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1. 发明申请

US20180172665A1 SYSTEMS AND METHODS FOR ASSESSING BLOOD PLATELET FUNCTION 审中-公开
公开(公告)号：US20180172665A1
公开(公告)日：2018-06-21
申请号：US15383995
申请日：2016-12-19
申请人： Medtronic, Inc.
发明人： Charlene Yuan , Trevor Huang , Tessy Kanayinkal
IPC分类号： G01N33/49 , G01N15/05 , G01N27/74
CPC分类号： G01N33/4905 , G01N15/05
摘要： A method carried out by a system configured to analyze blood. The method includes causing a ferromagnetic object to move in a chamber housing blood after clot initiation has been implicated. Movement of the object in the chamber is detected. The detected movement of the object is correlated with clot retraction of the blood. In some embodiments, the stop of detecting movement includes allowing the object to drop from a raised position and detecting a drop distance of the object. In related embodiments, the step of correlating detected movement with clot retraction includes reviewing a trace generated by a plurality of drop distances over time. In yet other embodiments, methods of the present disclosure can further including evaluating platelet function of the blood based upon assessed clot retraction.

2. 发明申请

US20160238621A1 Clot Protection and Detection Algorithm for Activated Clotting Time Testing 审中-公开
公开(公告)号：US20160238621A1
公开(公告)日：2016-08-18
申请号：US15135327
申请日：2016-04-21
申请人： Medtronic, Inc.
发明人： Daniel Cheek , Lawrence Erickson , Trevor Huang , Tessy Kanayinkal , Craig Petersen , Charlene Yuan
IPC分类号： G01N33/86
CPC分类号： G01N33/4905 , G01N33/86
摘要： Activated clotting time (ACT) tests detect blood clotting time based on the viscosity changes of a test sample, using a ferromagnetic washer lifted to the top of a test chamber and then dropped from the top via gravity; a drop time greater than a preset threshold value indicates clotting of the test sample. Blood samples which have high levels of heparin usually produce very weak clots that may easily be destroyed by the lifting movement of the washer. But if the clot threshold is set low to detect the weak clots, false detections occur during early testing cycles when activators are not fully suspended during the mixing cycle. Improved algorithms for lifting the washer and adjusting over time enable accurate detection of weak clots.

3. 发明申请

US20140273249A1 High Range Activated Clotting Time Assay Formulation 审中-公开
标题翻译：高范围活性凝血时间分析制剂
公开(公告)号：US20140273249A1
公开(公告)日：2014-09-18
申请号：US13795608
申请日：2013-03-12
申请人： MEDTRONIC, INC.
发明人： Charlene Yuan , Trevor C. Huang , Tessy Kanayinkal , Mary Jo Passenheim , Craig D. Petersen , Ivan Akunovich
IPC分类号： G01N33/86
CPC分类号： G01N33/86 , G01N33/4905
摘要： High range activated clotting time (HR-ACT) tests detect blood clotting time in blood samples which have high levels of heparin. Reagents such as calcium chloride and kaolin within the test apparatus trigger clotting. The cartridge is treated with a strong surface treatment process, such as an atmospheric plasma treatment, to increase the hydrophilic property of the test chamber, there may be a significant reduction in the kaolin concentration required to activate the blood sample and initiate the coagulation process. The kaolin concentration may be further reduced if the buffer component used in the buffer saline contains phosphate. The reduction of the kaolin concentration allows more calcium to be released from the kaolin to participate in the clotting process. The combined effect of adding a surface treatment to the cartridge to increase the hydrophilic property of reaction chamber and adding phosphate into buffered saline allows for clot detection of blood samples containing 5˜6 U/mL heparin.
摘要翻译：高程激活凝血时间（HR-ACT）测试检测血液样品中具有高水平肝素的凝血时间。试剂如氯化钙和高岭土等试剂触发凝血。用强大的表面处理方法（例如大气等离子体处理）处理该盒，以增加试验室的亲水性能，激活血液样品并开始凝固过程所需的高岭土浓度可能会显着降低。如果缓冲盐水中使用的缓冲液组分含有磷酸盐，则高岭土浓度可进一步降低。高岭土浓度的降低允许从高岭土释放更多的钙以参与凝固过程。加入表面处理以提高反应室的亲水性能并将磷酸盐添加到缓冲盐水中的综合效果允许凝块检测含有5〜6U / mL肝素的血液样品。

4. 发明申请

US20130144538A1 Clot Protection and Detection Algorithm for Activated Clotting Time Testing 有权
标题翻译：用于活化凝血时间测试的凝块保护和检测算法
公开(公告)号：US20130144538A1
公开(公告)日：2013-06-06
申请号：US13706453
申请日：2012-12-06
申请人： MEDTRONIC, INC.
发明人： Daniel Cheek , Lawrence Erickson , Trevor Huang , Tessy Kanayinkal , Craig Petersen , Charlene Yuan
IPC分类号： G01N33/49
CPC分类号： G01N33/4905 , G01N33/86
摘要： Activated clotting time (ACT) tests detect blood clotting time based on the viscosity changes of a test sample, using a ferromagnetic washer lifted to the top of a test chamber and then dropped from the top via gravity; a drop time greater than a preset threshold value indicates clotting of the test sample. Blood samples which have high levels of heparin usually produce very weak clots that may easily be destroyed by the lifting movement of the washer. But if the clot threshold is set low to detect the weak clots, false detections occur during early testing cycles when activators are not fully suspended during the mixing cycle. Improved algorithms for lifting the washer and adjusting over time enable accurate detection of weak clots.
摘要翻译：活化凝血时间（ACT）测试根据测试样品的粘度变化检测血液凝固时间，使用提升到测试室顶部的铁磁垫圈，然后通过重力从顶部滴落; 大于预设阈值的下降时间表示测试样品的凝血。具有高水平肝素的血液样品通常产生非常弱的凝块，这可能容易被洗涤器的提升运动所破坏。但是，如果凝块阈值设置为低以检测弱凝块，则在早期测试周期期间发生错误检测，当激活剂在混合循环期间未完全悬浮时。用于提升洗衣机和随时间调整的改进的算法可以准确检测弱凝块。

5. 发明授权

US11275076B2 Systems and methods for assessing blood platelet function 有权
公开(公告)号：US11275076B2
公开(公告)日：2022-03-15
申请号：US15383995
申请日：2016-12-19
申请人： Medtronic, Inc.
发明人： Charlene Yuan , Trevor Huang , Tessy Kanayinkal
IPC分类号： G01N33/49 , G01N15/05
摘要： A method carried out by a system configured to analyze blood. The method includes causing a ferromagnetic object to move in a chamber housing blood after clot initiation has been implicated. Movement of the object in the chamber is detected. The detected movement of the object is correlated with clot retraction of the blood. In some embodiments, the stop of detecting movement includes allowing the object to drop from a raised position and detecting a drop distance of the object. In related embodiments, the step of correlating detected movement with clot retraction includes reviewing a trace generated by a plurality of drop distances over time. In yet other embodiments, methods of the present disclosure can further including evaluating platelet function of the blood based upon assessed clot retraction.

6. 发明授权

US10371694B2 Clot protection and detection algorithm for activated clotting time testing 有权
公开(公告)号：US10371694B2
公开(公告)日：2019-08-06
申请号：US15135327
申请日：2016-04-21
申请人： Medtronic, Inc.
发明人： Daniel Cheek , Lawrence Erickson , Trevor Huang , Tessy Kanayinkal , Craig Petersen , Charlene Yuan
IPC分类号： G01N33/49 , G01N33/86
摘要： Activated clotting time (ACT) tests detect blood clotting time based on the viscosity changes of a test sample, using a ferromagnetic washer lifted to the top of a test chamber and then dropped from the top via gravity; a drop time greater than a preset threshold value indicates clotting of the test sample. Blood samples which have high levels of heparin usually produce very weak clots that may easily be destroyed by the lifting movement of the washer. But if the clot threshold is set low to detect the weak clots, false detections occur during early testing cycles when activators are not fully suspended during the mixing cycle. Improved algorithms for lifting the washer and adjusting over time enable accurate detection of weak clots.

7. 发明授权

US09429563B2 Multi-zone falling washer blood clot detection 有权
标题翻译：多区落下清洗器血块检测
公开(公告)号：US09429563B2
公开(公告)日：2016-08-30
申请号：US13706453
申请日：2012-12-06
申请人： Medtronic, Inc.
发明人： Daniel Cheek , Lawrence Erickson , Trevor Huang , Tessy Kanayinkal , Craig Petersen , Charlene Yuan
IPC分类号： G01N33/49
CPC分类号： G01N33/4905 , G01N33/86
摘要： Activated clotting time (ACT) tests detect blood clotting time based on the viscosity changes of a test sample, using a ferromagnetic washer lifted to the top of a test chamber and then dropped from the top via gravity; a drop time greater than a preset threshold value indicates clotting of the test sample. Blood samples which have high levels of heparin usually produce very weak clots that may easily be destroyed by the lifting movement of the washer. But if the clot threshold is set low to detect the weak clots, false detections occur during early testing cycles when activators are not fully suspended during the mixing cycle. Improved algorithms for lifting the washer and adjusting over time enable accurate detection of weak clots.
摘要翻译：活化凝血时间（ACT）测试根据测试样品的粘度变化检测血液凝固时间，使用提升到测试室顶部的铁磁垫圈，然后通过重力从顶部滴落; 大于预设阈值的下降时间表示测试样品的凝血。具有高水平肝素的血液样品通常产生非常弱的凝块，这可能容易被洗涤器的提升运动所破坏。但是，如果凝块阈值设置为低以检测弱凝块，则在早期测试周期期间发生错误检测，当激活剂在混合循环期间未完全悬浮时。用于提升洗衣机和随时间调整的改进的算法可以准确检测弱凝块。

8. 发明申请

US20130189789A1 High Range Activated Clotting Time Assay Formulation 审中-公开
标题翻译：高范围活性凝血时间分析制剂
公开(公告)号：US20130189789A1
公开(公告)日：2013-07-25
申请号：US13748922
申请日：2013-01-24
申请人： Medtronic, Inc.
发明人： Charlene Yuan , Trevor C. Huang , Tessy Kanayinkal , Mary Jo Passenheim
IPC分类号： G01N33/86
CPC分类号： G01N33/86 , G01N11/10 , G01N33/4905 , Y10T137/0402
摘要： High range activated clotting time (HR-ACT) tests detect blood clotting time in blood samples which have high levels of heparin. Reagents such as calcium chloride and kaolin within the test apparatus trigger clotting. Physical separation of the reagents from each other prevents interaction between them before the test sample introduction. In one embodiment, to improve dry kaolin re-suspension, kaolin may be suspended in water rather than buffered saline before being dispensed into the test chamber. The combination of removing the buffered saline and the calcium chloride from the kaolin suspension enables clot detection in blood samples containing 5-6 u/ml of heparin.
摘要翻译：高程激活凝血时间（HR-ACT）测试检测血液样品中具有高水平肝素的凝血时间。试剂如氯化钙和高岭土等试剂触发凝血。试剂彼此的物理分离在测试样品引入之前防止了它们之间的相互作用。在一个实施方案中，为了改善干燥的高岭土再悬浮，在分配到测试室中之前，高岭土可以悬浮在水中而不是缓冲盐水中。从高岭土悬浮液中除去缓冲盐水和氯化钙的组合使得能够在含有5-6u / ml肝素的血液样品中进行凝块检测。

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