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1. 发明授权

US09072775B2 Fluorescent emulsions for optical imaging 有权
标题翻译：用于光学成像的荧光乳液
公开(公告)号：US09072775B2
公开(公告)日：2015-07-07
申请号：US12527314
申请日：2008-02-14
申请人： Mathieu Goutayer , Isabelle Texier-Nogues , Jacques Fattaccioli , Jérôme Bibette , Anabela Da Silva
发明人： Mathieu Goutayer , Isabelle Texier-Nogues , Jacques Fattaccioli , Jérôme Bibette , Anabela Da Silva
IPC分类号： A61K49/00 , B01F17/00 , A61K9/107
CPC分类号： A61K49/0078 , A61K9/1075 , A61K49/0032 , A61K49/0056 , B01F17/0078
摘要： The invention relates to a fluorescent emulsion, to a diagnostic reagent containing the same, and to the use thereof in the preparation of a diagnostic reagent for in vivo fluorescence imaging.
摘要翻译：本发明涉及荧光乳剂，含有该荧光乳剂的诊断试剂及其在制备用于体内荧光成像的诊断试剂中的用途。

2. 发明申请

US20140045949A1 METHOD FOR FORMING DROPS OF A FIRST PHASE, DISPERSED IN A SECOND PHASE SUBSTANTIALLY IMMISCIBLE WITH THE FIRST PHASE 审中-公开
标题翻译：形成第一相的液滴的方法，在第二相中分散出来，与第一相不可靠
公开(公告)号：US20140045949A1
公开(公告)日：2014-02-13
申请号：US14003527
申请日：2012-03-07
申请人： Mathieu Goutayer , Jérôme Bibette
发明人： Mathieu Goutayer , Jérôme Bibette
IPC分类号： A61K8/81 , A61K8/891
CPC分类号： A61K8/8147 , A23D7/0053 , A23D7/02 , A23P10/30 , A61K8/062 , A61K8/11 , A61K8/31 , A61K8/891 , A61K8/922 , A61K9/10 , A61K9/5026 , A61K47/32 , A61K47/34 , A61K2800/412 , A61Q19/00 , B01J13/10
摘要： This method includes the provision of a first fluid (36) including the first phase and a first precursor polymer of the coacervate contained in the first phase, and the formation of drops of the first fluid (36) in a second fluid (40) intended to form the second phase (16). It includes the steps of introducing a second precursor polymer of the coacervate into the second fluid (40) and, during the formation of each drop (12), or once each drop (12) has been formed, for generating the coacervate layer by interaction between the first precursor polymer and the second precursor polymer at the interface between the first phase (14) and the second phase (16).
摘要翻译：该方法包括提供包含第一相的第一流体和包含在第一相中的凝聚层的第一前体聚合物的第一流体和在第二流体（40）中形成第一流体（40）的液滴以形成第二阶段（16）。它包括以下步骤：将凝聚层的第二前体聚合物引入第二流体（40）中，并且在形成每个液滴（12）期间，或者每个液滴（12）形成后，通过相互作用产生凝聚层在第一相（14）和第二相（16）之间的界面处在第一前体聚合物和第二前体聚合物之间。

3. 发明授权

US07217457B2 Composite particles, derived conjugates, preparation method and applications 有权
标题翻译：复合颗粒，衍生共轭物，制备方法和应用
公开(公告)号：US07217457B2
公开(公告)日：2007-05-15
申请号：US10475709
申请日：2002-05-06
申请人： Abdelhamid Elaissari , Franck Montagne , Eric Bosc , Christian Pichot , Bernard Mandrand , Jérôme Bibette , Olivier Mondain-Monval
发明人： Abdelhamid Elaissari , Franck Montagne , Eric Bosc , Christian Pichot , Bernard Mandrand , Jérôme Bibette , Olivier Mondain-Monval
IPC分类号： B32B5/16 , C08K3/00
CPC分类号： C08K9/08 , A61K41/0052 , A61K49/1854 , A61K49/1857 , A61K49/1887 , C08F291/00 , C08F292/00 , Y10T428/2991 , Y10T428/2998
摘要： The invention relates to composite particles comprising a hydrophobic polymer core and inorganic nanoparticles. Said hydrophobic polymer forms a polymer matrix inside which the inorganic nanoparticles are stabilized and distributed in a relatively homogenous manner. Said particles are at least partially surrounded by an amphophilic copolymer comprising a hydrophobic part and a hydrophilic part, said hydrophobic part being at least partially immobilized in the polymer matrix. The inventor also relates to the preparation method thereof, the conjugates comprising such particles and a ligand and the use of same in reactants and therapeutic compositions.
摘要翻译：本发明涉及包含疏水聚合物芯和无机纳米颗粒的复合颗粒。所述疏水性聚合物形成聚合物基质，无机纳米颗粒在该聚合物基质内稳定并以相对均匀的方式分布。所述颗粒至少部分被包含疏水部分和亲水部分的两亲共聚物包围，所述疏水部分至少部分地固定在聚合物基质中。发明人还涉及其制备方法，包含这种颗粒的配偶体和配体以及其在反应物和治疗组合物中的用途。

4. 发明授权

US09277759B2 Method for manufacturing capsule series, and related capsule series 有权
标题翻译：胶囊系列制造方法及相关胶囊系列
公开(公告)号：US09277759B2
公开(公告)日：2016-03-08
申请号：US13131971
申请日：2009-12-01
申请人： Jérôme Bibette , Liang-yin Chu , Enric Santanach Carreras , Audrey Royere , Nicolas Bremond
发明人： Jérôme Bibette , Liang-yin Chu , Enric Santanach Carreras , Audrey Royere , Nicolas Bremond
IPC分类号： A23L1/22 , A23P1/04 , A23L1/00 , A61K9/48
CPC分类号： A23L1/22016 , A23L27/72 , A23P10/30 , A61K9/4816 , A61K9/4833
摘要： A method includes separately conveying a first liquid solution (36) containing the first material and a second liquid solution (46) containing a liquid polyelectrolyte. The method includes forming of a series of drops (78) at the outlet (50), each drop (78) including a central core (80) formed from a first solution (36) and a peripheral film (82) formed from a second solution. The method includes immersing each drop (78) in a gelling solution (70) containing a reagent capable of reacting with the polyelectrolyte of the film (82) so as to form the gelled casing. The second solution (40) contains at least one surfactant before the former contacts the first solution (36).
摘要翻译：一种方法包括分别输送含有第一材料的第一液体溶液（36）和含有液体聚电解质的第二液体溶液（46）。该方法包括在出口（50）处形成一系列液滴（78），每个液滴（78）包括由第一溶液（36）形成的中心芯（80）和由第二溶液解。该方法包括将每个液滴（78）浸入含有能够与膜（82）的聚电解质反应的试剂的胶凝溶液（70）中以形成凝胶化的壳体。第二溶液（40）在前者接触第一溶液（36）之前含有至少一种表面活性剂。

5. 发明授权

US09145489B2 Process for preparing a masterbatch in the liquid phase 有权
标题翻译：在液相中制备母料的方法
公开(公告)号：US09145489B2
公开(公告)日：2015-09-29
申请号：US13995082
申请日：2011-12-21
申请人： Jérôme Bibette , Fernando Martinez Pedrero , Benoît De Gaudemaris , Julien Berriot
发明人： Jérôme Bibette , Fernando Martinez Pedrero , Benoît De Gaudemaris , Julien Berriot
IPC分类号： C08C1/14 , C08K5/54 , B60C1/00 , C08J3/22 , C08K3/34 , C08K9/06
CPC分类号： C08K5/5406 , B60C1/0016 , C08C1/14 , C08J3/226 , C08J2407/02 , C08J2409/10 , C08K3/34 , C08K9/06
摘要： The invention relates to a process for the preparation of a masterbatch in the liquid phase based on one or more diene elastomers and on one or more fillers which do not coagulate spontaneously with the said latex, comprising the following successive stages: preparation of a stable and homogeneous aqueous dispersion (C) by mixing one or more diene elastomer latexes (A) with one or more stable aqueous dispersions (B) of one or more fillers which do not coagulate spontaneously with the said latex and which are partially hydrophobized, homogenization of the aqueous dispersion (C), coagulation within the aqueous dispersion (C) of the diene elastomer latex with the fillers which do not coagulate spontaneously with the said latex by supplying mechanical energy, recovery of the coagulum, then drying the recovered coagulum in order to obtain the masterbatch.
摘要翻译：本发明涉及一种用于制备基于一种或多种二烯弹性体的液相中的母料和不与所述胶乳自发凝结的一种或多种填料的方法，包括以下连续步骤：制备稳定和通过将一种或多种二烯弹性体胶乳（A）与一种或多种不与所述胶乳自发凝结并且部分疏水化的一种或多种填料的稳定的水性分散体（B）混合，并将其部分疏水化，使均匀的水分散体（C）水分散体（C），在二烯弹性体胶乳的水分散体（C）内凝结，其中填料通过提供机械能而不与所述胶乳自发凝结，回收凝结物，然后干燥回收的凝结物，以获得母粒

6. 发明申请

US20150267008A1 METHOD FOR PREPARING A MASTERBATCH OF AN ELASTOMER AND AN INORGANIC REINFORCING FILLER 有权
标题翻译：制备弹性体和无机增强填料的主板的方法
公开(公告)号：US20150267008A1
公开(公告)日：2015-09-24
申请号：US14111756
申请日：2011-12-21
申请人： Jérôme Bibette , Fernando Martinez Pedrero , Benoît De Gaudemaris , Julien Berriot
发明人： Jérôme Bibette , Fernando Martinez Pedrero , Benoît De Gaudemaris , Julien Berriot
IPC分类号： C08J3/22
CPC分类号： C08J3/226 , B60C1/0016 , C08C1/15 , C08J3/215 , C08J2307/02 , C08J2409/00 , C08J2421/00 , C08K3/013 , C08K9/06 , C08L21/00 , C08K3/0033 , C08L7/00
摘要： The invention relates to a process for the preparation of a masterbatch of diene elastomer and reinforcing inorganic filler in accordance with the invention comprises the following successive stages: bringing into contact and mixing one or more aqueous dispersions (B) of one or more hydrophobized reinforcing inorganic fillers, which coagulate(s) spontaneously with the said latex, and one or more diene elastomer latexes (A) in order to obtain a coagulum, without requiring a coagulating agent, recovery of the coagulum, then drying the recovered coagulum in order to obtain the masterbatch.
摘要翻译：本发明涉及一种制备本发明的二烯弹性体和增强无机填料的母料的方法，包括以下连续步骤：使一种或多种疏水化增强无机填料的水性分散体（B）接触并混合填充剂，其与所述胶乳自发凝结，以及一种或多种二烯弹性体胶乳（A），以获得凝固物，而不需要凝固剂，回收凝结物，然后干燥回收的凝结物，以获得母粒

7. 发明申请

US20120003285A1 METHOD FOR MANUFACTURING CAPSULE SERIES, AND RELATED CAPSULE SERIES 有权
标题翻译：制造胶囊系列及相关胶囊系列的方法
公开(公告)号：US20120003285A1
公开(公告)日：2012-01-05
申请号：US13131971
申请日：2009-12-01
申请人： Jérôme Bibette , Liang-yin Chu , Enric Santanach Carreras , Audrey Royere , Nicolas Bremond
发明人： Jérôme Bibette , Liang-yin Chu , Enric Santanach Carreras , Audrey Royere , Nicolas Bremond
IPC分类号： A61K9/48 , B29C67/24 , A61K8/11 , A61K38/18 , A61K38/22 , A61P35/00 , A61P33/00 , A61P29/00 , A61P7/00 , A61P31/10 , A61P31/00 , A61K38/00 , A23L1/212 , A23D9/00 , A61J3/07
CPC分类号： A23L1/22016 , A23L27/72 , A23P10/30 , A61K9/4816 , A61K9/4833
摘要： A method includes separately conveying a first liquid solution (36) containing the first material and a second liquid solution (46) containing a liquid polyelectrolyte. The method includes forming of a series of drops (78) at the outlet (50), each drop (78) including a central core (80) formed from a first solution (36) and a peripheral film (82) formed from a second solution. The method includes immersing each drop (78) in a gelling solution (70) containing a reagent capable of reacting with the polyelectrolyte of the film (82) so as to form the gelled casing. The second solution (40) contains at least one surfactant before the former contacts the first solution (36).
摘要翻译：一种方法包括分别输送含有第一材料的第一液体溶液（36）和含有液体聚电解质的第二液体溶液（46）。该方法包括在出口（50）处形成一系列液滴（78），每个液滴（78）包括由第一溶液（36）形成的中心芯（80）和由第二溶液解。该方法包括将每个液滴（78）浸入含有能够与膜（82）的聚电解质反应的试剂的胶凝溶液（70）中以形成凝胶化的壳体。第二溶液（40）在前者接触第一溶液（36）之前含有至少一种表面活性剂。

8. 发明授权

US06866838B1 Composite nanospheres and their conjugates with biomolecules 有权
标题翻译：复合纳米球及其与生物分子的共轭物
公开(公告)号：US06866838B1
公开(公告)日：2005-03-15
申请号：US10129141
申请日：2000-11-06
申请人： Olivier Mondain-Monval , Abdelhamid Elaissari , Eric Bosc , Christian Pichot , Bernard Mandrand , Jérôme Bibette
发明人： Olivier Mondain-Monval , Abdelhamid Elaissari , Eric Bosc , Christian Pichot , Bernard Mandrand , Jérôme Bibette
IPC分类号： G01N33/545 , A61K9/51 , A61K31/7088 , A61K45/00 , A61K47/02 , A61K47/04 , A61K47/32 , A61K47/48 , A61K48/00 , A61P43/00 , C09D11/00 , G01N33/543 , A61B8/00 , A61K9/14 , B01J13/02
CPC分类号： G01N33/5434 , G01N2446/20 , G01N2446/64 , G01N2446/66 , Y10T428/2982 , Y10T428/2984 , Y10T428/2985 , Y10T428/2987
摘要： The invention concerns composite nanospheres having a diameter ranging between about 50 and 1000 nm plus or minus 5%, preferably between about 100 and 500 nm plus or minus 5% and advantageously between 100 and 200 nm plus or minus 5%, and comprising an essentially liquid core consisting of an organic phase and inorganic nanoparticles, distributed inside the organic phase, and a skin consisting of at least a hydrophilic polymer derived from the polymerisation of at least one water soluble monomer, in particular N-alkylacrylamide or a N—N-dialkylacrylamide; conjugates derived from said nanospheres; their preparation methods and their uses.
摘要翻译：本发明涉及直径范围在约50和1000nm之间的复合纳米球，加上或减少5％，优选在约100和500nm之间加上或减少5％，并且有利地在100和200nm之间加上或减少5％，并且包括基本上分布在有机相内部的有机相和无机纳米颗粒组成的液体芯，以及至少由至少一种水溶性单体，特别是N-烷基丙烯酰胺或NN-二烷基丙烯酰胺的聚合衍生的亲水性聚合物组成的皮肤; 源自所述纳米球的共轭物; 其制备方法及其用途。

9. 发明申请

US20140065658A1 Method for Monitoring A Reaction, And Reaction System For Implementing Same 审中-公开
标题翻译：监测反应的方法及其实施反应系统
公开(公告)号：US20140065658A1
公开(公告)日：2014-03-06
申请号：US14003002
申请日：2012-02-01
申请人： Fabien Bertholle , Jérôme Bibette , Jean-Marie Baudry , Nicolas Bremond , Larysa Baraban , Pascal Panizza
发明人： Fabien Bertholle , Jérôme Bibette , Jean-Marie Baudry , Nicolas Bremond , Larysa Baraban , Pascal Panizza
IPC分类号： C12Q1/02
CPC分类号： C12Q1/025 , A61K6/0023 , B01L3/502784 , B01L2200/0673 , B01L2300/0838 , B01L2300/088 , C12M23/16 , C12M25/01 , G01N35/08 , C08L79/08
摘要： The invention relates to a method for monitoring a reaction and to a reaction system which are inexpensive, compact, easy to implement, and enable the reaction medium to be fully supervised throughout the entire experiment. For this purpose, the invention relates to a reaction system, in particular for microorganism cultures, including: at least one vessel (M1) for the reaction medium (1, 1′), which is in fluid communication with an injection tube (10); at least one vessel (F1) for a carrier fluid (11) that is immiscible with the reaction medium (1, 1′), which is in fluid communication with a reaction tube (20); the injection tube (10) being mounted so as to lead into the reaction tube (20) such that individual drops (30) of the reaction medium can be injected into the reaction tube (20) and into the immiscible carrier fluid (11), so as to form a train of reaction chambers; at least one detector for monitoring a reaction; a means for classifying the reaction chambers; and at least one means for recirculating reaction chambers in front of at least one detector for monitoring a reaction.
摘要翻译：本发明涉及一种用于监测反应和反应体系的方法，该方法便宜，紧凑，易于实施，并且使得反应介质在整个实验中得到充分监督。为此目的，本发明涉及特别是用于微生物培养物的反应系统，其包括：用于与注入管（10）流体连通的至少一个用于反应介质（1,1'）的容器（M1） ; 用于与反应介质（1,1'）不混溶的与反应管（20）流体连通的载体流体（11）的至少一个容器（F1）; 注射管（10）被安装成引导到反应管（20）中，使得可以将反应介质的各个液滴（30）注射到反应管（20）中并进入不混溶的载体流体（11），形成反应室列; 用于监测反应的至少一个检测器; 用于对反应室进行分类的方法; 以及用于在至少一个检测器前面再循环反应室的至少一个装置，用于监测反应。

10. 发明授权

US07332353B2 Method for detecting analyte(s) using magnetic colloidal particles 有权
标题翻译：使用磁性胶体颗粒检测分析物的方法
公开(公告)号：US07332353B2
公开(公告)日：2008-02-19
申请号：US10496114
申请日：2002-11-20
申请人： Jean Baudry , Jérôme Bibette , Alain Rousseau
发明人： Jean Baudry , Jérôme Bibette , Alain Rousseau
IPC分类号： G01N33/553
CPC分类号： G01N33/5434
摘要： The invention concerns a method for detecting and/or quantifying at least an analyte in a liquid medium, characterized in that it consists in using magnetic colloidal particles functionalized at the surface with at least a ligand specific of the analyte to be detected and/or assayed and in that it comprises: contacting said particles with said medium to be analyzed; applying a magnetic field to said medium, at an intensity sufficient to cause said magnetic particles to be structured in the form of chains; maintaining said magnetic field for a sufficient time interval to enable coupling or combination of the analyte concerned with at least two specific ligands present respectively on two neighbouring particles of a chain; cancelling the magnetic field, and determining the presence and/or absence of said analyte and, as the case may be, its concentration via the presence and/or the absence of said permanent chains of magnetic particles.
摘要翻译：本发明涉及用于检测和/或定量液体介质中的至少一种分析物的方法，其特征在于它使用在表面官能化的至少一种被检测和/或分析的分析物的配体特异性的磁性胶体颗粒并且其包括：使所述颗粒与待分析的介质接触; 以足以使所述磁性颗粒以链的形式构造的强度向所述介质施加磁场; 保持所述磁场足够的时间间隔，以使所述分析物与分别存在于链的两个相邻颗粒上的至少两种特异性配体相耦合或组合; 消除磁场，并且通过所述永久磁性颗粒的存在和/或不存在来确定所述分析物的存在和/或不存在以及视情况而定的浓度。

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