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1. 发明申请

US20130260452A1 Methods For The Cryopreservation Of Mammalian Cells 审中-公开
标题翻译：哺乳动物细胞冷冻保存方法
公开(公告)号：US20130260452A1
公开(公告)日：2013-10-03
申请号：US13501381
申请日：2010-10-18
申请人： Mehmet Toner , Heidi Y. Elmoazzen , Thomas L. Toth , Yunseok Heo , Ho-Joon Lee , Nilay Chakraborty
发明人： Mehmet Toner , Heidi Y. Elmoazzen , Thomas L. Toth , Yunseok Heo , Ho-Joon Lee , Nilay Chakraborty
IPC分类号： G01N1/42
CPC分类号： C12N1/04 , A01N1/0268 , A01N1/0284 , G01N1/42
摘要： Manufactured capillary tubes can include: a tubular member; and a coating applied partially covering the tubular member, the coating defining a window where the tubular member is free of the coating. Kits containing and methods related to the capillary tubes can be used for the cryopreservation of cells.
摘要翻译：制造的毛细管可以包括：管状构件; 以及部分地覆盖管状构件的涂层，该涂层限定一个窗口，其中管状构件没有涂层。包含的试剂盒和与毛细管有关的方法可用于细胞的低温保存。

2. 发明授权

US09538745B2 Methods for the cryopreservation of cells 有权
标题翻译：细胞冷冻保存方法
公开(公告)号：US09538745B2
公开(公告)日：2017-01-10
申请号：US12226300
申请日：2007-04-12
申请人： Xiaoming He , Thomas L. Toth , Mehmet Toner , Jon Edd
发明人： Xiaoming He , Thomas L. Toth , Mehmet Toner , Jon Edd
IPC分类号： A01N1/02
CPC分类号： A01N1/02 , A01N1/0221 , A01N1/0268 , A01N1/0278
摘要： The present invention features novel methods for the cryopreservation of mammalian cell that combine the advantages of the slow-freezing and vitrification approaches while avoiding their shortcomings. Generally, the methods include the use of a capillary tube made of a thermally conductive wall material and a thin wall such that the ratio of the thermal conductivity of the wall material to the wall thickness is at least 1,000-500,000. The solution is then exposed to temperatures equal to or less than −80° C. and the vitrification solution containing the mammalian cells is cooled at a rate equal to or greater than 30,000-100,000,000° C./minute. The exposure of the capillary tube with a thermally conductive and thin wall allows for vitrification of the solution in the absence of ice formation. Cryoprotectants can also be added to the vitrification solution to further prevent ice formation.
摘要翻译：本发明的特征在于用于冷冻保存哺乳动物细胞的新方法，其结合了缓慢冷冻和玻璃化方法的优点，同时避免了它们的缺点。通常，这些方法包括使用由导热壁材料制成的毛细管和薄壁，使得壁材料的导热率与壁厚之比至少为1,000-500,000。然后将溶液暴露于等于或小于-80℃的温度，并将含有哺乳动物细胞的玻璃化溶液以等于或大于30,000-10000,000℃/分钟的速率冷却。毛细管与导热和薄壁的接触允许在没有冰层形成的情况下玻璃化溶液。也可以将冷冻保护剂加入到玻璃化溶液中以进一步防止冰层形成。

3. 发明申请

US20090305224A1 Methods for the Cryopreservation of Mammalian Cells 有权
标题翻译：哺乳动物细胞冷冻保存方法
公开(公告)号：US20090305224A1
公开(公告)日：2009-12-10
申请号：US12226300
申请日：2007-04-12
申请人： Xiaoming He , Thomas L. Toth , Mehmet Toner , Jon Edd
发明人： Xiaoming He , Thomas L. Toth , Mehmet Toner , Jon Edd
IPC分类号： A01N1/02 , C12N5/02
CPC分类号： A01N1/02 , A01N1/0221 , A01N1/0268 , A01N1/0278
摘要： The present invention features novel methods for the cryopreservation of mammalian cell that combine the advantages of the slow-freezing and vitrification approaches while avoiding their shortcomings. Generally, the methods include the use of a capillary tube made of a thermally conductive wall material and a thin wall such that the ratio of the thermal conductivity of the wall material to the wall thickness is at least 1,000-500,000. The solution is then exposed to temperatures equal to or less than −80° C. and the vitrification solution containing the mammalian cells is cooled at a rate equal to or greater than 30,000-100,000,000° C./minute. The exposure of the capillary tube with a thermally conductive and thin wall allows for vitrification of the solution in the absence of ice formation. Cryoprotectants can also be added to the vitrification solution to further prevent ice formation.
摘要翻译：本发明的特征在于用于冷冻保存哺乳动物细胞的新方法，其结合了缓慢冷冻和玻璃化方法的优点，同时避免了它们的缺点。通常，这些方法包括使用由导热壁材料制成的毛细管和薄壁，使得壁材料的导热率与壁厚之比至少为1,000-500,000。然后将溶液暴露于等于或小于-80℃的温度，并将含有哺乳动物细胞的玻璃化溶液以等于或大于30,000-10000,000℃/分钟的速率冷却。毛细管与导热和薄壁的接触允许在没有冰层形成的情况下玻璃化溶液。也可以将冷冻保护剂加入到玻璃化溶液中以进一步防止冰层形成。

4. 发明授权

US08199875B2 System and method of acquiring multi-energy CT imaging data 有权
标题翻译：获取多能CT成像数据的系统和方法
公开(公告)号：US08199875B2
公开(公告)日：2012-06-12
申请号：US12760862
申请日：2010-04-15
申请人： Naveen Chandra , Xiaoye Wu , Thomas L. Toth , Jiang Hsieh
发明人： Naveen Chandra , Xiaoye Wu , Thomas L. Toth , Jiang Hsieh
IPC分类号： A61B6/00
CPC分类号： A61B6/4035 , A61B6/032 , A61B6/4007 , A61B6/405 , A61B6/4241 , A61B6/482
摘要： A CT system includes a rotatable gantry having an opening for receiving an object to be scanned, and a controller configured to apply a first kVp for a first time period, apply a second kVp for a second time period, wherein the second time period is different from the first time period, acquire a first asymmetric view dataset during at least a portion of the first time period, acquire a second asymmetric view dataset during at least a portion of the second time period, and generate an image using the acquired first and second asymmetric view datasets.
摘要翻译： CT系统包括具有用于接收待扫描物体的开口的可旋转机架，以及被配置为在第一时间段施加第一kVp的控制器，在第二时间段施加第二kVp，其中第二时间段是不同的从所述第一时间段在所述第一时间段的至少一部分期间获取第一非对称视图数据集，在所述第二时间段的至少一部分期间获取第二非对称视图数据集，并且使用所获取的第一和第二时间段生成图像非对称视图数据集。

5. 发明授权

US07436933B2 Method of manufacturing, and a collimator mandrel having variable attenuation characteristics for a CT system 有权
标题翻译：具有可变衰减特性的CT系统的制造方法和准直器心轴
公开(公告)号：US07436933B2
公开(公告)日：2008-10-14
申请号：US11836337
申请日：2007-08-09
申请人： Rowland Saunders , Steven G. Ross , Thomas L. Toth
发明人： Rowland Saunders , Steven G. Ross , Thomas L. Toth
IPC分类号： G21K1/02
CPC分类号： G21K1/04 , G21K1/02
摘要： A method of manufacturing a collimator mandrel having variable attenuation characteristics is presented. The manufacturing process includes the placement of a layer of attenuating material on a core of base material. The layer of attenuating material is relatively thin and varies in thickness circumferentially around the core. The collimator mandrel may be manufactured by placing a cast about a core of non-attenuating material, filling a void between the cast and the core with an attenuating material, allowing the material to cure, and removing the cast from the assembly.
摘要翻译：提出了一种制造具有可变衰减特性的准直器心轴的方法。制造工艺包括将一层衰减材料放置在基材的芯上。衰减材料层相对较薄并且在芯周向周向地变化。可以通过将铸件围绕非衰减材料的芯放置在铸件和芯之间的空隙中，并用衰减材料来制造准直器心轴，从而允许材料固化，以及从组件移除铸件。

6. 发明授权

US07068750B2 System and method of x-ray flux management control 有权
标题翻译： x射线通量管理控制系统与方法
公开(公告)号：US07068750B2
公开(公告)日：2006-06-27
申请号：US10765582
申请日：2004-01-27
申请人： Thomas L. Toth , David M. Hoffman
发明人： Thomas L. Toth , David M. Hoffman
IPC分类号： A61B6/03 , G21K3/00
CPC分类号： A61B6/032 , A61B6/4035 , A61B6/4241 , A61B6/4488 , A61B6/469 , A61B6/488 , A61B6/544 , A61B6/583
摘要： A system and method of diagnostic imaging is provided that includes determining a position of a subject in a scanning bay and tailoring x-ray attenuation such that the specific position of the subject is taken into consideration. The present invention automatically selects a proper attenuation filter configuration, corrects patient centering, and corrects noise prediction errors, thereby increasing dose efficiency and tube output.
摘要翻译：提供了诊断成像的系统和方法，其包括确定扫描间隔中的对象的位置并调整x射线衰减，使得考虑对象的特定位置。本发明自动选择适当的衰减滤波器配置，校正患者居中，并且校正噪声预测误差，从而提高剂量效率和管输出。

7. 发明授权

US06310938B1 Methods and apparatus for calibrating CT x-ray beam tracking loop 有权
标题翻译：用于校准CT X射线束跟踪循环的方法和装置
公开(公告)号：US06310938B1
公开(公告)日：2001-10-30
申请号：US09384937
申请日：1999-08-27
申请人： Thomas L. Toth , George E. Seidenschnur , Neil B. Bromberg
发明人： Thomas L. Toth , George E. Seidenschnur , Neil B. Bromberg
IPC分类号： G21K100
CPC分类号： A61B6/583 , A61B6/4021 , G01N23/046 , G01N2223/419 , G01N2223/612
摘要： The present invention is, in one embodiment, a method for determining tracking control parameters for positioning an x-ray beam of a computed tomography imaging system having a movable collimator positionable in steps and a detector array including a plurality of rows of detector elements. The method includes steps of obtaining detector samples at a series of collimator step positions while determining a position of a focal spot of the x-ray beam; determining a beam position for each detector element at each collimator step utilizing the determined focal spot positions, a nominal focal spot length, and geometric parameters of the x-ray beam, collimator, and detector array; and determining a calibration parameter utilizing information so obtained. For example, in determining a target beam position at which to maintain the x-ray beam, a detector element differential error is determined according to ratios of successive collimator step positions; and a target beam position is selected for an isocenter element in accordance with the determined element differential errors.
摘要翻译：本发明在一个实施例中是一种用于确定跟踪控制参数的方法，所述跟踪控制参数用于定位具有可定位的可移动准直器的计算机断层摄影成像系统的X射线束和包括多行检测器元件的检测器阵列。该方法包括以下步骤：在确定X射线束的焦斑的位置的同时在一系列准直器步骤位置获得检测器样本; 使用所确定的焦点位置，标称焦点长度以及x射线束，准直仪和检测器阵列的几何参数来确定每个准直器步骤处的每个检测器元件的光束位置; 以及使用如此获得的信息来确定校准参数。例如，在确定维持X射线束的目标光束位置时，根据连续的准直仪台阶位置的比例来确定检测器元件差分误差; 并且根据确定的元件微分误差为等角点元件选择目标光束位置。

8. 发明授权

US06266434B1 Methods and apparatus for reducing spectral artifacts in a computed tomograph system 失效
标题翻译：用于减少计算机断层摄影系统中的光谱伪像的方法和装置
公开(公告)号：US06266434B1
公开(公告)日：2001-07-24
申请号：US09118397
申请日：1998-07-17
申请人： Thomas L. Toth , O. Erdogan Gurmen , Bing Shen
发明人： Thomas L. Toth , O. Erdogan Gurmen , Bing Shen
IPC分类号： A61B600
CPC分类号： A61B6/032 , A61B6/06 , A61B6/4021 , A61B6/4085 , A61B6/4411 , G01T1/2985
摘要： Methods and apparatus for reducing spectral artifacts in a computed tomography (CT) system are described. In one embodiment, the CT system includes a plurality of multislice detector modules, a detector housing and a collimator adjacent the detector modules. Each detector module is mounted to the detector housing and includes a scintillator array. The collimator includes a plurality of plates that are positioned so that a x-ray beam shadow is centered over gaps in the scintillator array. In operation, the collimator separates the x-ray beams so that the scintillator gaps are protected and the x-ray beams are prevented from projecting through the scintillator array elements along a shortened length path.
摘要翻译：描述了在计算机断层摄影（CT）系统中减少光谱伪影的方法和装置。在一个实施例中，CT系统包括多个多层检测器模块，与检测器模块相邻的检测器壳体和准直仪。每个检测器模块安装到检测器壳体并且包括闪烁体阵列。准直器包括多个板，其被定位成使得X射线束阴影以闪烁体阵列中的间隙为中心。在操作中，准直器分离x射线束，使得闪烁体间隙被保护，并且防止X射线束沿着缩短的长度路径突出通过闪烁体阵列元件。

9. 发明授权

US06198791B1 Scalable multislice imaging system 有权
标题翻译：可扩展多层成像系统
公开(公告)号：US06198791B1
公开(公告)日：2001-03-06
申请号：US09140289
申请日：1998-08-25
申请人： Hui David He , Hui Hu , Robert F. Senzig , Gary R. Strong , Guy M. Besson , David M. Hoffman , George E. Seidenschnur , Armin H. Pfoh , Jonathan A. Murray , Thomas L. Toth , Willi W. Hampel
发明人： Hui David He , Hui Hu , Robert F. Senzig , Gary R. Strong , Guy M. Besson , David M. Hoffman , George E. Seidenschnur , Armin H. Pfoh , Jonathan A. Murray , Thomas L. Toth , Willi W. Hampel
IPC分类号： A61B600
CPC分类号： A61B6/032 , A61B6/027 , A61B6/4085
摘要： The present invention is, in one aspect, an imaging system having a detector that has multiple detector cells extending along a z-axis, the detector being configured to collect multiple slices of data; and a scalable data acquisition system configured to convert signals from the detector to digital form, the scalable data acquisition system having a plurality of converter boards each with a plurality of channels, the channels and detector cells having an interweaved coupling to reduce susceptibility to band artifact.
摘要翻译：本发明在一个方面是一种具有检测器的成像系统，所述检测器具有沿z轴延伸的多个检测器单元，所述检测器被配置为收集多个数据片段; 以及可配置成将来自检测器的信号转换成数字形式的可伸缩数据采集系统，所述可伸缩数据采集系统具有多个转换器板，每个转换器板具有多个通道，所述通道和检测器单元具有交织耦合以减少对带状伪影的敏感性。

10. 发明授权

US6118840A Methods and apparatus to desensitize incident angle errors on a multi-slice computed tomograph detector 失效
标题翻译：在多层计算机断层摄影仪上对入射角误差进行脱敏的方法和装置
公开(公告)号：US6118840A
公开(公告)日：2000-09-12
申请号：US8912
申请日：1998-01-20
申请人： Thomas L. Toth , Hui David He , Gurmen O. Erdogan , Bing Shen
发明人： Thomas L. Toth , Hui David He , Gurmen O. Erdogan , Bing Shen
IPC分类号： H04N7/18 , A61B6/03 , G01N23/04 , G01T1/202 , G06T1/00
CPC分类号： G01T1/202 , G01N23/046 , G01T1/2985 , A61B6/032 , G01N2223/419
摘要： Scintillators having a geometric configurations that substantially prevent x-ray beams from passing entirely through a gap between adjacent scintillators are described. More particularly, if the scintillators are cut on an angle to form parallelogram or trapezoidal shapes, or if the detector module is tilted in the x-ray beam z-axis, an x-ray beam will not pass through a non-scintillating gap between adjacent scintillators over the range of focal spot positions. Such scintillators have an increased geometric efficiency compared to known scintillator constructions.
摘要翻译：描述了具有基本上防止X射线束完全穿过相邻闪烁体之间的间隙的几何构型的闪烁体。更具体地说，如果以一定角度切割闪烁体以形成平行四边形或梯形形状，或者如果检测器模块在x射线束z轴中倾斜，则X射线束将不会穿过X射线束之间的非闪烁间隙相邻的闪烁体在焦斑位置的范围内。与已知的闪烁体结构相比，这种闪烁体具有增加的几何效率。

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