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1. 发明申请

US20120121516A1 Emulsion Activatable by Ultrasounds and Method for Producing Same 审中-公开
标题翻译：超声波激活的乳液及其生产方法
公开(公告)号：US20120121516A1
公开(公告)日：2012-05-17
申请号：US13382745
申请日：2010-07-07
申请人： Patrick Tabeling , Mickael Tanter , Nicolas Pannacci , Olivier Couture , Mathias Fink
发明人： Patrick Tabeling , Mickael Tanter , Nicolas Pannacci , Olivier Couture , Mathias Fink
IPC分类号： A61K49/22 , A61P35/00 , A61K9/14 , A61K31/7088 , B82Y40/00 , B82Y5/00
CPC分类号： A61K9/0019 , A61B8/0833 , A61B8/481 , A61J3/00 , A61K9/0009 , A61K9/1075 , A61K41/0028
摘要： The invention relates to an emulsion that can be activated by ultrasounds, comprising, in an emulsion in an aqueous solution, microparticles having a diameter of less than 10 μm and containing an active agent and a gaseous precursor in a liquid form, encapsulated by a first emulsifier. The microparticles contain nanoparticles smaller than 1 μm, in an emulsion in the gaseous precursor, each nanoparticle comprising an inner liquid that contains the active agent and is encapsulated by a second emulsifier.
摘要翻译：本发明涉及一种能够被超声波激活的乳液，其在水溶液中的乳液中包含直径小于10μm的微粒，并且含有液体形式的活性剂和气体前体，其被第一乳化剂。微粒含有小于1μm的纳米颗粒，在气态前体中的乳液中，每个纳米颗粒包含含有活性剂并由第二乳化剂包封的内部液体。

2. 发明授权

US08019572B2 Method and apparatus for exploring by wave propagation 有权
标题翻译：通过波传播探索的方法和装置
公开(公告)号：US08019572B2
公开(公告)日：2011-09-13
申请号：US12277707
申请日：2008-11-25
申请人： Mathias Fink , Gabriel Montaldo , Mickael Tanter
发明人： Mathias Fink , Gabriel Montaldo , Mickael Tanter
IPC分类号： H03F1/26
CPC分类号： G01S7/52049 , A61B8/0816 , G01S7/52036 , G01S15/8977
摘要： A method of exploring by wave propagation, in which method an incident wave is emitted a plurality of times towards the same target zone (r0) in a diffusing medium, and then the backscattered signals generated by the waves are averaged.
摘要翻译：一种通过波传播进行探测的方法，在该方法中，向散射介质中的相同目标区域（r0）多次发射入射波，然后对由波产生的反向散射信号进行平均。

3. 发明申请

US20050277824A1 Non-invasive method of obtaining a pre-determined acoustic wave field in an essentially uniform medium which is concealed by a bone barrier, imaging method and device for carrying out said methods 有权
标题翻译：在由骨屏障隐藏的基本均匀的介质中获得预定的声波场的非侵入性方法，用于执行所述方法的成像方法和装置
公开(公告)号：US20050277824A1
公开(公告)日：2005-12-15
申请号：US10526561
申请日：2003-08-20
申请人： Jean-Francois Aubry , Mathias Fink , Mickael Tanter
发明人： Jean-Francois Aubry , Mathias Fink , Mickael Tanter
IPC分类号： A61F7/00 , A61B5/107 , A61B8/00 , A61N7/02 , G01S7/52 , A61B5/05
CPC分类号： A61B8/0816 , A61B5/107 , A61B5/7257 , A61B8/00 , A61B8/4218 , A61B8/4281 , A61B8/4455 , A61N7/02 , G01S7/52049
摘要： A non-invasive method of obtaining a target soundwave field in the brain by means of an array of transducers positioned outside the skull, the method comprising a training stage during which, on the basis of a three-dimensional image giving the porosity of the skull at all points, digital simulation is used to determine individual sound signals to be emitted by the transducers in order to obtain the target soundwave field in the brain. After the training stage, the array of transducers is used to locate the position of the array of transducers relative to the skull by echography and to ensure that the array of transducers is accurately positioned.
摘要翻译：一种通过位于颅骨外部的换能器阵列获得大脑中的目标声波场的非侵入性方法，该方法包括训练阶段，在该训练阶段期间，基于提供颅骨孔隙度的三维图像在所有点上，数字模拟用于确定由换能器发射的各个声音信号，以便获得大脑中的目标声波场。在训练阶段之后，传感器阵列用于通过回波测量来定位传感器阵列相对于颅骨的位置，并确保换能器阵列被精确定位。

4. 发明申请

US20050252295A1 Imaging method and device employing sherar waves 有权
标题翻译：使用sherar波的成像方法和装置
公开(公告)号：US20050252295A1
公开(公告)日：2005-11-17
申请号：US10526407
申请日：2003-08-12
申请人： Mathias Fink , Mickael Tanter
发明人： Mathias Fink , Mickael Tanter
IPC分类号： A61B8/08 , G01S7/52 , G01N29/04
CPC分类号： A61B8/485 , A61B8/08 , G01N2291/02827 , G01S7/52022 , G01S7/52042 , G01S7/52071 , G01S15/8915
摘要： An imaging method for observing the propagation of a shear wave simultaneously at a multitude of points in a diffusing viscoelastic medium. The shear wave is caused to be generated by firing at least one focused ultrasound compression wave into the viscoelastic medium by means of an array of transducers, and then emitting at a fast rate and using the same array of transducers, unfocused ultrasound compression waves serving to obtain a succession of images of the medium, and processing the images obtained in this way in deferred time in order to determine the movements of the medium during the propagation of the shear wave.
摘要翻译：一种用于在扩散粘弹性介质中在多个点处同时观察剪切波的传播的成像方法。通过借助于一组换能器将至少一个聚焦超声压缩波烧制到粘弹性介质中，然后以快速发射并使用相同的换能器阵列，产生剪切波，未聚焦的超声压缩波用于获得介质的一系列图像，并且以延迟时间处理以这种方式获得的图像，以便确定在剪切波传播期间介质的移动。

5. 发明授权

US10172527B2 Method and apparatus for measuring a physical parameter in mammal soft tissues by propagating shear waves 有权
公开(公告)号：US10172527B2
公开(公告)日：2019-01-08
申请号：US12533546
申请日：2009-07-31
申请人： Mathieu Pernot , Mickael Tanter , Mathieu Couade , Jean-Luc Gennisson , Mathias Fink
发明人： Mathieu Pernot , Mickael Tanter , Mathieu Couade , Jean-Luc Gennisson , Mathias Fink
IPC分类号： A61B8/00 , A61B5/021 , A61B5/00 , A61B5/01 , A61B5/02 , A61B8/08 , G01N29/06 , A61B18/02 , A61B18/18
摘要： Method for measuring a physical parameter in soft tissues of a mammal, in which a mechanical shear wave is propagated through the soft tissues and observation of the propagation leads to determine values of a shear wave propagation parameter. The physical parameter is computed on the basis of these values.

6. 发明申请

US20110190627A1 Method and Device for Marking a Medium, and Marker Usable in Such a Method 审中-公开
标题翻译：用于标记介质的方法和装置，以及在这种方法中可用的标记
公开(公告)号：US20110190627A1
公开(公告)日：2011-08-04
申请号：US13062290
申请日：2009-09-08
申请人： Mickael Tanter , Vincent Servois , Olivier Couture , Mathias Fink
发明人： Mickael Tanter , Vincent Servois , Olivier Couture , Mathias Fink
IPC分类号： A61B6/00
CPC分类号： A61K41/0028 , A61B90/39 , A61B2090/378 , A61B2090/3908 , A61B2090/3945 , A61B2090/395 , A61K49/0043 , A61K49/0091 , A61K49/223 , A61K49/225
摘要： To mark an area of interest in a target medium, an initially inactivated and ultrasound-activatable optical marker is added to the medium, and then an ultrasound activation beam is emitted, being focused on the area of interest in order to locally activate the marker, which then colors the area of interest.
摘要翻译：为了标记目标介质中的感兴趣区域，将最初失活的和可超声激活的光学标记添加到介质中，然后发射超声激活光束，聚焦在感兴趣的区域上以便局部激活标记物，然后再对该地区进行着色。

7. 发明申请

US20070274156A1 Sound-Wave Imaging Method And Apparatus 有权
标题翻译：声波成像方法和装置
公开(公告)号：US20070274156A1
公开(公告)日：2007-11-29
申请号：US10565617
申请日：2004-07-23
申请人： Mathias Fink , Gabriel Montaldo , Mickael Tanter
发明人： Mathias Fink , Gabriel Montaldo , Mickael Tanter
IPC分类号： G01S15/00
CPC分类号： G10K11/341 , G01N2291/02491 , G01N2291/0422 , G10K11/02
摘要： An ultrasound imaging method including an emission step during which an array of transducers is caused to emit at an ultrasound wave focused in a target medium by causing the excitation wave to pass through a reverberant solid object prior to reaching the target medium.
摘要翻译：一种超声成像方法，包括发射步骤，在所述发射步骤期间，通过使激发波在到达所述目标介质之前通过混响固体物体，使得通过聚焦在目标介质中的超声波发射换能器阵列。

8. 发明授权

US07679988B2 Sound-wave imaging method and apparatus 有权
标题翻译：声波成像方法和装置
公开(公告)号：US07679988B2
公开(公告)日：2010-03-16
申请号：US10565617
申请日：2004-07-23
申请人： Mathias Fink , Gabriel Montaldo , Mickael Tanter
发明人： Mathias Fink , Gabriel Montaldo , Mickael Tanter
IPC分类号： G03B42/06
CPC分类号： G10K11/341 , G01N2291/02491 , G01N2291/0422 , G10K11/02
摘要： An ultrasound imaging method including an emission step during which an array of transducers is caused to emit at an ultrasound wave focused in a target medium by causing the excitation wave to pass through a reverberant solid object prior to reaching the target medium.
摘要翻译：一种超声成像方法，包括发射步骤，在所述发射步骤期间，通过使激发波在到达所述目标介质之前通过混响固体物体，使得通过聚焦在目标介质中的超声波发射换能器阵列。

9. 发明申请

US20050273008A1 Method of generating a predetermined wave field 有权
标题翻译：产生预定波场的方法
公开(公告)号：US20050273008A1
公开(公告)日：2005-12-08
申请号：US10517047
申请日：2003-05-28
申请人： Gabriel Montaldo , Mathias Fink , Mickael Tanter
发明人： Gabriel Montaldo , Mathias Fink , Mickael Tanter
IPC分类号： A61B17/22 , A61B8/00 , A61B8/15 , A61B18/00 , G01S7/524 , G10K11/34 , H04B11/00 , H04R1/20 , H04R17/00
CPC分类号： G01S7/52049 , A61B8/15 , G10K11/34
摘要： The invention relates to a method of generating a predetermined objective wave field in a medium using a first network of transducers T1-Tn). The inventive method consists in first using each transducer i of the first network to emit an approximation of the signal ei(t). Subsequently, each transducer of a second network of transducers (T′1-T′m) is used to emit an error signal corresponding to the time reversal of the difference between the signals captured from said first emission and objective signals. Finally, approximation ei(t) is corrected by subtracting the time reversal of the signal captured by each transducer i using the error signal.
摘要翻译：本发明涉及一种使用变换器T 1 -T n）的第一网络在介质中产生预定目标波场的方法。本发明的方法包括首先使用第一网络的每个换能器i发射信号ei（t）的近似。随后，使用第二传感器网络（T'1-T'm）的每个换能器发射对应于从所述第一发射和目标信号捕获的信号之间的差的时间反转的误差信号。最后，通过使用误差信号减去由每个换能器i捕获的信号的时间反转来校正近似值ei（t）。

10. 发明申请

US20130301382A1 Method and Device for Ultrasound Imaging 有权
标题翻译：超声成像的方法和装置
公开(公告)号：US20130301382A1
公开(公告)日：2013-11-14
申请号：US13993224
申请日：2011-11-29
申请人： Olivier Couture , Mickael Tanter , Mathias Fink
发明人： Olivier Couture , Mickael Tanter , Mathias Fink
IPC分类号： G01S7/52
CPC分类号： G01S7/52 , G01S7/52041 , G01S7/52046
摘要： A method of high-resolution ultrasound imaging, in which transducers are made to emit ultrasound waves in a field of observations containing micro bubbles, by making the micro bubbles burst one by one in tandem with the emissions of ultrasound waves. At each shot j of an ultrasound wave, raw reverberated signals Sj(i,t) picked up by each transducer i are recorded, and then differential signals Vj(i,t) representative of variations between successive raw signals are determined, a parabolic function Pj(x) is fitted to the differential signals corresponding to each shot j, and then a crest Aj(x0,y0) of this function Pj, corresponding to the position of the micro bubble destroyed between shots j-1 and j, is determined.
摘要翻译：一种高分辨率超声成像方法，其中通过使微泡与超声波的发射一个接一个地突破，使得换能器在包含微气泡的观察领域中发射超声波。在超声波的每个镜头j处，记录由每个换能器i拾取的原始混响信号Sj（i，t），然后确定表示连续原始信号之间的变化的差分信号Vj（i，t），抛物线函数 Pj（x）被拟合到对应于每个镜头j的差分信号，然后确定对应于在镜头j-1和j之间破坏的微小气泡的位置的该功能Pj的顶点Aj（x0，y0）。

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