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    • 3. 发明申请
    • Method For Removing Sialic Acid and Method For Producing Asialoerythropoietin
    • 去除唾液酸的方法和生产Asialo促红细胞生成素的方法
    • US20090005540A1
    • 2009-01-01
    • US12087945
    • 2007-01-18
    • Masato Higuchi
    • Masato Higuchi
    • C07K14/00C07H1/06
    • C07K14/505
    • The object is to provide a method for removing a sialic acid that can be carried out simply at a low cost and a method for producing asialoerythropoietin using the same. The method for removing a sialic acid according to the present invention includes an acidifying and heating process of acidifying and heating a solution containing erythropoietin so as to remove a sialic acid bonded to an erythropoietin molecule. Further, the method for producing asialoerythropoietin according to the present invention includes a sialic acid removing process of removing a sialic acid bonded to an erythropoietin molecule by the method for removing a sialic acid according to the present invention.
    • 本发明的目的是提供一种可以简单地以低成本除去唾液酸的方法,以及使用该方法制备唾液促红细胞生成素的方法。 根据本发明的除去唾液酸的方法包括酸化和加热含有促红细胞生成素的溶液的酸化和加热方法,以除去与红细胞生成素分子结合的唾液酸。 此外,本发明的唾液酸促生成素的制造方法包括通过本发明的除去唾液酸的方法除去与红细胞生成素分子结合的唾液酸的唾液酸去除方法。
    • 9. 发明授权
    • Thin power supply unit
    • 薄电源单元
    • US5367431A
    • 1994-11-22
    • US964785
    • 1992-10-22
    • Tatsuo KunishiKouichi WatanabeMasanori EndoMasato Higuchi
    • Tatsuo KunishiKouichi WatanabeMasanori EndoMasato Higuchi
    • H01G9/00H01G9/08H01G11/00H01G11/10H01G11/66H01G11/74H01G11/78H01M2/10H01M2/20H01M2/30H01M6/16H01M6/46H01M10/05H01G1/035
    • H01G9/155H01G9/08H01M2/1066H01M2/204H01M6/46Y02E60/13
    • A plurality of flat power supply elements, each having a flat case for serving as an element terminal and an electrode plate arranged in the case in a close contact manner through an insulating layer for serving as another element terminal. An opening formed in the case for partially exposing the electrode plate. The flat power supply elements are bonded onto a flexible circuit board by an insulating bonding layer. A first external connection terminal which is provided on the circuit board is connected to the electrode plate of one power supply element through a first conductive member. A connecting conductor which is also provided on the circuit board is electrically connected to the case of this one power supply element through a second conductive member and connected to the electrode plate of another power supply element through a third conductive member. A second external connection terminal which is provided on the circuit board is electrically connected to the case of this another power supply element through a fourth conductive member. Thus, a plurality of flat power supply elements having excellent sealing structures are combined with each other to provide an integrated thin power supply unit with no increase in thickness.
    • 多个扁平电源元件,每个扁平电源元件具有用作元件端子的平坦壳体和以紧密接触方式布置在壳体中的绝缘层用作另一元件端子的电极板。 在用于部分暴露电极板的情况下形成的开口。 扁平电源元件通过绝缘接合层接合到柔性电路板上。 设置在电路板上的第一外部连接端子通过第一导电构件连接到一个电源元件的电极板。 还设置在电路板上的连接导体通过第二导电构件与该一个电源元件的壳体电连接,并且通过第三导电构件连接到另一个电源元件的电极板。 设置在电路板上的第二外部连接端子通过第四导电部件与该另一个电源元件的壳体电连接。 因此,具有优异的密封结构的多个扁平电源元件彼此组合以提供不增加厚度的集成薄电源单元。