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1. 发明授权

US6143799A Use of borate-polyol complexes in ophthalmic compositions 失效
公开(公告)号：US6143799A
公开(公告)日：2000-11-07
申请号：US109453
申请日：1998-07-02
申请人： Masood Chowhan , Nissanke L. Dassanayake
发明人： Masood Chowhan , Nissanke L. Dassanayake
IPC分类号： A61K9/00 , A61K9/08 , A61K33/22
CPC分类号： A61K9/0048 , Y10S134/901 , Y10S514/812 , Y10S514/839 , Y10S514/84 , Y10S514/912 , Y10S514/915
摘要： Water-soluble borate-polyol complexes are useful as buffers and/or antimicrobials in aqueous ophthalmic compositions, including those containing polyvinyl alcohol. These compositions have greater antimicrobial activity than comparable compositions containing typical borate buffers and unexpectedly increase the antimicrobial efficacy of other antimicrobial agents when used in combination. In addition, use of the borate-polyol complexes avoids the incompatibility problem typically associated with the combination of borate buffer and polyvinyl alcohol; therefore, the compositions disclosed herein may also contain polyvinyl alcohol.

2. 发明授权

US06849253B2 Use of borate-polyol complexes in ophthalmic compositions 失效
标题翻译：在眼科组合物中使用硼酸盐 - 多元醇配合物
公开(公告)号：US06849253B2
公开(公告)日：2005-02-01
申请号：US10302294
申请日：2002-11-22
申请人： Masood Chowhan , Nissanke L. Dassanayake
发明人： Masood Chowhan , Nissanke L. Dassanayake
IPC分类号： A61K9/00 , A61K9/08
CPC分类号： A61K9/0048 , Y10S134/901 , Y10S514/812 , Y10S514/839 , Y10S514/84 , Y10S514/912 , Y10S514/915
摘要： Water-soluble borate-polyol complexes are useful as buffers and/or antimicrobials in aqueous ophthalmic compositions, including those containing polyvinyl alcohol. These compositions have greater antimicrobial activity than comparable compositions containing typical borate buffers and unexpectedly increase the antimicrobial efficacy of other antimicrobial agents when used in combination. In addition, use of the borate-polyol complexes avoids the incompatibility problem typically associated with the combination of borate buffer and polyvinyl alcohol; therefore, the compositions disclosed herein may also contain polyvinyl alcohol.
摘要翻译：水溶性硼酸盐 - 多元醇配合物可用作水性眼用组合物中的缓冲剂和/或抗微生物剂，包括含有聚乙烯醇的那些。这些组合物具有比含有典型硼酸盐缓冲液的相当组合物更大的抗微生物活性，并且当组合使用时意外地增加其它抗微生物剂的抗微生物效力。此外，使用硼酸盐 - 多元醇复合物避免了通常与硼酸盐缓冲液和聚乙烯醇的组合相关的不相容性问题; 因此，本文公开的组合物还可以含有聚乙烯醇。

3. 发明授权

US06365636B1 Use of borate-polyol complexes in ophthalmic compositions 失效
标题翻译：在眼科组合物中使用硼酸盐 - 多元醇配合物
公开(公告)号：US06365636B1
公开(公告)日：2002-04-02
申请号：US09597310
申请日：2000-06-20
申请人： Masood Chowhan , Nissanke L. Dassanayake
发明人： Masood Chowhan , Nissanke L. Dassanayake
IPC分类号： A61K900
CPC分类号： A61K9/0048 , Y10S134/901 , Y10S514/812 , Y10S514/839 , Y10S514/84 , Y10S514/912 , Y10S514/915
摘要： Water-soluble borate-polyol complexes are useful as buffers and/or antimicrobials in aqueous ophthalmic compositions, including those containing polyvinyl alcohol. These compositions have greater antimicrobial activity than comparable compositions containing typical borate buffers and unexpectedly increase the antimicrobial efficacy of other antimicrobial agents when used in combination. In addition, use of the borate-polyol complexes avoids the incompatibility problem typically associated with the combination of borate buffer and polyvinyl alcohol; therefore, the compositions disclosed herein may also contain polyvinyl alcohol.
摘要翻译：水溶性硼酸盐 - 多元醇配合物可用作水性眼用组合物中的缓冲剂和/或抗微生物剂，包括含有聚乙烯醇的那些。这些组合物具有比含有典型硼酸盐缓冲液的相当组合物更大的抗微生物活性，并且当组合使用时意外地增加其它抗微生物剂的抗微生物效力。此外，使用硼酸盐 - 多元醇复合物避免了通常与硼酸盐缓冲液和聚乙烯醇的组合相关的不相容性问题; 因此，本文公开的组合物还可以含有聚乙烯醇。

4. 发明授权

US06503497B2 Use of borate-polyol complexes in ophthalmic compositions 失效
标题翻译：在眼科组合物中使用硼酸盐 - 多元醇配合物
公开(公告)号：US06503497B2
公开(公告)日：2003-01-07
申请号：US10027998
申请日：2001-12-19
申请人： Masood Chowhan , Nissanke L. Dassanayake
发明人： Masood Chowhan , Nissanke L. Dassanayake
IPC分类号： A61K900
CPC分类号： A61K9/0048 , Y10S134/901 , Y10S514/812 , Y10S514/839 , Y10S514/84 , Y10S514/912 , Y10S514/915
摘要： Water-soluble borate-polyol complexes are useful as buffers and/or antimicrobials in aqueous ophthalmic compositions, including those containing polyvinyl alcohol. These compositions have greater antimicrobial activity than comparable compositions containing typical borate buffers and unexpectedly increase the antimicrobial efficacy of other antimicrobial agents when used in combination. In addition, use of the boratepolyol complexes avoids the incompatibility problem typically associated with the combination of borate buffer and polyvinyl alcohol; therefore, the compositions disclosed herein may also contain polyvinyl alcohol.
摘要翻译：水溶性硼酸盐 - 多元醇配合物可用作水性眼用组合物中的缓冲剂和/或抗微生物剂，包括含有聚乙烯醇的那些。这些组合物具有比含有典型硼酸盐缓冲液的相当组合物更大的抗微生物活性，并且当组合使用时意外地增加其它抗微生物剂的抗微生物效力。此外，使用硼酸多元醇络合物避免了通常与硼酸盐缓冲液和聚乙烯醇的组合相关的不相容性问题; 因此，本文公开的组合物还可以含有聚乙烯醇。

5. 发明授权

US5811466A Use of borate-polyol complexes in ophthalmic compositions 失效
公开(公告)号：US5811466A
公开(公告)日：1998-09-22
申请号：US479281
申请日：1995-06-07
申请人： Masood Chowhan , Nissanke L. Dassanayake
发明人： Masood Chowhan , Nissanke L. Dassanayake
IPC分类号： A61K9/00 , A61L2/16
CPC分类号： A61K9/0048 , Y10S134/901 , Y10S514/812 , Y10S514/839 , Y10S514/84 , Y10S514/912 , Y10S514/915
摘要： Water-soluble borate-polyol complexes are useful as buffers and/or antimicrobials in aqueous ophthalmic compositions, including those containing polyvinyl alcohol. These compositions have greater antimicrobial activity than comparable compositions containing typical borate buffers and unexpectedly increase the antimicrobial efficacy of other antimicrobial agents when used in combination. In addition, use of the borate-polyol complexes avoids the incompatibility problem typically associated with the combination of borate buffer and polyvinyl alcohol; therefore, the compositions disclosed herein may also contain polyvinyl alcohol.

6. 发明授权

US07871602B2 Use of bis-amines to enhance the antimicrobial activity of aqueous compositions 有权
标题翻译：使用双胺来增强含水组合物的抗微生物活性
公开(公告)号：US07871602B2
公开(公告)日：2011-01-18
申请号：US12244907
申请日：2008-10-03
申请人： Nissanke L. Dassanayake , Thomas Christopher Carey , Ronald L. Schlitzer , David L. Meadows
发明人： Nissanke L. Dassanayake , Thomas Christopher Carey , Ronald L. Schlitzer , David L. Meadows
IPC分类号： A61K31/74
CPC分类号： C07C215/14 , C07C215/18
摘要： The use of bis-amines to enhance the antimicrobial activity of pharmaceutical compositions is described. The bis-amines are particularly useful for enhancing the antimicrobial activity of aqueous ophthalmic compositions, such as artificial tears or ocular lubricants, and solutions for disinfecting contact lenses.
摘要翻译：描述了使用双胺来增强药物组合物的抗微生物活性。双胺特别可用于增强水性眼用组合物如人造眼泪或眼部润滑剂的抗微生物活性，以及消毒隐形眼镜的溶液。

7. 发明申请

US20110124734A1 N-HALOGENATED AMINO ACID FORMULATIONS AND METHODS FOR CLEANING AND DISINFECTION 审中-公开
标题翻译： N-氢化氨基酸制剂及其清洗和消毒方法
公开(公告)号：US20110124734A1
公开(公告)日：2011-05-26
申请号：US13017643
申请日：2011-01-31
申请人： Masood A. Chowhan , Wesley Wehsin Han , L. Wayne Schneider , David W. Stroman , Nissanke L. Dassanayake
发明人： Masood A. Chowhan , Wesley Wehsin Han , L. Wayne Schneider , David W. Stroman , Nissanke L. Dassanayake
IPC分类号： A01N33/14 , A01P1/00 , C11D3/30 , C11D3/36
CPC分类号： A61K31/185 , A61K9/0048 , A61K33/02 , A61K45/06 , A61K47/183 , A61L12/14 , C11D1/62 , C11D3/0078 , C11D3/30 , C11D3/36 , C11D3/3955 , C11D3/3956 , C11D3/48 , A61K2300/00
摘要： The present invention relates to methods for disinfecting or cleaning a contact lens comprising contacting a contact lens with a formulation comprising a N-halogenated amino acid and a phase transfer agent for a time sufficient to disinfect or clean the lens. This specification further discloses a formulation for disinfecting a contact lens comprising an N-halogenated amino acid and a phase transfer agent.
摘要翻译：本发明涉及消毒或清洁隐形眼镜的方法，包括使隐形眼镜与包含N-卤代氨基酸和相转移剂的制剂接触足以消毒或清洁镜片的时间。本说明书进一步公开了一种消毒含有N-卤代氨基酸和相转移剂的隐形眼镜的制剂。

8. 发明申请

US20100303930A1 N-HALAMINE FORMULATIONS WITH ENHANCED ANTIMICROBIAL ACTIVITY 审中-公开
标题翻译：具有增强抗微生物活性的N-哈马胺配方
公开(公告)号：US20100303930A1
公开(公告)日：2010-12-02
申请号：US12789965
申请日：2010-05-28
申请人： Thomas Christopher Carey , Nissanke L. Dassanayake , Ronald L. Schlitzer , Howard Allen Ketelson
发明人： Thomas Christopher Carey , Nissanke L. Dassanayake , Ronald L. Schlitzer , Howard Allen Ketelson
IPC分类号： A01N59/08 , A01P1/00
CPC分类号： A01N59/00 , A01N25/02 , A01N25/08 , A01N25/34 , A01N33/14 , A01N43/40 , A01N2300/00
摘要： The present invention relates to antimicrobial formulations comprising an N-halamine and a quantity of sodium chlorite sufficient to enhance the antimicrobial efficacy of the N-halamine. The present invention is further directed to formulations for disinfecting a contact lens comprising an N-halamine and a quantity of sodium chlorite sufficient to enhance the antimicrobial efficacy of the N-halamine.
摘要翻译：本发明涉及包含N-卤胺和足够提高N-卤胺的抗微生物功效的一定量的亚氯酸钠的抗微生物制剂。本发明还涉及用于消毒隐形眼镜的制剂，其包含N-卤胺和足够增加N-卤胺的抗微生物功效的亚氯酸钠的量。

9. 发明申请

US20100158853A1 POLYALKYLENE OXIDE POLYQUATERNARY AMMONIUM BIOCIDES 有权
标题翻译：聚亚烷基氧化物多环芳烃生物
公开(公告)号：US20100158853A1
公开(公告)日：2010-06-24
申请号：US12536141
申请日：2009-08-05
申请人： Ryan DeSousa , Nissanke L. Dassanayake , Howard Allen Ketelson
发明人： Ryan DeSousa , Nissanke L. Dassanayake , Howard Allen Ketelson
IPC分类号： A01N33/12 , C08G73/00 , A01P1/00
CPC分类号： A01N33/12 , A61K9/0048 , A61K9/08 , C08G73/0206 , C08G73/0213 , C08G73/0226 , C08G73/024 , C08L79/02
摘要： Disclosed are polyquaternary ammonium polymers containing polyalkylene oxide groups according to formula (I) wherein [A]x, [B]y and [C]z are poly(alkylene oxides) each independently selected from the group consisting of poly(ethylene oxide), poly(propylene oxide), and poly(butylene oxide); Z is selected from the group consisting of —CH2CH═CHCH2—, —CH2CH2CH2CH2—, —CH2—C≡C—CH2—, —CH2CH2—O—CH2CH2—, —CH2—N(CH2CH2)2N—CH2—, —CH2CH(OH)CH(OH)CH2— and —CH2—C6H4—CH2—; R is —(CR1R2)mCR3R4— wherein m is an integer from 0 to 3 and R1, R2, R3 and R4 are independently selected from the group consisting of H, CH3 and CH2CH3; n is an integer from 1 to 30; x is either 0 or an integer from 2 to 20; y is an integer from 2 to 20; z is either 0 or an integer from 2 to 20; R′ is a branched or unbranched alkyl group having from 1 to 3 carbon atoms and is optionally substituted by one or two hydroxyl groups; Q1 and Q2 are independently selected from the group consisting of —CH2CH═CHCH2—X, —CH2C≡C—CH2—X, —N(R′)2, —N(R′)3, —N(R′)(R″), and —N(R′)2(R″), wherein X is a halogen atom and R″ is a benzyl group; and a stoichiometric amount of a pharmaceutically acceptable anion. Also disclosed are suitable methods of making the polymers, and methods of using the polymers.
摘要翻译：公开了含有根据式（I）的聚环氧烷基团的聚季铵盐聚合物，其中[A] x，[B] y和[C] z是聚（环氧烷），各自独立地选自聚环氧乙烷，聚（环氧丙烷）和聚（环氧丁烷）; Z选自-CH 2 CH = CHCH 2 - ， - CH 2 CH 2 CH 2 CH 2 - ， - CH 2-C≡C-CH 2 - ， - CH 2 CH 2 -O-CH 2 CH 2 - ， - CH 2 -N（CH 2 CH 2）2 N-CH 2 - ， - CH 2 CH （OH）CH（OH）CH 2 - 和-CH 2 -C 6 H 4 -CH 2 - ; R是 - （CR 1 R 2）m CR 3 R 4 - ，其中m是0-3的整数，R 1，R 2，R 3和R 4独立地选自H，CH 3和CH 2 CH 3; n为1〜30的整数， x是0或2到20的整数; y为2〜20的整数; z为0或2至20的整数; R'是具有1至3个碳原子并且任选地被一个或两个羟基取代的支链或非支链烷基; Q1和Q2独立地选自-CH2CH = CHCH2-X，-CH2C≡C-CH2-X，-N（R'）2，-N（R'）3，-N（R'）（ R“）和-N（R'）2（R”），其中X是卤素原子，R“是苄基; 和化学计量的药学上可接受的阴离子。还公开了制备聚合物的合适方法，以及使用聚合物的方法。

10. 发明授权

US5900213A Use of diamines to disinfect and clean contact lenses and preserve ophthalmic compositions 失效
标题翻译：使用二胺消毒和清洁隐形眼镜并保护眼用组合物
公开(公告)号：US5900213A
公开(公告)日：1999-05-04
申请号：US047584
申请日：1998-03-25
申请人： Nissanke L. Dassanayake , Ronald L. Schlitzer , Joonsup Park , Bahram Asgharian
发明人： Nissanke L. Dassanayake , Ronald L. Schlitzer , Joonsup Park , Bahram Asgharian
IPC分类号： A01N33/04 , A01N33/08 , A61L12/14 , C07C211/09 , C07C211/10 , C07C211/11 , C07C211/21 , C07C211/25 , C07C215/14 , A61L2/16
CPC分类号： C07C211/25 , A01N33/04 , A01N33/08 , A61L12/14 , C07C211/09 , C07C211/10 , C07C211/11 , C07C211/21 , C07C215/14 , Y10S514/839 , Y10S514/84
摘要： N,N-dialkyl and N'-alkylethylene diamines of the formula: ##STR1## wherein R, R.sup.1 and R.sup.2 are as described in the specification. The compounds are useful in disinfecting and cleaning contact lenses and preserving ophthalmic products.
摘要翻译： N，N-二烷基和N'-烷基乙炔二胺，其中R，R 1和R 2如说明书中所述。该化合物可用于消毒和清洁隐形眼镜并保护眼用产品。

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