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1. 发明申请

US20130045933A1 ALOE-EMODIN DERIVATIVES AND USE THEREOF FOR THE TREATMENT OF CANCER 审中-公开
标题翻译： ALOE-EMODIN衍生物及其用于治疗癌症的方法
公开(公告)号：US20130045933A1
公开(公告)日：2013-02-21
申请号：US13574558
申请日：2011-01-20
申请人： Micha Fridman , Elinor Briner-Goldstein , Zoharia Evron , Michael Frenkel , Ester Flescher
发明人： Micha Fridman , Eliezer Flescher , Elinor Briner-Goldstein , Zoharia Evron , Michael Frenkel
IPC分类号： C07H15/244 , A61P35/04 , A61P35/02 , A61K31/704 , A61P35/00
CPC分类号： C07H15/244 , A61K31/704
摘要： The present invention relates to anthracycline derivatives that are based on an Aloe-emodin (AE) backbone attached to a glycoside (an amino sugar or amino carba-sugar). These derivatives are useful as chemotherapeutic agents. Advantageously, these derivatives are potent cytotoxic agents against a variety of anthracycline-resistant tumors. In addition, they may have reduced cardiotoxicity. As such, the novel compounds of the invention offer an advantage over currently available drugs. The present invention further relates to methods for preparing the novel Aloe-Emodin Glycoside (AEG) based derivatives, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, especially as chemotherapeutic agents for prevention and treatment of cancers.
摘要翻译：本发明涉及基于连接于糖苷（氨基糖或氨基碳糖）的芦荟大黄素（AE）主链的蒽环类衍生物。这些衍生物可用作化学治疗剂。有利地，这些衍生物是针对各种耐蒽环霉素的肿瘤的有效的细胞毒性剂。此外，它们可能具有降低的心脏毒性。因此，本发明的新化合物比目前可用的药物具有优势。本发明还涉及用于制备新型芦荟大黄素苷（AEG）衍生物的方法，包括这些化合物的药物组合物，以及使用这些化合物和组合物，特别是作为预防和治疗癌症的化学治疗剂的方法。

2. 发明申请

US20120232797A1 METHOD AND APPARATUS FOR DETECTING AND MAPPING SUBSURFACE RESISTIVITY ANOMALIES 审中-公开
标题翻译：用于检测和绘制表面电阻异常的方法和装置
公开(公告)号：US20120232797A1
公开(公告)日：2012-09-13
申请号：US13415348
申请日：2012-03-08
申请人： Michael Frenkel , Sofia Davydycheva
发明人： Michael Frenkel , Sofia Davydycheva
IPC分类号： G06F19/00 , G01V3/12 , G06F17/18 , G01V9/00
CPC分类号： G01V3/06
摘要： A method for detecting a subterranean anomaly is provided. The method includes receiving signal data derived from a plurality of transmitters and at least one receiver; calculating a relationship for selected combinations of measurements provided by the signal data; estimating weighting factors for each transmitter, for a condition where there is a substantially equivalent potential across each of the transmitters; applying the weighting factors to the data; and identifying the anomaly in weighted data. Apparatus are also provided.
摘要翻译：提供了一种用于检测地下异常的方法。该方法包括接收从多个发射机和至少一个接收机导出的信号数据; 计算由所述信号数据提供的所选择的测量组合的关系; 估计每个发射机的加权因子，用于在每个发射机之间存在基本上等效的电位的情况; 将加权因子应用于数据; 并识别加权数据中的异常。还提供了装置。

3. 发明申请

US20080133139A1 SYSTEM AND METHOD FOR DETERMINING A MORE ACCURATE RESISTIVITY MODEL OF A GEOLOGICAL FORMATION USING TIME-LAPSE WELL LOGGING DATA 有权
标题翻译：使用时间差的井记录数据确定地质构造更准确的电阻率模型的系统和方法
公开(公告)号：US20080133139A1
公开(公告)日：2008-06-05
申请号：US11943689
申请日：2007-11-21
申请人： Michael Frenkel
发明人： Michael Frenkel
IPC分类号： G01V3/20 , G01V3/32 , G01V3/18
CPC分类号： G01V3/32
摘要： A system and a method for estimating a model of a geological formation are provided. The geological formation has a wellbore extending therethrough. The method includes obtaining a first resistivity log associated with the geological formation from a LWD sensor in the wellbore. The method further includes obtaining a second resistivity log associated with the geological formation from a WL sensor in the wellbore. The method further includes calculating a plurality of horizontal resistivity values associated with the geological formation by utilizing a first inversion technique and the first resistivity log. The method further includes obtaining a plurality of invaded zone resistivity values obtained from a micro-resistivity measurement device in the WL sensor. The method further includes calculating a plurality of invaded zone thickness values proximate the wellbore by utilizing a second inversion technique and the second resistivity log.
摘要翻译：提供了一种用于估计地质构造模型的系统和方法。地质构造具有延伸穿过其中的井眼。该方法包括从井眼中的LWD传感器获得与地质构造相关联的第一电阻率测井。该方法还包括从井眼中的WL传感器获得与地质构造相关联的第二电阻率测井。该方法还包括通过利用第一反演技术和第一电阻率测井来计算与地质构造相关联的多个水平电阻率值。该方法还包括获得从WL传感器中的微电阻率测量装置获得的多个入侵区电阻率值。该方法还包括通过利用第二反演技术和第二电阻率测井来计算靠近井筒的多个入侵区厚度值。

4. 发明授权

US08116979B2 System and method for determining a more accurate resistivity model of a geological formation using time-lapse well logging data 有权
标题翻译：使用定时测井数据确定地质构造更准确的电阻率模型的系统和方法
公开(公告)号：US08116979B2
公开(公告)日：2012-02-14
申请号：US11943689
申请日：2007-11-21
申请人： Michael Frenkel
发明人： Michael Frenkel
IPC分类号： G01V1/50 , G01V1/40 , G01V1/52 , G06F3/01
CPC分类号： G01V3/32
摘要： A system and a method for estimating a model of a geological formation are provided. The geological formation has a wellbore extending therethrough. The method includes obtaining a first resistivity log associated with the geological formation from a LWD sensor in the wellbore. The method further includes obtaining a second resistivity log associated with the geological formation from a WL sensor in the wellbore. The method further includes calculating a plurality of horizontal resistivity values associated with the geological formation by utilizing a first inversion technique and the first resistivity log. The method further includes obtaining a plurality of invaded zone resistivity values obtained from a micro-resistivity measurement device in the WL sensor. The method further includes calculating a plurality of invaded zone thickness values proximate the wellbore by utilizing a second inversion technique and the second resistivity log.
摘要翻译：提供了一种用于估计地质构造模型的系统和方法。地质构造具有延伸穿过其中的井眼。该方法包括从井眼中的LWD传感器获得与地质构造相关联的第一电阻率测井。该方法还包括从井眼中的WL传感器获得与地质构造相关联的第二电阻率测井。该方法还包括通过利用第一反演技术和第一电阻率测井来计算与地质构造相关联的多个水平电阻率值。该方法还包括获得从WL传感器中的微电阻率测量装置获得的多个入侵区电阻率值。该方法还包括通过利用第二反演技术和第二电阻率测井来计算靠近井筒的多个入侵区厚度值。

5. 发明授权

US5870690A Joint inversion processing method for resistivity and acoustic well log data 失效
标题翻译：电阻率和声测井数据联合反演处理方法
公开(公告)号：US5870690A
公开(公告)日：1999-02-09
申请号：US794896
申请日：1997-02-05
申请人： Michael Frenkel , Alberto G. Mezzatesta , Kurt-M. Strack , Xiaoming Tang , Keeva Vozoff
发明人： Michael Frenkel , Alberto G. Mezzatesta , Kurt-M. Strack , Xiaoming Tang , Keeva Vozoff
IPC分类号： G01V1/48 , G01V11/00 , G06F17/10 , G06F19/00
CPC分类号： G06F17/10 , G01V1/48 , G01V11/00
摘要： A method of joint inversion processing acoustic velocity and electrical resistivity well log data. The method includes generating an initial model of earth formations over an interval of interest. The initial model corresponds to earth formations for which the acoustic velocity and resistivity well log data have been measured. The initial model includes layers each having a geometry, a value of resistivity and a value of acoustic velocity. Acoustic velocity and resistivity data are synthesized based on the initial model. Differences are determined between the synthesized data and the measured data. The initial model is adjusted and the steps of synthesizing the log data and determining the differences are repeated until the differences reach a minimum, thereby generating a final model of the earth formations. The step of adjusting includes determining a coupling relationship between the acoustic velocity and the resistivity for the earth formations, and generating an inverse Jacobian matrix of sensitivity functions of the resistivity and acoustic velocity with respect to the geometry and the coupling relationship.
摘要翻译：一种联合反演处理声速和电阻率测井数据的方法。该方法包括在感兴趣的间隔内产生地层的初始模型。初始模型对应于测量声速和电阻率测井数据的地层。初始模型包括各自具有几何形状，电阻值和声速值的层。基于初始模型合成声速和电阻率数据。在合成数据和测量数据之间确定差异。调整初始模型，并重复合成对数数据和确定差异的步骤，直到差异达到最小值，从而生成地层的最终模型。调整步骤包括确定声速和地层的电阻率之间的耦合关系，以及生成相对于几何形状和耦合关系的电阻率和声速的灵敏度函数的逆雅可比矩阵。

6. 发明申请

US20070083330A1 Fast method for reconstruction of 3D formation rock properties using modeling and inversion of well-logging data 审中-公开
标题翻译：使用测井数据建模和反演重建3D地层岩性的快速方法
公开(公告)号：US20070083330A1
公开(公告)日：2007-04-12
申请号：US11540372
申请日：2006-09-29
申请人： Michael Frenkel
发明人： Michael Frenkel
IPC分类号： G01V3/18
CPC分类号： G01V3/20
摘要： A method and apparatus for interpretation of well log data. An inversion of the data is carried out using a sequence of short window inversions.
摘要翻译：用于解释测井数据的方法和装置。使用短窗口反转序列来进行数据的反转。

7. 发明申请

US20060095239A1 Multiscale multidimensional well log data inversion and deep formation imaging method 有权
标题翻译：多尺度多维测井数据反演和深层成像方法
公开(公告)号：US20060095239A1
公开(公告)日：2006-05-04
申请号：US11266537
申请日：2005-11-03
申请人： Michael Frenkel
发明人： Michael Frenkel
IPC分类号： G06G7/56
CPC分类号： G01V1/40 , G01V3/28
摘要： Different subsets of multiarray resistivity measurements are inverted using a corresponding resistivity model. The models are selected based at least in part on the resolution of the measurements. Results of the inversion are combined to give a single model consistent with the resolution and depth of penetration of each subset of the multiarray data.
摘要翻译：使用相应的电阻率模型反转不同的多阵列电阻率测量子集。至少部分地基于测量的分辨率选择模型。将反演的结果组合以给出与多阵列数据的每个子集的分辨率和穿透深度一致的单个模型。

8. 发明授权

US06411798B1 Method of assigning frequencies for use during wireless system drive testing 有权
标题翻译：在无线系统驱动测试期间分配使用频率的方法
公开(公告)号：US06411798B1
公开(公告)日：2002-06-25
申请号：US09321864
申请日：1999-05-28
申请人： Michael Frenkel , Chang Yu , Valery Budiansky
发明人： Michael Frenkel , Chang Yu , Valery Budiansky
IPC分类号： H04Q736
CPC分类号： H04W16/18 , H04W24/00 , H04W28/16
摘要： An automated method of assigning frequencies to sectors of a wireless telecommunications system for use during a drive test calculates a usage factor for each frequency that is assigned to the system to be tested. The usage factor for a particular frequency is equal to the number of sectors of the system to be tested to which the particular frequency is assigned. The method selects a sector and selects the frequency assigned to the selected sector with the smallest usage factor. The method keys up the selected frequency in the selected sector and keys down that frequency and the adjacent frequencies in each of the other sectors of the system to be tested. The method continues the foregoing sequence of steps until a unique frequency has been keyed up for each sector in the system to be tested.
摘要翻译：将频率分配给无线电信系统的扇区以在驱动测试期间使用的自动化方法计算分配给要测试的系统的每个频率的使用因子。特定频率的使用系数等于要分配特定频率的待测系统的扇区数。该方法选择扇区并选择分配给具有最小使用因子的所选扇区的频率。该方法将所选择的扇区中的所选择的频率按下，并按下该频率和要测试的系统的每个其它扇区中的相邻频率。该方法继续前述的步骤顺序，直到为了要测试的系统中的每个扇区键入唯一的频率。

9. 发明授权

US07324898B2 System and method for determining a more accurate resistivity model of a geological formation using time-lapse well logging data 有权
标题翻译：使用定时测井数据确定地质构造更准确的电阻率模型的系统和方法
公开(公告)号：US07324898B2
公开(公告)日：2008-01-29
申请号：US11075471
申请日：2005-03-09
申请人： Michael Frenkel
发明人： Michael Frenkel
IPC分类号： G01V5/04 , G06F7/48
CPC分类号： G01V3/38
摘要： A system and a method for estimating a model of a geological formation are provided. The geological formation has a wellbore extending therethrough. The method includes obtaining a first resistivity log associated with the geological formation from a LWD sensor in the wellbore. The method further includes obtaining a second resistivity log associated with the geological formation from a WL sensor in the wellbore. The method further includes calculating a plurality of horizontal resistivity values associated with the geological formation by utilizing a first inversion technique and the first resistivity log. The method further includes obtaining a plurality of invaded zone resistivity values obtained from a micro-resistivity measurement device in the WL sensor. The method further includes calculating a plurality of invaded zone thickness values proximate the wellbore by utilizing a second inversion technique and the second resistivity log.
摘要翻译：提供了一种用于估计地质构造模型的系统和方法。地质构造具有延伸穿过其中的井眼。该方法包括从井眼中的LWD传感器获得与地质构造相关联的第一电阻率测井。该方法还包括从井眼中的WL传感器获得与地质构造相关联的第二电阻率测井。该方法还包括通过利用第一反演技术和第一电阻率测井来计算与地质构造相关联的多个水平电阻率值。该方法还包括获得从WL传感器中的微电阻率测量装置获得的多个入侵区电阻率值。该方法还包括通过利用第二反演技术和第二电阻率测井来计算靠近井筒的多个入侵区厚度值。

10. 发明申请

US20060217888A1 System and method for determining a more accurate resistivity model of a geological formation using time-lapse well logging data 有权
标题翻译：使用定时测井数据确定地质构造更准确的电阻率模型的系统和方法
公开(公告)号：US20060217888A1
公开(公告)日：2006-09-28
申请号：US11075471
申请日：2005-03-09
申请人： Michael Frenkel
发明人： Michael Frenkel
IPC分类号： G01V9/00 , G06F19/00
CPC分类号： G01V3/38
摘要： A system and a method for estimating a model of a geological formation are provided. The geological formation has a wellbore extending therethrough. The method includes obtaining a first resistivity log associated with the geological formation from a LWD sensor in the wellbore. The method further includes obtaining a second resistivity log associated with the geological formation from a WL sensor in the wellbore. The method further includes calculating a plurality of horizontal resistivity values associated with the geological formation by utilizing a first inversion technique and the first resistivity log. The method further includes obtaining a plurality of invaded zone resistivity values obtained from a micro-resistivity measurement device in the WL sensor. The method further includes calculating a plurality of invaded zone thickness values proximate the wellbore by utilizing a second inversion technique and the second resistivity log.
摘要翻译：提供了一种用于估计地质构造模型的系统和方法。地质构造具有延伸穿过其中的井眼。该方法包括从井眼中的LWD传感器获得与地质构造相关联的第一电阻率测井。该方法还包括从井眼中的WL传感器获得与地质构造相关联的第二电阻率测井。该方法还包括通过利用第一反演技术和第一电阻率测井来计算与地质构造相关联的多个水平电阻率值。该方法还包括获得从WL传感器中的微电阻率测量装置获得的多个入侵区电阻率值。该方法还包括通过利用第二反演技术和第二电阻率测井来计算靠近井筒的多个入侵区厚度值。

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