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1. 发明授权

US07622563B2 Process for producing glycoside 有权
标题翻译：生产糖苷的方法
公开(公告)号：US07622563B2
公开(公告)日：2009-11-24
申请号：US10518640
申请日：2003-07-11
申请人： Masayuki Furuya , Hidetoshi Tsunoda , Tsuneji Suzuki , Akinori Nagatomo , Masaru Wada
发明人： Masayuki Furuya , Hidetoshi Tsunoda , Tsuneji Suzuki , Akinori Nagatomo , Masaru Wada
IPC分类号： C07H15/00
CPC分类号： A61K31/7034 , A61K8/602 , A61K2800/522 , A61Q5/12 , A61Q19/00 , A61Q19/02 , C07H15/203
摘要： A glycoside in which at least two phenolic hydroxyl groups of a compound having at least two phenolic hydroxyl groups in its molecule are glycosidically linked to anomeric carbon atoms of at least two sugar molecules can be prepared with high yield by a method including the step of allowing phenolic hydroxyl groups of a compound having at least two phenolic hydroxyl groups in its molecule to react with sugar molecules each having an acetylated hydroxyl group attached to an anomeric carbon atom in the presence of an organic solvent and an acid catalyst while removing acetic acid formed during the reaction from the reaction system.
摘要翻译：可以通过包括以下步骤的方法以高产率制备其分子中具有至少两个酚羟基的化合物的至少两个酚羟基与至少两个糖分子的异头碳原子糖基化连接的糖苷，所述方法包括以下步骤：在其分子中具有至少两个酚羟基的化合物的酚羟基与在有机溶剂和酸催化剂存在下连接到端基异构碳原子上的具有乙酰化羟基的糖分子反应，同时除去在反应体系的反应。

2. 发明申请

US20050272921A1 Process for producing glycoside 有权
标题翻译：生产糖苷的方法
公开(公告)号：US20050272921A1
公开(公告)日：2005-12-08
申请号：US10518640
申请日：2003-07-11
申请人： Masayuki Furuya , Hidetoshi Tsunoda , Tsuneji Suzuki , akinori Nagatomo , Masaru Wada
发明人： Masayuki Furuya , Hidetoshi Tsunoda , Tsuneji Suzuki , akinori Nagatomo , Masaru Wada
IPC分类号： A61K8/60 , A61K31/7034 , A61Q5/12 , A61Q19/00 , A61Q19/02 , C07H15/203 , C07H15/00
CPC分类号： A61K31/7034 , A61K8/602 , A61K2800/522 , A61Q5/12 , A61Q19/00 , A61Q19/02 , C07H15/203
摘要： A glycoside in which at least two phenolic hydroxyl groups of a compound having at least two phenolic hydroxyl groups in its molecule are glycosidically linked to anomeric carbon atoms of at least two sugar molecules can be prepared with high yield by a method including the step of allowing phenolic hydroxyl groups of a compound having at least two phenolic hydroxyl groups in its molecule to react with sugar molecules each having an acetylated hydroxyl group attached to an anomeric carbon atom in the presence of an organic solvent and an acid catalyst while removing acetic acid formed during the reaction from the reaction system.
摘要翻译：可以通过包括以下步骤的方法以高产率制备其分子中具有至少两个酚羟基的化合物的至少两个酚羟基与至少两个糖分子的异头碳原子糖基化连接的糖苷，所述方法包括以下步骤：在其分子中具有至少两个酚羟基的化合物的酚羟基与在有机溶剂和酸催化剂存在下连接到端基异构碳原子上的具有乙酰化羟基的糖分子反应，同时除去在反应体系的反应。

3. 发明申请

US20050085521A1 Optically active azole derivative and process for producing the same 失效
标题翻译：光学活性唑衍生物及其制备方法
公开(公告)号：US20050085521A1
公开(公告)日：2005-04-21
申请号：US10503469
申请日：2003-02-07
申请人： Tsuneji Suzuki , Hidetoshi Tsunoda
发明人： Tsuneji Suzuki , Hidetoshi Tsunoda
IPC分类号： C07D233/54 , C07D249/08 , C07D521/00 , A61K31/4178 , A61K31/4196
CPC分类号： C07D233/56 , C07D231/12 , C07D233/54 , C07D249/08 , Y02P20/55
摘要： A method for producing an optically active 2-phenyl-2,3,-dihydroxypropyl azole derivative, which is a useful compound in various fields. An optically active α-hydroxycarboxylic acid derivative represented by general formula (1) is used as a starting material and is allowed to react with an azole acetic acid derivative (2) to produce a new, optically active azole-alkyl ketone derivative (3). Subsequently, a new, optically active azole-methyl alcohol derivative (5) is produced by highly diastereoselective alkylation by an appropriate combination of a protective group and an organometallic reagent (4). Furthermore, the optically active azole-methyl alcohol derivative (5) is selectively deprotected to produce an optically active 2-phenyl-2,3-dihydroxypropyl azole derivative (6).
摘要翻译：光学活性的2-苯基-2,3-二羟基丙基唑衍生物的制造方法，其为各种领域的有用化合物。使用由通式（1）表示的光学活性α-羟基羧酸衍生物作为原料，并与唑类乙酸衍生物（2）反应，生成新的光学活性唑 - 烷基酮衍生物（3）。随后，通过保护基和有机金属试剂（4）的适当组合，通过高度非对映选择性烷基化产生新的光学活性唑 - 甲醇衍生物（5）。此外，光学活性的唑 - 甲醇衍生物（5）选择性脱保护，得到光学活性的2-苯基-2,3-二羟基丙基唑衍生物（6）。

4. 发明申请

US20080114053A1 Method for Producing Fluorinated Proline Derivative 审中-公开
标题翻译：生产氟化脯氨酸衍生物的方法
公开(公告)号：US20080114053A1
公开(公告)日：2008-05-15
申请号：US11795961
申请日：2006-01-26
申请人： Hidetoshi Tsunoda , Tsuneji Suzuki
发明人： Hidetoshi Tsunoda , Tsuneji Suzuki
IPC分类号： A61K31/401
CPC分类号： C07D207/16 , C07D207/22
摘要： An object of the present invention is to provide a method for efficiently producing a high-purity fluorinated proline derivative with high yield. A method for producing a compound represented by the general formula (2), (In the formula, R1 represents an unsubstituted or substituted alkyl group having 1 to 6 carbon atoms or the like, and R2 represents an unsubstituted or substituted alkyl group having 1 to 6 carbon atoms or the like, and R3 represents a hydroxyl group or the like) wherein a compound represented by the general formula (1) (In the formula, R1 and R2 are defined as in the general formula (1)) is reacted with a fluorination agent to obtain a reaction product containing the compound represented by the general formula (2) and a by-products; and bringing chlorine, bromine, iodine, hypochlorous acid, hypochlorite, hypobromous acid, hypobromite or N-halogenosuccinimide into action on the reaction product to chemically change the by-product.
摘要翻译：本发明的目的是提供一种以高产率有效地制备高纯度氟化脯氨酸衍生物的方法。一种制备由通式（2）表示的化合物的方法，（式中，R 1表示未取代或取代的碳原子数为1〜6的烷基等，R 2表示未取代或取代的烷基， 6个碳原子等，R3表示羟基等），其中由通式（1）表示的化合物（式中，R1和R2如通式（1）所定义）与式得到含有通式（2）表示的化合物和副产物的反应产物的氟化剂; 并使氯，溴，碘，次氯酸，次氯酸盐，次溴酸，次溴酸盐或N-卤代琥珀酰亚胺作用于反应产物以化学改变副产物。

5. 发明授权

US07271185B2 Optically active azole derivative and process for producing the same 失效
标题翻译：光学活性唑衍生物及其制备方法
公开(公告)号：US07271185B2
公开(公告)日：2007-09-18
申请号：US10503469
申请日：2003-02-07
申请人： Tsuneji Suzuki , Hidetoshi Tsunoda
发明人： Tsuneji Suzuki , Hidetoshi Tsunoda
IPC分类号： A61K31/41 , C07D249/04 , C07D249/08
CPC分类号： C07D233/56 , C07D231/12 , C07D233/54 , C07D249/08 , Y02P20/55
摘要： A method for producing an optically active 2-phenyl-2,3,-dihydroxypropyl azole derivative, which is a useful compound in various fields. An optically active α-hydroxycarboxylic acid derivative represented by general formula (1) is used as a starting material and is allowed to react with an azole acetic acid derivative (2) to produce a new, optically active azole-alkyl ketone derivative (3). Subsequently, a new, optically active azole-methyl alcohol derivative (5) is produced by highly diastereoselective alkylation by an appropriate combination of a protective group and an organometallic reagent (4). Furthermore, the optically active azole-methyl alcohol derivative (5) is selectively deprotected to produce an optically active 2-phenyl-2,3-dihydroxypropyl azole derivative (6)
摘要翻译：光学活性的2-苯基-2,3-二羟基丙基唑衍生物的制造方法，其为各种领域的有用化合物。使用由通式（1）表示的光学活性α-羟基羧酸衍生物作为原料，并与唑类乙酸衍生物（2）反应，生成新的光学活性唑 - 烷基酮衍生物（3）。随后，通过保护基和有机金属试剂（4）的适当组合，通过高度非对映选择性烷基化产生新的光学活性唑 - 甲醇衍生物（5）。此外，光学活性的唑 - 甲醇衍生物（5）选择性脱保护，得到光学活性的2-苯基-2,3-二羟基丙基唑衍生物（6）

6. 发明申请

US20130171514A1 CYCLIC SULFATE COMPOUND, NON-AQUEOUS ELECTROLYTE SOLUTION CONTAINING SAME, AND LITHIUM SECONDARY BATTERY 有权
标题翻译：循环硫酸盐化合物，含有相同电解质的非水溶液，以及锂二次电池
公开(公告)号：US20130171514A1
公开(公告)日：2013-07-04
申请号：US13820969
申请日：2011-10-21
申请人： Shigeru Mio , Mitsuo Nakamura , Kaichiro Haruta , Hidenobu Nogi , Satoko Fujiyama , Takashi Hayashi , Hidetoshi Tsunoda
发明人： Shigeru Mio , Mitsuo Nakamura , Kaichiro Haruta , Hidenobu Nogi , Satoko Fujiyama , Takashi Hayashi , Hidetoshi Tsunoda
IPC分类号： C07D327/10
CPC分类号： C07D327/10 , H01M10/0525 , H01M10/0567 , Y02E60/122 , Y02T10/7011
摘要： A non-aqueous electrolyte solution containing a cyclic sulfate compound represented by formula (I) is provided, wherein in formula (I), R1 represents a group represented by formula (II) or a group represented by formula (III); R2 represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms, a group represented by formula (II), or a group represented by formula (III); and in formula (II), R3 represents a halogen atom, an alkyl group having from 1 to 6 carbon atoms, a halogenated alkyl group having from 1 to 6 carbon atoms, an alkoxy group having from 1 to 6 carbon atoms, or a group represented by formula (IV).
摘要翻译：提供了含有式（I）表示的环状硫酸盐化合物的非水电解质溶液，式（I）中，R 1表示由式（II）表示的基团或由式（III）表示的基团。 R2表示氢原子，具有1-6个碳原子的烷基，由式（II）表示的基团或由式（III）表示的基团; 在式（II）中，R 3表示卤素原子，具有1-6个碳原子的烷基，具有1至6个碳原子的卤代烷基，具有1至6个碳原子的烷氧基或基团由式（IV）表示。

7. 发明授权

US5861520A Glycolipid analogs 失效
标题翻译：糖脂类似物
公开(公告)号：US5861520A
公开(公告)日：1999-01-19
申请号：US454630
申请日：1995-05-31
申请人： Seiichiro Ogawa , Hidetoshi Tsunoda , Jinichi Inokuchi
发明人： Seiichiro Ogawa , Hidetoshi Tsunoda , Jinichi Inokuchi
IPC分类号： C07C233/18 , C07C233/36 , C07C323/41 , C07C233/00
CPC分类号： C07C323/41 , C07C233/18 , C07C233/36 , C07C2101/16
摘要： The present invention provides a compound which is a glycolipid analog having a novel structure represented by the formula (1): ##STR1## wherein Z represents an imino group, an oxygen atom or a sulfur atom; m is an integer of from 3 to 12; and n is an integer of from 4 to 22; and shows a potent activity of inhibiting glycosidase and has potential physiological activities, for example, antiviral activity. The invention also provides a glycosidase inhibitor which comprises said glycolipid analog as an active ingredient.
摘要翻译：本发明提供了具有式（1）所示新结构的糖脂类似物的化合物：其中Z表示亚氨基，氧原子或硫原子; m为3〜12的整数， n为4〜22的整数。并且显示出抑制糖苷酶的有效活性并具有潜在的生理活性，例如抗病毒活性。本发明还提供一种糖苷酶抑制剂，其包含所述糖脂类似物作为活性成分。

8. 发明授权

US06670447B2 Amino acid N-carboxyanhydrides with acyl substituents on nitrogen atoms thereof 失效
标题翻译：在其氮原子上具有酰基取代基的氨基酸N-羧酸酐
公开(公告)号：US06670447B2
公开(公告)日：2003-12-30
申请号：US10070156
申请日：2002-03-04
申请人： Hidetoshi Tsunoda , Michiru Sekiguchi , Hajime Iizuka , Kazuya Sakai
发明人： Hidetoshi Tsunoda , Michiru Sekiguchi , Hajime Iizuka , Kazuya Sakai
IPC分类号： C07K1600
CPC分类号： C07D263/44 , C07C231/10 , C07C237/22 , C07D231/12 , C07D233/56 , C07D249/08 , C07D295/185 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/14 , C07D471/04 , C07D487/08
摘要： This invention provides amino acid N-carboxyanhydrides, each of which has an N-acyl substituent on its nitrogen atom, is represented by the following formula (1): readily reacts with nucleophilic reagents such as free amino acids, alcohols, anions or the like, and are intermediates useful for the high-yield production of amino acid derivatives, optically active compounds, peptides, polypeptides and the like useful in many fields lead by the fields of pharmaceuticals and agrochemicals, and also provides a process for the production of the amino acid N-carboxyanhydrides. Further, the present invention also provides a process for the production of diamides, which uses the compounds of the formula (1) and amine derivatives represented by the following formula (7): These diamides can also be suitably used for the production of amino acid derivatives, optically active compounds, peptides, polypeptides and the like.
摘要翻译：本发明提供氨基酸N-羧酸酐，其各自在其氮原子上具有N-酰基取代基，由下式（1）表示：容易与亲核试剂如游离氨基酸，醇，阴离子等反应并且是用于高产量生产氨基酸衍生物，光学活性化合物，肽，多肽等的中间体，其在许多领域中可用于药物和农用化学品的领域，并且还提供了制备氨基酸的方法酸性N-羧酸酐。此外，本发明还提供了使用式（1）的化合物和由下式（7）表示的胺衍生物的二酰胺的制备方法：这些二酰胺也可以适合用于制备氨基酸衍生物，光学活性化合物，肽，多肽等。

9. 发明授权

US09227950B2 Cyclic sulfate compound, non-aqueous electrolyte solution containing same, and lithium secondary battery 有权
标题翻译：环硫酸盐化合物，含有其的非水电解质溶液和锂二次电池
公开(公告)号：US09227950B2
公开(公告)日：2016-01-05
申请号：US13820969
申请日：2011-10-21
申请人： Shigeru Mio , Mitsuo Nakamura , Kaichiro Haruta , Hidenobu Nogi , Satoko Fujiyama , Takashi Hayashi , Hidetoshi Tsunoda
发明人： Shigeru Mio , Mitsuo Nakamura , Kaichiro Haruta , Hidenobu Nogi , Satoko Fujiyama , Takashi Hayashi , Hidetoshi Tsunoda
IPC分类号： H01M2/34 , C07D327/10 , H01M10/0525 , H01M10/0567
CPC分类号： C07D327/10 , H01M10/0525 , H01M10/0567 , Y02E60/122 , Y02T10/7011
摘要： A non-aqueous electrolyte solution containing a cyclic sulfate compound represented by formula (I) is provided, wherein in formula (I), R1 represents a group represented by formula (II) or a group represented by formula (III); R2 represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms, a group represented by formula (II), or a group represented by formula (III); and in formula (II), R3 represents a halogen atom, an alkyl group having from 1 to 6 carbon atoms, a halogenated alkyl group having from 1 to 6 carbon atoms, an alkoxy group having from 1 to 6 carbon atoms, or a group represented by formula (IV).
摘要翻译：提供了含有式（I）表示的环状硫酸盐化合物的非水电解质溶液，式（I）中，R 1表示由式（II）表示的基团或由式（III）表示的基团。 R2表示氢原子，具有1-6个碳原子的烷基，由式（II）表示的基团或由式（III）表示的基团; 在式（II）中，R 3表示卤素原子，具有1-6个碳原子的烷基，具有1至6个碳原子的卤代烷基，具有1至6个碳原子的烷氧基或基团由式（IV）表示。

10. 发明申请

US20090281332A1 PROCESS FOR PRODUCING ESTER OR ALCOHOL 审中-公开
标题翻译：生产酯或醇的方法
公开(公告)号：US20090281332A1
公开(公告)日：2009-11-12
申请号：US12305498
申请日：2007-06-19
申请人： Hidetoshi Tsunoda , Kouki Fukumura
发明人： Hidetoshi Tsunoda , Kouki Fukumura
IPC分类号： C07D207/16
CPC分类号： C07D403/02 , C07B2200/07 , C07C57/10 , C07C251/30 , C07C309/04 , C07C309/30 , C07D207/12 , C07D207/16 , C07D233/06
摘要： Provided is a process for producing an ester or alcohol using a fluoroimidinium sulfonate derivative represented by the general formula (9) or a fluoroimidinium carboxylate derivative represented by the general formula (6) and using as a raw material alcohol involving inversion of steric configuration. Further provided are a fluoroimidinium sulfonate derivative represented by the general formula (9), and a process for producing the same.
摘要翻译：提供使用由通式（9）表示的氟代嘧啶鎓磺酸盐衍生物或由通式（6）表示的氟代吡啶鎓羧酸酯衍生物并使用作为包含反式空间构型的原料醇的酯或醇的制备方法。进一步提供由通式（9）表示的氟代嘧啶鎓磺酸盐衍生物及其制备方法。

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