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1. 发明授权

US4657916A Quinoline-N-oxide derivative and pharmaceutical composition 失效
标题翻译：喹啉-N-氧化物衍生物和药物组合物
公开(公告)号：US4657916A
公开(公告)日：1987-04-14
申请号：US772693
申请日：1985-09-05
申请人： Masayuki Teranishi , Koji Suzuki , Hiroshi Kase , Shigeto Kitamura , Katsuichi Shuto , Kenji Omori
发明人： Masayuki Teranishi , Koji Suzuki , Hiroshi Kase , Shigeto Kitamura , Katsuichi Shuto , Kenji Omori
IPC分类号： A61K31/47 , A61P43/00 , C07D215/60 , C07D405/12 , C07F7/18
CPC分类号： C07D405/12 , C07D215/60
摘要： A quinoline-N-oxide derivative represented by the formula: ##STR1## wherein X is hydroxy, lower alkoxy, lower alkylthio, unsubstituted or substituted aralkyloxy, or unsubstituted or substituted aralkylthio; Y is a hydrogen atom or halogen atom; R.sub.1 is alkylene or alkenylene having 3 to 15 carbon atom; Z is hydroxymethyl, lower alkoxymethyl, unsubstituted or substituted aryloxymethyl, tetrahydropyranyloxymethyl, tetrahydrofuranyloxymethyl, unsubstituted or substituted arylsulfonyloxymethyl, lower alkylthiomethyl, unsubstituted or substituted arylthiomethyl, lower alkylsulfinylmethyl, unsubstituted or substituted arylsulfinylmethyl, lower alkylsulfonylmethyl, unsubstituted or substituted arylsulfonylmethyl, aminomethyl, --CH.sub.2 NHR.sub.2 (wherein R.sub.2 is lower alkyl, unsubstituted or substituted aralkyl, or unsubstituted or substituted aryl), --CH.sub.2 NR.sub.3 R.sub.4 (wherein R.sub.3 and R.sub.4 are lower alkyl, unsubstituted or substituted aralkyl, or unsubstituted or substituted aryl), --CH.sub.2 N.sup.+ R.sub.5 R.sub.6 R.sub.7 (wherein R.sub.5, R.sub.6, and R.sub.7 are lower alkyl, unsubstituted or substituted aralkyl, or unsubstituted or substituted aryl, where the counterion is an anion of acid or a hydroxyl ion), --COR.sub.8 (wherein R.sub.8 is a hydrogen atom, lower alkyl or hydroxy), --CH(OR.sub.9).sub.2 (wherein R.sub.9 is lower alkyl), iminomethyl, hydroxyiminomethyl, or a halogen atom and its salts, can very strongly inhibit the lipoxygenase and considerably suppress production and release of its metabolites, and thus are useful as preventive and healing agents for the diseases caused by the lipoxygenase metabolites.
摘要翻译：由下式表示的喹啉-N-氧化物衍生物：其中X为羟基，低级烷氧基，低级烷硫基，未取代或取代的芳烷氧基，或未取代或取代的芳烷硫基; Y是氢原子或卤素原子; R1是具有3至15个碳原子的亚烷基或亚烯基; Z是羟甲基，低级烷氧基甲基，未取代或取代的芳氧基甲基，四氢吡喃氧基甲基，四氢呋喃氧基甲基，未取代或取代的芳基磺酰氧基甲基，低级烷硫基甲基，未取代或取代的芳基硫代甲基，低级烷基亚磺酰基甲基，未取代或取代的芳基亚磺酰基甲基，低级烷基磺酰基甲基，未取代或取代的芳基磺酰基甲基，氨基甲基，-CH2NHR2（其中R 2是低级烷基，未取代或取代的芳烷基或未取代或取代的芳基），-CH 2 NR 3 R 4（其中R 3和R 4是低级烷基，未取代或取代的芳烷基，或未取代或取代的芳基），-CH 2 N + R 5 R 6 R 7（其中R 5，R 6 ，R 7为低级烷基，未取代或取代的芳烷基或未取代或取代的芳基，其中抗衡离子为酸或羟基离子的阴离子），-COR8（其中R8为氢原子，低级烷基或羟基），-CH （OR 9）2（其中R 9为低级烷基），亚氨基甲基，羟基亚氨基甲基或卤素原子及其盐可以非常强烈地抑制脂氧合酶，并显着抑制其代谢物的产生和释放，因此可用作由脂氧合酶代谢物引起的疾病的预防和治疗剂。

2. 发明授权

US4677125A Phosphorus-containing peptide derivatives 失效
标题翻译：含磷肽衍生物
公开(公告)号：US4677125A
公开(公告)日：1987-06-30
申请号：US902109
申请日：1986-08-29
申请人： Masayuki Teranishi , Mitsuru Takahashi , Hisayo Nomoto , Hiroshi Kase , Katsuichi Shuto , Kazuhiro Kubo , Akira Karasawa
发明人： Masayuki Teranishi , Mitsuru Takahashi , Hisayo Nomoto , Hiroshi Kase , Katsuichi Shuto , Kazuhiro Kubo , Akira Karasawa
IPC分类号： A61K38/00 , C07C59/68 , C07F9/38 , C07F9/40 , C07K5/06 , A61K37/02 , C07K5/08
CPC分类号： C07F9/3808 , C07C59/68 , C07F9/4006 , C07F9/4065 , C07K5/06191 , A61K38/00
摘要： Phosphorus-containing oligopeptide derivatives are prepared by synthetic methods. The compounds exhibit angiotensin converting enzyme-inhibiting action and are, therefore, useful as anti-hypertensive agents.
摘要翻译：通过合成方法制备含磷寡肽衍生物。化合物表现出血管紧张素转化酶抑制作用，因此可用作抗高血压药。

3. 发明授权

US4138485A Phenylalanine derivatives 失效
标题翻译：苯丙氨酸衍生物
公开(公告)号：US4138485A
公开(公告)日：1979-02-06
申请号：US771726
申请日：1977-02-24
申请人： Nobuhiro Nakamizo , Masayuki Teranishi , Ikuo Matsukuma , Katsuichi Shuto , Koji Yamada
发明人： Nobuhiro Nakamizo , Masayuki Teranishi , Ikuo Matsukuma , Katsuichi Shuto , Koji Yamada
IPC分类号： C07D295/185 , C07K5/065 , A61K31/535 , A61K31/27 , C07C153/11 , C07D211/06
CPC分类号： C07D295/185 , C07K5/06078
摘要： This invention relates to certain derivatives of phenylalanine having interesting pharmaceutical properties, in particular, a lipid-lowering activity.
摘要翻译：本发明涉及具有感兴趣的药物性质的苯丙氨酸的某些衍生物，特别是降脂活性。

4. 发明授权

US4588729A Treating convulsions with dihydrouracil derivatives 失效
标题翻译：用二氢尿嘧啶衍生物治疗惊厥
公开(公告)号：US4588729A
公开(公告)日：1986-05-13
申请号：US734607
申请日：1985-05-16
申请人： Masayuki Teranishi , Chikara Murakata , Ikuo Matsukuma , Katsuichi Shuto , Shunji Ichikawa
发明人： Masayuki Teranishi , Chikara Murakata , Ikuo Matsukuma , Katsuichi Shuto , Shunji Ichikawa
IPC分类号： A61K31/505 , A61P25/08 , C07D239/22 , A61K31/52
CPC分类号： C07D239/22 , A61K31/505
摘要： Offered is an anticonvulsive composition which comprises an effective amount of a dihydrouracil derivative represented by the formula: ##STR1## [wherein one of A and B is ##STR2## (wherein Y.sub.1, Y.sub.2 and Y.sub.3 are hydrogen atoms, lower alkyl groups, halogen atoms, nitro groups, amino groups, carboxyl groups, lower alkoxycarbonyl groups or trifluoromethyl groups), a naphthyl group or a diphenylmethyl group, and the other is a hydrogen atom, a lower alkyl group, a lower alkenyl group, a cyclopentyl group, a cyclohexyl group or ##STR3## (wherein Z.sub.1, Z.sub.2 and Z.sub.3 are hydrogen atoms, lower alkyl groups, halogen atoms or trifluoromethyl groups), R.sub.1, R.sub.2 and R.sub.3 are hydrogen atoms or lower alkyl groups, and X is an oxygen atom or a sulfur atom] and at least one pharmaceutically acceptable carrier.
摘要翻译：提供的是抗惊厥组合物，其包含有效量的由下式表示的二氢尿嘧啶衍生物：其中A和B之一为（其中Y1，Y2和Y3为氢原子，低级烷基，卤素原子硝基，氨基，羧基，低级烷氧基羰基或三氟甲基），萘基或二苯基甲基，另一个是氢原子，低级烷基，低级链烯基，环戊基，环己基基团或（其中Z1，Z2和Z3是氢原子，低级烷基，卤素原子或三氟甲基），R1，R2和R3是氢原子或低级烷基，X是氧原子或硫原子 ]和至少一种药学上可接受的载体。

5. 发明授权

US5190906A Alkyl aromatic hydrocarbon dehydrogenation catalyst and method for producing the catalyst 失效
标题翻译：烷基芳族烃脱氢催化剂及其制备方法
公开(公告)号：US5190906A
公开(公告)日：1993-03-02
申请号：US843919
申请日：1992-02-27
申请人： Akira Murakami , Hidemi Unei , Masayuki Teranishi , Masaki Ohta
发明人： Akira Murakami , Hidemi Unei , Masayuki Teranishi , Masaki Ohta
IPC分类号： B01J23/78 , B01J23/86 , B01J23/88 , B01J23/887 , C07B61/00 , C07C5/333 , C07C15/46
CPC分类号： B01J23/8872 , B01J23/78 , B01J23/8871 , C07C5/3332
摘要： In order to increase performances of an iron oxide-potassium oxide system catalyst to be used for an alkyl aromatic hydrocarbon dehydrogenation reaction in the presence of steam, there is provided an alkyl aromatic hydrocarbon dehydrogenation catalyst wherein a little amount of titanium oxide is added by the mixing and kneading method or by the preceding addition to iron oxide in the production of the iron oxide-potassium oxide system catalyst to be used for the alkyl aromatic hydrocarbon dehydrogenation reaction in the presence of steam. The iron oxide-potassium oxide system catalyst is allowed to contain a little amount of titanium oxide, whereby an activity can be remarkably increased, as well as a selectivity in the same conversion ratio can also be improved in the alkyl aromatic hydrocarbon dehydrogenation reaction, and further the obtained catalyst exhibits stable performances with time on stream.

6. 发明授权

US4390536A Piperidine derivatives 失效
公开(公告)号：US4390536A
公开(公告)日：1983-06-28
申请号：US352762
申请日：1982-02-26
申请人： Masayuki Teranishi , Hiroyuki Obase , Haruki Takai , Kazuhiro Kubo , Yutaka Kasuya
发明人： Masayuki Teranishi , Hiroyuki Obase , Haruki Takai , Kazuhiro Kubo , Yutaka Kasuya
IPC分类号： C07D211/58 , C07D417/04 , A61K31/54
CPC分类号： C07D211/58
摘要： New piperidine derivatives which have a useful pharmacological activity such as hypotensive activity are prepared.

7. 发明授权

US4344945A Piperidine derivatives 失效
标题翻译：哌啶衍生物
公开(公告)号：US4344945A
公开(公告)日：1982-08-17
申请号：US241727
申请日：1981-03-09
申请人： Masayuki Teranishi , Hiroyuki Obase , Haruki Takai , Kazuhiro Kubo , Yutaka Kasuya
发明人： Masayuki Teranishi , Hiroyuki Obase , Haruki Takai , Kazuhiro Kubo , Yutaka Kasuya
IPC分类号： C07D211/58 , C07D413/04 , A61K31/445 , A61K31/535 , C07D498/14
CPC分类号： C07D211/58
摘要： New piperidine derivatives which have a useful pharmacological activity such as hypotensive activity are prepared.
摘要翻译：制备具有有用药理活性如降血压活性的新的哌啶衍生物。

8. 发明授权

US5190700A Flame retardant for halogen-containing vinyl resins 失效
标题翻译：含卤乙烯基树脂的阻燃剂
公开(公告)号：US5190700A
公开(公告)日：1993-03-02
申请号：US574606
申请日：1990-08-29
申请人： Yoshitane Watanabe , Keitaro Suzuki , Kouji Shishido , Masayuki Teranishi , Masuo Shindo
发明人： Yoshitane Watanabe , Keitaro Suzuki , Kouji Shishido , Masayuki Teranishi , Masuo Shindo
IPC分类号： C08K3/16 , C08K3/22 , C08K13/02
CPC分类号： C08K3/2279 , C08K13/02 , C08K3/16
摘要： The present invention provides a power flame retardant for a halogen-containing vinyl resin, which comprises the following Components A, B and C. (A) 5 to 30 parts by weight of at least one of alkali metal compound of lithium, sodium and potassium calculated as the formula M.sub.2 O where M is an alkali metal; (B) 0.2 to 10 parts by weight of a perchloric acid radical in the form of the acid or a salt or amine thereof, calculated as perchloric acid radical; and (C) 1 to 50 parts by weight of a hydrophobic dispersing agent having a boiling point or a decomposition temperature of 200.degree. C. or higher. All the parts by weight are based on 100 parts by weight of antimony pentoxide (Sb.sub.2 O.sub.5). The flame retardant of the present invention does not impair transparency of the halogen-containing vinyl resin, and also does not worsen various physical properties such as thermal stability and weathering resistance. The invention also provides (1) flame retardant halogen containing resins and (2) a process for preparing the powdered flame retardant.
摘要翻译：本发明提供含卤乙烯基树脂的电力阻燃剂，其包含以下组分A，B和C.（A）5至30重量份的锂，钠和钾的碱金属化合物按公式M2O计算，其中M为碱金属; （B）0.2至10重量份以酸或其盐或胺形式的高氯酸基团，其计为高氯酸根; 和（C）1〜50重量份的沸点或分解温度为200℃以上的疏水性分散剂。所有重量份均基于100重量份的五氧化二锑（Sb 2 O 5）。本发明的阻燃剂不会损害含卤乙烯基树脂的透明性，也不会使各种物理性质如热稳定性和耐候性恶化。本发明还提供（1）阻燃卤素树脂和（2）制备阻燃剂的方法。

9. 发明授权

US4731198A Positively charged antimony pentoxide sol and preparation thereof 失效
标题翻译：正电荷五氧化二锑溶胶及其制备
公开(公告)号：US4731198A
公开(公告)日：1988-03-15
申请号：US846580
申请日：1986-03-31
申请人： Yoshitane Watanabe , Masayuki Teranishi , Keitaro Suzuki
发明人： Yoshitane Watanabe , Masayuki Teranishi , Keitaro Suzuki
IPC分类号： C08K3/22 , C01G30/00 , C01G35/00 , C01G37/00 , C08K3/00 , C08K3/24 , C08K9/02 , C09C1/00 , B01J13/00
CPC分类号： C09C1/0096 , C08K9/02 , C01P2006/12 , C01P2006/22 , C01P2006/80
摘要： Disclosed is a positively charged antimony pentoxide sol, comprising colloidal particles of antimony pentoxide sol coated on their surfaces with at least one of trivalent and tetravalent metals, the content of the metals being 1 to 50% by weight in terms of the metal oxide based on antimony pentoxide in the antimony pentoxide sol.When the positively charged antimony pentoxide sol of this invention is mixed with a cationic resin emulsion or an aqueous solution of a cationic water-soluble polymer, no agglomeration occurs and also, when it is added into an aqueous solution of an inorganic acid such as hydrochloric acid, sulfuric acid, nitric acid, etc., or an organic acid such as acetic acid, propionic acid, oxalic acid, maleic acid, etc., an aqueous solution of a metal salt or amine salts of these acids or an organic solvent such as an alcohol, no agglomeration occurs but it is well dispersed therein, and therefore it can be applicable for fields in which the antimony pentoxide sol of the prior art cannot satisfactorily be used.
摘要翻译：公开了一种带正电的五氧化二锑溶胶，其包含五氧化二锑溶胶表面上用至少一种三价和四价金属涂覆的胶体颗粒，金属含量为基于金属氧化物换算为1至50重量％五氧化二锑中的五氧化二锑。当将本发明的带正电荷的五氧化二锑溶胶与阳离子树脂乳液或阳离子水溶性聚合物的水溶液混合时，不发生附聚，并且当将其加入到无机酸如盐酸酸，硫酸，硝酸等，或有机酸如乙酸，丙酸，草酸，马来酸等，这些酸的金属盐或胺盐的水溶液或有机溶剂如作为醇，不发生凝聚，但是其分散良好，因此可以适用于现有技术的五氧化二锑溶胶不能令人满意地使用的领域。

10. 发明授权

US4770813A Process for preparing stable colloidal sols of antimony pentoxide in organic solvents 失效
标题翻译：在有机溶剂中制备稳定的五氧化二锑胶体溶胶的方法
公开(公告)号：US4770813A
公开(公告)日：1988-09-13
申请号：US934402
申请日：1986-11-24
申请人： Yoshitane Watanabe , Keitaro Suzuki , Masayuki Teranishi
发明人： Yoshitane Watanabe , Keitaro Suzuki , Masayuki Teranishi
IPC分类号： B01J13/00 , C01G30/00 , C09C1/00
CPC分类号： C01G30/005 , B01J13/0026 , C09C1/0096 , C01P2004/61 , C01P2006/10 , C01P2006/22 , C01P2006/80 , C01P2006/82 , C01P2006/90
摘要： There is disclosed a process for preparing stable colloidal sols of antimony pentoxide in organic solvents which comprises the steps of adjusting an amount of an organic base in an aqueous colloidal solution of antimony pentoxide to, in terms of % by weight, 2 to 30% based on antimony pentoxide in the aqueous colloidal solution of antimony pentoxide; adding an organic acid in an amount of 0.2 to 20%; and replacing a dispersing medium of the colloidal solution from water to an organic solvent.
摘要翻译：公开了一种在有机溶剂中制备稳定的五氧化二锑的胶体溶胶的方法，该方法包括以下步骤：将五氧化二锑胶体溶液中的有机碱的量调整至按重量％计为2-30％五氧化二锑水溶液中的五氧化二锑; 加入0.2〜20％的有机酸; 并将胶体溶液的分散介质从水替换为有机溶剂。

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