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1. 发明申请

US20100284932A1 FLUORESCENT EMULSIONS FOR OPTICAL IMAGING 有权
标题翻译：用于光学成像的荧光乳液
公开(公告)号：US20100284932A1
公开(公告)日：2010-11-11
申请号：US12527314
申请日：2008-02-14
申请人： Mathieu Goutayer , Isabelle Texier-Nogues , Jacques Fattaccioli , Jerome Bibette , Anabela Da Silva
发明人： Mathieu Goutayer , Isabelle Texier-Nogues , Jacques Fattaccioli , Jerome Bibette , Anabela Da Silva
IPC分类号： C09K11/06 , A61B5/00
CPC分类号： A61K49/0078 , A61K9/1075 , A61K49/0032 , A61K49/0056 , B01F17/0078
摘要： The invention relates to a fluorescent emulsion, to a diagnostic reagent containing the same, and to the use thereof in the preparation of a diagnostic reagent for in vivo fluorescence imaging.
摘要翻译：本发明涉及荧光乳剂，含有该荧光乳剂的诊断试剂及其在制备用于体内荧光成像的诊断试剂中的用途。

2. 发明授权

US09072775B2 Fluorescent emulsions for optical imaging 有权
标题翻译：用于光学成像的荧光乳液
公开(公告)号：US09072775B2
公开(公告)日：2015-07-07
申请号：US12527314
申请日：2008-02-14
申请人： Mathieu Goutayer , Isabelle Texier-Nogues , Jacques Fattaccioli , Jérôme Bibette , Anabela Da Silva
发明人： Mathieu Goutayer , Isabelle Texier-Nogues , Jacques Fattaccioli , Jérôme Bibette , Anabela Da Silva
IPC分类号： A61K49/00 , B01F17/00 , A61K9/107
CPC分类号： A61K49/0078 , A61K9/1075 , A61K49/0032 , A61K49/0056 , B01F17/0078
摘要： The invention relates to a fluorescent emulsion, to a diagnostic reagent containing the same, and to the use thereof in the preparation of a diagnostic reagent for in vivo fluorescence imaging.
摘要翻译：本发明涉及荧光乳剂，含有该荧光乳剂的诊断试剂及其在制备用于体内荧光成像的诊断试剂中的用途。

3. 发明授权

US10092506B2 Encapsulation of lipophilic or amphiphilic therapeutic agents in nano-emulsion 有权
公开(公告)号：US10092506B2
公开(公告)日：2018-10-09
申请号：US13058850
申请日：2009-08-14
申请人： Veronique Mourier-Robert , Jerome Bibette , Mathieu Goutayer , Fabrice Navarro y Garcia , Isabelle Texier-Nogues
发明人： Veronique Mourier-Robert , Jerome Bibette , Mathieu Goutayer , Fabrice Navarro y Garcia , Isabelle Texier-Nogues
IPC分类号： A61K9/00 , A61K47/69 , A61K41/00 , A61K9/107 , B82Y5/00
摘要： The present invention relates to a therapeutic agent formulation in the form of a nano-emulsion, comprising a continuous aqueous phase and at least one dispersed oily phase, in which the oily phase comprises further to the therapeutic agent, at least one amphiphilic lipid and at least one solubilizing lipid, and in which the aqueous phase comprises at least one polyalkoxylated cosurfactant.The invention also relates to a preparation method and use of this formulation.

4. 发明申请

US20100144899A1 METHOD FOR PREPARING NANO-EMULSIONS 审中-公开
标题翻译：制备纳米乳液的方法
公开(公告)号：US20100144899A1
公开(公告)日：2010-06-10
申请号：US12527371
申请日：2008-02-14
申请人： Mathieu Goutayer , Isabelle Texier-Nogues , Jerome Bibette
发明人： Mathieu Goutayer , Isabelle Texier-Nogues , Jerome Bibette
IPC分类号： A61K47/34 , A61K47/44 , A61P43/00
CPC分类号： A61K49/0078 , A61K9/1075 , A61K49/0032 , A61K49/0056 , B01F17/0078
摘要： The present invention relates to a method for preparing nano-emulsions comprising at least one aqueous continuous phase and at least one oily dispersed phase, comprising the steps of: (i) preparing the oily phase comprising at least one amphiphilic lipid and at least one solubilising lipid; (ii) dispersing the oily phase in an aqueous phase under the effect of sufficient shear force to form a nano-emulsion; and (iii) recovering the nano-emulsion thus formed.
摘要翻译：本发明涉及一种制备包含至少一种含水连续相和至少一种油分散相的纳米乳液的方法，其包括以下步骤：（i）制备包含至少一种两亲脂质和至少一种增溶的油相脂质; （ii）在足够剪切力的作用下将油相分散在水相中以形成纳米乳液; 和（iii）回收如此形成的纳米乳液。

5. 发明申请

US20110201695A1 Encapsulation of lipophilic or amphiphilic therapeutic agents in nano-emulsion 审中-公开
标题翻译：亲脂性或两亲治疗剂在纳米乳液中的包封
公开(公告)号：US20110201695A1
公开(公告)日：2011-08-18
申请号：US13058850
申请日：2009-08-14
申请人： Veronique Mourier-Robert , Jerome Bibette , Mathieu Goutayer , Fabrice Navarro y Garcia , Isabelle Texier-Nogues
发明人： Veronique Mourier-Robert , Jerome Bibette , Mathieu Goutayer , Fabrice Navarro y Garcia , Isabelle Texier-Nogues
IPC分类号： A61K47/44
CPC分类号： A61K9/0019 , A61K9/1075 , A61K41/0071 , A61K47/6907 , B82Y5/00
摘要： The present invention relates to a therapeutic agent formulation in the form of a nano-emulsion, comprising a continuous aqueous phase and at least one dispersed oily phase, in which the oily phase comprises further to the therapeutic agent, at least one amphiphilic lipid and at least one solubilising lipid, and in which the aqueous phase comprises at least one polyalkoxylated cosurfactant.The invention also relates to a preparation method and use of this formulation.
摘要翻译：本发明涉及纳米乳液形式的治疗剂制剂，其包含连续的水相和至少一种分散的油相，其中所述油相还包含所述治疗剂，至少一种两亲性脂质和至少一种增溶脂质，其中水相包含至少一种聚烷氧化辅助表面活性剂。本发明还涉及该制剂的制备方法和用途。

6. 发明授权

US09289517B2 Fluorescent emulsion of indocyanine green 有权
标题翻译：吲哚菁绿的荧光乳液
公开(公告)号：US09289517B2
公开(公告)日：2016-03-22
申请号：US13058851
申请日：2009-08-14
申请人： Mathieu Goutayer , Fabrice Navarro Y Garcia , Isabelle Texier-Nogues
发明人： Mathieu Goutayer , Fabrice Navarro Y Garcia , Isabelle Texier-Nogues
IPC分类号： A61K49/00
CPC分类号： A61K49/0078 , A61K49/0034
摘要： The present invention relates to a formulation of indocyanine green in the form of a nanoemulsion, comprising a continuous aqueous phase and at least one dispersed oily phase, in which the oily phase comprises indocyanine green, at least one amphiphilic lipid and at least one solubilizing lipid.It relates also to a process for the preparation and to the use of the formulation.
摘要翻译：本发明涉及纳米乳液形式的靛青绿的制剂，其包含连续水相和至少一种分散的油相，其中油相包含靛青绿，至少一种两亲脂质和至少一种增溶脂质。它还涉及制备和使用制剂的方法。

7. 发明申请

US20110200532A1 Fluorescent emulsion of indocyanine green 有权
标题翻译：吲哚菁绿的荧光乳液
公开(公告)号：US20110200532A1
公开(公告)日：2011-08-18
申请号：US13058851
申请日：2009-08-14
申请人： Mathieu Goutayer , Fabrice Navarro Y Garcia , Isabelle Texier-Nogues
发明人： Mathieu Goutayer , Fabrice Navarro Y Garcia , Isabelle Texier-Nogues
IPC分类号： A61K49/00
CPC分类号： A61K49/0078 , A61K49/0034
摘要： The present invention relates to a formulation of indocyanine green in the form of a nanoemulsion, comprising a continuous aqueous phase and at least one dispersed oily phase, in which the oily phase comprises indocyanine green, at least one amphiphilic lipid and at least one solubilising lipid.It relates also to a process for the preparation and to the use of the formulation.
摘要翻译：本发明涉及纳米乳液形式的靛青绿的制剂，其包含连续的水相和至少一种分散的油相，其中油相包含靛青绿，至少一种两亲脂质和至少一种增溶脂质。它还涉及制备和使用制剂的方法。

8. 发明申请

US20110274622A1 Nanocrystal Nano-Emulsion 有权
标题翻译：纳米乳液
公开(公告)号：US20110274622A1
公开(公告)日：2011-11-10
申请号：US13058849
申请日：2009-08-14
申请人： Isabelle Texier-Nogues , Toufic Daou , Mathieu Goutayer
发明人： Isabelle Texier-Nogues , Toufic Daou , Mathieu Goutayer
IPC分类号： A61K49/00 , A61K9/127 , B82Y5/00 , B82Y15/00
CPC分类号： A61K49/0067 , A61K9/0019 , A61K9/1075 , A61K41/0052 , A61K47/10 , A61K47/14 , A61K47/24 , A61K47/44 , A61K49/0078
摘要： The invention relates to a nanocrystal formulation in the form of a nano-emulsion, comprising a continuous aqueous phase and at least one dispersed oily phase, in which the oily phase comprises at least one amphiphilic lipid and at least one solubilising lipid, and in which the aqueous phase comprises a cosurfactant.The invention also relates to a method for the production of said formulation as well as uses within the fields of medical imaging, thermotherapy or phototherapy.
摘要翻译：本发明涉及纳米乳液形式的纳米晶体制剂，其包含连续的水相和至少一种分散的油相，其中油相包含至少一种两亲性脂质和至少一种增溶脂质，其中水相包含辅助表面活性剂。本发明还涉及生产所述制剂的方法以及在医学成像，热疗或光疗领域内的用途。

9. 发明申请

US20110195029A1 FLUORESCENT EMULSION 审中-公开
标题翻译：荧光乳液
公开(公告)号：US20110195029A1
公开(公告)日：2011-08-11
申请号：US13058984
申请日：2009-08-11
申请人： Laurent Guyon , Mathieu Goutayer , Fabrice Navarro Y Garcia , Isabelle Texier-Nogues
发明人： Laurent Guyon , Mathieu Goutayer , Fabrice Navarro Y Garcia , Isabelle Texier-Nogues
IPC分类号： A61K49/00
CPC分类号： A61K49/0078 , A61K9/107 , A61K47/36 , A61K47/44 , A61K49/0032 , A61K49/0034 , G01N33/533 , G01N33/582
摘要： The invention relates to a fluorescent emulsion, to its uses and to labelling reagents comprising it.The fluorescent emulsion of the invention is of the oil-in-water type, comprising at least one aqueous continuous phase in which droplets of at least one oil phase are dispersed, said oil phase droplets being stabilized by a surfactant layer, characterized in that it comprises at least one pair of labels, differing from one another, formed from a donor fluorescent label that absorbs at a wavelength λ1 and emits at a wavelength λ2, different from λ1, and an acceptor label that absorbs at the emission wavelength λ2 of the donor fluorescent label; in that the donor fluorescent label and the acceptor label are kept close together by the encapsulation of one of them in the oil phase droplets and either by linking the other of them to the oil phase droplet/aqueous phase interface, or by the encapsulation of the other of them in the oil phase droplets; and in that it comprises molecules of at least one amphiphilic surfactant and at least one solubilizing lipid.The fluorescent emulsion of the invention is applicable in the field of optical fluorescence imaging, in particular optical fluorescence biomedical imaging.
摘要翻译：本发明涉及荧光乳剂，其用途和标记包含它的试剂。本发明的荧光乳液是水包油型的，其包含至少一个水相连续相，其中分散有至少一个油相的液滴，所述油相液滴由表面活性剂层稳定，其特征在于它包含至少一对彼此不同的标签，由供体荧光标记物形成，所述供体荧光标记物以波长λ1吸收并以不同于λ1的波长λ2发射，并且以所述供体的发射波长λ2吸收的受体标记荧光标签因为供体荧光标记和受体标记通过将它们中的一个包封在油相液滴中并通过将另一个连接到油相液滴/水相界面而保持靠近在一起，或者通过将其他的在油相液滴中; 并且其包含至少一种两亲性表面活性剂和至少一种增溶脂质的分子。本发明的荧光乳剂可应用于光学荧光成像领域，特别是光学荧光生物医学成像领域。

10. 发明授权

US09180210B2 Nanocrystal nano-emulsion 有权
标题翻译：纳米晶纳米乳液
公开(公告)号：US09180210B2
公开(公告)日：2015-11-10
申请号：US13058849
申请日：2009-08-14
申请人： Isabelle Texier-Nogues , Toufic Daou , Mathieu Goutayer
发明人： Isabelle Texier-Nogues , Toufic Daou , Mathieu Goutayer
IPC分类号： A61K49/00 , A61K47/44 , A61K9/00 , A61K9/107 , A61K41/00 , A61K47/10 , A61K47/14 , A61K47/24
CPC分类号： A61K49/0067 , A61K9/0019 , A61K9/1075 , A61K41/0052 , A61K47/10 , A61K47/14 , A61K47/24 , A61K47/44 , A61K49/0078
摘要： A nanocrystal formulation in the form of a nano-emulsion includes a continuous aqueous phase and at least one dispersed oily phase, in which the oily phase has at least one amphiphilic lipid and at least one solubilising lipid, and in which the aqueous phase has a cosurfactant. The invention also relates to a method for the production of the formulation as well as uses within the fields of medical imaging, thermotherapy or phototherapy.
摘要翻译：纳米乳液形式的纳米晶体制剂包括连续的水相和至少一个分散的油相，其中油相具有至少一种两亲性脂质和至少一种增溶脂质，其中水相具有辅助表面活性剂。本发明还涉及制备该制剂的方法以及在医学成像，热疗或光疗领域中的用途。

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