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1. 发明申请

US20160097027A1 Engineering Of A Novel Breast Tumor Microenvironment On A Microfluidic Chip 有权
标题翻译：微流控芯片上的新型乳腺肿瘤微环境工程
公开(公告)号：US20160097027A1
公开(公告)日：2016-04-07
申请号：US14872920
申请日：2015-10-01
申请人： Mehdi Nikkhah , Roger D. Kamm , Danh Truong
发明人： Mehdi Nikkhah , Roger D. Kamm , Danh Truong
IPC分类号： C12M3/06 , C12M1/00 , C12M1/12
CPC分类号： C12M23/16 , B01L3/502707 , B01L3/502715 , B01L2300/0816 , B01L2300/12 , C12M25/14 , G01N33/5011
摘要： A microfluidic device for more accurately modeling the in vitro environment in which cancer occurs is disclosed. The device comprises a surface defining one or more microfluidic channels that may further comprise one or more endothelial cells, a first three dimensional scaffold comprising one or more cancer cells that is spatially separated from the one or more microfluidic channels, and a second three dimensional scaffold comprising one or more stromal cells, at least a portion of which is interposed between the one or more microfluidic channels and the first three dimensional scaffold. The second three dimensional scaffold is in fluid communication with both the first three dimensional scaffold and the one or more microfluidic channels. The device can be used to assay anti-cancer agents, or as a system for modeling the growth, behavior, or metastasis and tumor formation of cancer cells.
摘要翻译：公开了一种用于更准确地模拟发生癌症的体外环境的微流体装置。该装置包括限定一个或多个微流体通道的表面，其可以进一步包含一个或多个内皮细胞，第一三维支架，其包含一个或多个在空间上与一个或多个微流体通道分离的癌细胞，以及第二三维支架其包含一个或多个基质细胞，其至少一部分介于所述一个或多个微流体通道和所述第一三维支架之间。第二三维支架与第一三维支架和一个或多个微流体通道流体连通。该装置可用于测定抗癌剂，或用作对癌细胞的生长，行为或转移和肿瘤形成进行建模的系统。

2. 发明申请

US20180052151A1 Engineering of a Novel Breast Tumor Microenvironment on a Microfluidic Chip 审中-公开
公开(公告)号：US20180052151A1
公开(公告)日：2018-02-22
申请号：US15730335
申请日：2017-10-11
申请人： Mehdi Nikkhah , Danh Truong
发明人： Mehdi Nikkhah , Danh Truong
IPC分类号： G01N33/50 , B01L3/00
CPC分类号： G01N33/5011 , B01L3/502707 , B01L3/502715 , B01L2300/0816 , B01L2300/12 , C12M23/16 , C12M25/14
摘要： A microfluidic device for more accurately modeling the in vitro environment in which cancer occurs is disclosed. The microfluidic device includes a surface defining one or more microfluidic channels, a first three dimensional scaffold comprising one or more cancer cells that is spatially separated from the one or more microfluidic channels, a second three dimensional scaffold, at least a portion of which is contacting and in fluid communication with the first three dimensional scaffold, and that is spatially separated from the one or more microfluidic channels, and a third three dimensional scaffold, at least a portion of which is contacting and in fluid communication with the one or more microfluidic channels and the second three dimensional scaffold. The device can be used to assay anti-cancer agents, or as a system for modeling the growth, behavior, or metastasis and tumor formation of cancer cells.

3. 发明授权

US10712339B2 Engineering of a novel breast tumor microenvironment on a microfluidic chip 有权
公开(公告)号：US10712339B2
公开(公告)日：2020-07-14
申请号：US15730335
申请日：2017-10-11
申请人： Mehdi Nikkhah , Danh Truong
发明人： Mehdi Nikkhah , Danh Truong
IPC分类号： B01L3/00 , G01N33/50 , C12M1/00 , C12M3/00 , C12M3/06 , C12M1/12
摘要： A microfluidic device for more accurately modeling the in vitro environment in which cancer occurs is disclosed. The microfluidic device includes a surface defining one or more microfluidic channels, a first three dimensional scaffold comprising one or more cancer cells that is spatially separated from the one or more microfluidic channels, a second three dimensional scaffold, at least a portion of which is contacting and in fluid communication with the first three dimensional scaffold, and that is spatially separated from the one or more microfluidic channels, and a third three dimensional scaffold, at least a portion of which is contacting and in fluid communication with the one or more microfluidic channels and the second three dimensional scaffold. The device can be used to assay anti-cancer agents, or as a system for modeling the growth, behavior, or metastasis and tumor formation of cancer cells.

4. 发明授权

US10017724B2 Engineering of a novel breast tumor microenvironment on a microfluidic chip 有权
公开(公告)号：US10017724B2
公开(公告)日：2018-07-10
申请号：US14872920
申请日：2015-10-01
申请人： Mehdi Nikkhah , Roger D. Kamm , Danh Truong
发明人： Mehdi Nikkhah , Roger D. Kamm , Danh Truong
IPC分类号： B01L3/00 , G01N33/50 , C12M3/00 , C12M1/00 , C12M1/12 , C12M3/06
CPC分类号： C12M23/16 , B01L3/502707 , B01L3/502715 , B01L2300/0816 , B01L2300/12 , C12M25/14 , G01N33/5011
摘要： A microfluidic device for more accurately modeling the in vitro environment in which cancer occurs is disclosed. The device comprises a surface defining one or more microfluidic channels that may further comprise one or more endothelial cells, a first three dimensional scaffold comprising one or more cancer cells that is spatially separated from the one or more microfluidic channels, and a second three dimensional scaffold comprising one or more stromal cells, at least a portion of which is interposed between the one or more microfluidic channels and the first three dimensional scaffold. The second three dimensional scaffold is in fluid communication with both the first three dimensional scaffold and the one or more microfluidic channels. The device can be used to assay anti-cancer agents, or as a system for modeling the growth, behavior, or metastasis and tumor formation of cancer cells.

5. 发明申请

US20220339629A1 MICROFLUIDIC DEVICES AND METHODS INCORPORATING ASSAY UNITS WITH MULTIPLE 3D SCAFFOLD REGIONS 有权
公开(公告)号：US20220339629A1
公开(公告)日：2022-10-27
申请号：US17725076
申请日：2022-04-20
申请人： Mehdi Nikkhah , Ouse Sheblak
发明人： Mehdi Nikkhah , Ouse Sheblak
IPC分类号： B01L3/00
摘要： A microfluidic device includes multiple microfluidic assay units arranged on a substrate, with each assay unit including multiple scaffold regions each containing a three-dimensional scaffold with associated cells, and a media channel surrounding a fluid-permeable boundary portion of at least a second scaffold region, wherein a fluid-permeable interface between the media channel and the second scaffold region comprises a curved shape spanning an arc of more than 90 degrees. A third scaffold region may be provided. Boundaries between different scaffold regions, and between a scaffold region and the media channel, may include microposts that may be spaced apart in a curved configuration. A method for performing an assay utilizing such a device is further provided.

6. 发明授权

US07190141B1 Exoskeletal device for rehabilitation 失效
标题翻译：用于康复的外骨骼装置
公开(公告)号：US07190141B1
公开(公告)日：2007-03-13
申请号：US11342371
申请日：2006-01-27
申请人： Hashem Ashrafiuon , Mehdi Nikkhah
发明人： Hashem Ashrafiuon , Mehdi Nikkhah
IPC分类号： B25J5/00
CPC分类号： B25J9/0006
摘要： A modular exoskeletal device adapted to fit the lower extremities of a patient during rehabilitation. The device has only two actuators during the standing stage of rehabilitation. Two additional actuators can be added, as modules, during the walking stage of rehabilitation. The actuators are affixed to the patient and provide controlled motion to at least one of the joints of the patient. A stationary control unit is separated from the patient. The control unit communicates with and directs the actuators, and has a hybrid control algorithm, such that the actuator forces are adjusted as the patient regains control of some joint motions, which is based upon the sliding-mode control theory. A back brace is affixed to the patient and helps to keep the torso of the patient in a stable, substantially vertical position.
摘要翻译：一种模块化外骨骼装置，适于在康复期间适应患者的下肢。该装置在康复期间只有两个执行器。在康复的步行阶段，可以添加两个额外的执行器作为模块。致动器固定到患者身上，并向患者的至少一个关节提供受控的运动。静止控制单元与患者分离。控制单元与致动器通信并引导致动器，并且具有混合控制算法，使得当患者恢复对基于滑动模式控制理论的某些关节运动的控制时调节致动器力。后支架固定在患者身上，有助于将患者的躯干保持在稳定的，基本垂直的位置。

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