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1. 发明申请

US20070036705A1 Hollow silica particles and methods for making same 审中-公开
标题翻译：中空二氧化硅颗粒及其制备方法
公开(公告)号：US20070036705A1
公开(公告)日：2007-02-15
申请号：US11200917
申请日：2005-08-10
申请人： Matthew Butts , Sarah Genovese , Paul Glaser , Darryl Williams
发明人： Matthew Butts , Sarah Genovese , Paul Glaser , Darryl Williams
IPC分类号： C01B33/12
CPC分类号： C01B33/18
摘要： Methods for making hollow silica particle are disclosed, said particles made from a composition comprising a silicon-containing compound selected from the group consisting of tetraalkoxysilanes, trialkyloxysilanes and derivatives thereof, dialkoxysilanes and derivatives thereof, alkoxysilanes and derivatives thereof, silicone oligomers, oligomeric silsesquioxanes and silicone polymers distributed over a polymer template core that is eliminated from the particle. The particles of the present invention have a substantially uniform particle size and exhibit low permeability to liquids.
摘要翻译：公开了制备中空二氧化硅颗粒的方法，所述颗粒由包含选自四烷氧基硅烷，三烷氧基硅烷及其衍生物，二烷氧基硅烷及其衍生物，烷氧基硅烷及其衍生物，硅氧烷低聚物，低聚倍半硅氧烷，分散在聚合物模板芯上的硅氧烷聚合物被从颗粒中除去。本发明的颗粒具有基本均匀的颗粒尺寸并且对液体表现出低渗透性。

2. 发明申请

US20070036736A1 Hollow silica particles, compositions comprising them, and methods for making same 有权
标题翻译：中空二氧化硅颗粒，包含它们的组合物及其制备方法
公开(公告)号：US20070036736A1
公开(公告)日：2007-02-15
申请号：US11200591
申请日：2005-08-10
申请人： Karen Kalla , Matthew Butts , Darryl Williams , Sarah Genovese
发明人： Karen Kalla , Matthew Butts , Darryl Williams , Sarah Genovese
IPC分类号： A61K8/25 , C04B16/08
CPC分类号： C01B33/126 , A61K8/11 , A61K8/25 , A61K8/585 , A61K8/8117 , A61K8/891 , A61K8/894 , A61K2800/41 , A61K2800/412 , A61Q1/02 , A61Q1/06 , A61Q19/00 , A61Q19/007 , B01J13/02 , C01B33/12 , C01B33/18 , C01P2004/34 , C01P2004/51 , C01P2004/62
摘要： Methods for making and compositions comprising hollow silica particle are disclosed, said particles made from a composition comprising a silicon-containing compound selected from the group consisting of tetraalkoxysilanes, trialkyloxysilanes and derivatives thereof, dialkoxysilanes and derivatives thereof, alkoxysilanes and derivatives thereof, silicone oligomers, oligomeric silsesquioxanes and silicone polymers distributed over a polymer template core that is eliminated from the particle. The particles of the present invention have a substantially uniform particle size and exhibit low permeability to liquids.
摘要翻译：公开了制备方法和包含中空二氧化硅颗粒的组合物，所述颗粒由包含选自四烷氧基硅烷，三烷氧基硅烷及其衍生物，二烷氧基硅烷及其衍生物，烷氧基硅烷及其衍生物，硅氧烷低聚物，分散在从颗粒中除去的聚合物模板核心上的低聚倍半硅氧烷和硅氧烷聚合物。本发明的颗粒具有基本均匀的颗粒尺寸并且对液体表现出低渗透性。

3. 发明授权

US08562505B2 Uniform field magnetization and targeting of therapeutic formulations 有权
公开(公告)号：US08562505B2
公开(公告)日：2013-10-22
申请号：US12150864
申请日：2008-05-01
申请人： Robert J. Levy , Boris Polyak , Michael Chorny , Ivan Alferiev , Gennady Friedman , Darryl Williams , Ilia Fishbein
发明人： Robert J. Levy , Boris Polyak , Michael Chorny , Ivan Alferiev , Gennady Friedman , Darryl Williams , Ilia Fishbein
IPC分类号： A61N2/10
CPC分类号： A61K41/00 , A61K9/5094 , A61K9/5115 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K9/5169 , A61K9/5192 , A61K31/203 , A61K31/337 , A61K31/713 , A61K35/44 , A61K35/761 , A61K47/42 , A61K47/59 , A61K47/6455 , A61K47/6923 , A61K47/6929 , A61K48/0008 , A61K48/0041 , A61K48/0083 , C12N15/111 , C12N15/86 , C12N2320/32 , C12N2710/10343 , C12N2710/10345
摘要： Systems and methods for magnetic targeting of therapeutic particles are provided. Therapeutic particles comprise one or more magnetic or magnetizable materials and at least one therapeutic agent. Therapeutic particles are specifically targeted using uniform magnetic fields capable of magnetizing magnetizable materials, and can be targeted to particular locations in the body, or can be targeted for capture, containment, and removal. Also provided are bioresorbable nanoparticles prepared without the use of organic solvents, and methods for therapeutically using such bioresorbable nanoparticles.

4. 发明申请

US20130243862A1 PHOTOCHEMICAL ACTIVATION OF SURFACES FOR ATTACHING BIOMATERIAL 审中-公开
标题翻译：用于连接生物材料的表面的光化学活化
公开(公告)号：US20130243862A1
公开(公告)日：2013-09-19
申请号：US13606672
申请日：2012-09-07
申请人： Ivan Alferiev , Ilia Fishbein , Michael Chorny , Robert J. Levy , Benjamin Yellen , Darryl Williams
发明人： Ivan Alferiev , Ilia Fishbein , Michael Chorny , Robert J. Levy , Benjamin Yellen , Darryl Williams
IPC分类号： A61L27/16 , C08F120/06 , A61L27/54 , C08F126/02
CPC分类号： A61L27/16 , A61K31/765 , A61K31/785 , A61L27/50 , A61L27/54 , A61L2400/18 , B01J2219/00637 , B01J2219/00648 , C07K17/02 , C07K17/06 , C08F8/10 , C08F8/32 , C08F8/34 , C08F120/06 , C08F126/02 , C08F226/02 , C08F271/02 , C08F290/00 , C08F291/00 , C08G63/91 , C08J7/18 , C08L75/04
摘要： A water-soluble photo-activatable polymer including: a photo-activatable group adapted to be activated by an irradiation source and to form a covalent bond between the water-soluble photo-activatable polymer and a matrix having at least one carbon; a reactive group adapted to covalently react with a biomaterial for subsequent delivery of the biomaterial to a cell; a hydrophilic group; and a polymer precursor. A composition including a monomolecular layer of the water-soluble photo-activatable polymer and a matrix having at least one carbon, wherein the monomolecular layer is covalently attached to the matrix by a covalent bond between the photo-activatable group and the at least one carbon. The composition further includes a biomaterial having a plurality of active groups, wherein the biomaterial is covalently attached to the monomolecular layer by covalent bonding between the active groups and reactive groups. Also provided is a method for delivery of a biomaterial to a cell.
摘要翻译：一种水溶性可光活化聚合物，其包括：适于被辐照源活化并在所述水溶性可光活化聚合物与具有至少一个碳的基质之间形成共价键的可光致活化基团; 适于与生物材料共价反应的反应性基团，用于随后将生物材料递送至细胞; 亲水基团; 和聚合物前体。一种组合物，其包含水溶性可光活化聚合物的单分子层和具有至少一个碳的基质，其中单分子层通过可光致活化基团和至少一个碳之间的共价键共价连接到基质上。组合物还包括具有多个活性基团的生物材料，其中生物材料通过活性基团和反应性基团之间的共价键共价连接到单分子层上。还提供了将生物材料递送到细胞的方法。

5. 发明申请

US20050073239A1 Light sources with nanometer-sized VUV radiation-absorbing phosphors 失效
标题翻译：具有纳米尺寸VUV吸收荧光体的光源
公开(公告)号：US20050073239A1
公开(公告)日：2005-04-07
申请号：US10674376
申请日：2003-10-01
申请人： Alok Mani Srivastava , Anant Setlur , Sergio Loureiro , Darryl Williams , Mohan Manoharan
发明人： Alok Mani Srivastava , Anant Setlur , Sergio Loureiro , Darryl Williams , Mohan Manoharan
IPC分类号： C09K11/08 , C09K11/02 , C09K11/66 , C09K11/67 , C09K11/70 , C09K11/74 , C09K11/77 , H01J1/62 , H01J9/22 , H01J61/44
CPC分类号： H01J61/44 , C09K11/02 , C09K11/08 , C09K11/666 , C09K11/668 , C09K11/673 , C09K11/701 , C09K11/7478 , C09K11/7704 , C09K11/7706 , C09K11/7709 , C09K11/7712 , C09K11/7734 , C09K11/7739 , C09K11/774 , C09K11/7769 , C09K11/777 , C09K11/7774 , C09K11/7777 , C09K11/778 , C09K11/7787 , C09K11/7792 , C09K11/7793 , C09K11/7797 , Y10S977/95 , Y10T428/2991 , Y10T428/2993
摘要： A light source comprises: (a) a source of plasma discharge that emits electromagnetic radiation, a portion of which has wavelengths shorter than about 200 nm; and (b) a phosphor composition that comprises particles, each of the particles comprising at least a first phosphor and at least a second phosphor, the phosphor composition is disposed such that the first phosphor absorbs substantially the portion of EM radiation having wavelengths shorter than about 200 nm, and the first phosphor emits EM radiation having wavelengths longer than about 200 nm.
摘要翻译：光源包括：（a）发射电磁辐射的等离子体放电源，其一部分波长短于约200nm; 和（b）包含颗粒的荧光体组合物，每个颗粒至少包括第一荧光体和至少第二荧光体，磷光体组合物设置成使得第一荧光体基本上吸收波长短于约 200nm，并且第一荧光体发射具有大于约200nm的波长的EM辐射。

6. 发明授权

US6015322A Method of making spark ignition electrode assembly 有权
标题翻译：制作火花点火电极组件的方法
公开(公告)号：US6015322A
公开(公告)日：2000-01-18
申请号：US185250
申请日：1998-11-03
申请人： David Baker White , Darryl Williams
发明人： David Baker White , Darryl Williams
IPC分类号： F23Q3/00 , F24C3/10
CPC分类号： F23Q3/008 , F24C3/103
摘要： A spark ignition electrode assembly includes an electrode wire and an electrically insulative support member receiving and positioning the electrode wire proximate to the gas burner. The electrically insulative support member includes an upper body portion covering the electrode wire. The upper body portion contains a spark ignition passageway for communicating spark ignition discharge between the electrode wire and the gas burner. A ceramic material is formed to define the electrically insulative support member having an electrode wire receiving opening for receiving and positioning an electrode wire proximate to the gas burner and a spark ignition passageway for communicating spark ignition discharge between the electrode wire and the gas burner. The electrode wire is inserted in the electrode wire receiving opening and then the formed ceramic material including the inserted electrode wire is fired.
摘要翻译：火花点火电极组件包括电极线和电绝缘支撑构件，其接收并定位靠近气体燃烧器的电极线。电绝缘支撑构件包括覆盖电极线的上主体部分。上身部分包含用于在电极线和气体燃烧器之间连通火花点火放电的火花点火通道。形成陶瓷材料以限定具有用于接近和定位靠近气体燃烧器的电极线的电极线接收开口的电绝缘支撑构件和用于在电极线和气体燃烧器之间连通火花点火放电的火花点火通道。将电极线插入电极线接收开口中，然后将包括插入的电极线的形成的陶瓷材料烧制。

7. 发明申请

US20130096361A9 Uniform field magnetization and targeting of therapeutic formulations 有权
公开(公告)号：US20130096361A9
公开(公告)日：2013-04-18
申请号：US12150864
申请日：2008-05-01
申请人： Robert J. Levy , Boris Polyak , Michael Chorny , Ivan Alferiev , Gennady Friedman , Darryl Williams , Ilia Fishbein
发明人： Robert J. Levy , Boris Polyak , Michael Chorny , Ivan Alferiev , Gennady Friedman , Darryl Williams , Ilia Fishbein
IPC分类号： A61N2/00 , A61M31/00
CPC分类号： A61K41/00 , A61K9/5094 , A61K9/5115 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K9/5169 , A61K9/5192 , A61K31/203 , A61K31/337 , A61K31/713 , A61K35/44 , A61K35/761 , A61K47/42 , A61K47/59 , A61K47/6455 , A61K47/6923 , A61K47/6929 , A61K48/0008 , A61K48/0041 , A61K48/0083 , C12N15/111 , C12N15/86 , C12N2320/32 , C12N2710/10343 , C12N2710/10345
摘要： Systems and methods for magnetic targeting of therapeutic particles are provided. Therapeutic particles comprise one or more magnetic or magnetizable materials and at least one therapeutic agent. Therapeutic particles are specifically targeted using uniform magnetic fields capable of magnetizing magnetizable materials, and can be targeted to particular locations in the body, or can be targeted for capture, containment, and removal. Also provided are bioresorbable nanoparticles prepared without the use of organic solvents, and methods for therapeutically using such bioresorbable nanoparticles.

8. 发明申请

US20090216320A1 Magnetic Gradient Targeting And Sequestering Of Therapeutic Formulations And Therapeutic Systems Thereof 审中-公开
标题翻译：治疗配方及其治疗系统的磁性梯度靶向和螯合
公开(公告)号：US20090216320A1
公开(公告)日：2009-08-27
申请号：US12297971
申请日：2007-04-20
申请人： Robert J. Levy , Ivan Alferlev , Michael Chorny , Ilia Fishbein , Gennady Friedman , Boris Polyak , Darryl Williams
发明人： Robert J. Levy , Ivan Alferlev , Michael Chorny , Ilia Fishbein , Gennady Friedman , Boris Polyak , Darryl Williams
IPC分类号： A61M37/00 , A61N2/00 , A61F2/82
CPC分类号： A61K9/0009 , A61B2017/00876 , A61B2017/00893 , A61K9/0019 , A61L31/14 , A61L31/16 , A61L2300/624 , A61L2400/12 , A61N2/002 , A61N2/06
摘要： A therapeutic system and a method that uses stents, and/or other implantable devices (104) for local delivery of a therapeutic agent is disclosed. A therapeutic formulation (102) may include particles of a biocompatible magnetic or magnetizable material that carry the therapeutic agent, or magnetically responsive cells. The therapeutic formulation (102) is intravenously administered to a mammalian subject. A portion of the formulation (102) is delivered to the proximity of a device (104) implanted in the vascular system of the subject by externally generating a magnetic field gradient (106) on the implantable device (104). The portion of the therapeutic formulation (102) not delivered to the proximity of the implantable device (104) is removed from the vascular system. The method allows for the repeated administration of the same or different therapeutic agent, and further, has the option of locally injecting, or alternatively, peripherally administering, the therapeutic agent.
摘要翻译：公开了一种治疗系统和使用支架的方法，和/或用于局部递送治疗剂的其它可植入装置（104）。治疗剂（102）可以包括携带治疗剂或磁反应性细胞的生物相容性磁性或可磁化材料的颗粒。将治疗制剂（102）静脉内施用于哺乳动物受试者。制剂（102）的一部分通过在可植入装置（104）上外部产生磁场梯度（106）而输送到植入受试者的血管系统中的装置（104）附近。从血管系统中去除未被输送到可植入装置（104）附近的部分治疗剂（102）。该方法允许相同或不同的治疗剂的重复给药，此外，还可以选择局部注射或替代地外周施用治疗剂。

9. 发明申请

US20060147413A1 Photochemical activation of surfaces for attaching biomaterial 有权
公开(公告)号：US20060147413A1
公开(公告)日：2006-07-06
申请号：US11250877
申请日：2005-10-14
申请人： Ivan Alferiev , Ilia Fishbein , Michael Chorny , Robert Levy , Benjamin Yellen , Darryl Williams
发明人： Ivan Alferiev , Ilia Fishbein , Michael Chorny , Robert Levy , Benjamin Yellen , Darryl Williams
IPC分类号： A61K31/785 , A61K31/765 , C08F271/02
CPC分类号： C08G63/91 , A61K31/765 , A61K31/785 , A61L27/50 , A61L2400/18 , C07K17/02 , C08F8/10 , C08F8/32 , C08F8/34 , C08F226/02 , C08F271/02 , C08F290/00 , C08F291/00 , C08J7/18 , C08L75/04 , C08F120/06 , C08F126/02
摘要： A water-soluble photo-activatable polymer including: a photo-activatable group adapted to be activated by an irradiation source and to form a covalent bond between the water-soluble photo-activatable polymer and a matrix having at least one carbon; a reactive group adapted to covalently react with a biomaterial for subsequent delivery of the biomaterial to a cell; a hydrophilic group; and a polymer precursor. A composition including a monomolecular layer of the water-soluble photo-activatable polymer and a matrix having at least one carbon, wherein the monomolecular layer is covalently attached to the matrix by a covalent bond between the photo-activatable group and the at least one carbon. The composition further includes a biomaterial having a plurality of active groups, wherein the biomaterial is covalently attached to the monomolecular layer by covalent bonding between the active groups and reactive groups. Also provided is a method for delivery of a biomaterial to a cell.

10. 发明授权

US5924860A Thickwall gas burner assembly 失效
标题翻译：厚壁燃气灶组件
公开(公告)号：US5924860A
公开(公告)日：1999-07-20
申请号：US919914
申请日：1997-08-28
申请人： Dale Massey , Darryl Williams
发明人： Dale Massey , Darryl Williams
IPC分类号： F23D14/06 , F24C3/10 , F23Q3/00
CPC分类号： F23D14/06 , F24C3/103
摘要： A gas burner assembly is provided for use with a gas stove top. The gas burner assembly includes a burner base with an inlet receiving a mixture of gas and primary air. A burner cap is supported by the burner base. The burner base and the burner cap together define a burner fuel chamber. The burner cap includes a plurality of main burner ports where the air and gas mixture exits and burns in the presence of secondary air. A spark ignition assembly is operatively associated with the burner base for igniting the mixture. The burner cap includes an ignition pocket for capturing gas for reignition for drafts or door slam conditions. A venturi assembly communicates with the burner base inlet providing the air and gas mixture. The venturi assembly includes mounting features for mounting the gas burner assembly to the gas stove, thereby eliminating the need for fasteners to secure the burner base to the gas stove.
摘要翻译：提供了一种用于燃气灶顶部的气体燃烧器组件。气体燃烧器组件包括具有接收气体和一次空气的混合物的入口的燃烧器基座。燃烧器盖由燃烧器基座支撑。燃烧器基座和燃烧器盖一起限定燃烧器燃料室。燃烧器盖包括多个主燃烧器端口，其中空气和气体混合物在二次空气存在的情况下离开并燃烧。火花点火组件与燃烧器基座可操作地相关联，用于点燃混合物。燃烧器盖包括用于捕获气体的点火口，用于起草或门槛条件的重新点燃。文丘里组件与燃烧器基座入口连通，提供空气和气体混合物。文丘里组件包括用于将气体燃烧器组件安装到燃气灶的安装特征，从而消除了将燃烧器基座固定到燃气灶的紧固件的需要。

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