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1. 发明申请

US20140273249A1 High Range Activated Clotting Time Assay Formulation 审中-公开
标题翻译：高范围活性凝血时间分析制剂
公开(公告)号：US20140273249A1
公开(公告)日：2014-09-18
申请号：US13795608
申请日：2013-03-12
申请人： MEDTRONIC, INC.
发明人： Charlene Yuan , Trevor C. Huang , Tessy Kanayinkal , Mary Jo Passenheim , Craig D. Petersen , Ivan Akunovich
IPC分类号： G01N33/86
CPC分类号： G01N33/86 , G01N33/4905
摘要： High range activated clotting time (HR-ACT) tests detect blood clotting time in blood samples which have high levels of heparin. Reagents such as calcium chloride and kaolin within the test apparatus trigger clotting. The cartridge is treated with a strong surface treatment process, such as an atmospheric plasma treatment, to increase the hydrophilic property of the test chamber, there may be a significant reduction in the kaolin concentration required to activate the blood sample and initiate the coagulation process. The kaolin concentration may be further reduced if the buffer component used in the buffer saline contains phosphate. The reduction of the kaolin concentration allows more calcium to be released from the kaolin to participate in the clotting process. The combined effect of adding a surface treatment to the cartridge to increase the hydrophilic property of reaction chamber and adding phosphate into buffered saline allows for clot detection of blood samples containing 5˜6 U/mL heparin.
摘要翻译：高程激活凝血时间（HR-ACT）测试检测血液样品中具有高水平肝素的凝血时间。试剂如氯化钙和高岭土等试剂触发凝血。用强大的表面处理方法（例如大气等离子体处理）处理该盒，以增加试验室的亲水性能，激活血液样品并开始凝固过程所需的高岭土浓度可能会显着降低。如果缓冲盐水中使用的缓冲液组分含有磷酸盐，则高岭土浓度可进一步降低。高岭土浓度的降低允许从高岭土释放更多的钙以参与凝固过程。加入表面处理以提高反应室的亲水性能并将磷酸盐添加到缓冲盐水中的综合效果允许凝块检测含有5〜6U / mL肝素的血液样品。

2. 发明申请

US20130189789A1 High Range Activated Clotting Time Assay Formulation 审中-公开
标题翻译：高范围活性凝血时间分析制剂
公开(公告)号：US20130189789A1
公开(公告)日：2013-07-25
申请号：US13748922
申请日：2013-01-24
申请人： Medtronic, Inc.
发明人： Charlene Yuan , Trevor C. Huang , Tessy Kanayinkal , Mary Jo Passenheim
IPC分类号： G01N33/86
CPC分类号： G01N33/86 , G01N11/10 , G01N33/4905 , Y10T137/0402
摘要： High range activated clotting time (HR-ACT) tests detect blood clotting time in blood samples which have high levels of heparin. Reagents such as calcium chloride and kaolin within the test apparatus trigger clotting. Physical separation of the reagents from each other prevents interaction between them before the test sample introduction. In one embodiment, to improve dry kaolin re-suspension, kaolin may be suspended in water rather than buffered saline before being dispensed into the test chamber. The combination of removing the buffered saline and the calcium chloride from the kaolin suspension enables clot detection in blood samples containing 5-6 u/ml of heparin.
摘要翻译：高程激活凝血时间（HR-ACT）测试检测血液样品中具有高水平肝素的凝血时间。试剂如氯化钙和高岭土等试剂触发凝血。试剂彼此的物理分离在测试样品引入之前防止了它们之间的相互作用。在一个实施方案中，为了改善干燥的高岭土再悬浮，在分配到测试室中之前，高岭土可以悬浮在水中而不是缓冲盐水中。从高岭土悬浮液中除去缓冲盐水和氯化钙的组合使得能够在含有5-6u / ml肝素的血液样品中进行凝块检测。

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