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1. 发明申请

US20050144662A1 Knockout mouse 审中-公开
标题翻译：淘汰老鼠
公开(公告)号：US20050144662A1
公开(公告)日：2005-06-30
申请号：US10942954
申请日：2004-09-17
申请人： Masataka Nakamura , Kazuo Sugamura , Shoichi Takano , Kinya Nagata , Hiroyuki Hirai
发明人： Masataka Nakamura , Kazuo Sugamura , Shoichi Takano , Kinya Nagata , Hiroyuki Hirai
IPC分类号： A01K67/027 , C07K14/705 , C12N15/09 , C12N15/85 , G01N33/15 , G01N33/50
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C07K14/705
摘要： A knockout mouse whose genome includes an inactivated CRTH2 gene. The knockout mouse is obtained by subjecting to a serial passage a chimeric mouse originating from an early embryo to which a CRTH2-gene-knocked-out mouse embryonic stem cell has been introduced. Also disclosed is a detection method which includes employing, as an index, pathological condition of the knockout mouse to which the test substance has been administered, to thereby detect, in vivo, characteristics of a test substance in relation to CRTH2, or functions of CRTH2 in the living body.
摘要翻译：基因组的敲除小鼠，其包含失活的CRTH2基因。敲除小鼠通过连续通过源自已经引入了CRTH2基因敲除的小鼠胚胎干细胞的早期胚胎的嵌合小鼠获得。还公开了一种检测方法，其包括使用已经施用受检物质的敲除小鼠的病理状态作为指标，从而检测体内与CRTH2相关的测试物质的特征，或CRTH2的功能在活体内。

2. 发明授权

US5889160A Human IL-2 receptor .gamma.-chain molecule antibody 失效
标题翻译：人IL-2受体γ链分子抗体
公开(公告)号：US5889160A
公开(公告)日：1999-03-30
申请号：US902929
申请日：1997-07-30
申请人： Kazuo Sugamura , Toshikazu Takeshita , Hironobu Asao , Masataka Nakamura , Toshiro Shimamura , Manabu Suzuki , Junji Hamuro
发明人： Kazuo Sugamura , Toshikazu Takeshita , Hironobu Asao , Masataka Nakamura , Toshiro Shimamura , Manabu Suzuki , Junji Hamuro
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61P37/00 , C07K1/20 , C07K1/22 , C07K14/705 , C07K14/715 , C07K16/00 , C07K16/28 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/577 , G01N33/566
CPC分类号： C07K14/7155 , A61K38/00
摘要： The present invention relates to an IL-2 receptor .gamma. chain molecule, a DNA-sequence encoding the IL-2 receptor .gamma. chain molecule, a vector possessing said DNA-sequence, a cell transformed with said vector, a method for the production of an IL-2 receptor .gamma. chain molecule by culturing of said cell, an immune response regulatory agent comprising an IL-2 receptor .gamma. chain molecule and an antibody to an IL-2 receptor .gamma. chain molecule.
摘要翻译：本发明涉及IL-2受体γ链分子，编码IL-2受体γ链分子的DNA序列，具有所述DNA序列的载体，用所述载体转化的细胞，生产 IL-2受体γ链分子通过培养所述细胞，包含IL-2受体γ链分子和针对IL-2受体γ链分子的抗体的免疫应答调节剂。

3. 发明授权

US5705608A Human IL-2 receptor .gamma. chain molecule 失效
公开(公告)号：US5705608A
公开(公告)日：1998-01-06
申请号：US595974
申请日：1996-02-06
申请人： Kazuo Sugamura , Toshikazu Takeshita , Hironobu Asao , Masataka Nakamura , Toshiro Shimamura , Manabu Suzuki , Junji Hamuro
发明人： Kazuo Sugamura , Toshikazu Takeshita , Hironobu Asao , Masataka Nakamura , Toshiro Shimamura , Manabu Suzuki , Junji Hamuro
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61P37/00 , C07K1/20 , C07K1/22 , C07K14/705 , C07K14/715 , C07K16/00 , C07K16/28 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/577 , C07K1/00
CPC分类号： C07K14/7155 , A61K38/00
摘要： The present invention relates to an IL-2 receptor .gamma. chain molecule, a DNA-sequence encoding the IL-2 receptor .gamma. chain molecule, a vector possessing said DNA-sequence, a cell transformed with said vector, a method for the production of an IL-2 receptor .gamma. chain molecule by culturing of said cell, an immune response regulatory agent comprising an Il-2 receptor .gamma. chain molecule and an antibody to an IL-2 receptor .gamma. chain molecule. Both the Il-2 receptor .gamma. chain molecule and the antibody to the IL-2 receptor .gamma. chain molecule are very useful immune response regulatory agents.

4. 发明授权

US5510259A Human IL-2 receptor .gamma. chain molecule 失效
标题翻译：人IL-2受体γ链分子
公开(公告)号：US5510259A
公开(公告)日：1996-04-23
申请号：US52205
申请日：1993-04-22
申请人： Kazuo Sugamura , Toshikazu Takeshita , Hironobu Asao , Masataka Nakamura , Toshiro Shimamura , Manabu Suzuki , Junji Hamuro
发明人： Kazuo Sugamura , Toshikazu Takeshita , Hironobu Asao , Masataka Nakamura , Toshiro Shimamura , Manabu Suzuki , Junji Hamuro
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61P37/00 , C07K1/20 , C07K1/22 , C07K14/705 , C07K14/715 , C07K16/00 , C07K16/28 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/577 , C12N5/00 , C07H21/04 , C12N15/00
CPC分类号： C07K14/7155 , A61K38/00
摘要： The present invention relates to an IL-2 receptor .gamma. chain molecule, a DNA-sequence encoding the IL-2 receptor .gamma. chain molecule, a vector possessing said DNA-sequence, a cell transformed with said vector, a method for the production of an IL-2 receptor .gamma. chain molecule by culturing of said cell, an immune response regulatory agent comprising an Il-2 receptor .gamma. chain molecule and an antibody to an IL-2 receptor .gamma. chain molecule.Both the Il-2 receptor .gamma. chain molecule and the antibody to the IL-2 receptor .gamma. chain molecule are very useful immune response regulatory agents.
摘要翻译：本发明涉及IL-2受体γ链分子，编码IL-2受体γ链分子的DNA序列，具有所述DNA序列的载体，用所述载体转化的细胞，生产 IL-2受体γ链分子通过培养所述细胞，包含Il-2受体γ链分子和针对IL-2受体γ链分子的抗体的免疫应答调节剂。 IL-2受体γ链分子和IL-2受体γ链分子的抗体都是非常有用的免疫应答调节剂。

5. 发明授权

US10591749B2 Medical device, combination of coating solutions, and method for producing medical device 有权
公开(公告)号：US10591749B2
公开(公告)日：2020-03-17
申请号：US14238010
申请日：2012-08-10
申请人： Masataka Nakamura , Rumiko Kitagawa , Ryuta Tamiya
发明人： Masataka Nakamura , Rumiko Kitagawa , Ryuta Tamiya
IPC分类号： G02C7/04 , A61L27/52 , A61L27/34 , A61L27/18 , A61L27/50 , G02C7/16 , B29D11/00 , G02B1/04
摘要： Disclosed is a medical device having an elastic modulus of 100 kPa or more and 2,000 kPa or less, a water content of 10% by mass or less, a tensile elongation of 50% or more and 3,000% or less, and a dynamic contact angle (advancing angle) relative to a borate buffer of 80° or less. The present invention can significantly reduce or avoid a phenomenon of adhesion to a surface when contacted with a surface outside or inside the body, which has hitherto been regarded as a problem in a conventional medical device.

6. 发明授权

US09377562B2 Medical device, and method for producing same 有权
标题翻译：医疗器械及其制造方法
公开(公告)号：US09377562B2
公开(公告)日：2016-06-28
申请号：US14239074
申请日：2012-08-14
申请人： Kazuhiko Fujisawa , Rumiko Kitagawa , Masataka Nakamura
发明人： Kazuhiko Fujisawa , Rumiko Kitagawa , Masataka Nakamura
IPC分类号： G02C7/00 , A61L33/00 , A61K6/08 , G02B1/04 , A61L27/18 , A61L27/34 , A61L27/50 , A61L27/52 , B29D11/00 , G02C7/04 , G02B1/18
CPC分类号： G02B1/043 , A61L27/18 , A61L27/34 , A61L27/50 , A61L27/52 , A61L2400/10 , A61L2420/06 , A61L2430/16 , B29D11/00038 , B29D11/00865 , G02B1/18 , G02C7/04 , C08L33/00 , C08L83/04
摘要： A medical device includes a layer made of an acidic polymer and a basic polymer formed on at least a part of a surface of a base material, wherein at least one kind of an acidic polymer and a basic polymer forming the layers made of the acidic polymer and the basic polymer is a multi-component copolymer of three or more components.
摘要翻译：医疗装置包括由酸性聚合物制成的层和形成在基材表面的至少一部分上的碱性聚合物，其中至少一种酸性聚合物和形成由酸性聚合物制成的层的碱性聚合物碱性聚合物是三种以上成分的多组分共聚物。

7. 发明申请

US20140285765A1 MEDICAL DEVICE AND METHOD FOR PRODUCING SAME 有权
标题翻译：医疗装置及其制造方法
公开(公告)号：US20140285765A1
公开(公告)日：2014-09-25
申请号：US14239075
申请日：2012-08-14
申请人： Kazuhiko Fujisawa , Rumiko Kitagawa , Masataka Nakamura
发明人： Kazuhiko Fujisawa , Rumiko Kitagawa , Masataka Nakamura
IPC分类号： G02C7/04 , B29D11/00
CPC分类号： G02C7/049 , A61F2/14 , A61F2/16 , A61L27/18 , A61L27/34 , A61L27/50 , A61L27/52 , A61L2400/10 , A61L2420/06 , A61L2430/16 , B29D11/00038 , B29D11/00067 , G02B1/18 , G02C7/04 , C08L83/04 , C08L33/00
摘要： A medical device includes a layer made of an acidic polymer and a basic polymer formed on at least a part of a surface of a water-containing base material, wherein at least one kind of an acidic polymer and a basic polymer forming the acidic polymer or the basic polymer is a polymer having a hydroxy group.
摘要翻译：医疗装置包括在含水基材的表面的至少一部分上形成的由酸性聚合物和碱性聚合物构成的层，其中，至少一种酸性聚合物和形成酸性聚合物的碱性聚合物或碱性聚合物是具有羟基的聚合物。

8. 发明授权

US08771749B2 Stable bicarbonate ion-containing drug solution 有权
标题翻译：稳定的含碳酸氢根离子的药物溶液
公开(公告)号：US08771749B2
公开(公告)日：2014-07-08
申请号：US12680857
申请日：2008-10-06
申请人： Shigeto Oda , Tomohito Sadahiro , Masataka Nakamura , Syuichi Tanaka , Shogo Tokuoka , Hiroya Otani
发明人： Shigeto Oda , Tomohito Sadahiro , Masataka Nakamura , Syuichi Tanaka , Shogo Tokuoka , Hiroya Otani
IPC分类号： C09K3/00 , B65D25/08 , B65D25/04
CPC分类号： A61K33/42 , A61K9/0019 , A61K9/08 , A61K31/7004 , A61K33/06 , A61K33/10 , A61K33/14 , A61K45/06 , A61K47/02 , A61K47/26 , A61M1/1654 , B65D81/3261 , A61K2300/00
摘要： The invention relates to a stable bicarbonate ion-containing drug solution, particularly a bicarbonate-containing drug solution for dialysis in which the stability has been improved by the presence of a phosphate ion. Further, the invention relates to a drug solution for acute blood purification, particularly a dialysate and a substitution liquid for acute blood purification to be mixed before use containing the drug solution. Still further, the invention relates to a dialysate and a substitution liquid for acute blood purification to be mixed before use in which the formation of insoluble fine particles or precipitates is prevented for a long time after mixing and with which hypokalemeia and hypophosphatemia are not caused.
摘要翻译：本发明涉及一种稳定的含碳酸氢根离子的药物溶液，特别是一种用于透析的含碳酸氢盐的药物溶液，其中稳定性已通过存在磷酸根离子而得到改善。此外，本发明涉及用于急性血液净化的药物溶液，特别是在含有药物溶液的使用前混合的透析液和急性血液净化用替代液。此外，本发明涉及一种透析液和用于急性血液净化的替代液体，其在使用之前混合，其中混合后长时间防止形成不溶性细颗粒或沉淀物，并且不引起低钾血症和低血糖症。

9. 发明授权

US08637589B2 Silicone prepolymer solutions 有权
标题翻译：硅氧烷预聚物溶液
公开(公告)号：US08637589B2
公开(公告)日：2014-01-28
申请号：US12962575
申请日：2010-12-07
申请人： Kazuhiko Fujisawa , Mitsuru Yokota , Masataka Nakamura
发明人： Kazuhiko Fujisawa , Mitsuru Yokota , Masataka Nakamura
IPC分类号： G02B1/04
CPC分类号： C08F230/08 , C08K5/06 , C08L39/06 , G02B1/043 , C08L43/04
摘要： In one aspect, the invention relates to silicone prepolymer compositions comprising a silicone prepolymer and a solvent. A soluble silicone prepolymer can be provided having increased average silicon content, thereby attaining a desired oxygen permeability. A solvent can be provided with a desired balance between hydrophilicity and hydrophobicity by selection and modification of the solvent molecular structure, resulting in molded polymer films and articles that exhibit minimal or nonexistent eye irritation and exhibit highly transparent products. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译：一方面，本发明涉及包含硅氧烷预聚物和溶剂的硅氧烷预聚物组合物。可以提供具有增加的平均硅含量的可溶性硅氧烷预聚物，从而获得所需的氧渗透性。通过选择和改变溶剂分子结构，可以提供亲水性和疏水性之间的所需平衡的溶剂，导致模制的聚合物膜和表现出极少的或不存在的眼睛刺激并且表现出高度透明的产品的制品。该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。

10. 发明申请

US20110077322A1 Silicone Prepolymer Solutions 有权
标题翻译：硅酮预聚物解决方案
公开(公告)号：US20110077322A1
公开(公告)日：2011-03-31
申请号：US12962575
申请日：2010-12-07
申请人： Kazuhiko Fujisawa , Mitsuru Yokota , Masataka Nakamura
发明人： Kazuhiko Fujisawa , Mitsuru Yokota , Masataka Nakamura
IPC分类号： G02B1/04
CPC分类号： C08F230/08 , C08K5/06 , C08L39/06 , G02B1/043 , C08L43/04
摘要： In one aspect, the invention relates to silicone prepolymer compositions comprising a silicone prepolymer and a solvent. A soluble silicone prepolymer can be provided having increased average silicon content, thereby attaining a desired oxygen permeability. A solvent can be provided with a desired balance between hydrophilicity and hydrophobicity by selection and modification of the solvent molecular structure, resulting in molded polymer films and articles that exhibit minimal or nonexistent eye irritation and exhibit highly transparent products. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译：一方面，本发明涉及包含硅氧烷预聚物和溶剂的硅氧烷预聚物组合物。可以提供具有增加的平均硅含量的可溶性硅氧烷预聚物，从而获得所需的氧渗透性。通过选择和改变溶剂分子结构，可以提供亲水性和疏水性之间的所需平衡的溶剂，导致模制的聚合物膜和表现出极少的或不存在的眼睛刺激并且表现出高度透明的产品的制品。该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。

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