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1. 发明申请

US20030013973A1 System and methods of fluorescence, reflectance and light scattering spectroscopy for measuring tissue characteristics 有权
标题翻译：用于测量组织特征的荧光，反射率和光散射光谱的系统和方法
公开(公告)号：US20030013973A1
公开(公告)日：2003-01-16
申请号：US10052583
申请日：2002-01-18
申请人： Massachusetts Institute of Technology
发明人： Irene Georgakoudi , Michael S. Feld , Qingguo Zhang , Markus G. Mueller
IPC分类号： A61B006/00
CPC分类号： G01N21/6486 , A61B5/0059 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/1459 , A61B5/4331 , G01N21/47 , G01N21/64
摘要： The present invention utilizes a plurality of spectroscopic systems and methods to measure characteristics of tissue useful in the diagnosis of disease. In a preferred embodiment, a combination of fluorescence, reflectance and light scattered spectra can be measured and processed to provide biochemical, architectural and morphological state of tissue. The methods and systems can be used particularly in the early detection of carcinoma within tissue in vivo and in vitro.
摘要翻译：本发明利用多个光谱系统和方法来测量可用于疾病诊断的组织的特征。在优选的实施方案中，可以测量和处理荧光，反射率和光散射光谱的组合以提供组织的生物化学，建筑和形态状态。方法和系统可以特别用于体内和体外组织内癌的早期检测。

2. 发明申请

US20030191398A1 Systems and methods for spectroscopy of biological tissue 有权
标题翻译：生物组织光谱系统和方法
公开(公告)号：US20030191398A1
公开(公告)日：2003-10-09
申请号：US10178062
申请日：2002-06-21
申请人： Massachusetts Institute of Technology
发明人： Jason T. Motz , Luis H. Galindo , Martin Hunter , Ramachandra Dasari , Michael S. Feld
IPC分类号： A61B006/00
CPC分类号： A61B5/02007 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/0091 , A61B5/415 , A61B5/4312 , A61B5/4519 , A61B5/7232 , G01N21/474 , G01N21/65 , G01N2021/4745 , G01N2021/4759 , G01N2021/656
摘要： The system and method of the present invention relates to using spectroscopy, for example, Raman spectroscopic methods for diagnosis of tissue conditions such as vascular disease or cancer. In accordance with a preferred embodiment of the present invention, a system for measuring tissue includes a fiber optic probe having a proximal end, a distal end, and a diameter of 2 mm or less. This small diameter allows the system to be used for the diagnosis of coronary artery disease or other small lumens or soft tissue with minimal trauma. A delivery optical fiber is included in the probe coupled at the proximal end to a light source. A filter for the delivery fibers is included at the distal end. The system includes a collection optical fiber (or fibers) in the probe that collects Raman scattered radiation from tissue, the collection optical fiber is coupled at the proximal end to a detector. A second filter is disposed at the distal end of the collection fibers. An optical lens system is disposed at the distal end of the probe including a delivery waveguide coupled to the delivery fiber, a collection waveguide coupled to the collection fiber and a lens.
摘要翻译：本发明的系统和方法涉及使用光谱学，例如用于诊断诸如血管疾病或癌症的组织条件的拉曼光谱方法。根据本发明的优选实施例，用于测量组织的系统包括具有近端，远端和2mm或更小直径的光纤探针。这种小直径允许系统用于诊断冠状动脉疾病或其他小腔或软组织，具有最小的创伤。输送光纤包括在近端耦合到光源的探针中。用于输送纤维的过滤器包括在远端。该系统包括在探针中收集来自组织的拉曼散射辐射的收集光纤（或纤维），收集光纤在近端耦合到检测器。第二过滤器设置在收集纤维的远端。光学透镜系统设置在探头的远端，包括耦合到输送纤维的输送波导，耦合到收集光纤的收集波导和透镜。

3. 发明申请

US20020101593A1 Methods and systems using field-based light scattering spectroscopy 有权
标题翻译：使用基于场的光散射光谱的方法和系统
公开(公告)号：US20020101593A1
公开(公告)日：2002-08-01
申请号：US09844286
申请日：2001-04-27
申请人： Massachusetts Institute of Technology
发明人： Changhuei Yang , Adam P. Wax , Lev T. Perelman , Ramachandra R. Dasari , Michael S. Feld
IPC分类号： G01B009/02
CPC分类号： G01N21/4795 , A61B5/0059 , A61B5/0066 , G01N21/45
摘要： The present invention relates to systems and methods of field-based light scattering spectroscopy. These systems and methods provide for the diagnosis of tissue by measuring the size and distribution of cellular characteristics. Field based measurements provide phase information resulting from the interaction of scatterers within the material and the incident wavefront. These measurements can be used to provide three dimensional images of tissue.
摘要翻译：本发明涉及基于场的光散射光谱的系统和方法。这些系统和方法通过测量细胞特征的大小和分布来提供对组织的诊断。基于场的测量提供由材料内的散射体与入射波前的相互作用产生的相位信息。这些测量可用于提供组织的三维图像。

4. 发明申请

US20040186383A1 Systems and methods of molecular spectroscopy to provide for the diagnosis of tissue 审中-公开
标题翻译：分子光谱学的系统和方法为组织的诊断提供依据
公开(公告)号：US20040186383A1
公开(公告)日：2004-09-23
申请号：US10765754
申请日：2004-01-27
申请人： Massachusetts Institute of Technology
发明人： Richard P. Rava , Joseph J. Baraga , Michael S. Feld
IPC分类号： A61B006/00
CPC分类号： A61B5/0086 , A61B5/0071 , A61B5/0075 , A61B5/7203 , A61B5/7257 , A61B2562/0242 , G01N21/65 , G01N2021/656
摘要： Systems and methods for spectroscopic diagnosis and treatment are employed which utilize molecular spectroscopy to accurately diagnose the condition of tissue. Infrared Raman spectroscopy and infrared attenuated total reflectance measurements are performed utilizing a laser radiation source and a fourier transform spectrometer. Information acquired and analyzed in accordance with the invention provides accurate details of biochemical composition and pathologic condition.
摘要翻译：使用光谱诊断和治疗的系统和方法，其利用分子光谱来准确地诊断组织的状况。使用激光辐射源和傅立叶变换光谱仪进行红外拉曼光谱和红外衰减全反射率测量。根据本发明获得和分析的信息提供了生物化学成分和病理状况的准确细节。

5. 发明申请

US20040073120A1 Systems and methods for spectroscopy of biological tissue 审中-公开
标题翻译：生物组织光谱系统和方法
公开(公告)号：US20040073120A1
公开(公告)日：2004-04-15
申请号：US10407923
申请日：2003-04-04
申请人： Massachusetts Institute of Technology
发明人： Jason T. Motz , Luis H. Galindo , Martin Hunter , Abigail S. Haka , Saumil Gandhi , Ramachandra Dasari , Michael S. Feld
IPC分类号： A61B006/00
CPC分类号： A61B5/0086 , A61B1/07 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0091 , A61B5/415 , A61B5/441 , A61B5/4519 , A61B5/4872 , A61B5/6848 , A61B10/0233 , A61B2010/045 , G01N21/65 , G01N2021/656
摘要： The system and method of the present invention relates to using spectroscopy, for example, Raman spectroscopic methods for diagnosis of tissue conditions such as vascular disease or cancer. In accordance with a preferred embodiment of the present invention, a system for measuring tissue includes a fiber optic probe having a proximal end, a distal end, and a diameter of 2 mm or less. This small diameter allows the system to be used for the diagnosis of coronary artery disease or other small lumens or soft tissue with minimal trauma. A delivery optical fiber is included in the probe coupled at the proximal end to a light source. A filter for the delivery fibers is included at the distal end. The system includes a collection optical fiber (or fibers) in the probe that collects Raman scattered radiation from tissue, the collection optical fiber is coupled at the proximal end to a detector. A second filter is disposed at the distal end of the collection fibers. An optical lens system is disposed at the distal end of the probe including a delivery waveguide coupled to the delivery fiber, a collection waveguide coupled to the collection fiber and a lens.
摘要翻译：本发明的系统和方法涉及使用光谱学，例如用于诊断诸如血管疾病或癌症的组织条件的拉曼光谱方法。根据本发明的优选实施例，用于测量组织的系统包括具有近端，远端和2mm或更小直径的光纤探针。这种小直径允许系统用于诊断冠状动脉疾病或其他小腔或软组织，具有最小的创伤。输送光纤包括在近端耦合到光源的探针中。用于输送纤维的过滤器包括在远端。该系统包括在探针中收集来自组织的拉曼散射辐射的收集光纤（或纤维），收集光纤在近端耦合到检测器。第二过滤器设置在收集纤维的远端。光学透镜系统设置在探头的远端，包括耦合到输送纤维的输送波导，耦合到收集光纤的收集波导和透镜。

6. 发明申请

US20030191368A1 Fluorescence imaging endoscope 失效
标题翻译：荧光成像内窥镜
公开(公告)号：US20030191368A1
公开(公告)日：2003-10-09
申请号：US10393028
申请日：2003-03-20
申请人： Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc.
发明人： Thomas D. Wang , Michael S. Feld , Yang Wang , Jacques Van Dam , Stephen F. Fulghum
IPC分类号： A61B001/06 , A61B006/00
CPC分类号： G01J3/4406 , A61B1/00009 , A61B1/0005 , A61B1/043 , A61B1/05 , A61B1/07 , A61B5/0071 , A61B5/0084 , A61B5/415 , A61B5/418 , G01J3/02 , G01J3/0232 , G01J3/10 , G01N21/6456 , G01N2021/6417 , G01N2021/6421 , G01N2021/6484
摘要： The present invention relates to a fluorescence endoscope imaging system. The system uses first and second light sources to provide fluorescence and reflectance images of tissue being examined. An imaging device mounted at the distal end of the device is used to collect both images.
摘要翻译：本发明涉及一种荧光内窥镜成像系统。该系统使用第一和第二光源来提供正在检查的组织的荧光和反射图像。安装在设备远端的成像装置用于收集两个图像。

7. 发明申请

US20030112444A1 System and method for measuring optical distance 有权
标题翻译：用于测量光学距离的系统和方法
公开(公告)号：US20030112444A1
公开(公告)日：2003-06-19
申请号：US10024455
申请日：2001-12-18
申请人： Massachusetts Institute of Technology
发明人： Changhuei Yang , Adam Wax , Ramachandra R. Dasari , Michael S. Feld
IPC分类号： G01B009/02
CPC分类号： G01B9/02007 , G01B9/02002 , G01B9/02078 , G01B9/0209 , G01B2290/45 , G01J9/04 , G01N21/45
摘要： The methods of the present invention are directed at an accurate phase-based technique for measuring arbitrarily long optical distances with sub-nanometer precision. A preferred embodiment of the present invention method employs a interferometer, for example, a Michelson interferometer, with a pair of harmonically related light sources, one continuous wave (CW) and a second source having low coherence. By slightly adjusting the center wavelength of the low coherence source between scans of the target sample, the phase relationship between the heterodyne signals of the CW and low coherence light is used to measure the separation between reflecting interfaces with sub-nanometer precision. As the preferred embodiment of this method is completely free of 2null ambiguity, an issue that plagues most phase-based techniques, it can be used to measure arbitrarily long optical distances without loss of precision.
摘要翻译：本发明的方法涉及用于以亚纳米精度测量任意长的光学距离的精确的基于相位的技术。本发明方法的优选实施例采用干涉仪，例如迈克尔逊干涉仪，具有一对谐波相关的光源，一个连续波（CW）和具有低相干性的第二源。通过在目标样本的扫描之间稍微调整低相干光源的中心波长，使用CW的外差信号与低相干光之间的相位关系来测量具有亚纳米精度的反射界面之间的距离。由于该方法的优选实施例完全不存在2pi模糊度，这是一种困扰大多数基于相位的技术的问题，可以用于测量任意长的光学距离而不损失精度。

8. 发明申请

US20030065268A1 Optical computed tomography in a turbid media 审中-公开
标题翻译：浑浊介质中的光学计算机断层扫描
公开(公告)号：US20030065268A1
公开(公告)日：2003-04-03
申请号：US09848767
申请日：2001-05-04
申请人： Massachusetts Institute of Technology
发明人： Kun Chen , Lev T. Perelman , Qingguo Zhang , Ramachandra R. Dasari , Michael S. Feld
IPC分类号： A61B006/00
CPC分类号： G01N21/4795 , A61B5/0073
摘要： Photon migration methods are employed to image absorbing objects embedded in a turbid medium such as tissue. For improved resolution, early arriving photons are detected to provide data with image reconstruction based on optical computed tomography (CT). The CT method is generalized to take into account the distributions of photon paths. A point spread function (PSF) is expressed in terms of the Green's function for the transport equation. This PSF provides weighting functions for use in a generalized series expansion method. Measurements of turbid medium with scattering and absorption properties included coaxial transmission scans collected in two projections. Blurring associated with multiple scattering was removed and high-resolution images can be obtained.
摘要翻译：使用光子迁移方法来对包含在混浊介质（例如组织）中的吸收物体进行成像。为了提高分辨率，检测到早期到达的光子，以提供基于光学计算机断层摄影（CT）的图像重建的数据。 CT方法被广义化以考虑光子路径的分布。点扩散函数（PSF）以运输方程的格林函数表示。该PSF提供用于广义串联扩展方法的加权函数。具有散射和吸收特性的混浊介质的测量包括在两个投影中收集的同轴传播扫描。去除与多次散射相关联的模糊，并且可以获得高分辨率图像。

9. 发明申请

US20020171831A1 Polarized light scattering spectroscopy of tissue 失效
标题翻译：组织的偏振光散射光谱
公开(公告)号：US20020171831A1
公开(公告)日：2002-11-21
申请号：US10155194
申请日：2002-05-24
申请人： Massachusetts Institute of Technology
发明人： Vadim Backman , Ramanchandra R. Dasari , Rajan Gurjar , Irving Itzkan , Lev Perelman , Michael S. Feld
IPC分类号： G01J004/00
CPC分类号： A61B5/0084 , A61B5/0075
摘要： The present invention relates to the use of polarized light to measure properties of tissue. More particularly, polarized light can be used to detect dysplasia in tissue as the polarization of back-scattered light from such tissues is preserved while the contribution of diffusely scattered light from underlying tissues can be removed. A fiber optic system for delivery and collection of light can be used to measure tissues within the human body.
摘要翻译：本发明涉及使用偏振光来测量组织的性质。更具体地，偏振光可用于检测组织中的发育不良，因为来自这些组织的反向散射光的偏振被保留，同时可以去除来自下层组织的漫散射光的贡献。用于光的传送和收集的光纤系统可用于测量人体内的组织。

10. 发明申请

US20020143243A1 Fluorescence, reflectance and light scattering spectroscopy for measuring tissue 有权
标题翻译：用于测量组织的荧光，反射率和光散射光谱
公开(公告)号：US20020143243A1
公开(公告)日：2002-10-03
申请号：US09766879
申请日：2001-01-19
申请人： Massachusetts Institute of Technology
发明人： Irene Georgakoudi , Vadim Backman , Michael S. Feld
IPC分类号： A61B005/00
CPC分类号： G01N21/6486 , A61B5/0059 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/1459 , A61B5/4331 , G01N21/47 , G01N21/64
摘要： The present invention utilizes a plurality of spectroscopic techniques to measure characteristics of tissue useful in the diagnosis of disease. Fluorescence, reflectance and light scattered spectra can be measured and processed to determine the size, distribution and/or composition of tissue. The methods and systems can be used particularly in the early detection of carcinoma within tissue in vivo and in vitro.
摘要翻译：本发明利用多种光谱技术来测量可用于疾病诊断的组织的特征。可以测量和处理荧光，反射率和光散射光谱，以确定组织的大小，分布和/或组成。方法和系统可以特别用于体内和体外组织内癌的早期检测。

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