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1. 发明申请

US20140370490A1 HEART-LUNG PREPARATION AND METHOD OF USE 审中-公开
标题翻译：心肺制备和使用方法
公开(公告)号：US20140370490A1
公开(公告)日：2014-12-18
申请号：US14252116
申请日：2014-04-14
申请人： Medtronic, Inc.
发明人： Paul A Iaizzo , Timothy G Laske , Michael D Eggen , Ryan P Goff , Brian Howard
IPC分类号： A01N1/02 , G09B23/30
CPC分类号： A01N1/0247 , G09B23/303 , G09B23/306
摘要： An isolated heart or heart-lung preparation in which essentially normal pumping activity of all four chambers of the heart is preserved, allowing for the use of the preparation in conjunction with investigations of electrode leads, catheters, ablation methods, cardiac implants and other medical devices intended to be used in or on a beating heart. The system can be designed to be used within a Magnetic Resonance Imaging (MRI) unit or a X-ray computed tomography (CT) scanner. The preparation may also be employed to investigate heart and lung functions, in the presence or absence of such medical devices. In order to allow comparative imaging visualizations of either or simultaneously the heart and/or lung structures and devices located within the chambers of the heart or vessels or bronchi within the lungs, a clear perfusate such as a modified Krebs buffer solution with oxygenation is circulated through all four chambers of the heart and thus the coronary and/or pulmonary vasculatures. A ventilator with intubation tube can be used to inflate/deflate the lungs and/or provide oxygen to the isolated organs. The preparation and recordings of the preparation may be used in conjunction with the design, development and evaluation of devices for use in or on the heart and/or lungs, as well as for use as an investigational and teaching aid to assist physicians and students in understanding the operation of the cardiopulmonary system.
摘要翻译：孤立的心脏或心肺制剂，其中保留了心脏的所有四个腔室的基本上正常的泵送活性，允许使用制剂结合电极引线，导管，消融方法，心脏植入物和其他医疗装置的研究旨在用于或在一个跳动的心脏。该系统可以设计成在磁共振成像（MRI）单元或X射线计算机断层摄影（CT）扫描仪中使用。在存在或不存在这种医疗装置的情况下，该制剂也可用于研究心脏和肺功能。为了允许位于心脏或血管或肺内的支气管内的心脏和/或肺结构和装置的同时或同时进行比较成像可视化，清除灌注液（例如具有氧合的修饰的克雷伯斯缓冲溶液）循环通过心脏的所有四个腔室，因此冠状动脉和/或肺血管系统。具有插管的呼吸机可用于使肺膨胀/放气和/或向分离的器官提供氧气。制剂的制备和记录可以与用于心脏和/或肺部的装置的设计，开发和评价结合使用，以及用作辅助医师和学生的研究和教学辅助了解心肺系统的运作情况。

2. 发明授权

US09981135B2 Multi-chamber intracardiac pacing system 有权
公开(公告)号：US09981135B2
公开(公告)日：2018-05-29
申请号：US14645038
申请日：2015-03-11
申请人： Medtronic, Inc.
发明人： Yong K Cho , Wade M Demmer , Michael D Eggen , Kathryn Hilpisch , Michael F Hess , Todd J Sheldon , Saul E Greenhut
IPC分类号： A61N1/37 , A61N1/365 , A61N1/362 , A61N1/375 , A61N1/36 , A61B5/00 , A61B5/0464 , A61N1/372 , A61B5/0402
CPC分类号： A61N1/3706 , A61B5/0402 , A61B5/0464 , A61B5/686 , A61N1/36 , A61N1/3622 , A61N1/36592 , A61N1/37205 , A61N1/3756
摘要： A medical device system including at least a first implantable medical device and a second implantable medical device is configured to establish by a control module of the first implantable medical device whether the second implantable medical device is present in a patient and self-configure an operating mode of the control module in response to establishing that the second implantable medical device is present.

3. 发明授权

US09517336B2 Electrode assemblies and associated fixation members for implantable medical devices 有权
公开(公告)号：US09517336B2
公开(公告)日：2016-12-13
申请号：US14611838
申请日：2015-02-02
申请人： Medtronic, Inc.
发明人： Michael D Eggen , Zhongping Yang , Rick D McVenes , Noelle C. Hurtig , Raymond W Usher
IPC分类号： A61N1/05 , A61N1/372
CPC分类号： A61N1/0573 , A61N1/059 , A61N1/37205
摘要： A fixation member of an electrode assembly for an implantable medical device includes a tissue engaging portion extending along a circular path, between a piercing distal tip thereof and a fixed end of the member. The circular path extends around a longitudinal axis of the assembly. A helical structure of the assembly, which includes an electrode surface formed thereon and a piercing distal tip, also extends around the longitudinal axis and is located within a perimeter of the circular path. The tissue engaging portion of the fixation member extends from the distal tip thereof in a direction along the circular path that is the same as that in which the helical structure extends from the distal tip thereof. The electrode assembly may include a pair of the fixation members, wherein each tissue engaging portion may extend approximately one half turn along the circular path.

4. 发明授权

US09526891B2 Intracardiac medical device 有权
标题翻译：心内医疗器械
公开(公告)号：US09526891B2
公开(公告)日：2016-12-27
申请号：US14696141
申请日：2015-04-24
申请人： Medtronic, Inc.
发明人： Michael D Eggen , Vladimir Grubac , Jean M Carver , Ryan Goff , Thomas A Anderson
IPC分类号： A61N1/00 , A61N1/05 , A61N1/362 , A61M25/01
CPC分类号： A61N1/059 , A61M25/0147 , A61N1/057 , A61N1/0573 , A61N1/362 , A61N1/368 , A61N1/37205 , A61N1/3756 , A61N2001/058
摘要： An implantable pacemaker system includes a housing having a proximal end and a distal end. A control electronics subassembly defines the housing proximal end, and a battery subassembly defines the housing distal end. A distal fixation member extends from the housing distal end for fixing the housing distal end at an implant site. A pacing extension extends from the housing proximal end and carries a pacing cathode electrode. The pacing extension extends the pacing cathode electrode to a pacing site that is spaced apart from the implant site when the pacemaker is deployed in a patient's body.
摘要翻译：植入式起搏器系统包括具有近端和远端的壳体。控制电子部件组件限定外壳近端，电池子组件限定外壳远端。远侧固定构件从壳体远端延伸，用于将外壳远端固定在植入部位。起搏延伸部从壳体近端延伸并承载起搏阴极电极。当起搏器部署在患者体内时，起搏延伸部将起搏阴极电极延伸到与植入部位间隔开的起搏部位。

5. 发明授权

US08948883B2 Electrode assemblies and associated fixation members for implantable medical devices 有权
标题翻译：用于可植入医疗装置的电极组件和相关联的固定构件
公开(公告)号：US08948883B2
公开(公告)日：2015-02-03
申请号：US13869509
申请日：2013-04-24
申请人： Medtronic, Inc.
发明人： Michael D Eggen , Zhongping Yang , Rick D McVenes , Noelle C Hurtig , Raymond W Usher
IPC分类号： A61N1/05
CPC分类号： A61N1/0573 , A61N1/059 , A61N1/37205
摘要： A fixation member of an electrode assembly for an implantable medical device includes a tissue engaging portion extending along a circular path, between a piercing distal tip thereof and a fixed end of the member. The circular path extends around a longitudinal axis of the assembly. A helical structure of the assembly, which includes an electrode surface formed thereon and a piercing distal tip, also extends around the longitudinal axis and is located within a perimeter of the circular path. The tissue engaging portion of the fixation member extends from the distal tip thereof in a direction along the circular path that is the same as that in which the helical structure extends from the distal tip thereof. The electrode assembly may include a pair of the fixation members, wherein each tissue engaging portion may extend approximately one half turn along the circular path.
摘要翻译：用于可植入医疗装置的电极组件的固定构件包括沿圆形路径延伸的组织接合部分，其穿孔远端和构件的固定端之间。圆形路径围绕组件的纵向轴线延伸。包括其上形成的电极表面和穿刺的远端的组件的螺旋结构也围绕纵向轴线延伸并且位于圆形路径的周边内。固定构件的组织接合部分沿着与其螺旋结构从其远端延伸的方向相同的圆形路径的方向从其远端延伸。电极组件可以包括一对固定构件，其中每个组织接合部分可以沿着圆形路径延伸约一半匝。

6. 发明授权

US08630719B2 Implantable medical lead with biased electrode 有权
标题翻译：带有偏置电极的植入式医用导线
公开(公告)号：US08630719B2
公开(公告)日：2014-01-14
申请号：US13657475
申请日：2012-10-22
申请人： Medtronic, Inc.
发明人： Michael D Eggen , John L Sommer , Michael Ebert , David W Bourn , Gabriela C Molnar
IPC分类号： A61N1/04
CPC分类号： A61N1/056 , A61N1/05 , A61N1/0534 , A61N1/0551 , A61N2001/0585
摘要： This disclosure describes implantable medical leads that include a lead body and an electrode. A width of the electrode as measured along a longitudinal direction of the lead varies about the perimeter of the lead. The uneven width of the electrode may bias a stimulation field in a particular direction, e.g., a radial or transverse direction relative to the longitudinal axis of the lead. Electrodes with an uneven width may be useful for controlling the direction of propagation of the stimulation field in order to, for example, avoid phrenic nerve stimulation during LV pacing or neck muscle stimulation during vagal neurostimulation.
摘要翻译：本公开描述了包括引线体和电极的可植入医疗引线。沿着铅的纵向测量的电极的宽度围绕引线的周边变化。电极的不均匀宽度可以相对于引线的纵向轴线在特定方向（例如，径向或横向）偏置刺激场。具有不均匀宽度的电极可用于控制刺激场的传播方向，以便例如在迷走神经刺激期间在LV起搏或颈部肌肉刺激期间避免膈神经刺激。

7. 发明授权

US10478620B2 Interventional medical systems, devices, and methods of use 有权
公开(公告)号：US10478620B2
公开(公告)日：2019-11-19
申请号：US14518261
申请日：2014-10-20
申请人： Medtronic, Inc.
发明人： Michael D Eggen , James K Carney , Matthew D Bonner , Vladimir Grubac , Douglas S Hine , Thomas D Brostrom , John L Sommer
IPC分类号： A61N1/05 , A61N1/375
摘要： A relatively compact implantable medical device includes a fixation member formed by a plurality of fingers mounted around a perimeter of a distal end of a housing of the device; each finger is elastically deformable from a relaxed condition to an extended condition, to accommodate delivery of the device to a target implant site, and from the relaxed condition to a compressed condition, to accommodate wedging of the fingers between opposing tissue surfaces at the target implant site, wherein the compressed fingers hold a cardiac pacing electrode of the device in intimate tissue contact for the delivery of pacing stimulation to the site. Each fixation finger is preferably configured to prevent penetration thereof within the tissue when the fingers are compressed and wedged between the opposing tissue surfaces. The pacing electrode may be mounted on a pacing extension, which extends distally from the distal end of the device housing.

8. 发明授权

US10463853B2 Interventional medical systems 有权
公开(公告)号：US10463853B2
公开(公告)日：2019-11-05
申请号：US15410085
申请日：2017-01-19
申请人： Medtronic, Inc.
发明人： Ronald A Drake , Xin Chen , Michael D Eggen , Matthew D Bonner , Vladimir Grubac , Brian P Colin , Kenneth C Gardeski , Kevin R Seifert
IPC分类号： A61N1/05 , A61N1/368 , A61B5/00 , A61N1/375 , A61N1/362 , A61N1/372
摘要： An implantable medical device includes ventricular and atrial portions, and a flexible leadlet that extends therebetween. An open channel of the atrial portion, formed along a core thereof, is sized to receive the leadlet therein, when the leadlet is folded over on itself. An interventional medical system includes the device and a delivery tool; a tubular sidewall of the tool defines a lumen and has a tether extending therein. A slot formed in the sidewall extends proximally from an open end thereof, coincident with a distal opening of the lumen. When the atrial portion is contained within the lumen, a segment of the leadlet extends alongside the atrial portion; another segment of the leadlet, being folded over on itself, proximal to the atrial portion, has the tether engaged therewith. The slot may allow passage of the leadlet therethrough, when the atrial portion is positioned for deployment through the distal opening.

9. 发明授权

US10143838B2 Securing an implantable medical device in position while reducing perforations 有权
公开(公告)号：US10143838B2
公开(公告)日：2018-12-04
申请号：US15153914
申请日：2016-05-13
申请人： Medtronic, Inc.
发明人： Vladimir Grubac , Michael D Eggen , Kevin R Seifert
IPC分类号： A61N1/05
摘要： Methods and systems of making a medical electrical lead type having a set of tines. A system for implantation of a lead medical electrical lead in contact with heart tissue, comprises an elongated lead body; a set of curved tines mounted to and extending from a distal end of the lead body, the tines having a length (dD) and an effective cross sectional area, and a delivery catheter. The delivery catheter encloses the lead body and has a distal capsule portion enclosing the tines. The tines exerting a spring force against the capsule and provide a stored potential energy. The delivery catheter has an elastic, not stiff and low column strength ejection means for advancing the lead and tines distally from the capsule and fixating the tines within the heart tissue, the controllable and the stored potential energy of the tines together provide a deployment energy. The tines when so fixated in the tissue provide a fixation energy. The deployment energy and the fixation energy of the tines are equivalent.

10. 发明授权

US09943682B2 Method and apparatus for determining suitability of a lead implant location 有权
公开(公告)号：US09943682B2
公开(公告)日：2018-04-17
申请号：US14696242
申请日：2015-04-24
申请人： Medtronic, Inc.
发明人： Michael D Eggen , Tarek D Haddad , Paul A Iaizzo , Zhongping Yang
IPC分类号： A61N1/05 , A61N1/08
CPC分类号： A61N1/056 , A61N1/0573 , A61N1/08 , A61N2001/083
摘要： Method and systems of determining adequacy of fixation of a medical lead type having a fixation helix are disclosed. The lead of the medical lead type is placed at a desired location within a patient's body and the fixation helix is screwed into tissue at that location. One or more parameters, associated with the lead, are measured at the location. Based upon the measured one or more parameters, determining a number of turns that the helix is embedded into the tissue at the location.

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