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1. 发明授权

US4501919A Process for the production of serine derivatives 失效
标题翻译：生产丝氨酸衍生物的方法
公开(公告)号：US4501919A
公开(公告)日：1985-02-26
申请号：US152447
申请日：1980-05-22
申请人： Melvin V. Koch , Ambrogio Magni
发明人： Melvin V. Koch , Ambrogio Magni
IPC分类号： C07B41/02 , B01J31/02 , C07B31/00 , C07B61/00 , C07C67/00 , C07C227/16 , C07C229/22 , C07C229/36 , C07C255/59 , C07C51/353
CPC分类号： C07C227/16
摘要： Serine derivatives are synthesized by the condensation of an alkali metal salt of a glycine derivative and a carbonyl compound in the presence of a phase transfer catalyst.
摘要翻译：丝氨酸衍生物在相转移催化剂存在下，通过甘氨酸衍生物的碱金属盐与羰基化合物的缩合而合成。

2. 发明授权

US4824885A Process of (co) polymerization of alpha-olefins in the presence of antioxidants 失效
标题翻译：在抗氧化剂存在下，α-烯烃（共）聚合的方法
公开(公告)号：US4824885A
公开(公告)日：1989-04-25
申请号：US70179
申请日：1987-07-06
申请人： Ambrogio Magni , Erik Bersanetti
发明人： Ambrogio Magni , Erik Bersanetti
IPC分类号： C08F10/00 , C08K5/524 , C08K5/527 , C08K5/5333 , C08K5/52 , C08K5/53
CPC分类号： C08K5/527 , C08F10/00 , C08K5/524 , C08K5/5333
摘要： Stabilizers for organic polymers, consisting of one or more phosphorus-containing compounds of the family of alkyl- and/or phenyl-phosphites, alkyl- and/or phenyl-phosphonites, alkyl- and/or phenyl-diphosphonites, are directly added to the reaction mixture during the (co)polymerization of .alpha.-olefins or of mixtures thereof with other unsaturated monomers.The so-obtained polymeric compositions result perfectly stabilized, and show a thermo-oxidative resistance higher than that of the same polymeric compositions to which the same antioxidants have been added by a traditional route.
摘要翻译：由一种或多种烷基和/或苯基亚磷酸酯，烷基和/或苯基 - 亚膦酸酯，烷基和/或苯基 - 二膦酸酯的一种或多种含磷化合物组成的有机聚合物稳定剂直接加入到在α-烯烃或其混合物与其它不饱和单体的（共）聚合期间的反应混合物。如此获得的聚合物组合物完全稳定，并且显示比通过传统途径添加相同抗氧化剂的相同聚合物组合物的热氧化抗性更高。

3. 发明授权

US5767112A Muscle relaxant pharmaceutical compositions 失效
标题翻译：肌肉松弛药物组合物
公开(公告)号：US5767112A
公开(公告)日：1998-06-16
申请号：US586088
申请日：1996-01-16
申请人： Stefano Poli , Tiziano Crimella , Ambrogio Magni , Luigi Moro
发明人： Stefano Poli , Tiziano Crimella , Ambrogio Magni , Luigi Moro
IPC分类号： A61K9/127 , A61K9/19 , A61K31/58 , A61K47/18
CPC分类号： A61K9/0019 , A61K31/58 , A61K47/183 , A61K9/127 , A61K9/19
摘要： The invention relates to pharmaceutical compositions for parenteral administration. The compositions comprise an amount of neuromuscular blocking agent effective to produce muscular relaxation, and at least one zwitterionic substance having an isoionic point not greater than 7. The zwitterionic substance is present in an amount of between about 2 and about 30 percent by weight, based on the weight of the composition. The resulting composition has a pH of less than 7.
摘要翻译：本发明涉及用于肠胃外给药的药物组合物。组合物包含一定量的有效产生肌肉松弛的神经肌肉阻滞剂，以及至少一种具有不大于7的等离子点的两性离子物质。所述两性离子物质的存在量为约2重量％至约30重量％关于组合物的重量。所得组合物的pH值小于7。

4. 发明授权

US4868338A Method for acylating a naphthalene compound 失效
标题翻译：酰化萘化合物的方法
公开(公告)号：US4868338A
公开(公告)日：1989-09-19
申请号：US165704
申请日：1988-03-08
申请人： Ambrogio Magni , Giuseppina Visentin
发明人： Ambrogio Magni , Giuseppina Visentin
IPC分类号： C07D233/84 , B01J27/125 , B01J27/135 , B01J27/138 , C07B61/00 , C07C45/00 , C07C45/46 , C07C49/84 , C07C67/00 , C07C67/035 , C07C67/08 , C07C67/10 , C07C67/24 , C07C301/00 , C07C301/02 , C07C303/22
CPC分类号： C07C45/46 , C07C49/84
摘要： The acylation of a naphthalene compound, substituted in the 2-position with an electron-donating group, with a reactive derivative of a lower aliphatic acid, in an aprotic organic diluent and in the presence of a Friedel Crafts catalyst consisting of a halide of an element having at least two valences, is improved when maintaining constant at any time the molar ratio of the naphthalene compound to the acylating agent and that of the acylating agent to the Friedel Crafts catalyst within specific ranges.

5. 发明授权

US6090957A Process for preparing neuromuscular blocking agents and intermediates useful therefor 有权
标题翻译：制备神经肌肉阻滞剂及其有用的中间体的方法
公开(公告)号：US6090957A
公开(公告)日：2000-07-18
申请号：US165242
申请日：1998-10-01
申请人： Ambrogio Magni , Paride Grisenti
发明人： Ambrogio Magni , Paride Grisenti
IPC分类号： C07J11/00 , C07J31/00 , C07J43/00 , C07J71/00
CPC分类号： C07J43/003 , C07J11/00 , C07J31/006 , C07J71/001
摘要： The present invention provides new process of preparing neuromuscular blocking agents. The process include preparing neuromuscular blocking agents using the compounds of formula I: ##STR1## wherein R.sub.1 is=O and X is halo; and formula II: ##STR2## wherein R, and X are as defined above.
摘要翻译：本发明提供了制备神经肌肉阻滞剂的新方法。该方法包括使用式I化合物制备神经肌肉阻滞剂：其中R 1为= O且X为卤素; 和式II：其中R和X如上所定义。

6. 发明授权

US5175247A Method for removing AlCl.sub.3 -based catalyst residues from polymer mixtures 失效
标题翻译：从聚合物混合物中去除基于ALCL3的催化剂残留物的方法
公开(公告)号：US5175247A
公开(公告)日：1992-12-29
申请号：US562513
申请日：1990-08-03
申请人： Ambrogio Magni , Attilio Sioli
发明人： Ambrogio Magni , Attilio Sioli
IPC分类号： C08F6/08 , C08F6/02 , C08F6/06
CPC分类号： C08F6/02
摘要： A method is described for removing catalyst residues comprising AlCl.sub.3 and/or its complexes from polymer products deriving from the (co)polymerization of olefinic cuts, the method comprising bringing the polymerized mass into contact with organometallic compounds, treating the resultant mixture with water or with aqueous acid or basic solutions, and separating the organic phase, which is substantially free of inorganic residues.
摘要翻译：描述了一种从烯烃切割的（共）聚合衍生的聚合物产物中除去包含AlCl 3和/或其络合物的催化剂残留物的方法，该方法包括使聚合的物质与有机金属化合物接触，用水或与酸或碱性溶液，并分离基本上不含无机残留物的有机相。

7. 发明授权

US4661470A Ester derivatives of antibiotic L 17046 失效
公开(公告)号：US4661470A
公开(公告)日：1987-04-28
申请号：US797295
申请日：1985-11-12
申请人： Adriano Malabarba , Ambrogio Magni , Paolo Strazzolini , Bruno Cavalleri , Aldo Trani
发明人： Adriano Malabarba , Ambrogio Magni , Paolo Strazzolini , Bruno Cavalleri , Aldo Trani
IPC分类号： A61K38/00 , A61P31/04 , C07K1/113 , C07K9/00 , C07K14/195 , C07K14/41 , A61K37/02 , C07K5/12
CPC分类号： C07K9/008 , Y10S930/19
摘要： The present invention is directed to ester derivatives at the carboxylic function of the glycopeptidic antibiotic substance called antibiotic L 17046 with antimicrobial activity mainly against gram-positive bacteria.

8. 发明授权

US06043368A Method of making thieno-pyridine derivatives 失效
标题翻译：制备噻吩并吡啶衍生物的方法
公开(公告)号：US06043368A
公开(公告)日：2000-03-28
申请号：US707658
申请日：1996-09-04
申请人： Ambrogio Magni , Giovanni Signorelli
发明人： Ambrogio Magni , Giovanni Signorelli
IPC分类号： C07D495/04 , C07D333/14
CPC分类号： C07D495/04
摘要： The present invention provides a method of preparing thieno[3,2-c]pyridine derivatives of formula I: ##STR1## wherein R.sub.1 is selected from the group consisting of lower alkyl; lower alkylene phenyl; substituted lower alkylene phenyl wherein the phenyl is substituted from 1 to 3 times with lower alkyl, lower alkoxy, lower acyloxy, hydroxy, nitro and halo; lower alkylene naphthyl, lower alkylene thienyl; lower alkylene diphenyl; lower alkylene-hydroxy-phenyl; substituted lower alkylene-hydroxy-phenyl wherein the phenyl is substituted from 1 to 3 times with lower alkyl, lower alkoxy, lower acyloxy, hydroxy, nitro, and halo; lower alkylene-hydroxy-naphthyl; lower alkylene-hydroxy-thienyl; lower alkylene-hydroxy-diphenyl, and R.sub.2 is H or lower alkylene. The method comprises reacting a compound of a formula II: ##STR2## with a cyclic dioxy or cyclic dithio in the presence of catalyst.
摘要翻译：本发明提供制备式I的噻吩并[3,2-c]吡啶衍生物的方法：其中R 1选自低级烷基; 低级亚烷基苯基; 取代的低级亚烷基苯基，其中苯基与低级烷基，低级烷氧基，低级酰氧基，羟基，硝基和卤素取代1至3倍; 低级亚烷基萘基，低级亚烷基噻吩基; 低级亚烷基二苯基; 低级亚烷基 - 羟基苯基; 取代的低级亚烷基 - 羟基 - 苯基，其中苯基与低级烷基，低级烷氧基，低级酰氧基，羟基，硝基和卤素取代1〜3倍。低级亚烷基 - 羟基 - 萘基; 低级亚烷基 - 羟基 - 噻吩基; 低级亚烷基 - 羟基 - 二苯基，R 2为H或低级亚烷基。该方法包括在催化剂存在下使式II化合物与环状二氧基或环状二硫基反应。

9. 发明授权

US5986142A Process for preparing bicycloheptanamine compounds 失效
标题翻译：制备双环庚胺化合物的方法
公开(公告)号：US5986142A
公开(公告)日：1999-11-16
申请号：US935812
申请日：1997-09-23
申请人： Ambrogio Magni , Giovanni Signorelli
发明人： Ambrogio Magni , Giovanni Signorelli
IPC分类号： C07C209/62 , C07C211/38 , C07C211/34
CPC分类号： C07C209/62 , C07C2102/42
摘要： The present invention provides a process for preparing compounds of Formula I: ##STR1## wherein R.sub.1 is methyl by reduction of a camphene intermediate with a reducing agent.
摘要翻译：本发明提供了制备式I化合物的方法：其中R 1是通过用还原剂还原阮内酯的甲基。

10. 发明授权

US5817803A Process for preparing neuromuscular blocking agents and intermediates useful therefor 失效
公开(公告)号：US5817803A
公开(公告)日：1998-10-06
申请号：US761631
申请日：1996-12-06
申请人： Ambrogio Magni , Paride Grisenti
发明人： Ambrogio Magni , Paride Grisenti
IPC分类号： C07J11/00 , C07J31/00 , C07J43/00 , C07J71/00
CPC分类号： C07J43/003 , C07J11/00 , C07J31/006 , C07J71/001
摘要： The present invention provides new process of preparing neuromuscular blocking agents. The process include preparing neuromuscular blocking agents using the compounds of formula I: ##STR1## wherein R.sub.1 is .dbd.O and X is halo; and formula II: ##STR2## wherein R.sub.1 and X are as defined above.

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