效来选择第二候选刺激参数组之一。所述神经刺激器用所选择的第二候选刺激参数组中的一个编程。

10. 发明授权

US08688217B2 Method to detect proper lead connection in an implantable stimulation system 失效
标题翻译：在可植入的刺激系统中检测适当引线连接的方法
公开(公告)号：US08688217B2
公开(公告)日：2014-04-01
申请号：US12494043
申请日：2009-06-29
申请人： Daniel Aghassian , Michael A. Moffitt , Christopher B. Gould , Marco Henry Gin , Jordi Parramon
发明人： Daniel Aghassian , Michael A. Moffitt , Christopher B. Gould , Marco Henry Gin , Jordi Parramon
IPC分类号： A61N1/08
CPC分类号： A61N1/37 , A61B2562/227 , A61N1/3752 , A61N2001/083 , G01R31/043 , H01R13/5224 , H01R24/58 , H01R2201/12
摘要： An implantable pulse generator or external trial stimulator for coupling to a lead with a distal end and a proximal end, the lead comprising at least one terminal disposed at the proximal end. The implantable pulse generator comprises a connector for receiving the proximal end of the lead, the connector having at least one contact, and a sensor configured and arranged for detecting electrical connectivity between the implantable pulse generator or external trial stimulator and the lead, the sensor comprising at least one sensor contact, the sensor contact being configured and arranged for electrically coupling to a terminal of the lead and at least one of the contacts of the connector when the lead is fully inserted in the connector and thereby detecting electrical connectivity between the implantable pulse generator or external trial stimulator and the lead.
摘要翻译：一种可植入脉冲发生器或用于与远端和近端耦合到引线的外部试用刺激器，所述引线包括设置在近端的至少一个端子。可植入脉冲发生器包括用于接收引线的近端的连接器，连接器具有至少一个触点，以及配置和布置成用于检测可植入脉冲发生器或外部试用刺激器与引线之间的电连接的传感器，所述传感器包括至少一个传感器触点，所述传感器触头被构造和布置成当所述引线完全插入所述连接器中时电连接到所述引线的端子和所述连接器的至少一个触头，从而检测所述可植入脉冲之间的电连接发电机或外部试用刺激器和铅。

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