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1. 发明申请

US20110269719A1 PHARMACEUTICAL COMPOSITIONS WITH PHOSPHONIUM ANTIMICROBIAL AGENTS 审中-公开
标题翻译：具有磷酸盐抗微生物剂的药物组合物
公开(公告)号：US20110269719A1
公开(公告)日：2011-11-03
申请号：US13093995
申请日：2011-04-26
申请人： Masood A. Chowhan , Wesley Wehsin Han , L. Wayne Schneider
发明人： Masood A. Chowhan , Wesley Wehsin Han , L. Wayne Schneider
IPC分类号： A61K31/66 , A61P27/02 , A61P31/00
CPC分类号： A61K31/66 , A61K9/0043 , A61K9/0046 , A61K9/0048 , A61K31/662 , A61K33/42 , A61K2300/00
摘要： The present invention is related to pharmaceutical compositions that include a phosphonium antimicrobial agent. In a preferred embodiment, the present invention relates to an otic, nasal or ophthalmic composition (e.g., an aqueous ophthalmic solution) that includes a phosphonium salt compound as an antimicrobial agent. The compositions typically possess sufficient antimicrobial activity to satisfy USP preservative efficacy requirements and/or similar preservative standards (e.g., EP and JP).
摘要翻译：本发明涉及包含鏻抗微生物剂的药物组合物。在优选的实施方案中，本发明涉及包含鏻盐化合物作为抗微生物剂的耳用组合物，鼻或眼用组合物（例如，眼用水溶液）。组合物通常具有足够的抗微生物活性以满足USP防腐功效要求和/或类似的防腐标准（例如EP和JP）。

2. 发明申请

US20110124734A1 N-HALOGENATED AMINO ACID FORMULATIONS AND METHODS FOR CLEANING AND DISINFECTION 审中-公开
标题翻译： N-氢化氨基酸制剂及其清洗和消毒方法
公开(公告)号：US20110124734A1
公开(公告)日：2011-05-26
申请号：US13017643
申请日：2011-01-31
申请人： Masood A. Chowhan , Wesley Wehsin Han , L. Wayne Schneider , David W. Stroman , Nissanke L. Dassanayake
发明人： Masood A. Chowhan , Wesley Wehsin Han , L. Wayne Schneider , David W. Stroman , Nissanke L. Dassanayake
IPC分类号： A01N33/14 , A01P1/00 , C11D3/30 , C11D3/36
CPC分类号： A61K31/185 , A61K9/0048 , A61K33/02 , A61K45/06 , A61K47/183 , A61L12/14 , C11D1/62 , C11D3/0078 , C11D3/30 , C11D3/36 , C11D3/3955 , C11D3/3956 , C11D3/48 , A61K2300/00
摘要： The present invention relates to methods for disinfecting or cleaning a contact lens comprising contacting a contact lens with a formulation comprising a N-halogenated amino acid and a phase transfer agent for a time sufficient to disinfect or clean the lens. This specification further discloses a formulation for disinfecting a contact lens comprising an N-halogenated amino acid and a phase transfer agent.
摘要翻译：本发明涉及消毒或清洁隐形眼镜的方法，包括使隐形眼镜与包含N-卤代氨基酸和相转移剂的制剂接触足以消毒或清洁镜片的时间。本说明书进一步公开了一种消毒含有N-卤代氨基酸和相转移剂的隐形眼镜的制剂。

3. 发明申请

US20100160342A1 Compositions of Topical Ocular Solutions to Deliver Effective Concentrations of Active Agent to the Posterior Segment of the Eye 审中-公开
标题翻译：局部眼部解决方案的组合，将活性剂的有效浓度提供给眼后部
公开(公告)号：US20100160342A1
公开(公告)日：2010-06-24
申请号：US12633322
申请日：2009-12-08
申请人： Masood A. Chowhan , Wesley Wehsin Han , L. Wayne Schneider
发明人： Masood A. Chowhan , Wesley Wehsin Han , L. Wayne Schneider
IPC分类号： A61K31/496 , A61P27/02
CPC分类号： A61K31/506 , A61K9/0048
摘要： The present invention relates to development of efficacious pharmaceutical compositions comprising an active agent, such as the free base or hydrochloride salt of tandospirone, for topical delivery to the eye for the treatment of retinal disorders.
摘要翻译：本发明涉及开发有效的药物组合物，其包含活性剂，例如坦多罗酮的游离碱或盐酸盐，用于局部递送至眼睛以治疗视网膜病症。

4. 发明申请

US20080093247A1 PACKAGING MATERIALS FOR FORMULATIONS CONTAINING 2-PYRROLIDONE DERIVATIVES 审中-公开
标题翻译：包含2-吡咯烷酮衍生物的制剂的包装材料
公开(公告)号：US20080093247A1
公开(公告)日：2008-04-24
申请号：US11923032
申请日：2007-10-24
申请人： Wesley Wehsin Han , Masood A. Chowhan , Jang-Shing Chiou , L. Wayne Schneider , Bhagwati P. Kabra
发明人： Wesley Wehsin Han , Masood A. Chowhan , Jang-Shing Chiou , L. Wayne Schneider , Bhagwati P. Kabra
IPC分类号： B65D81/26
CPC分类号： A61K47/32 , A61K9/0048 , A61K47/16 , A61K47/18 , A61K47/26
摘要： Packaging materials substantially lacking adsorptive and absorptive properties for 2-pyrrolidone derivatives are provided. The packaged products described herein provide for retention of the 2-pyrrolidone derivative within the formulation thereby maintaining the integrity of such formulations. Packaged products are useful for ophthalmic, otic, and nasal applications. Ophthalmic application includes therapeutic uses and contact lens care uses.
摘要翻译：提供了基本上不含2-吡咯烷酮衍生物的吸附和吸收性质的包装材料。本文所述的包装产品提供在制剂内保留2-吡咯烷酮衍生物，从而保持这种制剂的完整性。包装的产品可用于眼科，耳用和鼻腔应用。眼科应用包括治疗用途和隐形眼镜护理用途。

5. 发明授权

US06429227B1 Hydroxyeicosatetraenoate salts, compositions and methods of use in treating dry eye disorders 有权
标题翻译：羟基二十四酸盐，用于治疗干眼症的组合物和方法
公开(公告)号：US06429227B1
公开(公告)日：2002-08-06
申请号：US09694615
申请日：2000-10-23
申请人： L. Wayne Schneider , Raymond E. Conrow , Daniel A. Gamache , Terri Pasquine , John M. Yanni , Haresh G. Bhagat
发明人： L. Wayne Schneider , Raymond E. Conrow , Daniel A. Gamache , Terri Pasquine , John M. Yanni , Haresh G. Bhagat
IPC分类号： A61K31215
CPC分类号： C07C51/42 , C07C59/42 , C07C59/58 , Y10S514/912
摘要： HETE salts, the preparation of HETE salts, the preparation of stable and efficacious HETE compositions, HETE compositions and methods of use for treating dry eye are disclosed.
摘要翻译：公开了HETE盐，HETE盐的制备，稳定且有效的HETE组合物的制备，HETE组合物和用于治疗干眼症的方法。

6. 发明授权

US08268299B2 Self preserved aqueous pharmaceutical compositions 有权
标题翻译：自我保护的水性药物组合物
公开(公告)号：US08268299B2
公开(公告)日：2012-09-18
申请号：US11858781
申请日：2007-09-20
申请人： Bhagwati P. Kabra , Masood A. Chowhan , L. Wayne Schneider , Wesley Wehsin Han
发明人： Bhagwati P. Kabra , Masood A. Chowhan , L. Wayne Schneider , Wesley Wehsin Han
IPC分类号： A61K31/74 , A61K33/32 , A61K33/22 , A01N25/00 , A01N59/16 , A01N59/14
CPC分类号： A61K9/0048 , A61K47/02 , A61K47/10 , A61K47/26 , Y02A50/465 , Y02A50/473
摘要： The present invention is directed to the provision of multi-dose, self-preserved ophthalmic compositions. The compositions possess sufficient antimicrobial activity to satisfy USP preservative efficacy requirements, as well as similar preservative standards (e.g., EP and JP), without requiring the presence of conventional anti-microbial preservative agents, such as benzalkonium chloride. The compositions are effectively preserved by a balanced ionic buffer system containing zinc ions at a concentration of 0.04 to 0.9 mM, preferably 0.04 to 0.4 mM. One aspect of the balanced buffer system is limitation of the amount of buffering anions present to a concentration of 15 mM or less, preferably 5 mM or less. In a preferred embodiment, the compositions also contain borat or, most preferably, one or more borate/polyol complexes. The use of propylene glycol as the polyol in such complexes is strongly preferred. Limiting the amount of divalent metals other than zinc and the amount of ionized salts present has also been determined to be important to maximize the antimicrobial activity of the balanced buffer systems.
摘要翻译：本发明涉及提供多剂量，自我保存的眼用组合物。组合物具有足够的抗微生物活性以满足USP防腐功效要求，以及类似的防腐标准品（例如EP和JP），而不需要存在常规的抗微生物防腐剂，例如苯扎氯铵。通过含有浓度为0.04至0.9mM，优选0.04至0.4mM的锌离子的平衡离子缓冲系统有效地保护了组合物。平衡缓冲系统的一个方面是存在的缓冲剂阴离子的量的限制为15mM或更低，优选5mM或更低的浓度。在优选的实施方案中，组合物还含有硼酸盐或最优选一种或多种硼酸盐/多元醇配合物。在这种络合物中使用丙二醇作为多元醇是非常优选的。限制锌以外的二价金属的量和存在的离子盐的量也被确定为使平衡缓冲体系的抗菌活性最大化是重要的。

7. 发明申请

US20090197838A1 ANTIMICROBIAL N-HALOGENATED AMINO ACID SALTS 审中-公开
标题翻译：抗微生物N-氢化氨基酸
公开(公告)号：US20090197838A1
公开(公告)日：2009-08-06
申请号：US12112390
申请日：2008-04-30
申请人： L. Wayne Schneider , Wesley Wehsin Han , Masood A. Chowhan , David W. Stroman , W. Dennis Dean , Michael S. Gaines
发明人： L. Wayne Schneider , Wesley Wehsin Han , Masood A. Chowhan , David W. Stroman , W. Dennis Dean , Michael S. Gaines
IPC分类号： A01N57/12 , C07F9/06 , A01P1/00
CPC分类号： C07C303/32 , A01N37/44 , A01N41/08 , A61K31/145 , A61L12/08 , A61L12/10 , A01N33/12 , A01N57/20 , A01N2300/00 , C07C309/14
摘要： The present invention relates to a formulation comprising a N-halogenated amino acid and a phase transfer agent. The present invention also describes a method for disinfecting and/or cleaning a contact lens comprising contacting a contact lens with a formulation comprising a N-halogenated amino acid salt for a time sufficient to disinfect and/or clean the lens.
摘要翻译：本发明涉及包含N-卤代氨基酸和相转移剂的制剂。本发明还描述了一种消毒和/或清洁隐形眼镜的方法，包括使隐形眼镜与包含N-卤代氨基酸盐的制剂接触足以消毒和/或清洁镜片的时间。

8. 发明授权

US5849792A Storage-stable prostaglandin compositions 失效
标题翻译：储存稳定的前列腺素组合物
公开(公告)号：US5849792A
公开(公告)日：1998-12-15
申请号：US738629
申请日：1996-10-29
申请人： L. Wayne Schneider
发明人： L. Wayne Schneider
IPC分类号： A61K31/557 , A61K31/5575 , A61K47/44 , A61P27/02 , A61P27/06 , A61P43/00
CPC分类号： A61K31/5575 , A61K47/44
摘要： The use of polyethoxylated castor oils in prostaglandin compositions greatly enhances the prostaglandin's chemical stability.
摘要翻译：在前列腺素组合物中使用聚乙氧基化蓖麻油大大提高了前列腺素的化学稳定性。

9. 发明授权

US08323630B2 Self-preserved aqueous pharmaceutical compositions 有权
标题翻译：自我保护的水性药物组合物
公开(公告)号：US08323630B2
公开(公告)日：2012-12-04
申请号：US13086950
申请日：2011-04-14
申请人： Bhagwati P. Kabra , Masood A. Chowhan , L. Wayne Schneider , Wesley Wehsin Han
发明人： Bhagwati P. Kabra , Masood A. Chowhan , L. Wayne Schneider , Wesley Wehsin Han
IPC分类号： A61K31/74 , A61K33/32 , A61K33/22 , A01N25/00 , A01N59/16 , A01N59/14
CPC分类号： A61K9/0048 , A61K47/02 , A61K47/10 , A61K47/26 , Y02A50/465 , Y02A50/473
摘要： The present invention is directed to the provision of multi-dose, self-preserved ophthalmic compositions. The compositions possess sufficient antimicrobial activity to satisfy USP preservative efficacy requirements, as well as similar preservative standards (e.g., EP and JP), without requiring the presence of conventional anti-microbial preservative agents, such as benzalkonium chloride. The compositions are effectively preserved by a balanced ionic buffer system containing zinc ions at a concentration of 0.04 to 0.9 mM, preferably 0.04 to 0.4 mM. One aspect of the balanced buffer system is limitation of the amount of buffering anions present to a concentration of 15 mM or less, preferably 5 mM or less. In a preferred embodiment, the compositions also contain borate or, most preferably, one or more borate/polyol complexes. The use of propylene glycol as the polyol in such complexes is strongly preferred. Limiting the amount of divalent metals other than zinc and the amount of ionized salts present has also been determined to be important to maximize the antimicrobial activity of the balanced buffer systems.
摘要翻译：本发明涉及提供多剂量，自我保存的眼用组合物。组合物具有足够的抗微生物活性以满足USP防腐功效要求，以及类似的防腐标准品（例如EP和JP），而不需要存在常规的抗微生物防腐剂，例如苯扎氯铵。通过含有浓度为0.04至0.9mM，优选0.04至0.4mM的锌离子的平衡离子缓冲系统有效地保护了组合物。平衡缓冲系统的一个方面是存在的缓冲剂阴离子的量的限制为15mM或更低，优选5mM或更低的浓度。在优选的实施方案中，组合物还含有硼酸盐或最优选一种或多种硼酸盐/多元醇络合物。在这种络合物中使用丙二醇作为多元醇是非常优选的。限制锌以外的二价金属的量和存在的离子盐的量也被确定为使平衡缓冲体系的抗菌活性最大化是重要的。

10. 发明申请

US20110082145A1 OLOPATADINE COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：奥帕他汀组合物及其用途
公开(公告)号：US20110082145A1
公开(公告)日：2011-04-07
申请号：US12896056
申请日：2010-10-01
申请人： L. Wayne Schneider , Wesley Wehsin Han , Masood A. Chowhan
发明人： L. Wayne Schneider , Wesley Wehsin Han , Masood A. Chowhan
IPC分类号： A61K31/5377 , A61K31/496 , A61P37/08 , A61P29/00 , A61P27/02 , A61P27/00 , A61P17/00
CPC分类号： A61K31/5377 , A61K9/0014 , A61K9/0043 , A61K9/0048 , A61K31/335 , A61K31/435 , A61K31/496
摘要： The invention provides solution compositions comprising olopatadine and a PDE4 inhibitor compound of Formula I: The invention also provides methods for treating allergic and inflammatory diseases. More particularly, the present invention relates to formulations of olopatadine and their use for treating and/or preventing allergic or inflammatory disorders of the eye, nose, skin, and ear.
摘要翻译：本发明提供了包含奥洛他定和式I的PDE4抑制剂化合物的溶液组合物：本发明还提供了治疗过敏性和炎性疾病的方法。更具体地，本发明涉及奥洛他定的制剂及其用于治疗和/或预防眼睛，鼻子，皮肤和耳朵的过敏或炎症性疾病的用途。

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