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1. 发明授权

US10500306B2 Method and device for producing a bioartificial tissue construct 有权
公开(公告)号：US10500306B2
公开(公告)日：2019-12-10
申请号：US14367247
申请日：2012-12-20
申请人： Medizinische Hockschule Hannover
发明人： Thomas Aper , Mathias Wilhelmi , Axel Haverich
IPC分类号： B29C41/20 , A61L27/22 , A61L27/38 , A61L27/50 , C12M3/00 , A61F2/06 , A61F2/07 , A61F2/90 , A61L27/06 , B29C41/04 , B29C41/36 , B29C41/38 , B29K101/00 , B29L31/00
CPC分类号： A61L27/225 , A61F2/062 , A61F2/07 , A61F2/90 , A61L27/06 , A61L27/3804 , A61L27/3808 , A61L27/3826 , A61L27/3834 , A61L27/507 , B29C41/04 , B29C41/36 , B29C41/38 , C12M21/08 , C12M23/48 , B29K2101/00 , B29K2901/00 , B29K2905/00 , B29L2031/753
摘要： The tissue construct with viable cells in an extracellular matrix made of fibrin is produced with a special method, in which a matrix material and cells are shaped into a hollow body, in particular a tubular hollow body, by means of a rotational casting method in a hollow mould (1), the method comprising the following steps: (a) introduction of cells of at least one cell type and/or a fibrinogen preparation into the rotating hollow mould (1) with the aid of an applicator (4), said applicator (4) being displaced along the rotational axis during the introduction and step (a) being performed one or more times; (b) continuation of the rotation process until the fibrinogen solidifies into a dimensionally stable matrix, obtaining a primarily solidified tissue construct; (c) removal of the tissue construct from the mould. The construct can also he obtained in a relatively short time from autologous materials.

2. 发明申请

US20140343662A1 Method and Device for Producing a Bioartificial Tissue Construct 审中-公开
标题翻译：生物人造组织构建方法和装置
公开(公告)号：US20140343662A1
公开(公告)日：2014-11-20
申请号：US14367247
申请日：2012-12-20
申请人： Medizinische Hockschule Hannover
发明人： Thomas Aper , Mathias Wilhelmi , Axel Haverich
IPC分类号： A61L27/22 , B29C41/38 , A61L27/06 , A61F2/07 , A61F2/90 , B29C41/04 , B29C41/36
摘要： The tissue construct with viable cells in an extracellular matrix made of fibrin is produced with a special method, in which a matrix material and cells are shaped into a hollow body, in particular a tubular hollow body, by means of a rotational casting method in a hollow mould (1), the method comprising the following steps: (a) introduction of cells of at least one cell type and/or a fibrinogen preparation into the rotating hollow mould (1) with the aid of an applicator (4), said applicator (4) being displaced along the rotational axis during the introduction and step (a) being performed one or more times; (b) continuation of the rotation process until the fibrinogen solidifies into a dimensionally stable matrix, obtaining a primarily solidified tissue construct; (c) removal of the tissue construct from the mould. The construct can also he obtained in a relatively short time from autologous materials.
摘要翻译：用纤维蛋白制成的细胞外基质中的活细胞的组织构建体用特殊的方法制备，其中基质材料和细胞通过旋转浇铸方法成形为中空体，特别是管状中空体空心模具（1），所述方法包括以下步骤：（a）借助于施用器（4）将至少一种细胞类型的细胞和/或纤维蛋白原制剂引入所述旋转的中空模具（1）中，所述在引入期间，施加器（4）沿着旋转轴线移位，并且步骤（a）执行一次或多次; （b）继续旋转过程，直到纤维蛋白原固化成尺寸稳定的基质，获得主要凝固的组织构建体; （c）从模具中去除组织构建体。该构造物也可以在相对较短的时间内从自体材料中获得。

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