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    • 5. 发明申请
    • Method For Removing Sialic Acid and Method For Producing Asialoerythropoietin
    • 去除唾液酸的方法和生产Asialo促红细胞生成素的方法
    • US20090005540A1
    • 2009-01-01
    • US12087945
    • 2007-01-18
    • Masato Higuchi
    • Masato Higuchi
    • C07K14/00C07H1/06
    • C07K14/505
    • The object is to provide a method for removing a sialic acid that can be carried out simply at a low cost and a method for producing asialoerythropoietin using the same. The method for removing a sialic acid according to the present invention includes an acidifying and heating process of acidifying and heating a solution containing erythropoietin so as to remove a sialic acid bonded to an erythropoietin molecule. Further, the method for producing asialoerythropoietin according to the present invention includes a sialic acid removing process of removing a sialic acid bonded to an erythropoietin molecule by the method for removing a sialic acid according to the present invention.
    • 本发明的目的是提供一种可以简单地以低成本除去唾液酸的方法,以及使用该方法制备唾液促红细胞生成素的方法。 根据本发明的除去唾液酸的方法包括酸化和加热含有促红细胞生成素的溶液的酸化和加热方法,以除去与红细胞生成素分子结合的唾液酸。 此外,本发明的唾液酸促生成素的制造方法包括通过本发明的除去唾液酸的方法除去与红细胞生成素分子结合的唾液酸的唾液酸去除方法。